Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
Ubiquinol may combat Alzheimer's effects
We explored the effects of ubiquinol, a form of coenzyme Q10, on Alzheimer's disease through a model using 3xTG-AD mice. Our research aimed to understand how disrupted protein modules in the brain correlate with the progression of Alzheimer's, particularly in terms of oxidative stress and protein regulation.
By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.
Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.
Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.
By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.
Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.
Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.
Read More
9
We examined the potential benefits of Coenzyme Q10 (CoQ10) in addressing cognitive impairments associated with Alzheimer's disease, specifically looking at its impact when paired with scopolamine. The study involved Wistar rats receiving varying doses of CoQ10 alongside scopolamine over a six-week period. By evaluating behavior and biochemical changes, we aimed to understand how CoQ10 might protect against the cognitive decline brought about by scopolamine.
Our findings indicated that CoQ10 notably improved memory and cognitive abilities in the rats, as evidenced by enhanced performance in tests like the novel object recognition and Morris water maze. Additionally, we found that CoQ10 helped counteract the oxidative stress and biochemical disturbances typically induced by scopolamine, including positive changes in important signaling pathways related to neuronal health.
Ultimately, these results underscore the neuroprotective capabilities of CoQ10 in the context of scopolamine-induced cognitive decline, suggesting it could inhibit factors like oxidative stress and amyloid deposition. While the study had some limitations due to the co-administration with scopolamine, the potential of CoQ10 shines as a promising avenue for further exploration in treating Alzheimer's disease.
Our findings indicated that CoQ10 notably improved memory and cognitive abilities in the rats, as evidenced by enhanced performance in tests like the novel object recognition and Morris water maze. Additionally, we found that CoQ10 helped counteract the oxidative stress and biochemical disturbances typically induced by scopolamine, including positive changes in important signaling pathways related to neuronal health.
Ultimately, these results underscore the neuroprotective capabilities of CoQ10 in the context of scopolamine-induced cognitive decline, suggesting it could inhibit factors like oxidative stress and amyloid deposition. While the study had some limitations due to the co-administration with scopolamine, the potential of CoQ10 shines as a promising avenue for further exploration in treating Alzheimer's disease.
Read More
8
Coenzyme Q10 shows cognitive promise
We conducted an intriguing study to evaluate how coenzyme Q10 (Q10) might influence learning and memory in the context of Alzheimer's disease, particularly in older rats that had been induced with β-amyloid (Aβ). We grouped 40 Wistar rats into four categories: a control group, a group receiving Aβ, a group receiving Q10, and one group that received both Q10 and Aβ.
Over a four-week period, we administered Q10 daily to see if it could bolster cognitive functions, such as memory and learning. We utilized various tests to measure the rats’ performance, including the novel object recognition test, the Morris water maze, and the passive avoidance learning test. By looking at the levels of certain biochemical markers, we assessed any potential oxidative stress or neurodegeneration.
Our findings were promising, suggesting that Q10 supplementation could mitigate the decline in learning, memory, and synaptic plasticity that typically accompanies aging and Aβ exposure. Although the study faced limitations, such as combining Q10 with Aβ exposure, our observations indicate that Q10 might bring about some improvement in cognitive function, pointing towards a potential avenue for enhancing quality of life for individuals with Alzheimer's.
Over a four-week period, we administered Q10 daily to see if it could bolster cognitive functions, such as memory and learning. We utilized various tests to measure the rats’ performance, including the novel object recognition test, the Morris water maze, and the passive avoidance learning test. By looking at the levels of certain biochemical markers, we assessed any potential oxidative stress or neurodegeneration.
Our findings were promising, suggesting that Q10 supplementation could mitigate the decline in learning, memory, and synaptic plasticity that typically accompanies aging and Aβ exposure. Although the study faced limitations, such as combining Q10 with Aβ exposure, our observations indicate that Q10 might bring about some improvement in cognitive function, pointing towards a potential avenue for enhancing quality of life for individuals with Alzheimer's.
Read More
Most Useful Reviews
8
Improved mood
Coenzyme Q10 is a vital compound produced by the liver, crucial for energy production (ATP). It declines with age, often leading to health issues. Daily requirements vary: around 50 mg for the young and up to 300 mg for the older population. Supplements can help. After five days on Coenzyme Q10, I noticed an uplift in my mood, increased energy, and improved sleep. It's an excellent supplement, particularly beneficial for managing Alzheimer, and I highly recommend it. Doctor's Best offers great value!
