Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 251 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
Most Useful Reviews
9
Supports heart health
393 people found this helpful
This product works excellently! Coenzyme Q10 is vital for heart health and energy production, also acting as a powerful immunomodulator. It can even help slow down aging. I suggest combining it with Omega 3 for better results. Just be cautious as it may lower blood pressure. I've ordered numerous supplements from iHerb, and I believe they can aid in maintaining our health.
Read More
9
Reduced arrhythmia attacks
281 people found this helpful
My experience with Coenzyme Q10 began after my mother suffered a heart attack at 75, having endured numerous heart-related issues for years. After starting her on this enzyme, her arrhythmia attacks ceased within five months. Alongside Omega 3, she regularly takes it for heart health. My husband and I also take it, noting increased energy and symptom improvements. This product significantly aids those with heart disease.
Read More
9
Improves post-COVID health
132 people found this helpful
As a post-COVID patient, I struggled with many side effects, impacting my daily routine. Since starting CoQ10, I've noticed significant health improvements, including my heart health and endurance. This supplement helps protect against oxidative damage post-virus.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 251 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
393 people found this helpful
This product works excellently! Coenzyme Q10 is vital for heart health and energy production, also acting as a powerful immunomodulator. It can even help slow down aging. I suggest combining it with Omega 3 for better results. Just be cautious as it may lower blood pressure. I've ordered numerous supplements from iHerb, and I believe they can aid in maintaining our health.
Read More
9
Reduced arrhythmia attacks
281 people found this helpful
My experience with Coenzyme Q10 began after my mother suffered a heart attack at 75, having endured numerous heart-related issues for years. After starting her on this enzyme, her arrhythmia attacks ceased within five months. Alongside Omega 3, she regularly takes it for heart health. My husband and I also take it, noting increased energy and symptom improvements. This product significantly aids those with heart disease.
Read More
9
Improves post-COVID health
132 people found this helpful
As a post-COVID patient, I struggled with many side effects, impacting my daily routine. Since starting CoQ10, I've noticed significant health improvements, including my heart health and endurance. This supplement helps protect against oxidative damage post-virus.
Read More
9
Support after 30
62 people found this helpful
This supplement is essential for those over 30, as our bodies produce less CoQ10 with age. As someone with a wheelchair lifestyle, I find that additional CoQ10 helps maintain my heart health and overall well-being.
Read More
7.5
Increased alertness
1051 people found this helpful
Excellent! Initially hesitant to try this supplement, I’ve been taking these capsules for a week and noticed a significant increase in my alertness. I expected my heart rate to normalise, but it hasn't changed much. However, my blood pressure has increased to 120 over 70 from 100. I take one capsule in the morning, as taking two made me too energised to sleep. I highly recommend it—it's effective!
Read More
Frequently Asked Questions
9
Reduced arrhythmia attacks
281 people found this helpful
My experience with Coenzyme Q10 began after my mother suffered a heart attack at 75, having endured numerous heart-related issues for years. After starting her on this enzyme, her arrhythmia attacks ceased within five months. Alongside Omega 3, she regularly takes it for heart health. My husband and I also take it, noting increased energy and symptom improvements. This product significantly aids those with heart disease.
9
Breathe easier
7 people found this helpful
I ordered CoQ10 for my mother, who struggled with occasional breathlessness that felt alarming, especially at night. After just two weeks, she no longer experiences this issue. I'm now ordering another bottle for my aunt as I trust this product really helps with heart disease.
7.5
Increased alertness
1051 people found this helpful
Excellent! Initially hesitant to try this supplement, I’ve been taking these capsules for a week and noticed a significant increase in my alertness. I expected my heart rate to normalise, but it hasn't changed much. However, my blood pressure has increased to 120 over 70 from 100. I take one capsule in the morning, as taking two made me too energised to sleep. I highly recommend it—it's effective!
9
Heart rate controlled
9 people found this helpful
I have experienced a rapid heart rate and heart issues since pregnancy. After starting Coenzyme and fish oil, my heart rate improved remarkably from 130 to 75 within days. This was the first time in three years that my heart rate became manageable. I no longer face palpitations or tightness in my chest. I am grateful for this product!
9
Heart pain relief
36 people found this helpful
FOR THE HEART – truly beneficial! I wondered for a long time why my heart ached and I experienced shortness of breath. After taking this coenzyme, my heart pain has almost disappeared, which is really important at my age!
9
Improves post-COVID health
132 people found this helpful
As a post-COVID patient, I struggled with many side effects, impacting my daily routine. Since starting CoQ10, I've noticed significant health improvements, including my heart health and endurance. This supplement helps protect against oxidative damage post-virus.
9
Heart pain alleviated
12 people found this helpful
This antioxidant genuinely works. I experienced some heart discomfort during strength training and skin issues. After a week of taking this supplement, my heart complaints ceased, my skin became vibrant, and I gained energy. Training has become easier, and I feel more motivated. This has made a significant difference during workouts, and I'm thankful for the change.
9
Supports heart health
393 people found this helpful
This product works excellently! Coenzyme Q10 is vital for heart health and energy production, also acting as a powerful immunomodulator. It can even help slow down aging. I suggest combining it with Omega 3 for better results. Just be cautious as it may lower blood pressure. I've ordered numerous supplements from iHerb, and I believe they can aid in maintaining our health.
9
Cardiovascular disease protection
12 people found this helpful
Research indicates that combining CoQ10 with selenium significantly lowers the risk of cardiovascular diseases by over 50%. This powerful synergy enhances heart function and offers long-term protection against heart disease, making it crucial for maintaining heart health.
