Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size:  1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*

Top Medical Research Studies

9.5
We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.

Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.

Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
Read More
8
Omega-3s reduce headache frequency
We conducted a randomized controlled trial to explore whether increasing omega-3 fatty acids would help reduce headaches in adults suffering from migraines.

Over 16 weeks, 182 participants followed three different dietary plans focusing on varying levels of omega-3s while monitoring headache impact.

Though the diets with higher omega-3 levels did show a reduction in headache frequency and severity, they didn't significantly improve overall quality of life. This suggests that omega-3s may help with headaches but not enhance daily functioning.
Read More
8
Omega-3 fish oil reduces headaches
We explored the effects of a 12-week omega-3 fish oil supplement, Omega3Q10, among older adults dealing with high blood pressure and cholesterol. The study included 97 participants, who were split between the omega-3 group and a control group receiving soybean oil.

While both groups saw improvements in cholesterol levels, those taking Omega3Q10 experienced greater benefits in managing blood pressure and reported fewer headaches. An impressive 95.5% of omega-3 participants were headache-free after the trial, compared to just 71.4% in the soybean oil group.

This suggests that omega-3 fish oil may be a valuable addition for older adults looking to improve both heart health and reduce headache symptoms.
Read More

Most Useful Reviews

9
Headache relief
1 people found this helpful
I used to prefer animal omega, but it didn't suit me. This omega combined with 5-htp interestingly alleviated my headache. The price-quality ratio is satisfactory.
Read More
9
Headache improvement
The quality is excellent. This vegetarian omega-3 is better than fish oil for me. It has helped alleviate my headaches, and the taste is acceptable.
Read More
9
Great alternative
Finally, I've found a good vegan omega! Unlike fish oil, which causes headaches and heartburn, this product is a fantastic alternative. The only downside is it goes out of stock quickly.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
  • All Researches
9.5
We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.

Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.

Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
Read More
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.

Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.

This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Read More
9
Omega-3 diet improves headaches
We examined how adjusting omega-3 and omega-6 fatty acids influences chronic headaches and overall well-being. In a randomized trial with 67 participants suffering from severe headaches, those who increased omega-3 intake while decreasing omega-6 saw significant improvements in their headaches and reductions in psychological distress.

Over 12 weeks, participants in this dietary intervention reported better mental and physical health, which also helped decrease the number of headache days. Overall, this approach not only targets headache relief but also enhances quality of life.
Read More
8
Omega-3s reduce headache frequency
We conducted a randomized controlled trial to explore whether increasing omega-3 fatty acids would help reduce headaches in adults suffering from migraines.

Over 16 weeks, 182 participants followed three different dietary plans focusing on varying levels of omega-3s while monitoring headache impact.

Though the diets with higher omega-3 levels did show a reduction in headache frequency and severity, they didn't significantly improve overall quality of life. This suggests that omega-3s may help with headaches but not enhance daily functioning.
Read More
8
Omega-3 fish oil reduces headaches
We explored the effects of a 12-week omega-3 fish oil supplement, Omega3Q10, among older adults dealing with high blood pressure and cholesterol. The study included 97 participants, who were split between the omega-3 group and a control group receiving soybean oil.

While both groups saw improvements in cholesterol levels, those taking Omega3Q10 experienced greater benefits in managing blood pressure and reported fewer headaches. An impressive 95.5% of omega-3 participants were headache-free after the trial, compared to just 71.4% in the soybean oil group.

This suggests that omega-3 fish oil may be a valuable addition for older adults looking to improve both heart health and reduce headache symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 5 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Headache relief
1 people found this helpful
I used to prefer animal omega, but it didn't suit me. This omega combined with 5-htp interestingly alleviated my headache. The price-quality ratio is satisfactory.
Read More
9
Headache improvement
The quality is excellent. This vegetarian omega-3 is better than fish oil for me. It has helped alleviate my headaches, and the taste is acceptable.
Read More
9
Great alternative
Finally, I've found a good vegan omega! Unlike fish oil, which causes headaches and heartburn, this product is a fantastic alternative. The only downside is it goes out of stock quickly.
Read More
9
Effective against headaches
This distinctive product is suitable for vegetarians, with an acceptable taste and price. After using this omega, my wife's headaches disappeared, so I will order more in the future.
Read More
7.5
Headaches reduced
1 people found this helpful
Wonderful. Although I am not vegan, I like this omega oil. It does not give me a headache like other omegas and the softgels are a manageable size for the kids.
Read More

Frequently Asked Questions

9
Effective against headaches
This distinctive product is suitable for vegetarians, with an acceptable taste and price. After using this omega, my wife's headaches disappeared, so I will order more in the future.
9
Great alternative
Finally, I've found a good vegan omega! Unlike fish oil, which causes headaches and heartburn, this product is a fantastic alternative. The only downside is it goes out of stock quickly.
9
Headache relief
1 people found this helpful
I used to prefer animal omega, but it didn't suit me. This omega combined with 5-htp interestingly alleviated my headache. The price-quality ratio is satisfactory.
7
EPA supplementation may reduce migraines
We conducted a randomized, placebo-controlled trial to explore the effects of daily 2000 mg of eicosapentaenoic acid (EPA) on chronic migraines. Over 8 weeks, participants recorded their headache symptoms, with some taking EPA and others receiving a placebo.