Read More
7
Supports brain function
Coenzyme Q10 enhances endurance, aids recovery from exertion, and is beneficial for athletes. It supports heart health by maintaining blood vessel elasticity, reducing blood pressure spikes. Furthermore, it promotes energy in brain cells, aiding information retention and potentially delaying Alzheimer progression. Even in the presence of such conditions, it may slow their advancement. This substance indirectly supports immune function and accelerates collagen synthesis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
CoQ10 shows promise in Alzheimer’s care
We explored the effects of coenzyme Q10 (CoQ10) in treating Alzheimer's disease in a study involving seventy rats. The animals were divided into various groups to assess the impact of CoQ10 on memory and cognitive functions, especially in scenarios where they were also treated with donepezil, a commonly used Alzheimer's medication.
Our findings indicated that CoQ10 significantly improved memory and locomotion in rats that had experienced cognitive decline due to the combined effects of D-galactose and aluminum chloride treatments, which are commonly used to mimic Alzheimer's in animal models. The treatment helped reduce oxidative stress and inflammation linked to Alzheimer's, while also regulating important pathways and microRNAs that play a role in brain health.
Notably, CoQ10 not only enhanced neurotransmitter levels but also decreased the accumulation of amyloid-beta plaques, a hallmark of Alzheimer’s disease. This suggests that CoQ10 has potential as a protective agent against the neuronal damage associated with Alzheimer's.
Importantly, the combination of CoQ10 and donepezil showed promising results, suggesting a synergistic effect that could benefit Alzheimer’s treatment strategies.
Our findings indicated that CoQ10 significantly improved memory and locomotion in rats that had experienced cognitive decline due to the combined effects of D-galactose and aluminum chloride treatments, which are commonly used to mimic Alzheimer's in animal models. The treatment helped reduce oxidative stress and inflammation linked to Alzheimer's, while also regulating important pathways and microRNAs that play a role in brain health.
Notably, CoQ10 not only enhanced neurotransmitter levels but also decreased the accumulation of amyloid-beta plaques, a hallmark of Alzheimer’s disease. This suggests that CoQ10 has potential as a protective agent against the neuronal damage associated with Alzheimer's.
Importantly, the combination of CoQ10 and donepezil showed promising results, suggesting a synergistic effect that could benefit Alzheimer’s treatment strategies.
Read More
9
CoQ10 aids in cognitive protection
We aimed to investigate how coenzyme Q10 (CoQ10) influences cognitive impairment associated with aluminum chloride, a compound known to induce neurotoxicity and mimic Alzheimer's disease symptoms. This study focused on older male mice, evaluating the long-term effects of offering both CoQ10 and curcumin. Each was given in a low dose of 100 mg/kg for 28 days, while the mice were exposed to aluminum chloride to trigger memory challenges.
The results were quite telling. Mice treated with the combination of CoQ10 and curcumin showed significant improvements in their cognitive functions compared to those treated with just one of the substances at a higher dose. For instance, performance on various tests designed to assess memory and learning abilities, such as the Y-maze and the Morris-water maze, improved after the dual treatment.
Importantly, co-administration of CoQ10 and curcumin also appeared to restore a healthy balance in oxidative stress levels, which is crucial, as imbalances contribute to the cognitive decline associated with aging and neurotoxicity. The study highlighted that while aluminum chloride increased levels of an enzyme known to break down acetylcholine—a neurotransmitter essential for memory—the combination treatment effectively reversed this effect, leading to better overall brain health and structure.
The results were quite telling. Mice treated with the combination of CoQ10 and curcumin showed significant improvements in their cognitive functions compared to those treated with just one of the substances at a higher dose. For instance, performance on various tests designed to assess memory and learning abilities, such as the Y-maze and the Morris-water maze, improved after the dual treatment.
Importantly, co-administration of CoQ10 and curcumin also appeared to restore a healthy balance in oxidative stress levels, which is crucial, as imbalances contribute to the cognitive decline associated with aging and neurotoxicity. The study highlighted that while aluminum chloride increased levels of an enzyme known to break down acetylcholine—a neurotransmitter essential for memory—the combination treatment effectively reversed this effect, leading to better overall brain health and structure.
Read More
9
CoQ10 shows promise for Alzheimer's
We set out to understand the protective potential of Coenzyme Q10 (CoQ10) against cognitive dysfunction associated with Alzheimer’s disease. Our study involved 70 male albino rats, which were divided into various groups including control, those treated with donepezil alone, CoQ10 alone, and others receiving combinations of the two treatments.
Through our assessments, we looked at different factors such as memory enhancement, neuronal function, and the modulation of critical enzymes like BACE-1 and GSK-3β, known for their roles in amyloid beta production and cognitive decline.
What we found was promising: CoQ10 treatment led to improvements in memory, increased movement activity, and boosted neuronal differentiation. This was primarily linked to its inhibitory effect on the BACE-1 and GSK-3β enzymes. Furthermore, our observations were supported by detailed examinations of brain tissue, specifically focusing on the hippocampus, which is crucial for memory.
