Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Moderately Good
Based on 113 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Read More
Most Useful Reviews
9
Cessation of arrhythmia
281 people found this helpful
After my mother suffered a heart attack, she began taking Coenzyme Q10. Initially at 60-90 mg daily, her arrhythmia attacks ceased after 5 months. For two years, she has continued with 100 mg daily, resulting in noticeable health improvements. I started taking Q10 at 50 mg daily, feeling more energetic and noticing improved gum health. This product has transformed our lives, and friends have also begun taking it based on our experience.
Read More
9
Cholesterol side effect relief
62 people found this helpful
I recommend CoQ10 for energy and antioxidant support, especially for those on cholesterol-lowering medication to lessen side effects. It's also beneficial for heart patients and individuals with Parkinson's disease, aiding nervous system function.
Read More
9
Heart pain reduction
36 people found this helpful
I've been using CoQ10 and noticed substantial improvements; my heart pain has nearly vanished, which is essential for my age. I feel much better, and this product has become a key part of my health routine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We explored the connection between acute heart attacks and potential liver and kidney complications, specifically focusing on the role of coenzyme Q10 (Q10). In our study, we examined male rats divided into groups—some receiving normal saline and others pretreated with Q10 for 28 days, followed by an induced heart attack using isoprenaline (ISO).
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Read More
9
We explored the effectiveness of coenzyme Q10 (CoQ10) when used alongside epigallocatechin gallate (EGCG) in protecting heart cells after a myocardial infarction (MI). The study focused on liposome nanoparticles made with distearyl phosphatidylcholine (DSPC) to deliver these compounds effectively. By doing this, we aimed to see whether this combination could reduce oxidative stress and cell death in heart tissue.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Read More
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
Coenzyme Q10 may aid heart recovery
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 113 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cessation of arrhythmia
281 people found this helpful
After my mother suffered a heart attack, she began taking Coenzyme Q10. Initially at 60-90 mg daily, her arrhythmia attacks ceased after 5 months. For two years, she has continued with 100 mg daily, resulting in noticeable health improvements. I started taking Q10 at 50 mg daily, feeling more energetic and noticing improved gum health. This product has transformed our lives, and friends have also begun taking it based on our experience.
Read More
9
Cholesterol side effect relief
62 people found this helpful
I recommend CoQ10 for energy and antioxidant support, especially for those on cholesterol-lowering medication to lessen side effects. It's also beneficial for heart patients and individuals with Parkinson's disease, aiding nervous system function.
Read More
9
Heart pain reduction
36 people found this helpful
I've been using CoQ10 and noticed substantial improvements; my heart pain has nearly vanished, which is essential for my age. I feel much better, and this product has become a key part of my health routine.
Read More
9
Angina relief
34 people found this helpful
After my mother began taking Coenzyme Q10, she quickly no longer experienced pain while climbing stairs. Previously, she struggled with angina and could barely walk without discomfort. This product has significantly enhanced her quality of life at an affordable price.
Read More
7.5
Reduces heart attack risk
24 people found this helpful
The combination of CoQ10 and selenium has significantly reduced cardiovascular mortality. A study showed 5.9% of those taking supplements died from heart disease compared to 12.6% receiving a placebo. They also demonstrated enhanced cardiac function. Both are vital for energy production and combat oxidative stress. It's remarkable how they work together to help protect the heart, especially since CoQ10 levels decrease naturally with age. I believe this supplement is essential for heart health.
Read More
Frequently Asked Questions
9
Breathing improvement
7 people found this helpful
I purchased this for my mother, who often felt breathless during activities. After two weeks on CoQ10, her breathing difficulties vanished. She’s continued using it and it has made a noticeable difference. I also ordered it for my aunt as I believe it to be a perfect gift for her health.
9
Heart pain reduction
36 people found this helpful
I've been using CoQ10 and noticed substantial improvements; my heart pain has nearly vanished, which is essential for my age. I feel much better, and this product has become a key part of my health routine.
