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SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
CoQ10 improves UC symptoms
Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial.
Direct focus on UC treatment.
We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.
Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.
Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.
Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Read More
9
CoQ10 shows potential in UC treatment
Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis.
Directly addresses CoQ10's effects
We investigated Coenzyme Q10 (CoQ10) and its potential to protect against ulcerative colitis (UC), a condition that is becoming increasingly common worldwide. The research involved inducing UC in rats using acetic acid and then administering various doses of CoQ10 over eight consecutive days. This approach allowed us to assess both the protective and curative effects of CoQ10 on colon health.
Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.
Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.
Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Read More
9
Co-Q10 shows promise for UC
Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats.
Directly investigates Co-Q10 effects
We explored whether Coenzyme Q10 (Co-Q10) might offer protective benefits against ulcerative colitis (UC) using a study involving adult male albino rats. To simulate UC, we administered iodoacetamide to the rats, allowing us to observe the potential impact of Co-Q10 on this condition.
Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.
Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.
Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Read More
Most Useful Reviews
8.8
Reduced ulcer symptoms
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
Read More
8.8
Improves ulcer healing
Taking Q10 provides significant antioxidant benefits, such as helping to heal ulcers, improving blood vessel protection, and lowering blood pressure. It also supports immune function and can help prevent cancer and ageing.
Read More
8.8
Ulcer prevention support
With ageing, Coenzyme Q10 levels decline, which is concerning. Long-term use can support immune function and assist in healing ulcers, while also helping to prevent cancer and lower blood pressure.
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
9
CoQ10 improves UC symptoms
Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial.
Direct focus on UC treatment.
We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.
Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.
Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.
Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Read More
9
CoQ10 shows potential in UC treatment
Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis.
Directly addresses CoQ10's effects
We investigated Coenzyme Q10 (CoQ10) and its potential to protect against ulcerative colitis (UC), a condition that is becoming increasingly common worldwide. The research involved inducing UC in rats using acetic acid and then administering various doses of CoQ10 over eight consecutive days. This approach allowed us to assess both the protective and curative effects of CoQ10 on colon health.
Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.
Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.
Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Read More
9
Co-Q10 shows promise for UC
Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats.
Directly investigates Co-Q10 effects
We explored whether Coenzyme Q10 (Co-Q10) might offer protective benefits against ulcerative colitis (UC) using a study involving adult male albino rats. To simulate UC, we administered iodoacetamide to the rats, allowing us to observe the potential impact of Co-Q10 on this condition.
Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.
Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.
Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Read More
9
CoQ10 promotes corneal healing
Topical Coenzyme Q10 Eye Drops as an Adjuvant Treatment in Challenging Refractory Corneal Ulcers: A Case Series and Literature Review.
Moderate relevance due to methodology
We explored the effectiveness of coenzyme Q10 (CoQ10) eye drops as a treatment for difficult-to-heal corneal ulcers. In this case series, we looked at six patients whose corneal ulcers were not responding to standard therapies. The patients included three with neurotrophic corneal ulcers, two with postinfectious ulcers, and one with Stevens-Johnson syndrome.
Each patient received CoQ10 eye drops in addition to their existing treatments. We monitored their progress closely and took corneal images during follow-up visits. Remarkably, all patients showed signs of improvement after starting CoQ10, with some healing within just one to two weeks.
By four to eight weeks, four cases had completely healed. Importantly, no adverse reactions were noted throughout the treatment period. Our findings suggest that CoQ10 eye drops could be a valuable addition to therapies for patients dealing with stubborn corneal ulcers, offering renewed hope for those who have struggled with healing.
Each patient received CoQ10 eye drops in addition to their existing treatments. We monitored their progress closely and took corneal images during follow-up visits. Remarkably, all patients showed signs of improvement after starting CoQ10, with some healing within just one to two weeks.
By four to eight weeks, four cases had completely healed. Importantly, no adverse reactions were noted throughout the treatment period. Our findings suggest that CoQ10 eye drops could be a valuable addition to therapies for patients dealing with stubborn corneal ulcers, offering renewed hope for those who have struggled with healing.
Read More
9
CoQ10 shows promise for ulcers
Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats.
Combination therapy limits isolation effects
We set out to understand how coenzyme Q10 (CoQ10) impacts ulcerative colitis, a chronic inflammatory bowel condition. In our study, we induced colitis in rats using a 3% acetic acid injection and administered CoQ10 alongside amlodipine for eight days prior to this induction.
Our findings revealed that both CoQ10 and amlodipine offered protective effects against the inflammation caused by the acetic acid. They significantly lowered harmful substances in the colon tissue, such as malondialdehyde and various inflammatory markers. Additionally, these treatments seemed to restore the normal structure of the colon when examined under a microscope.
Interestingly, the combination of CoQ10 and amlodipine proved more effective than either treatment alone, boosting antioxidant activity and restoring energy levels in the cells. This study highlights CoQ10 as a potentially beneficial component in managing ulcerative colitis symptoms, thanks to its antioxidant and anti-inflammatory properties.
Our findings revealed that both CoQ10 and amlodipine offered protective effects against the inflammation caused by the acetic acid. They significantly lowered harmful substances in the colon tissue, such as malondialdehyde and various inflammatory markers. Additionally, these treatments seemed to restore the normal structure of the colon when examined under a microscope.
Interestingly, the combination of CoQ10 and amlodipine proved more effective than either treatment alone, boosting antioxidant activity and restoring energy levels in the cells. This study highlights CoQ10 as a potentially beneficial component in managing ulcerative colitis symptoms, thanks to its antioxidant and anti-inflammatory properties.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.8
Reduced ulcer symptoms
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
Read More
8.8
Improves ulcer healing
Taking Q10 provides significant antioxidant benefits, such as helping to heal ulcers, improving blood vessel protection, and lowering blood pressure. It also supports immune function and can help prevent cancer and ageing.
8.8
Ulcer prevention support
With ageing, Coenzyme Q10 levels decline, which is concerning. Long-term use can support immune function and assist in healing ulcers, while also helping to prevent cancer and lower blood pressure.
8.8
Supports ulcer treatment
Coenzyme Q10 is a beneficial antioxidant for cardiovascular health and supports the immune system. It can assist in the treatment of ulcers and prevent conditions like coronary heart disease, especially in older adults who may see a decline in its synthesis with age.
