We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
Effective for allergies
4 people found this helpful
Another fabulous product by Doctor’s Best. As an allergy sufferer, I need to take daily zinc supplements, and I struggle to find soy-free options. I trust that these products are safe and contain top-quality ingredients. They significantly improve my allergy symptoms very quickly. They represent great value for money.
Read More
7.5
Life-changing zinc supplement
This is undoubtedly the best and most potent zinc supplement! My entire life improves when I take it; everything seems brighter, and I feel happier. It energises me, but it can make me quite hungry, so it’s better to take it with food. It has truly healed many issues in my body, including my gut, energy, allergies, brain fog, and mental health. I love this stuff!
Read More
7.5
Great for skin allergies
A good product that comes in a large quantity at a reasonable price, suitable for kosher consumers as it is vegetarian. I mainly use this when dealing with a skin allergy, in combination with vitamin C and vitamin A, to help my body combat the allergy. I am satisfied with the results.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
Another fabulous product by Doctor’s Best. As an allergy sufferer, I need to take daily zinc supplements, and I struggle to find soy-free options. I trust that these products are safe and contain top-quality ingredients. They significantly improve my allergy symptoms very quickly. They represent great value for money.
Read More
7.5
Life-changing zinc supplement
This is undoubtedly the best and most potent zinc supplement! My entire life improves when I take it; everything seems brighter, and I feel happier. It energises me, but it can make me quite hungry, so it’s better to take it with food. It has truly healed many issues in my body, including my gut, energy, allergies, brain fog, and mental health. I love this stuff!
Read More
7.5
Great for skin allergies
A good product that comes in a large quantity at a reasonable price, suitable for kosher consumers as it is vegetarian. I mainly use this when dealing with a skin allergy, in combination with vitamin C and vitamin A, to help my body combat the allergy. I am satisfied with the results.
Read More
6
Supports immune health
Good for enhancing the immune system and managing allergies.
Read More
Frequently Asked Questions
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, many individuals report experiencing improvements in their allergy symptoms quite quickly after starting on zinc supplements. For instance, one user noted that these supplements significantly improved their allergy symptoms very quickly Read Review. Similarly, another reviewer describes a broad range of health benefits, including relief from allergies, stating they noticed a transformation in their overall wellbeing when taking the supplement Read Review.
However, the specific timeframe for noticeable results can vary among individuals. Some users find that combining zinc with other vitamins enhances its efficacy against allergies Read Review. As a result, while several reviews suggest a relatively quick response, the exact duration may depend on personal health factors and concurrent supplementation.
This supplement, particularly zinc in conjunction with quail egg-based supplements, shows promising support in managing allergic rhinitis, according to several studies. One research investigation found that this combination significantly improved respiratory function and alleviated common allergy symptoms such as nasal congestion and sneezing while also reducing reliance on conventional allergy medications [1]. Another study pointed to the benefits of intranasal zinc in patients with Japanese cedar pollinosis, indicating that it may relieve allergy symptoms by affecting cellular mechanisms linked to immune responses [2].
The overall evidence suggests that zinc plays a critical role in immune function and may combat various allergic diseases, including allergic rhinitis and atopic dermatitis [6]. Zinc supplementation has been associated with a decrease in immune signaling molecules related to allergic reactions, which further reinforces its potential effectiveness in allergy management [3]. However, as with any supplement, individual responses can vary, and those with specific allergies, such as egg allergies, should exercise caution. As always, consulting with a healthcare professional before starting any new supplement regimen is advisable.
Users report a range of improvements in their allergy symptoms after incorporating zinc supplements into their daily routine. One user specifically noted that these supplements significantly alleviated their allergy symptoms in a very short period, emphasizing their effectiveness for those prone to such issues Read Review. Additionally, another reviewer experienced a broader spectrum of health benefits, including relief from allergies, gut issues, and even mental clarity, suggesting a holistic improvement in their overall wellbeing when taking the supplement Read Review.
Furthermore, it was mentioned that combining zinc with vitamins C and A helped in managing skin allergies more effectively, indicating that users often find stronger results when utilizing zinc in conjunction with other dietary supplements Read Review. Overall, while many report positive outcomes, individual results can vary based on personal health conditions and additional supplementation strategies.
Users report that combining this zinc supplement with other vitamins, particularly vitamin C and vitamin A, can enhance its effectiveness in managing allergies. One reviewer specifically mentioned using this combination to combat skin allergies successfully, indicating a synergistic effect that may improve overall outcomes in allergy treatment Read Review.
Additionally, users generally express satisfaction with the supplement's ability to alleviate allergy symptoms on its own, noting significant improvements in their conditions after consistent use. For instance, one user emphasized the rapid reduction in their allergy symptoms after starting the zinc supplementation, thereby highlighting its potential benefits both independently and alongside other supplements Read Review.
According to user reviews, many people find zinc supplements effective for managing allergy symptoms, though specific dosing recommendations are not universally mentioned. One user highlights the importance of taking daily zinc supplements to experience significant improvements in their allergy symptoms, indicating a routine daily intake may be beneficial (Read Review). Another review emphasizes the general overall health benefits from zinc, including its positive impact on allergies, though it doesn't specify a particular dosage (Read Review).
Additionally, a user mentions combining zinc with vitamin C and A often for skin allergies, suggesting that it may be helpful to consider multi-nutrient approaches for enhanced effects (Read Review). While there is no consensus on the exact right dose from these reviews, many users agree that zinc supplements contribute positively towards allergy relief and overall immune system enhancement (Read Review).
9
Effective for allergies
4 people found this helpful
Another fabulous product by Doctor’s Best. As an allergy sufferer, I need to take daily zinc supplements, and I struggle to find soy-free options. I trust that these products are safe and contain top-quality ingredients. They significantly improve my allergy symptoms very quickly. They represent great value for money.
7.5
Life-changing zinc supplement
This is undoubtedly the best and most potent zinc supplement! My entire life improves when I take it; everything seems brighter, and I feel happier. It energises me, but it can make me quite hungry, so it’s better to take it with food. It has truly healed many issues in my body, including my gut, energy, allergies, brain fog, and mental health. I love this stuff!
7.5
Great for skin allergies
A good product that comes in a large quantity at a reasonable price, suitable for kosher consumers as it is vegetarian. I mainly use this when dealing with a skin allergy, in combination with vitamin C and vitamin A, to help my body combat the allergy. I am satisfied with the results.
6
Supports immune health
Good for enhancing the immune system and managing allergies.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. 10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. 10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. 10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. 10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. 10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. 10.1016/j.biopha.2024.117129