5/9/2025
Last update
5/9/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
1
Triggered migraines suspected
11 people found this helpful
After using these for a few weeks, I've had severe migraine headaches upon waking. Stopping the product reduced the headaches, leading me to suspect that one ingredient, mannitol, triggers migraines for some individuals. I'm disappointed, but my husband can try what's left.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
- All Researches
9
We investigated a unique case where a 14-year-old girl experienced prolonged headaches and nausea due to cerebral venous thrombosis linked to a rare genetic mutation. Elevated homocysteine levels were discovered during examinations, leading to anticoagulation therapy.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Read More
9
We explored the effects of vitamin B6 treatment in a unique case involving a 25-year-old man who experienced headaches and memory issues due to a specific genetic condition. This condition caused a build-up of branched-chain amino acids (BCAAs) like valine and leucine in the bloodstream, leading to neurological symptoms.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
Read More
9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
1
Triggered migraines suspected
11 people found this helpful
After using these for a few weeks, I've had severe migraine headaches upon waking. Stopping the product reduced the headaches, leading me to suspect that one ingredient, mannitol, triggers migraines for some individuals. I'm disappointed, but my husband can try what's left.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Singh J, Dinkar A, Gupta P, Atam V. Vitamin B12 deficiency in northern India tertiary care: Prevalence, risk factors and clinical characteristics. J Family Med Prim Care. 2022;11:2381. 10.4103/jfmpc.jfmpc_650_21
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15:365. 10.4103/jpn.JPN_130_19
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Sureja VP, Kheni DB, Dubey VP, Kansagra J, Soni ZK, et al. Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study. Cureus. 2023;15:e42832. 10.7759/cureus.42832
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. 10.23736/S0026-4946.19.05533-6
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. 10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Wang XL, Li CJ, Xing Y, Yang YH, Jia JP. Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene. J Inherit Metab Dis. 2015;38:855. 10.1007/s10545-015-9814-z
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Villegas-Salas E, Ponce de León R, Juárez-Perez MA, Grubb GS. Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. Contraception. 1997;55:245.
- Jarisch R, Wantke F. Wine and headache. Int Arch Allergy Immunol. 1996;110:7.
- Bernstein AL. Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990;585:250.
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. 10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. 10.1017/S000711452300137X
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
