Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
The product is found useful for the following medical conditions
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
10
Dizziness is gone
Most Useful Review
3 people found this helpful
I was anaemic before taking Vegan B12 with folic acid & B6. I frequently felt dizzy, resembling vertigo. After taking one tablet daily alongside Vit B complex, my dizziness diminished. Now, one month later, my dizziness has completely disappeared. Excellent recovery! My hair also no longer falls out easily. Thank you very much.
Updated: Mar 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
9
Effective treatment
Most Useful Review
1 people found this helpful
I received a recommendation to order this product during my first visit to the reproductologist. Tests indicated a tendency towards folic acid deficiency and elevated homocysteine levels. After a month of taking the product, my indicators improved significantly and were adjusted to the desired limits. Conclusion: this product is effective, and I plan to continue taking it regularly.
Updated: Mar 2026
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 9 Reviews
8.5
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
9
Relief from pain
Most Useful Review
10 people found this helpful
I highly recommend it. After exercising, I often feel tired and experience bone pain. Taking this product helps me recover, and I feel fine by the next day. My mother also uses it for her hands, which often hurt from cleaning and cooking. After taking a pill, she wakes up pain-free the next day. I was advised by a doctor to use it, as it has numerous benefits, including energy restoration and relief from bone pain.
Updated: Mar 2026
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Vitamin B6 and cardiac health
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
9
Reduced tension
Most Useful Review
3 people found this helpful
The product is excellent. I experienced chest pain and muscle tension due to Vitamin B12 deficiency, but after using this product for two days, the tension significantly eased. I continued for ten days and stopped when symptoms improved. The quality is great, and the taste is pleasant, with ample packaging lasting a long time, used only during symptoms for better health 🌹.
Updated: Apr 2025
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Improved B12 levels
Most Useful Review
In the spring of last year, my tests revealed low B12 levels, and my doctor advised me to take vitamin B12 along with folic acid and vitamin B6. I took the supplements for three months, paused for a month, and then continued for another three months. My B12 values have significantly improved and are nearly at the optimal level. I hope they return to normal.
Updated: Apr 2025
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
9
Normalised back pain
Most Useful Review
I've been pleased with this B12 product, which has helped normalise my low B12 levels and subsequently reduced my back pain.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
9
Normalises heart function
Most Useful Review
Easy to take; the tablets dissolve quickly with a lovely aftertaste. This supplement benefits the heart and blood vessels, and seems to have normalised my menstrual cycle, making it more manageable.
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
7.5
Cost-effective solution
Most Useful Review
4 people found this helpful
Excellent cost and service! I bought this product from iHerb, and it arrived promptly. I love using the sublingual tablets, which dissolve quickly with a nice citrus flavour. If you have B12 deficiency, this product is highly recommended, as my blood test shows elevated levels of B12. It's worth it, lasting about three months.
Updated: Mar 2026
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
7.5
Relieved tension
Most Useful Review
3 people found this helpful
The product is excellent. I initially suffered from knee pain alongside symptoms of Vitamin B12 deficiency, such as joint discomfort and muscle tension. After using this product for just two days, it alleviated much of the tension. I used it for ten days and found great improvement. The quality is superb, with a pleasant sweet taste, and the packaging lasts a long time since it’s only needed during symptom flare-ups. Overall, I experienced significant health benefits.
Updated: Apr 2025
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.1
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
7
Effective for allergies
Most Useful Review
1 people found this helpful
I absolutely love this Vitamin B12; it melts effortlessly under the tongue and has a lovely taste! When combined with B complex, it provides that essential energy boost. I've also realised that it assists me with my seasonal allergies.
Updated: Apr 2026
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.1
7.5
Helps leg cramps
Most Useful Review
2 people found this helpful
A good balance of vitamins. It has helped my mum with her leg cramps and varicose veins. We buy it regularly and it's suitable for vegetarians and vegans.
Updated: Apr 2026
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.9
USERS' SCORE
Good
Based on 23 Reviews
8
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
8
Calmer emotions
Most Useful Review
18 people found this helpful
B12 is essential for maintaining good iron stores, and its active form is well absorbed. I noticed that low B12 can lead to irritability and aggression, so I supplement with B vitamins, especially B12 and magnesium glycinate, which helps me feel calmer and reduces anxiety. I find that B vitamins are a necessity for me. Although this product includes inactive forms of B6 and folic acid, its effectiveness for hair health is excellent. The tablets taste unpleasant but dissolve quickly.
Updated: Apr 2026
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
9
Depression relief
Most Useful Review
My depression is gone.
Updated: Apr 2026
Data last updated:
