Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size:  1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%

Top Medical Research Studies

8
Vitamin B6 and cardiac health
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.

Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.

While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Read More
8
Folic acid improves angina symptoms
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.

Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.

Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Read More
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.

Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.

This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Read More

Most Useful Reviews

9
Reduced tension
3 people found this helpful
The product is excellent. I experienced chest pain and muscle tension due to Vitamin B12 deficiency, but after using this product for two days, the tension significantly eased. I continued for ten days and stopped when symptoms improved. The quality is great, and the taste is pleasant, with ample packaging lasting a long time, used only during symptoms for better health 🌹.
Read More
9
Improved heart function
2 people found this helpful
This is a superb product! B vitamins assist in reducing cholesterol, aid digestion, and support the metabolism of proteins, fats, and carbohydrates. They help heal wounds faster and normalise heart function, leading to less chest pain. Daily intake of B vitamins is vital, as they are water-soluble and need to be replenished regularly.
Read More
9
Chest pain relief
I experienced chest pain in my feet, which subsided after about three days of using this product. It worked effectively in alleviating my discomfort.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
  • All Researches
9.5
Pernicious anemia and thromboembolism
We explored a case involving a 46-year-old woman who experienced chest pain and hemoptysis, leading to the discovery of a pulmonary thromboembolism. Upon further evaluation, we found that her homocysteine levels were high and that she had low vitamin B12 and iron levels due to pernicious anemia.

Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.

Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.

In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Read More
9.5
Vitamin B12 not isolated in study
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.

In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.

Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
We examined the connection between vitamin B6 treatment and the management of chest pain linked to pulmonary thromboembolism. Our study included two young male patients diagnosed with protein C and protein S deficiencies, known contributors to blood clot formation.

The patients experienced notable symptoms such as chest pain along with pain in their lower limbs. After thorough assessments, which included color Doppler flow imaging and CT angiography, we discovered that both patients had deep vein thrombosis and pulmonary embolism.

Upon diagnosing their conditions, vitamin B6 was incorporated into their treatment plan alongside standard anticoagulant therapies. Following this addition, we observed significant symptom improvement. However, it is essential to highlight that while vitamin B6 may enhance treatment outcomes, its isolated effect on chest pain is not conclusively established within the scope of our findings.

We should consider the possibility of congenital thrombophilia in young individuals suffering recurrent venous thrombotic events. Monitoring plasma levels of protein C and S remains crucial for proper diagnosis and treatment. Overall, the findings suggest potential benefits from vitamin B6 in assisting with symptom relief in specific contexts, although more research would be beneficial to fully understand its role in managing chest pain.
Read More
8
Vitamin B6 and cardiac health
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.

Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.

While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Read More
8
Folic acid improves angina symptoms
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.

Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.

Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced tension
3 people found this helpful
The product is excellent. I experienced chest pain and muscle tension due to Vitamin B12 deficiency, but after using this product for two days, the tension significantly eased. I continued for ten days and stopped when symptoms improved. The quality is great, and the taste is pleasant, with ample packaging lasting a long time, used only during symptoms for better health 🌹.
Read More
9
Improved heart function
2 people found this helpful
This is a superb product! B vitamins assist in reducing cholesterol, aid digestion, and support the metabolism of proteins, fats, and carbohydrates. They help heal wounds faster and normalise heart function, leading to less chest pain. Daily intake of B vitamins is vital, as they are water-soluble and need to be replenished regularly.
Read More
9
Chest pain relief
I experienced chest pain in my feet, which subsided after about three days of using this product. It worked effectively in alleviating my discomfort.
Read More
7.5
Eased leg pain
3 people found this helpful
I've been using this for almost a month and noticed that while my hair loss continues, the chest pain and nerve pain in my legs have eased significantly. I recommend taking it after light meals with plenty of water. The pills are small and easy to swallow.
Read More

Frequently Asked Questions

9
Reduced tension
3 people found this helpful
The product is excellent. I experienced chest pain and muscle tension due to Vitamin B12 deficiency, but after using this product for two days, the tension significantly eased. I continued for ten days and stopped when symptoms improved. The quality is great, and the taste is pleasant, with ample packaging lasting a long time, used only during symptoms for better health 🌹.
9
Chest pain relief
I experienced chest pain in my feet, which subsided after about three days of using this product. It worked effectively in alleviating my discomfort.
7.5
Eased leg pain
3 people found this helpful
I've been using this for almost a month and noticed that while my hair loss continues, the chest pain and nerve pain in my legs have eased significantly. I recommend taking it after light meals with plenty of water. The pills are small and easy to swallow.
9
Improved heart function
2 people found this helpful
This is a superb product! B vitamins assist in reducing cholesterol, aid digestion, and support the metabolism of proteins, fats, and carbohydrates. They help heal wounds faster and normalise heart function, leading to less chest pain. Daily intake of B vitamins is vital, as they are water-soluble and need to be replenished regularly.
In our exploration of the role of vitamin B6 treatment, we investigated how it influences the risk of heart attacks in patients with stable angina and a specific genetic variant of the MTHFD1 gene. This study included a large group of 2,381 individuals and was part of a randomized trial focused on B vitamin interventions.

