' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Questionable
Based on 10 Reviews
5.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9.5
Coenzyme Q10 alleviates nausea
[Mitochondrial encephalomyopathy (focal cytochrome c oxidase deficiency) with transient episodes of muscle weakness and elevation of serum creatine kinase activity].
High relevance for coenzyme Q10
We explored the effects of coenzyme Q10 treatment in a 17-year-old boy with mitochondrial encephalomyopathy, characterized by episodes of muscle weakness and related symptoms such as fatigue, nausea, and vomiting. This patient experienced three episodes over several years, during which his serum creatine kinase levels spiked.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
Read More
8
CoQ10 reduces migraine-related nausea
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.
Direct evaluation of CoQ10
We conducted a double-blind, randomized, placebo-controlled study to investigate how coenzyme Q10 (CoQ10) impacts nausea in patients dealing with migraines. Our research involved 42 participants who were given either 300 mg of CoQ10 a day or a placebo over the course of three months.
Throughout the study, we observed that CoQ10 did indeed show significant results in reducing the frequency of migraine attacks and the number of headache days, alongside improvement in nausea symptoms. In the third month of treatment, 47.6% of those taking CoQ10 responded positively in terms of attack frequency. This was quite a contrast to the 14.4% response rate for those on placebo.
The data indicates that CoQ10 is not only effective but also well tolerated by participants. This presents a promising option for those seeking relief from migraine-associated nausea. Overall, CoQ10 appears to offer such patients a viable treatment alternative, with its significant benefits becoming clearer over time.
Throughout the study, we observed that CoQ10 did indeed show significant results in reducing the frequency of migraine attacks and the number of headache days, alongside improvement in nausea symptoms. In the third month of treatment, 47.6% of those taking CoQ10 responded positively in terms of attack frequency. This was quite a contrast to the 14.4% response rate for those on placebo.
The data indicates that CoQ10 is not only effective but also well tolerated by participants. This presents a promising option for those seeking relief from migraine-associated nausea. Overall, CoQ10 appears to offer such patients a viable treatment alternative, with its significant benefits becoming clearer over time.
Read More
7
Co-Q shows promise for CVS
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study.
Direct evidence on Co-Q's efficacy
We explored the effects of coenzyme Q10 (Co-Q) as a treatment for cyclic vomiting syndrome (CVS), a disorder characterized by recurrent and severe episodes of nausea and vomiting. Our approach involved gathering feedback through an online survey from individuals with CVS and their parents.
In our comparison, 22 participants were taking Co-Q while 162 were using amitriptyline, the typical standard-of-care treatment. We noticed that nearly 68% of those on Co-Q experienced at least a 50% reduction in nausea severity and other related symptoms, similar to 72% of those taking amitriptyline.
Notably, Co-Q users reported no side effects, whereas half of the amitriptyline users did, leading to 21% discontinuing their treatment. This raises an important point about the tolerability of Co-Q compared to amitriptyline, as 77% of Co-Q participants felt the benefits outweighed any perceived risks, compared to just 47% of those on amitriptyline.
Overall, our findings suggest that Co-Q could be a promising option for managing nausea in CVS, especially considering its favorable safety profile. This new insight encourages further research through clinical trials to rigorously evaluate Co-Q’s effectiveness.
In our comparison, 22 participants were taking Co-Q while 162 were using amitriptyline, the typical standard-of-care treatment. We noticed that nearly 68% of those on Co-Q experienced at least a 50% reduction in nausea severity and other related symptoms, similar to 72% of those taking amitriptyline.
Notably, Co-Q users reported no side effects, whereas half of the amitriptyline users did, leading to 21% discontinuing their treatment. This raises an important point about the tolerability of Co-Q compared to amitriptyline, as 77% of Co-Q participants felt the benefits outweighed any perceived risks, compared to just 47% of those on amitriptyline.
Overall, our findings suggest that Co-Q could be a promising option for managing nausea in CVS, especially considering its favorable safety profile. This new insight encourages further research through clinical trials to rigorously evaluate Co-Q’s effectiveness.