Our findings suggest that EPA may significantly reduce the frequency of migraine attacks and improve overall quality of life for chronic migraine sufferers. However, we believe that more research is needed for a clearer understanding of its benefits and dosage.
9.5
We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.

Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.

Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
8
Omega-3 diet improves headache relief
We explored how modifying our diet to increase omega-3 fatty acids while decreasing omega-6 can impact headache pain. In a study involving 55 chronic headache patients, we found that this dietary approach significantly boosted beneficial omega-3-derived compounds in the bloodstream and reduced harmful omega-6 derivatives.

These changes were closely linked to notable improvements in headache intensity and psychological well-being. Ultimately, our findings suggest that adjusting our intake of these fatty acids may offer a valuable method for alleviating chronic headaches and improving overall mental health.
This cross-sectional study explored whether eating more long-chain omega-3 fatty acids could help reduce headaches in the U.S. population.

We analyzed data from over 12,000 adults, looking at their reported headaches and dietary intake of omega-3s like EPA and DHA.

Our findings showed that higher intake of these omega-3 fats was linked to a lower chance of experiencing severe headaches or migraines, especially among non-Mexican Hispanics. This suggests that omega-3 fatty acids could play a role in headache prevention.
8
Omega-3s reduce headache frequency
We conducted a randomized controlled trial to explore whether increasing omega-3 fatty acids would help reduce headaches in adults suffering from migraines.

Over 16 weeks, 182 participants followed three different dietary plans focusing on varying levels of omega-3s while monitoring headache impact.

Though the diets with higher omega-3 levels did show a reduction in headache frequency and severity, they didn't significantly improve overall quality of life. This suggests that omega-3s may help with headaches but not enhance daily functioning.

References

  1. Yeh EL, Yang CP, Lin SW, Wang HF. Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients. Brain Behav. 2024;14:e70149. doi:10.1002/brb3.70149
  2. Mohammadnezhad G, Assarzadegan F, Koosha M, Esmaily H. Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial. Headache. 2025;65:153. doi:10.1111/head.14808
  3. Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019
  4. Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. doi:10.1016/j.jpain.2022.10.008
  5. Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. doi:10.1016/j.cct.2022.106851
  6. Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. doi:10.1136/bmj.n1448
  7. Honarvar NM, Soveid N, Abdolahi M, Djalali M, Hatami M, et al. Anti-Neuroinflammatory Properties of n-3 Fatty Acids and Nano- Curcumin on Migraine Patients from Cellular to Clinical Insight: A Randomized, Double-Blind and Placebo-Controlled Trial. Endocr Metab Immune Disord Drug Targets. 2021;21:365. doi:10.2174/1871530320666200729144430
  8. Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, et al. The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Endocr Metab Immune Disord Drug Targets. 2019;19:874. doi:10.2174/1871530319666190212170140
  9. Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. doi:10.1016/j.plefa.2018.06.008
  10. Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. doi:10.1016/j.plefa.2017.11.002
  11. Shen T, Xing G, Zhu J, Zhang S, Cai Y, et al. Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol. Lipids Health Dis. 2017;16:253. doi:10.1186/s12944-017-0617-0
  12. Soveyd N, Abdolahi M, Djalali M, Hatami M, Tafakhori A, et al. The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients. CNS Neurol Disord Drug Targets. 2018;16:1120. doi:10.2174/1871527317666171213154749
  13. Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, et al. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017;69:371. doi:10.1007/s00251-017-0992-8
  14. Soares AA, Louçana PMC, Nasi EP, Sousa KMH, Sá OMS, et al. A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline. Nutr Neurosci. 2018;21:219. doi:10.1080/1028415X.2016.1266133
  15. Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. doi:10.1016/j.jpain.2015.04.007
  16. Ramsden CE, Faurot KR, Zamora D, Palsson OS, MacIntosh BA, et al. Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysis of a randomized trial. Pain. 2015;156:587. doi:10.1097/01.j.pain.0000460348.84965.47
  17. Domenichiello AF, Jensen JR, Zamora D, Horowitz M, Yuan ZX, et al. Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache. Pain. 2020;161:2775. doi:10.1097/j.pain.0000000000001983
  18. Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
  19. Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. doi:10.1016/j.pain.2013.07.028
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