9
Magic dietary supplement
3 people found this helpful
This Q10 supplement works wonders for cardiovascular issues. After six months, I noticed relief from arrhythmia and heart ailments. Pairing it with omega has kept my energy high and health robust.
9
Angina relief
34 people found this helpful
After my mother began taking Coenzyme Q10, she quickly no longer experienced pain while climbing stairs. Previously, she struggled with angina and could barely walk without discomfort. This product has significantly enhanced her quality of life at an affordable price.
9
Better heart rate
9 people found this helpful
I experienced a rapid heart rate and poor heart function for years, but since starting Coenzyme Q10 and fish oil combined with exercise, my heart rate has normalised to 75. I no longer suffer from palpitations or chest tightness, and I'm grateful for this product. It has truly worked wonders alongside good diet and exercise.
9
Heart pain relief
12 people found this helpful
As an excellent antioxidant, I noticed my heart pain during strength training completely vanished after a week on this supplement. My skin improved, I gained energy and motivation, and everything felt easier, as if I was getting better rest. I’m grateful for this product; it truly has transformed my training experience.
9
Eased heart attacks
12 people found this helpful
I inadvertently started taking CoQ10 after receiving a bottle as a gift, as I was suffering severe heart attacks during exercise. Since taking it, the severity and frequency of the attacks have significantly decreased. I would recommend it to others.
9
Pain relief
4 people found this helpful
I ordered this for my brother, who has heart issues. After just a few days, his pain and seizures have significantly diminished over the month. Initially sceptical about American pills, he now continually asks for more CoQ10. I fully recommend it, especially as it’s far more affordable than what we have here.
9
Supports heart health
6 people found this helpful
CoQ10 has significantly reduced my tachycardia, angina pectoris, and heart pain. Once I stopped taking it, I noticed its absence; it improves energy, skin, and heart health. As we age, our CoQ10 levels decrease, making supplementation essential. I take it daily with other vitamins; careful advice from a doctor is crucial. At fifty, I believe this has improved my heart function and overall health.
9
Cholesterol side effect relief
62 people found this helpful
I recommend CoQ10 for energy and antioxidant support, especially for those on cholesterol-lowering medication to lessen side effects. It's also beneficial for heart patients and individuals with Parkinson's disease, aiding nervous system function.
7.5
Reduces heart attack risk
24 people found this helpful
The combination of CoQ10 and selenium has significantly reduced cardiovascular mortality. A study showed 5.9% of those taking supplements died from heart disease compared to 12.6% receiving a placebo. They also demonstrated enhanced cardiac function. Both are vital for energy production and combat oxidative stress. It's remarkable how they work together to help protect the heart, especially since CoQ10 levels decrease naturally with age. I believe this supplement is essential for heart health.
9
Protects against heart issues
12 people found this helpful
Combining CoQ10 and selenium can reduce cardiovascular mortality by over 50%. They improve heart function and protect against oxidative stress. It's essential for preventing heart disease. I highly recommend this combination for heart health.
8
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
8
CoQ10 improves heart recovery markers
We conducted a study to see how coenzyme Q10 (CoQ10) might help patients recovering from a heart attack, specifically those experiencing ST-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). In this randomized trial, seventy patients were split into two groups: one received standard treatments along with CoQ10, while the other received standard treatment plus a placebo.
We measured various markers in the patients' blood to assess oxidative stress—this refers to the imbalance between antioxidants and harmful reactive molecules in the body. While the changes in these markers at 6 and 24 hours were similar for both groups, we saw significant benefits for the CoQ10 group at the 72-hour mark. Specifically, those taking CoQ10 had higher levels of protective antioxidants like superoxide dismutase and catalase, and lower levels of the harmful substance malondialdehyde.
Overall, this suggests that CoQ10 could play a valuable role in reducing oxidative stress and may help with heart muscle recovery after reperfusion, the process following a heart attack when blood supply is restored. However, it's worth noting that the plasma activity of another antioxidant, glutathione peroxidase, didn’t show significant differences between the two groups.