9
Decreased arrhythmias
13 people found this helpful
Having suffered from irregular heartbeats, I noticed a marked decrease in both PACs and PVCs after increasing my CoQ10 dosage to 100 mg per day. This improvement has made a significant impact on my daily life; I no longer have to worry about these heart issues.
9
Heart protection benefit
37 people found this helpful
The best preparation for the heart! I bought this product recently and I'm very pleased. It works effectively, protecting my heart during exercise, especially for those over 40. The main component, coenzyme Q10, is a natural aid for improving the body's energy and has a beneficial impact on the cardiovascular system. With ageing, the body's production declines, so supplementation is vital, particularly for managing heart disease and fatigue.
9
Angina easement
34 people found this helpful
The best heart protection! My mother has relieved her angina with this supplement. Previously constrained, she's now able to climb stairs comfortably after just a week of taking coenzyme Q10, significantly improving her quality of life!
We explored how Coenzyme Q10 (CoQ10) combined with ultrasound-targeted microbubble destruction (UTMD) could help treat diabetic cardiomyopathy (DCM) in rats. In our study, we took a close look at the heart health of diabetic rats after using these innovative treatments. Specifically, we used a group of 60 male rats, inducing diabetes in most of them and setting up control groups for comparison.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
7
We explored the effects of coenzyme Q10 (CoQ10) on heart disease, particularly in relation to diabetic cardiomyopathy, a common complication for those with diabetes. The study discussed various treatment options for heart issues stemming from diabetes, highlighting how CoQ10 might play a role.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
7
We investigated the connection between coenzyme Q10 and heart disease, specifically looking into its effects on dilated cardiomyopathy, a condition that weakens heart muscles and affects their ability to pump blood. Our study revealed that a long noncoding RNA, known as DCRT, plays a key role in maintaining mitochondrial function within heart cells. When DCRT levels drop, it leads to dysfunction in the mitochondria, which are crucial for energy production in the heart.
We observed that administering coenzyme Q10 could partially alleviate the mitochondrial dysfunction caused by the loss of DCRT. This is promising because it suggests that coenzyme Q10 might help in improving heart function in patients suffering from similar conditions. While the effects were noted, it's essential to remember that the research indicates only a partial mitigation of the issue, rather than a complete cure.
Ultimately, our findings point to the importance of DCRT in heart health and highlight the potential of coenzyme Q10 as a supportive treatment strategy, particularly in addressing the mitochondrial dysfunction often seen in heart diseases like dilated cardiomyopathy.
We observed that administering coenzyme Q10 could partially alleviate the mitochondrial dysfunction caused by the loss of DCRT. This is promising because it suggests that coenzyme Q10 might help in improving heart function in patients suffering from similar conditions. While the effects were noted, it's essential to remember that the research indicates only a partial mitigation of the issue, rather than a complete cure.
Ultimately, our findings point to the importance of DCRT in heart health and highlight the potential of coenzyme Q10 as a supportive treatment strategy, particularly in addressing the mitochondrial dysfunction often seen in heart diseases like dilated cardiomyopathy.
8
Coenzyme Q10 aids thyroid function
We conducted a study to explore the impact of coenzyme Q10 on thyroid health and overall well-being in a group of elderly individuals with low selenium levels. This was a rigorous, randomized, placebo-controlled trial that lasted 48 months, during which participants received either selenium yeast combined with coenzyme Q or a placebo.
Our findings revealed that supplementation with selenium and coenzyme Q significantly improved thyroid hormone levels, which is crucial for regulating various bodily functions. Better thyroid hormone levels are linked to enhanced heart health, and we also observed a positive effect on cardiovascular mortality rates and the overall quality of life in the participants.
While we addressed the role of coenzyme Q10, it is important to note that it was administered alongside selenium. This makes it challenging to isolate its effects on heart disease, so we can't definitively conclude the specific impact of coenzyme Q10 alone on heart health from this study.
Overall, our research shines a light on the potential benefits of selenium and coenzyme Q supplementation for an elderly population, particularly in relation to thyroid function and quality of life, while hinting at broader implications for heart health as well.
Our findings revealed that supplementation with selenium and coenzyme Q significantly improved thyroid hormone levels, which is crucial for regulating various bodily functions. Better thyroid hormone levels are linked to enhanced heart health, and we also observed a positive effect on cardiovascular mortality rates and the overall quality of life in the participants.
While we addressed the role of coenzyme Q10, it is important to note that it was administered alongside selenium. This makes it challenging to isolate its effects on heart disease, so we can't definitively conclude the specific impact of coenzyme Q10 alone on heart health from this study.
Overall, our research shines a light on the potential benefits of selenium and coenzyme Q supplementation for an elderly population, particularly in relation to thyroid function and quality of life, while hinting at broader implications for heart health as well.
References
- Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. 10.3390/ijms26052204
- Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. 10.3390/antiox14020243
- Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. 10.14715/cmb/2025.70.1.13
- Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. 10.3760/cma.j.cn112137-20240605-01273
- Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. 10.1186/s12872-024-04232-z
- Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. 10.7150/ijms.99359
- Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. 10.1080/14796678.2024.2352308
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
- Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
- Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. 10.1016/j.freeradbiomed.2024.06.027
- Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. 10.3855/jidc.18776
- Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. 10.1161/CIRCULATIONAHA.123.067861
- Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. 10.3390/ijms25095027
- Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024;22:191. 10.1186/s12916-024-03411-1
- Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, et al. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sci. 2024;348:122688. 10.1016/j.lfs.2024.122688
- Seo JS. Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series. Medicine (Baltimore). 2024;103:e37447. 10.1097/MD.0000000000037447
