Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Read More
9
We aimed to understand the effect of coenzyme Q10 (CoQ10) on inflammation and immune response in a mouse model of rheumatoid arthritis (RA). This condition is notorious for causing chronic joint pain and damage, and we wanted to see if CoQ10 could help mitigate these issues. To explore this, we administered CoQ10 or a control solution to mice with zymosan-induced arthritis for seven weeks.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Read More
8
CoQ10 reduces inflammation in arthritis
We conducted a thorough investigation to determine how coenzyme Q10 (CoQ10) supplementation affects rheumatoid arthritis. In a well-structured double-blind, randomized controlled trial, 44 patients participated, with half receiving CoQ10 capsules and the other half a placebo over two months.
When we analyzed the results, we discovered that patients taking CoQ10 experienced a notable decrease in malondialdehyde (MDA), a marker of oxidative stress. This finding suggests that CoQ10 can help manage oxidative stress levels effectively. Additionally, there was a significant reduction in tumor necrosis factor alpha (TNF-α), an inflammatory cytokine, in those taking CoQ10.
However, while CoQ10 showed promise, we did not observe significant differences in total antioxidant capacity or interleukin-6 levels between the groups. Overall, CoQ10 supplementation appears beneficial in reducing certain inflammatory markers in rheumatoid arthritis patients, pointing towards its potential as a supportive treatment in managing this chronic condition.
When we analyzed the results, we discovered that patients taking CoQ10 experienced a notable decrease in malondialdehyde (MDA), a marker of oxidative stress. This finding suggests that CoQ10 can help manage oxidative stress levels effectively. Additionally, there was a significant reduction in tumor necrosis factor alpha (TNF-α), an inflammatory cytokine, in those taking CoQ10.
However, while CoQ10 showed promise, we did not observe significant differences in total antioxidant capacity or interleukin-6 levels between the groups. Overall, CoQ10 supplementation appears beneficial in reducing certain inflammatory markers in rheumatoid arthritis patients, pointing towards its potential as a supportive treatment in managing this chronic condition.
Read More
Most Useful Reviews
9
Significant improvement
4 people found this helpful
This product is excellent, particularly for the elderly and those with arthritis and muscle inflammation. After suffering from widespread pain in my back and joints, my condition improved significantly after taking it for over a month. I take 200 mg per day with breakfast and recommend it strongly.
Read More
7.5
Joint improvement
2 people found this helpful
I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.
Read More
9
Mobility assistance
I suffer from arthritis, and CoQ10 helps with my joint mobility. This product is excellent quality, and I am very satisfied with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
- All Researches
9
We investigated how coenzyme Q10 (CoQ10) could help those suffering from osteoarthritis (OA), a common joint disease that leads to cartilage breakdown. In our study, we used a group of male Wistar rats that were specifically induced to develop OA using a chemical known as monosodium iodoacetate (MIA). To see if CoQ10 could make a difference, we orally administered CoQ10 encapsulated in micelles to these rats.
The results were promising. Our findings showed that the CoQ10-micelles treatment significantly reduced symptoms of OA, such as pain, inflammation, and tissue destruction. We also noted a decrease in key inflammatory markers in the rats’ tissues, which suggests that CoQ10 might help lessen the inflammation associated with OA.
Furthermore, when we looked at OA chondrocytes—cells that make up cartilage—the CoQ10-micelles treatment resulted in lower expression of markers related to inflammation and cell death. This indicates not only a potential therapeutic effect of CoQ10 but also presents a novel approach to managing arthritis symptoms.
Overall, our study suggests that CoQ10-micelles could be a valuable addition to OA treatment options, offering hopeful prospects for those affected by this debilitating condition.
The results were promising. Our findings showed that the CoQ10-micelles treatment significantly reduced symptoms of OA, such as pain, inflammation, and tissue destruction. We also noted a decrease in key inflammatory markers in the rats’ tissues, which suggests that CoQ10 might help lessen the inflammation associated with OA.
