Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
8
Vitamin B6 improves cholesterol and metabolism
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
Most Useful Reviews
7.5
Supports cholesterol management
28 people found this helpful
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
Read More
7.5
Improves cholesterol levels
6 people found this helpful
B12 in the easily digestible form of methylcobalamin is effective at speeding up metabolism and lowering high cholesterol. It also aids in nutrient synthesis and heart function. The tablets are small with a pleasant sour taste. Ideal for those over 50 to maintain cognitive function; acne may be a possible side effect.
Read More
7.5
Cost-effective solution
4 people found this helpful
Excellent cost and service! I bought this product from iHerb, and it arrived promptly. I love using the sublingual tablets, which dissolve quickly with a nice citrus flavour. If you have B12 deficiency, this product is highly recommended, as my blood test shows elevated levels of B12. It's worth it, lasting about three months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
Read More
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
9
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
Read More
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cholesterol management
28 people found this helpful
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
Read More
7.5
Improves cholesterol levels
6 people found this helpful
B12 in the easily digestible form of methylcobalamin is effective at speeding up metabolism and lowering high cholesterol. It also aids in nutrient synthesis and heart function. The tablets are small with a pleasant sour taste. Ideal for those over 50 to maintain cognitive function; acne may be a possible side effect.
Read More
7.5
Cost-effective solution
4 people found this helpful
Excellent cost and service! I bought this product from iHerb, and it arrived promptly. I love using the sublingual tablets, which dissolve quickly with a nice citrus flavour. If you have B12 deficiency, this product is highly recommended, as my blood test shows elevated levels of B12. It's worth it, lasting about three months.
Read More
7.5
Vegan-friendly supplement
1 people found this helpful
I have felt significant improvement since starting B12, particularly beneficial after over a decade of being vegan. It's effectively addressed several issues I faced, including those associated with high cholesterol.
Read More
9
Energy booster
This vitamin is very reasonably priced and easy to take. I feel considerably more energetic, making it a product I would highly recommend for those managing high cholesterol.
Read More
Frequently Asked Questions
7.5
Vegan-friendly supplement
1 people found this helpful
I have felt significant improvement since starting B12, particularly beneficial after over a decade of being vegan. It's effectively addressed several issues I faced, including those associated with high cholesterol.
9
Energy booster
This vitamin is very reasonably priced and easy to take. I feel considerably more energetic, making it a product I would highly recommend for those managing high cholesterol.
9
Beneficial for wellness
2 people found this helpful
This product is remarkable! B vitamins assist in lowering high cholesterol, enhancing digestion, and improving wound healing. By replenishing vitamins daily, I noticed better skin health too. As B vitamins are water-soluble and not stored in the body, it's essential to consume them regularly for overall well-being.
7.5
Supports cholesterol management
28 people found this helpful
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
7.5
Improves cholesterol levels
6 people found this helpful
B12 in the easily digestible form of methylcobalamin is effective at speeding up metabolism and lowering high cholesterol. It also aids in nutrient synthesis and heart function. The tablets are small with a pleasant sour taste. Ideal for those over 50 to maintain cognitive function; acne may be a possible side effect.
7
We examined a multi-ingredient supplement (MIS) featuring red yeast rice and omega-3 fatty acids to see how it impacts cholesterol levels in patients without cardiovascular disease.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
7
B12 treatment shows no significant cholesterol benefit
We explored the effects of a daily combination of plant sterols, fish oil, and B vitamins on cholesterol levels in hypercholesterolemic young individuals over 16 weeks.
While we observed significant reductions in total cholesterol and LDL cholesterol, the impact of B12 treatment specifically did not lead to marked improvements in high cholesterol.
Interestingly, triacylglycerol levels decreased slightly but were not statistically significant. Overall, this evidence suggests that while the combination may help manage cholesterol, B12 does not create a standout difference on its own.
While we observed significant reductions in total cholesterol and LDL cholesterol, the impact of B12 treatment specifically did not lead to marked improvements in high cholesterol.
Interestingly, triacylglycerol levels decreased slightly but were not statistically significant. Overall, this evidence suggests that while the combination may help manage cholesterol, B12 does not create a standout difference on its own.
8
Vitamin B6 improves cholesterol and metabolism
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
References
- Wright N, Wilson L, Smith M, Duncan B, McHugh P. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes. 2017;7:e256. doi:10.1038/nutd.2017.3
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
- Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, et al. Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia. Clin Ter. 2013;164:e147. doi:10.7417/CT.2013.1556
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
- Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003
- Morón de Salim AR, Garcés Pasamontes A. [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]. Arch Latinoam Nutr. 2005;55:28.
- Devaraj S, Jialal I, Vega-López S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler Thromb Vasc Biol. 2004;24:e25.
- MacMahon M, Kirkpatrick C, Cummings CE, Clayton A, Robinson PJ, et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis. 2000;10:195.
- Defraigne JO, Pirenne J, Swinnen JC, Honore P, Jacquet N, et al. [Value and limits of bypassing the distal ileum in the treatment of hypercholesterolemia]. J Chir (Paris). 1990;127:76.
- Nikkila EA, Miettinen TA, Lanner A. Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine. Atherosclerosis. 1976;24:407.
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. doi:10.3389/fnut.2025.1545301
- Xie RP, Liang XF, Peng D, Zhang QW, Wu DL, et al. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish Physiol Biochem. 2023;49:1063. doi:10.1007/s10695-023-01223-3
- Abbas Torki S, Bahadori E, Shekari S, Fathi S, Gholamalizadeh M, et al. Association between the index of nutritional quality and lipid profile in adult women. Endocrinol Diabetes Metab. 2022;5:e358. doi:10.1002/edm2.358
- Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F. The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women. Clin Nutr Res. 2021;10:230. doi:10.7762/cnr.2021.10.3.230
- Zhang Q, Zhang DL, Zhou XL, Li Q, He N, et al. Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia. Endocr Metab Immune Disord Drug Targets. 2021;21:2260. doi:10.2174/1871530321666210809152555
- Shabbir M, Afsar T, Razak S, Almajwal A, Khan MR. Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice. Lipids Health Dis. 2020;19:46. doi:10.1186/s12944-020-01231-9
- Li J, Yin L, Wang L, Li J, Huang P, et al. Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019;97:4865. doi:10.1093/jas/skz338
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
- Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. 2024;14:19052. doi:10.1038/s41598-024-69728-2
