5/21/2025
Last update
5/21/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
Coenzyme Q10 shows effectiveness against migraines
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Read More
7
Co-Q10 reduces oxidative stress in migraines
We aimed to understand how Coenzyme Q10 (Co-Q10) could help reduce oxidative stress and improve cholesterol levels in individuals suffering from migraines. This involved a well-structured clinical trial with 84 female participants, all diagnosed with episodic migraines. For a period of 12 weeks, half of the participants took a daily dose of Co-Q10, while the other half received a placebo.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
Read More
8
We explored how coenzyme Q10 could potentially help alleviate headaches, particularly for those suffering from migraines. This study painted a detailed picture of migraine's link to nutritional deficiencies, particularly the role of vital nutrients in reducing the frequency and intensity of migraine attacks.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
Read More
Most Useful Reviews
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
Read More
2
No headache relief
6 people found this helpful
Not for me. I purchased this brand of CoQ10 to combine it with the magnesium I already take in hopes of addressing my migraines. The capsule is a bit large but easy to take, with a neutral flavour and reasonable price. Unfortunately, I experienced dreadful nausea and headache the next afternoon and only felt better after stopping it two nights later, realising it was the cause of my discomfort. I'm truly disappointed that it didn't work out for me.
Read More
9
Migraines disappeared
1 people found this helpful
Excellent! For months, I woke up with mild headaches and felt lethargic. After taking CoQ10, I saw a difference in just 4 days. Now, after 6 days, I haven’t experienced a headache in the mornings and my energy levels have notably improved. I don’t know how it works, but I’m extremely happy with the results!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9.5
Coenzyme Q10 reduces migraine symptoms
We engaged in a study that aimed to explore the impact of Coenzyme Q10 when combined with L-carnitine on migraine symptoms. Our research involved 56 participants aged between 20 and 40 years, all experiencing migraine headaches. They were randomly divided into two groups: one received daily doses of 30 mg of Coenzyme Q10 and 500 mg of L-carnitine, while the other group got placebo tablets.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
Read More
9
We assessed how nonprescription therapies, including coenzyme Q10, affect headaches related to vestibular migraine (VM). In a detailed study conducted over two years with participants diagnosed with VM, we encouraged patients to optimize their lifestyle through proper sleep, hydration, exercise, and nutrition.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
Read More
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
Read More
9
Combined supplement shows promise
We explored the use of a dietary supplement combining magnesium, vitamin B2, feverfew, andrographis paniculata, and coenzyme Q10 to prevent episodic migraines. This pilot study involved 113 patients in Greece who followed the treatment for three months after a one-month baseline period.
Our main focus was on how this supplementation affected the number of migraine days each month. We also tracked changes in pain intensity, the use of acute medications for migraines, and the overall quality of life through various assessment tools.
The results indicated that the combination supplement, including coenzyme Q10, seemed effective in reducing monthly migraine days. However, since this was a single-arm study without a control group, we can't pinpoint the specific contribution of coenzyme Q10 alone. A randomized, placebo-controlled trial would be essential to confirm these promising findings and clarify the role of each component in the mix.
Our main focus was on how this supplementation affected the number of migraine days each month. We also tracked changes in pain intensity, the use of acute medications for migraines, and the overall quality of life through various assessment tools.
The results indicated that the combination supplement, including coenzyme Q10, seemed effective in reducing monthly migraine days. However, since this was a single-arm study without a control group, we can't pinpoint the specific contribution of coenzyme Q10 alone. A randomized, placebo-controlled trial would be essential to confirm these promising findings and clarify the role of each component in the mix.
Read More
9
We evaluated how effectively Coenzyme Q10, along with several other nutraceuticals, can help in preventing headaches in children and adolescents. The study involved 99 children aged 6 to 17 who were experiencing primary headaches. Over a period of 12 months, we monitored their headache frequency and the need for pain relief medications both before and after treatment.
Among the different treatments we used, Coenzyme Q10 was included in a combination called compound n°3, alongside magnesium oxide, Partenium, and Vitamin B2. Our findings showed that all three treatment compounds significantly reduced headache frequency and the reliance on pain relief medications. However, Coenzyme Q10’s effectiveness varied; it was found to be less effective than other combinations for certain types of headaches.
Overall, we found that nutraceuticals like Coenzyme Q10 are generally well-received by both parents and children and they seem to provide a promising alternative in headache management. While not every combination showed uniform effectiveness, our research supports the potential of these supplements in making headaches more manageable for children.
Among the different treatments we used, Coenzyme Q10 was included in a combination called compound n°3, alongside magnesium oxide, Partenium, and Vitamin B2. Our findings showed that all three treatment compounds significantly reduced headache frequency and the reliance on pain relief medications. However, Coenzyme Q10’s effectiveness varied; it was found to be less effective than other combinations for certain types of headaches.