Furthermore, when we looked at OA chondrocytes—cells that make up cartilage—the CoQ10-micelles treatment resulted in lower expression of markers related to inflammation and cell death. This indicates not only a potential therapeutic effect of CoQ10 but also presents a novel approach to managing arthritis symptoms.
Overall, our study suggests that CoQ10-micelles could be a valuable addition to OA treatment options, offering hopeful prospects for those affected by this debilitating condition.
Read More
9
We investigated the effects of coenzyme Q10 (CoQ10), a well-known antioxidant, on arthritis, specifically using a unique hybrid formulation known as liposome/gold hybrid nanoparticles (LGNP-CoQ10). Over a span of ten weeks, we administered both CoQ10 and LGNP-CoQ10 orally to mice suffering from collagen-induced arthritis.
Our analysis included various histological methods to understand the inflammation in their joint tissues. The results were promising—LGNP-CoQ10 significantly reduced levels of pro-inflammatory cytokines, which are key players in inflammation. Additionally, we observed lower numbers of Th17 cells and cells expressing phosphorylated STAT3, both linked to inflammatory processes, in the treated mice.
Further experiments with human peripheral blood mononuclear cells (PBMCs) showed that those treated with LGNP-CoQ10 had notably reduced levels of IL-17, an important cytokine in the development of arthritis. These findings suggest that LGNP-CoQ10 could be a valuable therapeutic option for managing rheumatoid arthritis, targeting key inflammatory pathways. Overall, our study highlights the potential of CoQ10 in treating arthritis through innovative delivery methods.
Our analysis included various histological methods to understand the inflammation in their joint tissues. The results were promising—LGNP-CoQ10 significantly reduced levels of pro-inflammatory cytokines, which are key players in inflammation. Additionally, we observed lower numbers of Th17 cells and cells expressing phosphorylated STAT3, both linked to inflammatory processes, in the treated mice.
Further experiments with human peripheral blood mononuclear cells (PBMCs) showed that those treated with LGNP-CoQ10 had notably reduced levels of IL-17, an important cytokine in the development of arthritis. These findings suggest that LGNP-CoQ10 could be a valuable therapeutic option for managing rheumatoid arthritis, targeting key inflammatory pathways. Overall, our study highlights the potential of CoQ10 in treating arthritis through innovative delivery methods.
Read More
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Read More
9
We looked into how coenzyme Q10 (CoQ10) works when paired with metformin to tackle arthritis, particularly in a mouse model of collagen-induced arthritis (CIA). Both CoQ10 and metformin have shown promise in reducing inflammation associated with arthritis, but it was intriguing to see how they perform together. Our findings revealed that this combination significantly lessened joint inflammation and reduced markers tied to immune responses, such as Th17 differentiation and IgG production.
We also noted that the combination encouraged the development of regulatory T cells, which play a vital role in keeping the immune system balanced. Interestingly, the partnership between metformin and CoQ10 appeared to slow down the formation of osteoclasts, cells that can contribute to joint damage.
Moreover, we observed a decrease in inflammatory proteins like interleukin-1β, interleukin-6, and tumor necrosis factor-alpha in immune cells following treatment. Encouragingly, this combo also seemed to enhance mitochondrial function, which is often disrupted in arthritis, thereby improving energy use in cells involved in the inflammatory process. Overall, our study suggests that the combination of metformin and CoQ10 may potentially offer new avenues for managing arthritis by not only reducing its severity but also addressing underlying mitochondrial dysfunction.
We also noted that the combination encouraged the development of regulatory T cells, which play a vital role in keeping the immune system balanced. Interestingly, the partnership between metformin and CoQ10 appeared to slow down the formation of osteoclasts, cells that can contribute to joint damage.
Moreover, we observed a decrease in inflammatory proteins like interleukin-1β, interleukin-6, and tumor necrosis factor-alpha in immune cells following treatment. Encouragingly, this combo also seemed to enhance mitochondrial function, which is often disrupted in arthritis, thereby improving energy use in cells involved in the inflammatory process. Overall, our study suggests that the combination of metformin and CoQ10 may potentially offer new avenues for managing arthritis by not only reducing its severity but also addressing underlying mitochondrial dysfunction.