Read More
Most Useful Reviews
0
Felt nauseous
This product is heavy on the stomach. After a week, I felt nausea and a persistent taste of black pepper. Others experienced acne. Perhaps it should be taken without BioPerine, as I had no such reaction with a similar drug from another brand.
Read More
9.5
Headaches ceased
Good composition, fast delivery, high-quality packaging; nothing was damaged. The capsules are slightly large but are easy to swallow and taste citrusy. I take one capsule daily as a supplement with meals. After 10 days, I noticed the benefits; my headaches have stopped, and I have more energy. My mood is excellent throughout the day. I recommend it, especially for those interested in sports or on a diet, as omega 3 replenishes what the body lacks.
Read More
0
Stomach pain
This product did not suit me, as I experienced stomach pains and nausea, prompting me to stop taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
9.5
Coenzyme Q10 aids nausea relief
High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series.
Study suggests promising efficacy
We explored the effectiveness of coenzyme Q10 in treating cyclic vomiting syndrome (CVS), a condition marked by frequent and severe nausea and vomiting. Our investigation involved reviewing the outcomes of 30 patients who followed a treatment plan that included coenzyme Q10 and L-carnitine, along with amitriptyline for those who needed additional support. This approach aimed to alleviate the debilitating symptoms of CVS, which often intertwines with migraine headaches and mitochondrial dysfunction.
Remarkably, our findings showed that vomiting episodes completely resolved in 23 patients, while a few others experienced significant improvements. Specifically, three individuals saw their vomiting decrease by over 75%, and one experienced a more modest reduction. This successful outcome highlights the potential role of coenzyme Q10 as part of a comprehensive treatment strategy for CVS.
Importantly, we noted that most patients who adhered to the prescribed treatment reported substantial benefits, reinforcing the value of combining mitochondrial-targeted cofactors with traditional medications. Overall, our study suggests that coenzyme Q10, particularly when monitored carefully, can be an effective ally in reducing nausea and managing CVS symptoms.
Remarkably, our findings showed that vomiting episodes completely resolved in 23 patients, while a few others experienced significant improvements. Specifically, three individuals saw their vomiting decrease by over 75%, and one experienced a more modest reduction. This successful outcome highlights the potential role of coenzyme Q10 as part of a comprehensive treatment strategy for CVS.
Importantly, we noted that most patients who adhered to the prescribed treatment reported substantial benefits, reinforcing the value of combining mitochondrial-targeted cofactors with traditional medications. Overall, our study suggests that coenzyme Q10, particularly when monitored carefully, can be an effective ally in reducing nausea and managing CVS symptoms.
Read More
9.5
Coenzyme Q10 alleviates nausea
[Mitochondrial encephalomyopathy (focal cytochrome c oxidase deficiency) with transient episodes of muscle weakness and elevation of serum creatine kinase activity].
High relevance for coenzyme Q10
We explored the effects of coenzyme Q10 treatment in a 17-year-old boy with mitochondrial encephalomyopathy, characterized by episodes of muscle weakness and related symptoms such as fatigue, nausea, and vomiting. This patient experienced three episodes over several years, during which his serum creatine kinase levels spiked.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
Read More
8
CoQ10 reduces migraine-related nausea
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.
Direct evaluation of CoQ10
We conducted a double-blind, randomized, placebo-controlled study to investigate how coenzyme Q10 (CoQ10) impacts nausea in patients dealing with migraines. Our research involved 42 participants who were given either 300 mg of CoQ10 a day or a placebo over the course of three months.
Throughout the study, we observed that CoQ10 did indeed show significant results in reducing the frequency of migraine attacks and the number of headache days, alongside improvement in nausea symptoms. In the third month of treatment, 47.6% of those taking CoQ10 responded positively in terms of attack frequency. This was quite a contrast to the 14.4% response rate for those on placebo.
The data indicates that CoQ10 is not only effective but also well tolerated by participants. This presents a promising option for those seeking relief from migraine-associated nausea. Overall, CoQ10 appears to offer such patients a viable treatment alternative, with its significant benefits becoming clearer over time.
