' 
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
9
White button mushrooms reduce cholesterol
White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats.
Study shows significant findings
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Direct impact on cholesterol levels.
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
8
Vitamin B6 improves cholesterol and metabolism
The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women.
Addresses cholesterol treatment efficacy
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
Most Useful Reviews
8.8
Supports cholesterol management
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
Read More
8.8
Improves cholesterol levels
B12 in the easily digestible form of methylcobalamin is effective at speeding up metabolism and lowering high cholesterol. It also aids in nutrient synthesis and heart function. The tablets are small with a pleasant sour taste. Ideal for those over 50 to maintain cognitive function; acne may be a possible side effect.
Read More
8.8
Cost-effective solution
Excellent cost and service! I bought this product from iHerb, and it arrived promptly. I love using the sublingual tablets, which dissolve quickly with a nice citrus flavour. If you have B12 deficiency, this product is highly recommended, as my blood test shows elevated levels of B12. It's worth it, lasting about three months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9
Vitamin B12 aids cholesterol management
Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia.
Moderate effectiveness demonstrated
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
Read More
9
White button mushrooms reduce cholesterol
White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats.
Study shows significant findings
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
PIB lowers cholesterol levels
[Value and limits of bypassing the distal ileum in the treatment of hypercholesterolemia].
Limited effectiveness in atherosclerosis prevention
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
9
Vitamin B6 may improve cholesterol
Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study.
Potential confounding factors exist.
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
Read More
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Direct impact on cholesterol levels.
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Supports cholesterol management
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
Read More
8.8
Improves cholesterol levels
B12 in the easily digestible form of methylcobalamin is effective at speeding up metabolism and lowering high cholesterol. It also aids in nutrient synthesis and heart function. The tablets are small with a pleasant sour taste. Ideal for those over 50 to maintain cognitive function; acne may be a possible side effect.
Read More
8.8
Cost-effective solution
Excellent cost and service! I bought this product from iHerb, and it arrived promptly. I love using the sublingual tablets, which dissolve quickly with a nice citrus flavour. If you have B12 deficiency, this product is highly recommended, as my blood test shows elevated levels of B12. It's worth it, lasting about three months.
Read More
8.8
Vegan-friendly supplement
I have felt significant improvement since starting B12, particularly beneficial after over a decade of being vegan. It's effectively addressed several issues I faced, including those associated with high cholesterol.
9.5
Energy booster
This vitamin is very reasonably priced and easy to take. I feel considerably more energetic, making it a product I would highly recommend for those managing high cholesterol.