Read More
9
We aimed to understand the effect of coenzyme Q10 (CoQ10) on inflammation and immune response in a mouse model of rheumatoid arthritis (RA). This condition is notorious for causing chronic joint pain and damage, and we wanted to see if CoQ10 could help mitigate these issues. To explore this, we administered CoQ10 or a control solution to mice with zymosan-induced arthritis for seven weeks.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
4 people found this helpful
This product is excellent, particularly for the elderly and those with arthritis and muscle inflammation. After suffering from widespread pain in my back and joints, my condition improved significantly after taking it for over a month. I take 200 mg per day with breakfast and recommend it strongly.
Read More
7.5
Joint improvement
2 people found this helpful
I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.
Read More
9
Mobility assistance
I suffer from arthritis, and CoQ10 helps with my joint mobility. This product is excellent quality, and I am very satisfied with the results.
Read More
9
Pain relief
I purchased this product for my rheumatoid arthritis, and it significantly relieved my pain.
Read More
7.5
Pain reduction
1 people found this helpful
My mother uses these along with hyaluronic acid and other supplements for arthritis prevention. Her knee pain has decreased, and her overall tone has improved.
Read More
Frequently Asked Questions
9
Significant improvement
4 people found this helpful
This product is excellent, particularly for the elderly and those with arthritis and muscle inflammation. After suffering from widespread pain in my back and joints, my condition improved significantly after taking it for over a month. I take 200 mg per day with breakfast and recommend it strongly.
7.5
Joint improvement
2 people found this helpful
I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.
9
Pain relief
I purchased this product for my rheumatoid arthritis, and it significantly relieved my pain.
9
Mobility assistance
I suffer from arthritis, and CoQ10 helps with my joint mobility. This product is excellent quality, and I am very satisfied with the results.
7.5
Pain reduction
1 people found this helpful
My mother uses these along with hyaluronic acid and other supplements for arthritis prevention. Her knee pain has decreased, and her overall tone has improved.
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
8
We investigated the effects of coenzyme Q10 (CoQ10) on alleviating pain and preventing cartilage degradation in a model of osteoarthritis (OA) using rats. To induce OA, we injected monosodium iodoacetate (MIA) directly into the knee joints of the rats. We began administering CoQ10 four days after this injection and assessed pain levels using a specialized test known as the von Frey assessment.
Our findings revealed that CoQ10 showed promise as a treatment for OA. We noticed a significant decrease in pain sensitivity among the rats treated with CoQ10. This was demonstrated by an increase in both pain withdrawal latency and threshold, indicating less pain. Furthermore, CoQ10 appeared to protect cartilage health, as we observed reduced signs of cartilage degradation in the affected joints.
On a cellular level, we found that CoQ10 treatment led to a decrease in several inflammatory markers associated with OA, including matrix metalloproteinase-13 (MMP-13) and interleukins such as IL-1β and IL-6. The presence of these markers typically indicates inflammation and tissue breakdown, so their reduction suggests that CoQ10 helps to manage inflammation effectively.
Overall, our study suggests that CoQ10 can be beneficial for those suffering from osteoarthritis by not only alleviating pain but also by protecting joint cartilage from further damage. This highlights the potential of CoQ10 as a therapeutic option in managing osteoarthritis.
Our findings revealed that CoQ10 showed promise as a treatment for OA. We noticed a significant decrease in pain sensitivity among the rats treated with CoQ10. This was demonstrated by an increase in both pain withdrawal latency and threshold, indicating less pain. Furthermore, CoQ10 appeared to protect cartilage health, as we observed reduced signs of cartilage degradation in the affected joints.
On a cellular level, we found that CoQ10 treatment led to a decrease in several inflammatory markers associated with OA, including matrix metalloproteinase-13 (MMP-13) and interleukins such as IL-1β and IL-6. The presence of these markers typically indicates inflammation and tissue breakdown, so their reduction suggests that CoQ10 helps to manage inflammation effectively.
Overall, our study suggests that CoQ10 can be beneficial for those suffering from osteoarthritis by not only alleviating pain but also by protecting joint cartilage from further damage. This highlights the potential of CoQ10 as a therapeutic option in managing osteoarthritis.
