Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Moderately Good
Based on 77 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
8
CoQ10 improves cholesterol removal functions
We conducted a 24-week study to see how coenzyme Q10 (CoQ10) might help people with high cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL) function. A total of 101 participants with dyslipidemia were randomly assigned to either a CoQ10 group, which received 120 mg daily, or a placebo group.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
Read More
Most Useful Reviews
9
Energy production boost
31 people found this helpful
BEST FRIENDS! Coenzyme Q-10 helps produce energy in the body and acts as an antioxidant. CoQ10 controls high blood pressure and maintains energy metabolism, aiding in heart health and even supporting the immune system. It is absorbed better with fats!
Read More
7.5
Satisfied results
27 people found this helpful
Q10 is a crucial supplement as it decreases with age, necessary for heart health and supporting cholesterol levels. I take it twice a year and am completely satisfied, highly recommend it!
Read More
9
Normal pulse
17 people found this helpful
I give my parents this excellent drug for cardiovascular support. My mother’s pulse has normalised significantly since taking it. It offers good absorption and a year's supply is very economical.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
- All Researches
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
9
Combined supplements lower cholesterol
We conducted a study to explore the lipid-lowering effects of a dietary supplement that included coenzyme Q10 as well as other natural extracts. Specifically, we wanted to see how these components could help lower cholesterol levels in individuals with mild hypercholesterolemia. Our study involved 105 participants who had slightly elevated low-density lipoprotein (LDL) cholesterol levels, categorized as mild hypercholesterolemia, and were randomly split into different treatment groups for eight weeks.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
Read More
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
We explored the effects of a combination of monacolin K, berberine, and coenzyme Q10 on cholesterol levels in individuals with moderate hypercholesterolemia and cardiovascular risk. This study involved patients divided into two groups: one received the nutraceutical preparation, while the other was given a placebo.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
Read More
8
In this study, we explored how a dietary supplement, which includes coenzyme Q10 among other natural ingredients, affects high cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, Armolipid, was given daily to 84 young participants, aiming to see if it could positively impact their cholesterol levels over time.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 77 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energy production boost
31 people found this helpful
BEST FRIENDS! Coenzyme Q-10 helps produce energy in the body and acts as an antioxidant. CoQ10 controls high blood pressure and maintains energy metabolism, aiding in heart health and even supporting the immune system. It is absorbed better with fats!
Read More
7.5
Satisfied results
27 people found this helpful
Q10 is a crucial supplement as it decreases with age, necessary for heart health and supporting cholesterol levels. I take it twice a year and am completely satisfied, highly recommend it!
Read More
9
Normal pulse
17 people found this helpful
I give my parents this excellent drug for cardiovascular support. My mother’s pulse has normalised significantly since taking it. It offers good absorption and a year's supply is very economical.
Read More
9
Cholesterol medication aid
14 people found this helpful
An excellent product! Coenzyme Q10 is beneficial for health, particularly for those on cholesterol medications. It supports overall well-being. I respect this company and recommend their product.
Read More
9
Decreased irregularities
13 people found this helpful
I was diagnosed with heart irregularities and took 60 mg of CoQ10 daily. After switching to 100 mg capsules, I noticed significantly fewer occurrences of these irregularities. This improvement is likely linked to the higher dosage.
Read More
Frequently Asked Questions
9
Fast results
7 people found this helpful
Following spinal surgery, my doctor recommended CoQ10 to aid healing and manage my high cholesterol. After a month of taking it, my levels were surprisingly high, prompting me to reduce to two capsules a day. The Bioperine improves absorption, and I appreciate the veggie capsules.
9
Supports heart health
8 people found this helpful
Energy and well-being! I've been taking this supplement for a month on my doctor's advice to combat high cholesterol and promote heart health. The vegetarian capsules are small and easy to swallow. I feel more cheerful and less fatigued. Coenzyme Q10 is essential for those with cardiovascular issues, especially when under stress or physical strain. My family takes it regularly, finding it beneficial even in prophylactic doses.
9
Effective for heart
3 people found this helpful
My mother, who suffers from high blood pressure and severe seizures, started taking CoQ10 on her doctor's advice. She noticed a remarkable improvement, with fewer attacks and increased energy, finding it much more effective than previous medications.
9
Decreased irregularities
13 people found this helpful
I was diagnosed with heart irregularities and took 60 mg of CoQ10 daily. After switching to 100 mg capsules, I noticed significantly fewer occurrences of these irregularities. This improvement is likely linked to the higher dosage.
9
Relieves leg pain
2 people found this helpful
I take medication for high cholesterol that causes leg pain. Since I started this supplement in the morning, I hardly experience any pain. When I stopped, the pain returned, so a homeopath advised me to continue taking it.
9
Improved blood pressure
1 people found this helpful
I purchased Q10 for my dad about 22 months ago, and he no longer requires medication for high blood pressure. He feels amazing, although he still needs to manage his diet.
9
Cholesterol management
1 people found this helpful
I depend on CoQ10 combined with Omega and Lecithin to manage my cholesterol. Since starting this routine, my cholesterol has dropped by 100 points, and my "good" cholesterol has increased.
9
Satisfied with effects
2 people found this helpful
I am very satisfied with this product so far. I take it alongside my Simvastatin 20 mg for high cholesterol. I've switched to taking it at lunchtime with a high-fat meal, and since then, I have not experienced the aches and pains that I previously had without CoQ10. I have always taken just CoQ10 but am pleased with your product's results thus far.
