Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 43 Reviews
8.5
Supplement Facts
Serving Size: 1 drop (0.028 ml or 0.001 fl oz)
Serving Per Container: 90
Amount Per Serving
%DV
Vitamin D3 (Cholecalciferol)
10 mcg (400 IU)
100%

Top Medical Research Studies

8
Vitamin D3 impacts allergy severity
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.

Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.

Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.

Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.

Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.

Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.

Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.

In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More

Most Useful Reviews

9
No allergies
586 people found this helpful
Good day. Today, I'm reviewing liquid vitamin D3 for children. I liked these vitamins. The quality is good, and they caused no allergies. The dispenser is convenient, and the composition includes only vitamin D and coconut oil. The packaging is nice, and the size is small. The taste and smell are neutral, which is perfect for children. I recommend these vitamins for maintaining your child's immunity.
Read More
9
No allergies
26 people found this helpful
This natural vitamin D oil solution does not affect sleep and has a pure composition. I noticed results almost immediately. I recommend it as it does not cause allergies.
Read More
7.5
No allergies
9 people found this helpful
This working vitamin D was a great alternative. I previously used aquadetry, which caused allergies and had no effects. After using this product, my child's conditions improved rapidly, and I gave just 1-2 drops.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
  • All Researches
8
Vitamin D3 may support asthma treatment
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.

Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.

However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.

Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Read More
8
Vitamin D3 impacts allergy severity
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.

Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.

Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.

Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.

Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.

Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.

Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.

In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.

Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.

Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.

Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Read More

User Reviews

USERS' SCORE
Good
Based on 43 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
No allergies
586 people found this helpful
Good day. Today, I'm reviewing liquid vitamin D3 for children. I liked these vitamins. The quality is good, and they caused no allergies. The dispenser is convenient, and the composition includes only vitamin D and coconut oil. The packaging is nice, and the size is small. The taste and smell are neutral, which is perfect for children. I recommend these vitamins for maintaining your child's immunity.
Read More
9
No allergies
26 people found this helpful
This natural vitamin D oil solution does not affect sleep and has a pure composition. I noticed results almost immediately. I recommend it as it does not cause allergies.
Read More
7.5
No allergies
9 people found this helpful
This working vitamin D was a great alternative. I previously used aquadetry, which caused allergies and had no effects. After using this product, my child's conditions improved rapidly, and I gave just 1-2 drops.
Read More
9
No allergies
8 people found this helpful
I had a terrible experience with aquadetrim due to allergies. However, these drops are fantastic. My baby takes them without noticing—they're tasteless. Since starting them, I’ve noticed improvements in hair growth, and thankfully, there have been no allergies yet.
Read More
9
No allergies
6 people found this helpful
This vitamin D3 for kids is excellent! Its benefits are immense, enhancing calcium absorption and bone health. It’s tasty and convenient to take, with no allergies reported.
Read More

Frequently Asked Questions

9
No allergies
26 people found this helpful
This natural vitamin D oil solution does not affect sleep and has a pure composition. I noticed results almost immediately. I recommend it as it does not cause allergies.
9
No allergies
6 people found this helpful
I'm very pleased! The results were noticeable right away; my child’s bones grew stronger, and they were happy to take it without any colic or allergies. It's been a smooth process.
9
No allergies
3 people found this helpful
I like these vitamins. No allergies have occurred. After three weeks, I noticed my child's hair began to grow. I’ll continue to order them.
9
No allergies
5 people found this helpful
This vitamin is wonderful! Living on the first floor, my child had rickety physique and weak hair. After trying this, their hair grew significantly, and they've become more active, with no allergies.
9
No allergies
586 people found this helpful
Good day. Today, I'm reviewing liquid vitamin D3 for children. I liked these vitamins. The quality is good, and they caused no allergies. The dispenser is convenient, and the composition includes only vitamin D and coconut oil. The packaging is nice, and the size is small. The taste and smell are neutral, which is perfect for children. I recommend these vitamins for maintaining your child's immunity.
7.5
No allergies
9 people found this helpful
This working vitamin D was a great alternative. I previously used aquadetry, which caused allergies and had no effects. After using this product, my child's conditions improved rapidly, and I gave just 1-2 drops.
0
Watch for rashes
4 people found this helpful
Be cautious; my child developed a rash after starting vitamin D, which we thought was serious, but after stopping it, the rash subsided. There were no other allergy symptoms.
9
No allergies
5 people found this helpful
D3 is essential for children from birth, aiding various body systems and the immune system. Due to limited sunny days, I give it to my child, and it’s well-tolerated. No allergies have been observed, making it a staple in our routine.
9
Safe for allergies
1 people found this helpful
Ideal for toddlers. One drop contains 400 IU of vitamin D3, without taste or smell. It doesn't cause adverse reactions or affect sleep. This patented drug is perfect for babies under one, especially those with allergies.
9
No allergies
8 people found this helpful
I had a terrible experience with aquadetrim due to allergies. However, these drops are fantastic. My baby takes them without noticing—they're tasteless. Since starting them, I’ve noticed improvements in hair growth, and thankfully, there have been no allergies yet.
10
Good for allergies
Great for kids with various allergies; it works well.
7
Vitamin D3 reduces allergy cytokines
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.

Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.

Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.

Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
8
Vitamin D3 impacts allergy severity
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.

Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.

Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
7
Vitamin D3 may reduce eczema risk
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.

Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.

In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.

References

  1. Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
  2. Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis. J Immunol. 2024;213:831. doi:10.4049/jimmunol.2400078
  3. Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
  4. Al-Allaff RGM, Bakr Al-Sawaf TM. Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis. Pak J Biol Sci. 2024;27:27. doi:10.3923/pjbs.2024.27.34
  5. Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. doi:10.2174/0127722708281623240116100806
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