8
CoQ10 aids arthritis treatment safety
We explored the impact of coenzyme Q10 (CoQ10) in combination with methotrexate (MTX) for treating arthritis, particularly looking at its potential to minimize liver damage often associated with MTX use. Our research involved rat models that were categorized into various treatment groups, including healthy, arthritic, and those receiving either MTX, CoQ10, or a combination of both.
We found that CoQ10 not only boosted the anti-arthritis benefits of MTX but also played a crucial role in protecting the liver from the harmful effects of the medication. The combination treatment showed improved liver health indicators and reduced signs of liver stress and inflammation.
Through our findings, we saw how CoQ10 effectively balanced out the oxidative stress and reduced the levels of inflammatory mediators, such as TNF-α and IL-6, that are elevated due to MTX. This suggests that CoQ10 may serve as a valuable adjuvant therapy, optimizing the use of MTX for arthritis while safeguarding against liver damage.
We found that CoQ10 not only boosted the anti-arthritis benefits of MTX but also played a crucial role in protecting the liver from the harmful effects of the medication. The combination treatment showed improved liver health indicators and reduced signs of liver stress and inflammation.
Through our findings, we saw how CoQ10 effectively balanced out the oxidative stress and reduced the levels of inflammatory mediators, such as TNF-α and IL-6, that are elevated due to MTX. This suggests that CoQ10 may serve as a valuable adjuvant therapy, optimizing the use of MTX for arthritis while safeguarding against liver damage.
7
In an effort to explore new treatments for arthritis, we used the adjuvant arthritis model in Lewis rats to evaluate various substances, including coenzyme Q10 (CoQ10), alongside standard therapy using methotrexate (Mtx). We administered Mtx at a dosage of 0.3 mg/kg twice weekly, while CoQ10 was given in daily doses of 20 mg/kg.
Our findings showed that CoQ10, along with other antioxidants, contributed to reducing oxidative stress in arthritis without being hindered by the specific structure of the compounds used. However, we also observed that the clinical measurements, such as hind paw volume, indicated that CoQ10 wasn’t the most effective on its own, with pinosylvin showing better results.
Overall, while combining CoQ10 with methotrexate improved the therapeutic effects more than methotrexate alone, it is essential to recognize that the study did not fully isolate the effects of CoQ10. We found that antioxidant combinations generally enhanced biochemical or immunological outcomes compared to methotrexate used alone, suggesting that CoQ10 can be beneficial when included in combination therapies for managing rheumatoid arthritis.
Our findings showed that CoQ10, along with other antioxidants, contributed to reducing oxidative stress in arthritis without being hindered by the specific structure of the compounds used. However, we also observed that the clinical measurements, such as hind paw volume, indicated that CoQ10 wasn’t the most effective on its own, with pinosylvin showing better results.
Overall, while combining CoQ10 with methotrexate improved the therapeutic effects more than methotrexate alone, it is essential to recognize that the study did not fully isolate the effects of CoQ10. We found that antioxidant combinations generally enhanced biochemical or immunological outcomes compared to methotrexate used alone, suggesting that CoQ10 can be beneficial when included in combination therapies for managing rheumatoid arthritis.
7
We explored the potential benefits of coenzyme Q10 as a complementary treatment for arthritis, particularly when paired with traditional disease-modifying anti-rheumatic drugs (DMARDs) like methotrexate. This combination therapy has gained attention due to coenzyme Q10's anti-inflammatory and antioxidant properties, which might enhance the overall effectiveness of arthritis management while mitigating some of the adverse side effects associated with standard DMARDs.
During our review of recent studies, we noted that coenzyme Q10 showed promising results in both laboratory models and clinical settings. Some clinical trials indicated that patients experienced better outcomes when coenzyme Q10 was used alongside standard treatments. However, it’s important to acknowledge that the full extent of its isolated effects on arthritis isn't definitively established, largely because it often appears in combination with other therapies.