These findings suggest that Coenzyme Q10 might be a valuable player in addressing Alzheimer’s disease, especially when used alongside other treatments like donepezil.
Through our assessments, we looked at different factors such as memory enhancement, neuronal function, and the modulation of critical enzymes like BACE-1 and GSK-3β, known for their roles in amyloid beta production and cognitive decline.
What we found was promising: CoQ10 treatment led to improvements in memory, increased movement activity, and boosted neuronal differentiation. This was primarily linked to its inhibitory effect on the BACE-1 and GSK-3β enzymes. Furthermore, our observations were supported by detailed examinations of brain tissue, specifically focusing on the hippocampus, which is crucial for memory.
These findings suggest that Coenzyme Q10 might be a valuable player in addressing Alzheimer’s disease, especially when used alongside other treatments like donepezil.
Read More
9
We examined the potential benefits of Coenzyme Q10 (CoQ10) in addressing cognitive impairments associated with Alzheimer's disease, specifically looking at its impact when paired with scopolamine. The study involved Wistar rats receiving varying doses of CoQ10 alongside scopolamine over a six-week period. By evaluating behavior and biochemical changes, we aimed to understand how CoQ10 might protect against the cognitive decline brought about by scopolamine.
Our findings indicated that CoQ10 notably improved memory and cognitive abilities in the rats, as evidenced by enhanced performance in tests like the novel object recognition and Morris water maze. Additionally, we found that CoQ10 helped counteract the oxidative stress and biochemical disturbances typically induced by scopolamine, including positive changes in important signaling pathways related to neuronal health.
Ultimately, these results underscore the neuroprotective capabilities of CoQ10 in the context of scopolamine-induced cognitive decline, suggesting it could inhibit factors like oxidative stress and amyloid deposition. While the study had some limitations due to the co-administration with scopolamine, the potential of CoQ10 shines as a promising avenue for further exploration in treating Alzheimer's disease.
Our findings indicated that CoQ10 notably improved memory and cognitive abilities in the rats, as evidenced by enhanced performance in tests like the novel object recognition and Morris water maze. Additionally, we found that CoQ10 helped counteract the oxidative stress and biochemical disturbances typically induced by scopolamine, including positive changes in important signaling pathways related to neuronal health.
Ultimately, these results underscore the neuroprotective capabilities of CoQ10 in the context of scopolamine-induced cognitive decline, suggesting it could inhibit factors like oxidative stress and amyloid deposition. While the study had some limitations due to the co-administration with scopolamine, the potential of CoQ10 shines as a promising avenue for further exploration in treating Alzheimer's disease.
Read More
9
CoQ10 shows promise for Alzheimer's
We explored the potential of coenzyme Q10 (CoQ10) in treating Alzheimer's disease by using a novel delivery method through exosomes derived from adipose-derived stem cells. In our study, rats with Alzheimer's, induced by a chemical called Streptozotocin, were given various treatments: standalone CoQ10, exosomes, or a combination of both—CoQ10-loaded exosomes.
Through tests designed to gauge memory and cognitive ability, like the Morris water maze and passive avoidance tests, we observed that the combination treatment with CoQ10-loaded exosomes significantly improved memory compared to the other groups. Our results also indicated a notable increase in Brain-Derived Neurotrophic Factor (BDNF) levels and higher cell density in the brains of the rats treated with CoQ10-loaded exosomes, suggesting a more pronounced neuroprotective effect.
The findings point to the possibility that delivering CoQ10 via exosomes could enhance its beneficial impact against Alzheimer's. This could be due to the unique regenerative properties of the exosomes, paving the way for innovative treatment strategies in battling this debilitating disease.
Through tests designed to gauge memory and cognitive ability, like the Morris water maze and passive avoidance tests, we observed that the combination treatment with CoQ10-loaded exosomes significantly improved memory compared to the other groups. Our results also indicated a notable increase in Brain-Derived Neurotrophic Factor (BDNF) levels and higher cell density in the brains of the rats treated with CoQ10-loaded exosomes, suggesting a more pronounced neuroprotective effect.
The findings point to the possibility that delivering CoQ10 via exosomes could enhance its beneficial impact against Alzheimer's. This could be due to the unique regenerative properties of the exosomes, paving the way for innovative treatment strategies in battling this debilitating disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Improved mood
Coenzyme Q10 is a vital compound produced by the liver, crucial for energy production (ATP). It declines with age, often leading to health issues. Daily requirements vary: around 50 mg for the young and up to 300 mg for the older population. Supplements can help. After five days on Coenzyme Q10, I noticed an uplift in my mood, increased energy, and improved sleep. It's an excellent supplement, particularly beneficial for managing Alzheimer, and I highly recommend it. Doctor's Best offers great value!
