Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg

Top Medical Research Studies

9
CoQ10 improves UC symptoms
We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.

Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.

Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Read More
9
CoQ10 shows potential in UC treatment
We investigated Coenzyme Q10 (CoQ10) and its potential to protect against ulcerative colitis (UC), a condition that is becoming increasingly common worldwide. The research involved inducing UC in rats using acetic acid and then administering various doses of CoQ10 over eight consecutive days. This approach allowed us to assess both the protective and curative effects of CoQ10 on colon health.

Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.

Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Read More
We explored whether Coenzyme Q10 (Co-Q10) might offer protective benefits against ulcerative colitis (UC) using a study involving adult male albino rats. To simulate UC, we administered iodoacetamide to the rats, allowing us to observe the potential impact of Co-Q10 on this condition.

Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.

Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Read More

Most Useful Reviews

7.5
Reduced ulcer symptoms
4 people found this helpful
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
Read More
7.5
Improves ulcer healing
Taking Q10 provides significant antioxidant benefits, such as helping to heal ulcers, improving blood vessel protection, and lowering blood pressure. It also supports immune function and can help prevent cancer and ageing.
Read More
7.5
Ulcer prevention support
With ageing, Coenzyme Q10 levels decline, which is concerning. Long-term use can support immune function and assist in healing ulcers, while also helping to prevent cancer and lower blood pressure.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
  • All Researches
9
CoQ10 improves UC symptoms
We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.

Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.

Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
Read More
9
CoQ10 shows potential in UC treatment
We investigated Coenzyme Q10 (CoQ10) and its potential to protect against ulcerative colitis (UC), a condition that is becoming increasingly common worldwide. The research involved inducing UC in rats using acetic acid and then administering various doses of CoQ10 over eight consecutive days. This approach allowed us to assess both the protective and curative effects of CoQ10 on colon health.

Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.

Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.
Read More
We explored whether Coenzyme Q10 (Co-Q10) might offer protective benefits against ulcerative colitis (UC) using a study involving adult male albino rats. To simulate UC, we administered iodoacetamide to the rats, allowing us to observe the potential impact of Co-Q10 on this condition.

Our observations revealed that Co-Q10 demonstrated significant anti-oxidant and anti-inflammatory effects. Specifically, we noted an increase in catalase activity and glutathione content, which are both indicators of enhanced cellular protection. On the other hand, Co-Q10 treatment led to a reduction in harmful substances, including myeloperoxidase activity, malondialdehyde content, and the production of nitrates and nitrites.

Overall, these findings suggest that Co-Q10 could play a promising role in protecting against UC through its anti-oxidant and anti-inflammatory properties. Given the favorable results observed in this experimental setup, it seems prudent to consider Co-Q10 for further clinical trials aimed at treating ulcerative colitis in humans.
Read More
9
CoQ10 promotes corneal healing
We explored the effectiveness of coenzyme Q10 (CoQ10) eye drops as a treatment for difficult-to-heal corneal ulcers. In this case series, we looked at six patients whose corneal ulcers were not responding to standard therapies. The patients included three with neurotrophic corneal ulcers, two with postinfectious ulcers, and one with Stevens-Johnson syndrome.

Each patient received CoQ10 eye drops in addition to their existing treatments. We monitored their progress closely and took corneal images during follow-up visits. Remarkably, all patients showed signs of improvement after starting CoQ10, with some healing within just one to two weeks.

By four to eight weeks, four cases had completely healed. Importantly, no adverse reactions were noted throughout the treatment period. Our findings suggest that CoQ10 eye drops could be a valuable addition to therapies for patients dealing with stubborn corneal ulcers, offering renewed hope for those who have struggled with healing.
Read More
We set out to understand how coenzyme Q10 (CoQ10) impacts ulcerative colitis, a chronic inflammatory bowel condition. In our study, we induced colitis in rats using a 3% acetic acid injection and administered CoQ10 alongside amlodipine for eight days prior to this induction.

Our findings revealed that both CoQ10 and amlodipine offered protective effects against the inflammation caused by the acetic acid. They significantly lowered harmful substances in the colon tissue, such as malondialdehyde and various inflammatory markers. Additionally, these treatments seemed to restore the normal structure of the colon when examined under a microscope.

Interestingly, the combination of CoQ10 and amlodipine proved more effective than either treatment alone, boosting antioxidant activity and restoring energy levels in the cells. This study highlights CoQ10 as a potentially beneficial component in managing ulcerative colitis symptoms, thanks to its antioxidant and anti-inflammatory properties.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Reduced ulcer symptoms
4 people found this helpful
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
Read More
7.5
Improves ulcer healing
Taking Q10 provides significant antioxidant benefits, such as helping to heal ulcers, improving blood vessel protection, and lowering blood pressure. It also supports immune function and can help prevent cancer and ageing.
Read More
7.5
Ulcer prevention support
With ageing, Coenzyme Q10 levels decline, which is concerning. Long-term use can support immune function and assist in healing ulcers, while also helping to prevent cancer and lower blood pressure.
Read More
7.5
Supports ulcer treatment
Coenzyme Q10 is a beneficial antioxidant for cardiovascular health and supports the immune system. It can assist in the treatment of ulcers and prevent conditions like coronary heart disease, especially in older adults who may see a decline in its synthesis with age.
Read More