10
Supports heart function
1 people found this helpful
I give this to my child with secondary mitochondrial dysfunction alongside PQQ. Doctor's Best CoQ10 aids heart function and promotes energy production, which is vital as it declines with stress, free radicals, and aging.
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
7
We gathered insights from a comprehensive review that examined how coenzyme Q10 supplementation affects cholesterol levels in people with diabetic nephropathy. The review analyzed findings from multiple randomized controlled trials to assess the effectiveness of this treatment.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
9
We explored the effects of a combination of monacolin K, berberine, and coenzyme Q10 on cholesterol levels in individuals with moderate hypercholesterolemia and cardiovascular risk. This study involved patients divided into two groups: one received the nutraceutical preparation, while the other was given a placebo.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
4
We conducted a clinical trial to investigate how Coenzyme Q10 (Co-Q10) affects cholesterol levels in women suffering from migraines. Over 12 weeks, 84 females aged 18-50 were split into two groups: one received a daily dose of 400 mg of Co-Q10 while the other received a placebo.
At the end of the study, we found that Co-Q10 supplementation significantly increased levels of high-density lipoprotein (HDL-C), often referred to as "good" cholesterol. This suggests a positive shift in the lipid profile for those taking Co-Q10. However, it did not have a noticeable effect on other cholesterol levels like low-density lipoprotein (LDL), triglycerides, or total cholesterol.
Moreover, the trial revealed an interesting detail: participants experienced a significant reduction in malondialdehyde (MDA) levels, a marker of oxidative stress, highlighting some antioxidant benefits from Co-Q10. It's worth noting that while we saw improvements in HDL-C levels, we did not measure enough change in cholesterol overall to establish Co-Q10 as a definitive treatment for high cholesterol.
At the end of the study, we found that Co-Q10 supplementation significantly increased levels of high-density lipoprotein (HDL-C), often referred to as "good" cholesterol. This suggests a positive shift in the lipid profile for those taking Co-Q10. However, it did not have a noticeable effect on other cholesterol levels like low-density lipoprotein (LDL), triglycerides, or total cholesterol.
Moreover, the trial revealed an interesting detail: participants experienced a significant reduction in malondialdehyde (MDA) levels, a marker of oxidative stress, highlighting some antioxidant benefits from Co-Q10. It's worth noting that while we saw improvements in HDL-C levels, we did not measure enough change in cholesterol overall to establish Co-Q10 as a definitive treatment for high cholesterol.
8
CoQ10 improves cholesterol removal functions
We conducted a 24-week study to see how coenzyme Q10 (CoQ10) might help people with high cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL) function. A total of 101 participants with dyslipidemia were randomly assigned to either a CoQ10 group, which received 120 mg daily, or a placebo group.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. 10.3390/biom14121608
- Cho KH, Lee Y, Bahuguna A, Lee SH, Yang CE, et al. The Consumption of Beeswax Alcohol (BWA, Raydel) Improved Zebrafish Motion and Swimming Endurance by Protecting the Brain and Liver from Oxidative Stress Induced by 24 Weeks of Supplementation with High-Cholesterol and D-Galactose Diets: A Comparative Analysis Between BWA and Coenzyme Q. Antioxidants (Basel). 2024;13. 10.3390/antiox13121488
- Zhao M, Tian Z, Zhao D, Kuang H, Liang Y, et al. Associations between dietary coenzyme Q10 intake and lipid profiles in adults: a national cross-sectional study. Front Nutr. 2024;11:1472002. 10.3389/fnut.2024.1472002
- Cho KH, Bahuguna A, Lee Y, Lee SH, Kim JE. Twenty-Week Dietary Supplementation with Beeswax Alcohol (BWA; Raydel) Ameliorates High-Cholesterol-Induced Long-Term Dyslipidemia and Organ Damage in Hyperlipidemic Zebrafish in a Dose-Dependent Manner: A Comparative Analysis Between BWA and Coenzyme Q. Pharmaceuticals (Basel). 2024;17. 10.3390/ph17111434
- Cai L, Huang Y, Li X, Cao D, Liu F. Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. Front Endocrinol (Lausanne). 2024;15:1385872. 10.3389/fendo.2024.1385872
- Hu X, Wang W, Su X, Peng H, Tan Z, et al. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ. 2023;11:e16410. 10.7717/peerj.16410
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Angelopoulos N, Paparodis RD, Androulakis I, Boniakos A, Argyrakopoulou G, et al. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023;15. 10.3390/nu15122682
- Liu Z, Tian Z, Zhao D, Liang Y, Dai S, et al. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022;108:232. 10.1210/clinem/dgac585
- Fahmy MIM, Sayed RH, El-Yamany MF, El-Naggar R, A Eliwa H. Rosuvastatin and co-enzyme Q improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden. Biomed Pharmacother. 2022;153:113526. 10.1016/j.biopha.2022.113526
- Zou J, Tian Z, Zhao Y, Qiu X, Mao Y, et al. Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia. Nutrition. 2022;101:111703. 10.1016/j.nut.2022.111703
- Martinez-Martin F, Corbella E, Sarasa I, Trias F, Petitbò D, et al. Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk. Semergen. 2022;48:403. 10.1016/j.semerg.2022.04.005