Read More
7
Supports brain function
Coenzyme Q10 enhances endurance, aids recovery from exertion, and is beneficial for athletes. It supports heart health by maintaining blood vessel elasticity, reducing blood pressure spikes. Furthermore, it promotes energy in brain cells, aiding information retention and potentially delaying Alzheimer progression. Even in the presence of such conditions, it may slow their advancement. This substance indirectly supports immune function and accelerates collagen synthesis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nawar NF, Beltagy DM, Tousson E, El-Keey MM, Mohamed TM. Coenzyme Q10 alleviates AlCl and D-galactose induced Alzheimer via modulating oxidative burden and TLR-4/MAPK pathways and regulation microRNA in rat brain. Toxicol Res (Camb). 2025;14:tfaf031. doi:10.1093/toxres/tfaf031
- Luo Q, Ye X, Xu J, Sun Z, Wang P, et al. Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice. Drug Deliv Transl Res. 2025. doi:10.1007/s13346-025-01814-y
- Puoyan-Majd S, Parnow A, Rashno M, Heidarimoghadam R, Komaki A. Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High-Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid-Beta (Aβ) Plaque Formation in the Hippocampus of Aβ-Induced Alzheimer's Disease Rats. CNS Neurosci Ther. 2025;31:e70221. doi:10.1111/cns.70221
- Rasheed N, Hussain HK, Rehman Z, Sabir A, Ashraf W, et al. Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice. Exp Gerontol. 2025;199:112659. doi:10.1016/j.exger.2024.112659
- Nawar NF, Beltagy DM, Mohamed TM, Tousson EM, El-Keey MM. Anti-oxidant activity of coenzyme Q10 against AlCl/D-galactose in albino rat induced cognitive dysfunctions: Behavioral, biochemical, and BACE-1/GSK-3β alterations. Toxicol Res (Camb). 2024;13:tfae131. doi:10.1093/toxres/tfae131
- Wang L, Wei Y, Sun Z, Tai W, Li H, et al. Effectiveness and mechanisms of combined use of antioxidant nutrients in protecting against oxidative stress-induced neuronal loss and related neurological deficits. CNS Neurosci Ther. 2024;30:e14886. doi:10.1111/cns.14886
- Abu-Elfotuh K, Tolba AMA, Hussein FH, Hamdan AME, Rabeh MA, et al. Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways. Pharmaceutics. 2023;15. doi:10.3390/pharmaceutics15082063
- Abuelezz SA, Hendawy N. Spotlight on Coenzyme Q10 in scopolamine-induced Alzheimer's disease: oxidative stress/PI3K/AKT/GSK 3ß/CREB/BDNF/TrKB. J Pharm Pharmacol. 2023;75:1119. doi:10.1093/jpp/rgad048
- Kumar P, Singh A, Kumar A, Kumar R, Pal R, et al. Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer's Disease. Biomedicines. 2023;11. doi:10.3390/biomedicines11051422
- Puoyan-Majd S, Parnow A, Rashno M, Heidarimoghadam R, Komaki A. The Protective Effects of High-Intensity Interval Training Combined with Q10 Supplementation on Learning and Memory Impairments in Male Rats with Amyloid-β-Induced Alzheimer's Disease. J Alzheimers Dis. 2024;99:S67. doi:10.3233/JAD-230096
- Llanos-González E, Sancho-Bielsa FJ, Frontiñán-Rubio J, Rabanal-Ruíz Y, García-Carpintero S, et al. Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12030747
- Jiang X, Guo Y, Cui L, Huang L, Guo Q, et al. Study of Diet Habits and Cognitive Function in the Chinese Middle-Aged and Elderly Population: The Association between Folic Acid, B Vitamins, Vitamin D, Coenzyme Q10 Supplementation and Cognitive Ability. Nutrients. 2023;15. doi:10.3390/nu15051243
- Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Coenzyme Q10 and Dementia: A Systematic Review. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12020533
- Asadbegi M, Komaki H, Faraji N, Taheri M, Safari S, et al. Effectiveness of coenzyme Q10 on learning and memory and synaptic plasticity impairment in an aged Aβ-induced rat model of Alzheimer's disease: a behavioral, biochemical, and electrophysiological study. Psychopharmacology (Berl). 2023;240:951. doi:10.1007/s00213-023-06338-2
- Tian Z, Wang P, Huang K, Yu J, Zhang M, et al. Photobiomodulation for Alzheimer's disease: photoelectric coupling effect on attenuating Aβ neurotoxicity. Lasers Med Sci. 2023;38:39. doi:10.1007/s10103-022-03692-z
- Sheykhhasan M, Amini R, Soleimani Asl S, Saidijam M, Hashemi SM, et al. Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease. Biomed Pharmacother. 2022;152:113224. doi:10.1016/j.biopha.2022.113224