We measured various markers in the patients' blood to assess oxidative stress—this refers to the imbalance between antioxidants and harmful reactive molecules in the body. While the changes in these markers at 6 and 24 hours were similar for both groups, we saw significant benefits for the CoQ10 group at the 72-hour mark. Specifically, those taking CoQ10 had higher levels of protective antioxidants like superoxide dismutase and catalase, and lower levels of the harmful substance malondialdehyde.
Overall, this suggests that CoQ10 could play a valuable role in reducing oxidative stress and may help with heart muscle recovery after reperfusion, the process following a heart attack when blood supply is restored. However, it's worth noting that the plasma activity of another antioxidant, glutathione peroxidase, didn’t show significant differences between the two groups.
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
8
We explored the potential benefits of coenzyme Q10 (CoQ10) in reducing the risk of heart attacks. In a well-structured clinical trial involving 892 patients with hypertension, participants were divided into two groups: one received 100 mg of CoQ10 daily alongside their standard treatment, while the other group only received standard therapy.
Our findings revealed that those taking CoQ10 experienced fewer cases of both non-fatal and fatal heart attacks over a 12-month period. Specifically, the incidence of non-fatal heart attacks was lower in the CoQ10 group at 5.4% compared to 8.4% in the placebo group. For fatal heart attacks, rates were 1.5% versus 3.1%, illustrating a promising trend towards heart health improvement.
Based on these results, we believe that incorporating CoQ10 into treatment plans for high-risk patients may be a valuable approach. This could not only enhance patient outcomes but also alleviate some of the burden on healthcare systems struggling with heart disease.
Our findings revealed that those taking CoQ10 experienced fewer cases of both non-fatal and fatal heart attacks over a 12-month period. Specifically, the incidence of non-fatal heart attacks was lower in the CoQ10 group at 5.4% compared to 8.4% in the placebo group. For fatal heart attacks, rates were 1.5% versus 3.1%, illustrating a promising trend towards heart health improvement.
Based on these results, we believe that incorporating CoQ10 into treatment plans for high-risk patients may be a valuable approach. This could not only enhance patient outcomes but also alleviate some of the burden on healthcare systems struggling with heart disease.
7
We explored the potential effects of coenzyme Q10 (CoQ10) supplementation on heart attacks and related cardiovascular issues. This supplement, known for its role in energy production and its antioxidant properties, has generated interest as a possible support in managing heart health.
Several randomized clinical trials have looked into the impact of CoQ10 on heart attack patients and those dealing with conditions like heart failure and hypertension. These studies have noted promising decreases in inflammatory markers and oxidative stress, which are crucial factors in heart disease.
However, while the results are encouraging, many studies included diverse cardiovascular issues rather than focusing solely on heart attacks. More extensive research with larger groups of patients will be necessary to claim CoQ10's effectiveness specifically for heart attack treatment. It's vital to continue evaluating this supplement's role while we await further scientific findings.
Several randomized clinical trials have looked into the impact of CoQ10 on heart attack patients and those dealing with conditions like heart failure and hypertension. These studies have noted promising decreases in inflammatory markers and oxidative stress, which are crucial factors in heart disease.
However, while the results are encouraging, many studies included diverse cardiovascular issues rather than focusing solely on heart attacks. More extensive research with larger groups of patients will be necessary to claim CoQ10's effectiveness specifically for heart attack treatment. It's vital to continue evaluating this supplement's role while we await further scientific findings.
We investigated whether coenzyme Q10 (CoQ10) could help prevent kidney injury caused by contrast dye during heart procedures in patients experiencing a type of heart attack known as STEMI. In our study, 150 patients undergoing primary percutaneous coronary intervention (PCI) were divided into two groups. One group received CoQ10 alongside standard intravenous hydration, while the other received a placebo.