Throughout the study, we observed that CoQ10 did indeed show significant results in reducing the frequency of migraine attacks and the number of headache days, alongside improvement in nausea symptoms. In the third month of treatment, 47.6% of those taking CoQ10 responded positively in terms of attack frequency. This was quite a contrast to the 14.4% response rate for those on placebo.
The data indicates that CoQ10 is not only effective but also well tolerated by participants. This presents a promising option for those seeking relief from migraine-associated nausea. Overall, CoQ10 appears to offer such patients a viable treatment alternative, with its significant benefits becoming clearer over time.
Read More
7
Co-Q shows promise for CVS
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study.
Direct evidence on Co-Q's efficacy
We explored the effects of coenzyme Q10 (Co-Q) as a treatment for cyclic vomiting syndrome (CVS), a disorder characterized by recurrent and severe episodes of nausea and vomiting. Our approach involved gathering feedback through an online survey from individuals with CVS and their parents.
In our comparison, 22 participants were taking Co-Q while 162 were using amitriptyline, the typical standard-of-care treatment. We noticed that nearly 68% of those on Co-Q experienced at least a 50% reduction in nausea severity and other related symptoms, similar to 72% of those taking amitriptyline.
Notably, Co-Q users reported no side effects, whereas half of the amitriptyline users did, leading to 21% discontinuing their treatment. This raises an important point about the tolerability of Co-Q compared to amitriptyline, as 77% of Co-Q participants felt the benefits outweighed any perceived risks, compared to just 47% of those on amitriptyline.
Overall, our findings suggest that Co-Q could be a promising option for managing nausea in CVS, especially considering its favorable safety profile. This new insight encourages further research through clinical trials to rigorously evaluate Co-Q’s effectiveness.
In our comparison, 22 participants were taking Co-Q while 162 were using amitriptyline, the typical standard-of-care treatment. We noticed that nearly 68% of those on Co-Q experienced at least a 50% reduction in nausea severity and other related symptoms, similar to 72% of those taking amitriptyline.
Notably, Co-Q users reported no side effects, whereas half of the amitriptyline users did, leading to 21% discontinuing their treatment. This raises an important point about the tolerability of Co-Q compared to amitriptyline, as 77% of Co-Q participants felt the benefits outweighed any perceived risks, compared to just 47% of those on amitriptyline.
Overall, our findings suggest that Co-Q could be a promising option for managing nausea in CVS, especially considering its favorable safety profile. This new insight encourages further research through clinical trials to rigorously evaluate Co-Q’s effectiveness.
Read More
User Reviews
USERS' SCORE
Questionable
Based on 10 Reviews
5.7
9.5
Headaches ceased
Good composition, fast delivery, high-quality packaging; nothing was damaged. The capsules are slightly large but are easy to swallow and taste citrusy. I take one capsule daily as a supplement with meals. After 10 days, I noticed the benefits; my headaches have stopped, and I have more energy. My mood is excellent throughout the day. I recommend it, especially for those interested in sports or on a diet, as omega 3 replenishes what the body lacks.
Read More
9.5
Headaches ceased
Very pleased with the fast delivery and high-quality packaging. The capsules are slightly large but easy to swallow. I take one daily with meals. After 10 days, I noticed benefits; my headaches have stopped. I have more energy and my mood has improved. I recommend it, particularly for those into sports or dieting, as omega 3 replenishes the body's needs.
Read More
9.5
Reduced headache pain
This product transformed my life. After years of headaches, I tried CoQ10, initially on sale for Valentine's Day. After landing on this specific product, my pain now drops to a 1-2 on a scale of 1-10. It allows me to enjoy life again! If I miss a dose, the pain returns, but taking it again resolves the issue. I've also experienced increased energy and shared this with others who feel energized as well.
Read More
3.8
Caused nausea
I experienced severe nausea after starting Doctor's Best CoQ10, which troubled me for a week until I realised it was the cause. My husband had no issues with it, but it was not suitable for me.
2.5
Nausea and discomfort
I initially considered CoQ10 for its antioxidant purposes, but after taking it, I experienced a bit of nausea.
