Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
USERS' SCORE
Good
Based on 15 Reviews
8.6
Supplement Facts
Serving Size: 3 capsules
Amount Per Serving
%DV
Quercetin
600 mg
*
Nettle Extract (Urtica dioica)(leaf)
600 mg
*
Top Medical Research Studies
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
8
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Read More
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
Most Useful Reviews
9
Breathing easy
48 people found this helpful
IT WORKS! I suffer from allergies and sinusitis year-round, relying on over-the-counter medications daily. Concerned about the long-term effects of drugs, I was pleasantly surprised that this past week has been one of my best since using this product without any medication. My breathing is now unencumbered and free-flowing. There’s only a hint of watery eyes, but otherwise, this experience has been a blessing. I highly recommend this product to fellow sufferers; it truly works!
Read More
9
Pollen relief
22 people found this helpful
A blessing! This spring, I experienced the worst hay fever since moving here. I used to rely on antihistamines to manage symptoms, but after trying a quercetin/nettle combination, I became almost symptom-free. I used to struggle with burning eyes, sleeplessness, and severe itchiness. A neighbour who took the same supplement found relief from his strong antihistamines too. While not everyone may have the same results, it has worked wonders for both of us.
Read More
9
Seasonal control
16 people found this helpful
These capsules could give you your life back! This is my third summer taking them, and they have made a world of difference for my seasonal allergies. I still experience an itchy roof of my mouth, but I no longer suffer from itchy, watery eyes, a runny nose, or continuous sneezing. It's a histamine blocker and immune system builder that should be taken at the start of allergy season, before symptoms commence. This product really works!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
- All Researches
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Read More
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Read More
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
9
Holo-BLG offers allergy protection
We investigated how the milk protein beta-lactoglobulin (BLG), particularly its holo form, could shield against pollen allergies. In our study, BALB/c mice received nasal pretreatments with holo-BLG containing quercetin-iron complexes before being exposed to birch pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Breathing easy
48 people found this helpful
IT WORKS! I suffer from allergies and sinusitis year-round, relying on over-the-counter medications daily. Concerned about the long-term effects of drugs, I was pleasantly surprised that this past week has been one of my best since using this product without any medication. My breathing is now unencumbered and free-flowing. There’s only a hint of watery eyes, but otherwise, this experience has been a blessing. I highly recommend this product to fellow sufferers; it truly works!
Read More
9
Pollen relief
22 people found this helpful
A blessing! This spring, I experienced the worst hay fever since moving here. I used to rely on antihistamines to manage symptoms, but after trying a quercetin/nettle combination, I became almost symptom-free. I used to struggle with burning eyes, sleeplessness, and severe itchiness. A neighbour who took the same supplement found relief from his strong antihistamines too. While not everyone may have the same results, it has worked wonders for both of us.
Read More
9
Seasonal control
16 people found this helpful
These capsules could give you your life back! This is my third summer taking them, and they have made a world of difference for my seasonal allergies. I still experience an itchy roof of my mouth, but I no longer suffer from itchy, watery eyes, a runny nose, or continuous sneezing. It's a histamine blocker and immune system builder that should be taken at the start of allergy season, before symptoms commence. This product really works!
Read More
10
Effective solution
8 people found this helpful
Allergy herbal solution that actually works! Allergies are the worst, but this brand of nettles and quercetin works incredibly well. In times when sneezing can get you kicked out of a shop, controlling allergy symptoms is essential, and this does the job effectively.
Read More
9
Super effective
7 people found this helpful
This works. This product is super effective in controlling allergies.
Read More
Frequently Asked Questions
7.5
Helps during allergy season
Great quality. I usually take one at night before bed during allergy season, and it truly helps.
9
Great allergy suppressor
Good for allergies. I bought it as it was recommended for allergies, and the quercetin seems to have excellent allergy-suppressing properties. The quality is very good.
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
7
We investigated how quercetin works alongside fucoidan to help manage allergies, particularly type I hypersensitivity like hay fever. Our findings showed that when quercetin was taken together with fucoidan, even lower amounts could still provide significant anti-allergic effects.
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
References
- Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. 10.1016/j.compbiomed.2025.109754
- Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. 10.3746/pnf.2025.30.1.68
- Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. 10.3390/cells12222602
- Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. 10.3390/ijms232012163
- Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. 10.26355/eurrev_202206_29072
- Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. 10.3389/fimmu.2021.611474
- Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. 10.1016/j.intimp.2018.11.025
- Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. 10.3390/ijms19092652
- Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. 10.1007/s10616-017-0129-9
- Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. 10.1021/jf405486c
- Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
- Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. 10.1007/s00011-009-0039-1
- Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. 10.1016/j.intimp.2008.07.006
- Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
- Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