CoQ10 was given orally, starting with a 400 mg dose before the procedure, followed by 200 mg twice a day for three days post-procedure. We closely monitored serum creatinine levels and assessed kidney function at various points after the procedure. Additionally, we measured levels of certain antioxidants and markers of oxidative stress before and after the PCI.
Our findings suggested that supplementing with CoQ10 may be beneficial for preventing contrast-induced acute kidney injury. Thus, it appears that CoQ10 can serve as a useful addition to hydration strategies in protecting the kidneys during critical cardiac interventions.
CoQ10 was given orally, starting with a 400 mg dose before the procedure, followed by 200 mg twice a day for three days post-procedure. We closely monitored serum creatinine levels and assessed kidney function at various points after the procedure. Additionally, we measured levels of certain antioxidants and markers of oxidative stress before and after the PCI.
Our findings suggested that supplementing with CoQ10 may be beneficial for preventing contrast-induced acute kidney injury. Thus, it appears that CoQ10 can serve as a useful addition to hydration strategies in protecting the kidneys during critical cardiac interventions.
References
- Chidebe EO, Moke EG, Asiwe JN, Ben-Azu B, Demaki WE, et al. Therapeutic effect of coenzyme-Q10 pretreatment on isoprenaline-induced cardiogenic hepatorenal complications in rats. Int J Physiol Pathophysiol Pharmacol. 2024;16:126. 10.62347/PFXZ9903
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
- Pan W, Zhou G, Hu M, Li G, Zhang M, et al. Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway. BMC Cardiovasc Disord. 2024;24:76. 10.1186/s12872-024-03729-x
- Lei W, Yang J, Wang J, Xiao Z, Zhou P, et al. Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction. Biomater Sci. 2023;11:6862. 10.1039/d3bm00857f
- Ahmadimoghaddam D, Talebi SS, Rahmani A, Zamanirafe M, Parvaneh E, et al. Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur J Clin Pharmacol. 2023;79:1341. 10.1007/s00228-023-03546-9
- Mokhtari B, Badalzadeh R. Mitochondria-targeted combination treatment strategy counteracts myocardial reperfusion injury of aged rats by modulating autophagy and inflammatory response. Mol Biol Rep. 2023;50:3973. 10.1007/s11033-023-08318-3
- Li D, Zhang G, Wang Z, Guo J, Liu Y, et al. Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. Eur J Pharmacol. 2023;943:175569. 10.1016/j.ejphar.2023.175569
- Yazdi A, Shirmohammadi K, Parvaneh E, Entezari-Maleki T, Hosseini SK, et al. Effects of coenzyme Q10 supplementation on oxidative stress biomarkers following reperfusion in STEMI patients undergoing primary percutaneous coronary intervention. J Cardiovasc Thorac Res. 2023;15:250. 10.34172/jcvtr.2023.31817
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
- Shah IA, Memon M, Ansari S, Kumar R, Chandio SA, et al. Role of Coenzyme Q10 in Prophylaxis of Myocardial Infarction. Cureus. 2021;13:e13137. 10.7759/cureus.13137
- Fontaine F, Legallois D, Créveuil C, Chtourou M, Coulbault L, et al. Is plasma concentration of coenzyme Q10 a predictive marker for left ventricular remodelling after revascularization for ST-segment elevation myocardial infarction?. Ann Clin Biochem. 2021;58:327. 10.1177/00045632211001100
- Martelli A, Testai L, Colletti A, Cicero AFG. Coenzyme Q: Clinical Applications in Cardiovascular Diseases. Antioxidants (Basel). 2020;9. 10.3390/antiox9040341
- Singh RB, Fedacko J, Mojto V, Pella D. Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome. Antioxidants (Basel). 2018;7. 10.3390/antiox7080099
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- Sharifi MH, Eftekhari MH, Ostovan MA, Rezaianazadeh A. Effects of a therapeutic lifestyle change diet and supplementation with Q10 plus L-carnitine on quality of life in patients with myocardial infarction: A randomized clinical trial. J Cardiovasc Thorac Res. 2017;9:21. 10.15171/jcvtr.2017.03
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