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SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
CoQ10 shows promise for RA
Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.
Study directly assesses CoQ10 effects
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Read More
9
CoQ10 shows promise for arthritis
Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice.
Study provides supportive evidence
We aimed to understand the effect of coenzyme Q10 (CoQ10) on inflammation and immune response in a mouse model of rheumatoid arthritis (RA). This condition is notorious for causing chronic joint pain and damage, and we wanted to see if CoQ10 could help mitigate these issues. To explore this, we administered CoQ10 or a control solution to mice with zymosan-induced arthritis for seven weeks.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Read More
8
CoQ10 reduces inflammation in arthritis
Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial.
Direct evaluation of CoQ10's effects.
We conducted a thorough investigation to determine how coenzyme Q10 (CoQ10) supplementation affects rheumatoid arthritis. In a well-structured double-blind, randomized controlled trial, 44 patients participated, with half receiving CoQ10 capsules and the other half a placebo over two months.
When we analyzed the results, we discovered that patients taking CoQ10 experienced a notable decrease in malondialdehyde (MDA), a marker of oxidative stress. This finding suggests that CoQ10 can help manage oxidative stress levels effectively. Additionally, there was a significant reduction in tumor necrosis factor alpha (TNF-α), an inflammatory cytokine, in those taking CoQ10.
However, while CoQ10 showed promise, we did not observe significant differences in total antioxidant capacity or interleukin-6 levels between the groups. Overall, CoQ10 supplementation appears beneficial in reducing certain inflammatory markers in rheumatoid arthritis patients, pointing towards its potential as a supportive treatment in managing this chronic condition.
When we analyzed the results, we discovered that patients taking CoQ10 experienced a notable decrease in malondialdehyde (MDA), a marker of oxidative stress. This finding suggests that CoQ10 can help manage oxidative stress levels effectively. Additionally, there was a significant reduction in tumor necrosis factor alpha (TNF-α), an inflammatory cytokine, in those taking CoQ10.
However, while CoQ10 showed promise, we did not observe significant differences in total antioxidant capacity or interleukin-6 levels between the groups. Overall, CoQ10 supplementation appears beneficial in reducing certain inflammatory markers in rheumatoid arthritis patients, pointing towards its potential as a supportive treatment in managing this chronic condition.
Read More
Most Useful Reviews
5.8
Significant improvement
This product is excellent, particularly for the elderly and those with arthritis and muscle inflammation. After suffering from widespread pain in my back and joints, my condition improved significantly after taking it for over a month. I take 200 mg per day with breakfast and recommend it strongly.
Read More
8.8
Joint improvement
I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.
Read More
9.5
Mobility assistance
I suffer from arthritis, and CoQ10 helps with my joint mobility. This product is excellent quality, and I am very satisfied with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
9
CoQ10 reduces osteoarthritis symptoms
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death.
Direct examination of CoQ10 efficacy
We investigated how coenzyme Q10 (CoQ10) could help those suffering from osteoarthritis (OA), a common joint disease that leads to cartilage breakdown. In our study, we used a group of male Wistar rats that were specifically induced to develop OA using a chemical known as monosodium iodoacetate (MIA). To see if CoQ10 could make a difference, we orally administered CoQ10 encapsulated in micelles to these rats.
The results were promising. Our findings showed that the CoQ10-micelles treatment significantly reduced symptoms of OA, such as pain, inflammation, and tissue destruction. We also noted a decrease in key inflammatory markers in the rats’ tissues, which suggests that CoQ10 might help lessen the inflammation associated with OA.
Furthermore, when we looked at OA chondrocytes—cells that make up cartilage—the CoQ10-micelles treatment resulted in lower expression of markers related to inflammation and cell death. This indicates not only a potential therapeutic effect of CoQ10 but also presents a novel approach to managing arthritis symptoms.
Overall, our study suggests that CoQ10-micelles could be a valuable addition to OA treatment options, offering hopeful prospects for those affected by this debilitating condition.
The results were promising. Our findings showed that the CoQ10-micelles treatment significantly reduced symptoms of OA, such as pain, inflammation, and tissue destruction. We also noted a decrease in key inflammatory markers in the rats’ tissues, which suggests that CoQ10 might help lessen the inflammation associated with OA.
Furthermore, when we looked at OA chondrocytes—cells that make up cartilage—the CoQ10-micelles treatment resulted in lower expression of markers related to inflammation and cell death. This indicates not only a potential therapeutic effect of CoQ10 but also presents a novel approach to managing arthritis symptoms.
Overall, our study suggests that CoQ10-micelles could be a valuable addition to OA treatment options, offering hopeful prospects for those affected by this debilitating condition.
Read More
9
CoQ10 shows potential in arthritis
Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting.
Key findings on arthritis treatment
We investigated the effects of coenzyme Q10 (CoQ10), a well-known antioxidant, on arthritis, specifically using a unique hybrid formulation known as liposome/gold hybrid nanoparticles (LGNP-CoQ10). Over a span of ten weeks, we administered both CoQ10 and LGNP-CoQ10 orally to mice suffering from collagen-induced arthritis.
Our analysis included various histological methods to understand the inflammation in their joint tissues. The results were promising—LGNP-CoQ10 significantly reduced levels of pro-inflammatory cytokines, which are key players in inflammation. Additionally, we observed lower numbers of Th17 cells and cells expressing phosphorylated STAT3, both linked to inflammatory processes, in the treated mice.