Overall, we found that nutraceuticals like Coenzyme Q10 are generally well-received by both parents and children and they seem to provide a promising alternative in headache management. While not every combination showed uniform effectiveness, our research supports the potential of these supplements in making headaches more manageable for children.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
Read More
2
No headache relief
6 people found this helpful
Not for me. I purchased this brand of CoQ10 to combine it with the magnesium I already take in hopes of addressing my migraines. The capsule is a bit large but easy to take, with a neutral flavour and reasonable price. Unfortunately, I experienced dreadful nausea and headache the next afternoon and only felt better after stopping it two nights later, realising it was the cause of my discomfort. I'm truly disappointed that it didn't work out for me.
Read More
9
Migraines disappeared
1 people found this helpful
Excellent! For months, I woke up with mild headaches and felt lethargic. After taking CoQ10, I saw a difference in just 4 days. Now, after 6 days, I haven’t experienced a headache in the mornings and my energy levels have notably improved. I don’t know how it works, but I’m extremely happy with the results!
Read More
9
Reduced migraine attacks
CoQ10 has transformed my wife's experience with migraines. Previously, she suffered from intense headache episodes. Since using CoQ10, there’s been a significant reduction in her migraines. It's like a magical solution that supports her well-being, allowing her to regain energy and happiness.
Read More
9
Headaches resolved
This product improves sleep, and my headaches and migraines have disappeared. My head feels much better now.
Read More
Frequently Asked Questions
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
9
Migraines disappeared
1 people found this helpful
Excellent! For months, I woke up with mild headaches and felt lethargic. After taking CoQ10, I saw a difference in just 4 days. Now, after 6 days, I haven’t experienced a headache in the mornings and my energy levels have notably improved. I don’t know how it works, but I’m extremely happy with the results!
7.5
Headache prevention
I take this daily as a dietary supplement. My elderly parents take two capsules each morning to prevent headaches. After a break, I noticed feeling less cheerful with headaches occurring more often. Once I returned to the regimen, everything improved within two weeks.
7.5
Fewer migraines
2 people found this helpful
My wife includes CoQ10 in her daily regimen to manage her migraines. A small study indicated that in 80 patients diagnosed with migraine, there was over a 50% reduction in migraine frequency monthly. This suggests that CoQ10 may effectively reduce both the frequency and severity of headaches.
9
No headaches noted
I read that coenzyme is very necessary for people with migraines. I drank it for half a year and really did not have a headache.
7.5
Increased energy
2 people found this helpful
My husband and I both use this product. I’ve noticed a significant increase in my energy levels and improved focus. Along with fresh omega and Dr. Best betaine HCI pepsin, I feel so much healthier. Thank you, Dr. Best!
7.5
Pressure and headaches
I ordered this for my mother to stabilise her blood pressure and support her heart after losing her father. Her blood pressure normalised, and she stopped complaining of headaches, and her overall condition improved. She continues to take her doctor's prescribed medications alongside this product.
7
We explored the effects of coenzyme Q10, a popular herbal supplement, on headache relief, particularly migraine attacks. The study aggregated data from various clinical trials to assess how effective coenzyme Q10 is in reducing the frequency, severity, and duration of migraines.
The findings reveal that coenzyme Q10 can indeed help reduce the frequency of migraine headaches. However, when it comes to the severity and duration, the results were mixed, indicating that while some users might experience better outcomes, others may not notice significant improvements.
Ultimately, coenzyme Q10 appears to be a safe option, with no concerning side effects reported. This makes it a compelling choice for those seeking a natural alternative, particularly for individuals who may have experienced unwanted effects from traditional pharmaceuticals.
The findings reveal that coenzyme Q10 can indeed help reduce the frequency of migraine headaches. However, when it comes to the severity and duration, the results were mixed, indicating that while some users might experience better outcomes, others may not notice significant improvements.
Ultimately, coenzyme Q10 appears to be a safe option, with no concerning side effects reported. This makes it a compelling choice for those seeking a natural alternative, particularly for individuals who may have experienced unwanted effects from traditional pharmaceuticals.
8
We delved into the effects of coenzyme Q10 (CoQ10) on migraine headaches, specifically looking at how it might reduce the severity, frequency, and duration of these painful episodes. The study was a systematic review and meta-analysis that included randomized control trials comparing CoQ10 with a placebo, ensuring that we had a robust method for analysis.