By following participants for nearly five years, we found that a significant number had suffered acute myocardial infarction (AMI). Remarkably, those with the MTHFD1 polymorphism showed an increased risk of AMI, especially if they were treated with vitamin B6 alone or in combination with folic acid and vitamin B12.

Although these findings raise interesting points about the relationship between vitamin B treatment and heart health, we need to note that for patients on a placebo or only folic acid/B12, the expected connection was absent. This indicates that while vitamin B6 may play a role in modifying risk for certain individuals, it doesn’t necessarily protect against chest pain linked to heart attacks universally.
We examined the connection between vitamin B6 treatment and the management of chest pain linked to pulmonary thromboembolism. Our study included two young male patients diagnosed with protein C and protein S deficiencies, known contributors to blood clot formation.

The patients experienced notable symptoms such as chest pain along with pain in their lower limbs. After thorough assessments, which included color Doppler flow imaging and CT angiography, we discovered that both patients had deep vein thrombosis and pulmonary embolism.

Upon diagnosing their conditions, vitamin B6 was incorporated into their treatment plan alongside standard anticoagulant therapies. Following this addition, we observed significant symptom improvement. However, it is essential to highlight that while vitamin B6 may enhance treatment outcomes, its isolated effect on chest pain is not conclusively established within the scope of our findings.

We should consider the possibility of congenital thrombophilia in young individuals suffering recurrent venous thrombotic events. Monitoring plasma levels of protein C and S remains crucial for proper diagnosis and treatment. Overall, the findings suggest potential benefits from vitamin B6 in assisting with symptom relief in specific contexts, although more research would be beneficial to fully understand its role in managing chest pain.
7
Vitamin B6 in chest pain study
We assessed the impact of vitamin B6 as part of a combined therapy on a patient experiencing chest pain and associated conditions. The patient, a 53-year-old woman, had stable angina and a history of unexplained miscarriages, prompting a thorough evaluation of her health issues.

During the assessment, it became clear that she had moderate hyperhomocysteinemia, which is linked to various cardiovascular and obstetrical conditions. The treatment regimen included vitamin B6 alongside folic acid and vitamin B12, aimed at lowering homocysteine levels while managing her angina.

After two months of this combined therapy, we noted a significant reduction in homocysteine levels by 28.6% and an improvement in the patient's clinical condition. However, it's essential to mention that despite these positive changes in homocysteine levels and overall health, there's still debate about the effectiveness of vitamin B6 alone in preventing future cardiovascular events.

Current literature indicates that while vitamin supplementation can help lower homocysteine, it has not yet been definitively proven to reduce the recurrence of cardiac issues. Therefore, while vitamin B6 contributed to this patient's treatment, more research is needed to determine its standalone effectiveness on chest pain.
8
Vitamin B6 and cardiac health
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.

Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.

While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.

References

  1. Ding YP, Pedersen EK, Johansson S, Gregory JF, Ueland PM, et al. B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. Nutr Metab Cardiovasc Dis. 2016;26:495. doi:10.1016/j.numecd.2015.12.009
  2. Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. doi:10.3969/j.issn.1672-7347.2013.09.018
  3. Hoţoleanu C, Chouky E. Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages. Rom J Intern Med. 2012;50:313.
  4. Benzinger P, Alscher DM. [Untreated homocystinuria in adulthood]. Dtsch Med Wochenschr. 2005;130:2439.
  5. Ellis JM, McCully KS. Prevention of myocardial infarction by vitamin B6. Res Commun Mol Pathol Pharmacol. 1995;89:208.
  6. Guo H, Chi J, Xing Y, Wang P. Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina. Indian J Med Res. 2009;129:279.
  7. Morrissey D, Sun Y, Koilpillai S, Kropf J, Carlan SJ. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Case Rep Med. 2022;2022:7306070. doi:10.1155/2022/7306070
  8. Løland KH, Bleie Ø, Strand E, Ueland PM, Nordrehaug JE, et al. Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. PLoS One. 2013;8:e70101. doi:10.1371/journal.pone.0070101
  9. Küpeli E, Cengiz C, Cila A, Karnak D. Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier. Clin Appl Thromb Hemost. 2008;14:365. doi:10.1177/1076029607305101
  10. Alroy S, Preis M, Barzilai M, Cassel A, Lavie L, et al. Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation. Isr Med Assoc J. 2007;9:321.
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