Further experiments with human peripheral blood mononuclear cells (PBMCs) showed that those treated with LGNP-CoQ10 had notably reduced levels of IL-17, an important cytokine in the development of arthritis. These findings suggest that LGNP-CoQ10 could be a valuable therapeutic option for managing rheumatoid arthritis, targeting key inflammatory pathways. Overall, our study highlights the potential of CoQ10 in treating arthritis through innovative delivery methods.
Our analysis included various histological methods to understand the inflammation in their joint tissues. The results were promising—LGNP-CoQ10 significantly reduced levels of pro-inflammatory cytokines, which are key players in inflammation. Additionally, we observed lower numbers of Th17 cells and cells expressing phosphorylated STAT3, both linked to inflammatory processes, in the treated mice.
Further experiments with human peripheral blood mononuclear cells (PBMCs) showed that those treated with LGNP-CoQ10 had notably reduced levels of IL-17, an important cytokine in the development of arthritis. These findings suggest that LGNP-CoQ10 could be a valuable therapeutic option for managing rheumatoid arthritis, targeting key inflammatory pathways. Overall, our study highlights the potential of CoQ10 in treating arthritis through innovative delivery methods.
Read More
9
CoQ10 shows promise for RA
Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.
Study directly assesses CoQ10 effects
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.
However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.
In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.
Read More
9
CoQ10 shows promise for arthritis
Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis.
Focuses on combination therapy effects
We looked into how coenzyme Q10 (CoQ10) works when paired with metformin to tackle arthritis, particularly in a mouse model of collagen-induced arthritis (CIA). Both CoQ10 and metformin have shown promise in reducing inflammation associated with arthritis, but it was intriguing to see how they perform together. Our findings revealed that this combination significantly lessened joint inflammation and reduced markers tied to immune responses, such as Th17 differentiation and IgG production.
We also noted that the combination encouraged the development of regulatory T cells, which play a vital role in keeping the immune system balanced. Interestingly, the partnership between metformin and CoQ10 appeared to slow down the formation of osteoclasts, cells that can contribute to joint damage.
Moreover, we observed a decrease in inflammatory proteins like interleukin-1β, interleukin-6, and tumor necrosis factor-alpha in immune cells following treatment. Encouragingly, this combo also seemed to enhance mitochondrial function, which is often disrupted in arthritis, thereby improving energy use in cells involved in the inflammatory process. Overall, our study suggests that the combination of metformin and CoQ10 may potentially offer new avenues for managing arthritis by not only reducing its severity but also addressing underlying mitochondrial dysfunction.
We also noted that the combination encouraged the development of regulatory T cells, which play a vital role in keeping the immune system balanced. Interestingly, the partnership between metformin and CoQ10 appeared to slow down the formation of osteoclasts, cells that can contribute to joint damage.
Moreover, we observed a decrease in inflammatory proteins like interleukin-1β, interleukin-6, and tumor necrosis factor-alpha in immune cells following treatment. Encouragingly, this combo also seemed to enhance mitochondrial function, which is often disrupted in arthritis, thereby improving energy use in cells involved in the inflammatory process. Overall, our study suggests that the combination of metformin and CoQ10 may potentially offer new avenues for managing arthritis by not only reducing its severity but also addressing underlying mitochondrial dysfunction.
Read More
9
CoQ10 shows promise for arthritis
Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice.
Study provides supportive evidence
We aimed to understand the effect of coenzyme Q10 (CoQ10) on inflammation and immune response in a mouse model of rheumatoid arthritis (RA). This condition is notorious for causing chronic joint pain and damage, and we wanted to see if CoQ10 could help mitigate these issues. To explore this, we administered CoQ10 or a control solution to mice with zymosan-induced arthritis for seven weeks.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Throughout the study, we observed that CoQ10 substantially reduced the severity of arthritis in the mice. Specifically, it significantly lowered the levels of certain inflammatory markers and the proliferation of Th17 immune cells, which are known to contribute to the disease process. We found that CoQ10 also played a role in decreasing the formation of osteoclasts—cells that break down bone—as well as other harmful inflammatory mediators.
Our findings showed that CoQ10 promotes a healthier balance between Th17 cells and regulatory T (Treg) cells. In cultured cells, both mouse and human, CoQ10 reduced Th17 cell numbers while boosting Treg cell counts. This suggests that CoQ10 could be an effective therapeutic option for managing rheumatoid arthritis, potentially leading to a reduction in symptoms and joint damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
9.5
Mobility assistance
I suffer from arthritis, and CoQ10 helps with my joint mobility. This product is excellent quality, and I am very satisfied with the results.
9.5
Pain relief
I purchased this product for my rheumatoid arthritis, and it significantly relieved my pain.
9.5
Increased energy
I gave these to my mother without telling her what they do. After six days, she mentioned feeling more energetic and capable of doing things she couldn't before. She has arthritis and other issues, and I'll definitely order these again for her as they seem to boost her energy effectively.
Read More
8.8
Joint improvement
I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.
Read More
8.8
Joint regeneration
Very good quality with safe ingredients suitable for all ages. It contains a high concentration of Coenzyme Q10 amine, packed well, and is beneficial for arthritis. The fast absorption and good taste contribute to the regeneration of connective tissue.