While the findings are encouraging, the study also highlights the limitations associated with using phytochemicals like coenzyme Q10. Issues with solubility, permeability, and bioavailability can interfere with their effectiveness as standalone treatments or when combined with DMARDs. We emphasized that innovative delivery systems and formulations may be necessary to optimize the therapeutic benefits of coenzyme Q10 for arthritis patients. In conclusion, coenzyme Q10 holds potential as an adjuvant therapy, but further research is essential to fully understand its role in arthritis treatment.
During our review of recent studies, we noted that coenzyme Q10 showed promising results in both laboratory models and clinical settings. Some clinical trials indicated that patients experienced better outcomes when coenzyme Q10 was used alongside standard treatments. However, it’s important to acknowledge that the full extent of its isolated effects on arthritis isn't definitively established, largely because it often appears in combination with other therapies.
While the findings are encouraging, the study also highlights the limitations associated with using phytochemicals like coenzyme Q10. Issues with solubility, permeability, and bioavailability can interfere with their effectiveness as standalone treatments or when combined with DMARDs. We emphasized that innovative delivery systems and formulations may be necessary to optimize the therapeutic benefits of coenzyme Q10 for arthritis patients. In conclusion, coenzyme Q10 holds potential as an adjuvant therapy, but further research is essential to fully understand its role in arthritis treatment.
References
- Freire de Carvalho J, Skare T. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review. Clin Nutr ESPEN. 2024;59:63. 10.1016/j.clnesp.2023.11.016
- Na HS, Woo JS, Kim JH, Lee JS, Um IG, et al. Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. PLoS One. 2022;17:e0270351. 10.1371/journal.pone.0270351
- Kucharská J, Poništ S, Vančová O, Gvozdjáková A, Uličná O, et al. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiol Res. 2021;70:723.
- Kour G, Haq SA, Bajaj BK, Gupta PN, Ahmed Z. Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends. Pharmacol Res. 2021;169:105618. 10.1016/j.phrs.2021.105618
- Jhun J, Moon J, Ryu J, Shin Y, Lee S, et al. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One. 2020;15:e0241080. 10.1371/journal.pone.0241080
- Nachvak SM, Alipour B, Mahdavi AM, Aghdashi MA, Abdollahzad H, et al. Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Clin Rheumatol. 2019;38:3367. 10.1007/s10067-019-04723-x
- Lee SY, Lee SH, Jhun J, Seo HB, Jung KA, et al. A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance. J Med Food. 2018;21:39. 10.1089/jmf.2017.3952
- Jhun J, Lee S, Kim SY, Na HS, Kim EK, et al. Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis. Immunopharmacol Immunotoxicol. 2016;38:103. 10.3109/08923973.2015.1122619
- Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, Alipour B. Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Arch Med Res. 2015;46:527. 10.1016/j.arcmed.2015.08.006
- Jhun J, Lee SH, Byun JK, Jeong JH, Kim EK, et al. Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice. Immunol Lett. 2015;166:92. 10.1016/j.imlet.2015.05.012
- Tawfik MK. Combination of coenzyme Q10 with methotrexate suppresses Freund's complete adjuvant-induced synovial inflammation with reduced hepatotoxicity in rats: Effect on oxidative stress and inflammation. Int Immunopharmacol. 2015;24:80. 10.1016/j.intimp.2014.11.018
- Lee J, Hong YS, Jeong JH, Yang EJ, Jhun JY, et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS One. 2013;8:e69362. 10.1371/journal.pone.0069362
- Bauerová K, Poništ S, Mihalová D, Dráfi F, Kuncírová V. Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress. Interdiscip Toxicol. 2011;4:33. 10.2478/v10102-011-0007-9
- Bauerova K, Paulovicova E, Mihalova D, Drafi F, Strosova M, et al. Combined methotrexate and coenzyme Q₁₀ therapy in adjuvant-induced arthritis evaluated using parameters of inflammation and oxidative stress. Acta Biochim Pol. 2010;57:347.
- Bauerova K, Kucharska J, Mihalova D, Navarova J, Gvozdjakova A, et al. Effect of coenzyme Q(10) supplementation in the rat model of adjuvant arthritis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005;149:501.