Our findings indicated that CoQ10 can indeed be beneficial for adults suffering from migraines. It showed promise in reducing both the duration and the frequency of migraine attacks. However, while the results are encouraging, we noted that CoQ10's efficacy could be influenced when combined with other treatments, which slightly complicates the understanding of its isolated effects.
Overall, our exploration suggests that CoQ10 is a valuable option for those looking for ways to manage migraine headaches. As we look toward the future, more research might further clarify its role in migraine treatment and enhance our understanding of how best to utilize this compound.
Our findings indicated that CoQ10 can indeed be beneficial for adults suffering from migraines. It showed promise in reducing both the duration and the frequency of migraine attacks. However, while the results are encouraging, we noted that CoQ10's efficacy could be influenced when combined with other treatments, which slightly complicates the understanding of its isolated effects.
Overall, our exploration suggests that CoQ10 is a valuable option for those looking for ways to manage migraine headaches. As we look toward the future, more research might further clarify its role in migraine treatment and enhance our understanding of how best to utilize this compound.
7
We observed that coenzyme Q10 may have potential benefits for individuals suffering from headaches, specifically migraines. Although the evidence for its effectiveness is categorized as Level C, suggesting that it has not undergone extensive testing, the preliminary outcomes show a low rate of adverse events associated with its use.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
While we acknowledge that the available studies do not provide definitive conclusions, this antioxidant has been noted for its role in energy production and mitochondrial function, which may be responsible for its positive effects on migraine prevention. However, we recognize the need for more rigorous clinical trials to better establish its efficacy before making broad recommendations.
In summary, coenzyme Q10 appears to offer a promising avenue for headache relief, but it is crucial to approach its use with caution until more conclusive evidence is available.
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
7
We explored the impact of coenzyme Q10 in treating headaches, particularly in children and adolescents. The review highlighted various complementary therapies for primary headaches and indicated that coenzyme Q10, along with other dietary supplements like riboflavin, magnesium, and vitamin D, may offer some benefits.
While evidence suggests that coenzyme Q10 could aid in reducing headaches, it’s important to understand that it was evaluated alongside other treatments. This means the exact contribution of coenzyme Q10 on its own might be less clear. We noted that patients experiencing headaches often turn to complementary therapies due to a perceived lack of adequate medical care.
Overall, our findings suggest that coenzyme Q10 could be a part of a broader strategy to manage headaches. Its potential effectiveness highlights the need for more in-depth studies to isolate its benefits and understand how it fits into headache treatment plans.
While evidence suggests that coenzyme Q10 could aid in reducing headaches, it’s important to understand that it was evaluated alongside other treatments. This means the exact contribution of coenzyme Q10 on its own might be less clear. We noted that patients experiencing headaches often turn to complementary therapies due to a perceived lack of adequate medical care.
Overall, our findings suggest that coenzyme Q10 could be a part of a broader strategy to manage headaches. Its potential effectiveness highlights the need for more in-depth studies to isolate its benefits and understand how it fits into headache treatment plans.
9.5
Coenzyme Q10 reduces migraine symptoms
We engaged in a study that aimed to explore the impact of Coenzyme Q10 when combined with L-carnitine on migraine symptoms. Our research involved 56 participants aged between 20 and 40 years, all experiencing migraine headaches. They were randomly divided into two groups: one received daily doses of 30 mg of Coenzyme Q10 and 500 mg of L-carnitine, while the other group got placebo tablets.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
8
We've looked into how coenzyme Q10 impacts headaches, particularly in those who suffer from migraines. Research suggests that this vitamin-like substance can help prevent headaches with minimal side effects, making it an appealing option for those seeking relief.
In fact, studies indicate that coenzyme Q10’s effectiveness in preventing migraines is comparable to some commonly prescribed medications, such as topiramate and propranolol. This is encouraging news for patients, especially since these traditional medications can come with a host of side effects.
Overall, it seems that coenzyme Q10 is a well-tolerated and potentially effective approach for migraine prevention. This makes it a viable first-line option for many sufferers, including children and adolescents, who may benefit from its natural profile without the burden of harsh side effects.
In fact, studies indicate that coenzyme Q10’s effectiveness in preventing migraines is comparable to some commonly prescribed medications, such as topiramate and propranolol. This is encouraging news for patients, especially since these traditional medications can come with a host of side effects.
Overall, it seems that coenzyme Q10 is a well-tolerated and potentially effective approach for migraine prevention. This makes it a viable first-line option for many sufferers, including children and adolescents, who may benefit from its natural profile without the burden of harsh side effects.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Quintana S, Russo M, Torelli P. Nutraceuticals and migraine: further strategy for the treatment of specific conditions. Neurol Sci. 2022;43:6565. 10.1007/s10072-022-06250-1
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