Frequently Asked Questions

7.5
Reduced ulcer symptoms
4 people found this helpful
I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.
7.5
Improves ulcer healing
Taking Q10 provides significant antioxidant benefits, such as helping to heal ulcers, improving blood vessel protection, and lowering blood pressure. It also supports immune function and can help prevent cancer and ageing.
7.5
Ulcer prevention support
With ageing, Coenzyme Q10 levels decline, which is concerning. Long-term use can support immune function and assist in healing ulcers, while also helping to prevent cancer and lower blood pressure.
7.5
Supports ulcer treatment
Coenzyme Q10 is a beneficial antioxidant for cardiovascular health and supports the immune system. It can assist in the treatment of ulcers and prevent conditions like coronary heart disease, especially in older adults who may see a decline in its synthesis with age.
9
CoQ10 improves UC symptoms
We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.

Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.

Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.
8
CoQ10 shows promise for UC
In a recent study, we explored the potential benefits of Coenzyme Q10 (CoQ10) for individuals diagnosed with mild-to-moderate ulcerative colitis (UC). The research was conducted as a randomized double-blind trial with 88 participants, who were assigned to receive either CoQ10 supplements or a placebo for two months.

During the study, we measured various factors such as inflammation and antioxidant levels, as well as specific antimicrobial peptides and microRNA expressions. We relied on a combination of clinical assessments, including questionnaires that evaluated colitis activity and quality of life.

Our findings suggest that CoQ10 supplementation can effectively reduce inflammation in patients dealing with UC, particularly during remission phases. This could indicate that CoQ10 may be a valuable addition to the treatment regimen for those struggling with this chronic condition.

Overall, this study provides promising insights into the role of Coenzyme Q10 as a supportive therapy for individuals with ulcerative colitis, highlighting its potential impact on their health and well-being.
8
CoQ10 reduces alcohol-induced ulcers
We explored the effects of Coenzyme Q10 (CoQ10) on stomach ulcers caused by alcohol consumption in rats. In this study, we used a group of 64 female Wistar albino rats, which were divided into eight groups. Some received Famotidine, a common ulcer medication, while others received varying doses of CoQ10. After a week of treatment, the rats were given ethanol to induce gastric lesions.

Our findings revealed that rats pre-treated with either Famotidine or CoQ10 showed significantly less damage to their gastric mucosa compared to those that didn't receive the treatments. The results were promising, indicating that CoQ10 could be effective in reducing the severity of alcohol-induced gastric damage. Specifically, lower levels of malondialdehyde, a marker of oxidative stress, were observed in rats treated with CoQ10.

Overall, our study suggests that CoQ10 may be beneficial for protecting the stomach lining against the harmful effects of alcohol. As research progresses, this could pave the way for new therapies aimed at treating gastric ulcers.
8
CoQ10 shows gastric protective effects
We examined the potential gastroprotective effects of Coenzyme Q10 (CoQ10) in a study focused on dealing with gastric ulcers caused by indomethacin, a common medication that can lead to gastric damage. Our findings reveal that rats treated with indomethacin experienced significant gastric lesions, increased permeability in their blood vessels, and notable imbalances in important compounds like prostaglandin E₂ and glutathione.

Interestingly, when we pretreat these rats with CoQ10, we observed a marked reduction in the gastric injuries, as well as an improvement in vascular permeability and a decrease in harmful lipid peroxides. CoQ10 also helped restore the levels of prostaglandin E₂ and glutathione, which are vital for protecting the gastric lining, and increased nitric oxide production beyond normal levels.

It’s worth noting that while CoQ10 showed promising results, it did not significantly change mucus production compared to standard treatments like sucralfate. This study illustrates that CoQ10 may play a beneficial role in protecting the stomach by improving vascular health and enhancing the redox status without adversely affecting mucus levels.
9
CoQ10 shows potential in UC treatment
We investigated Coenzyme Q10 (CoQ10) and its potential to protect against ulcerative colitis (UC), a condition that is becoming increasingly common worldwide. The research involved inducing UC in rats using acetic acid and then administering various doses of CoQ10 over eight consecutive days. This approach allowed us to assess both the protective and curative effects of CoQ10 on colon health.

Our findings revealed that CoQ10 significantly alleviated the symptoms of UC. Specifically, it reduced weight loss, improved colon appearance, and decreased inflammation markers in the rats. Notably, we observed that CoQ10 works through pathways that enhance antioxidant defenses and reduce inflammation and cell death. These benefits seem to be linked to the modulation of specific cellular pathways.

Remarkably, CoQ10 also improved the balance between oxidants and antioxidants, suggesting its role in restoring colon health. As we continued to analyze the effects, we noticed that increasing doses of CoQ10 corresponded with more pronounced improvements, which points to a dose-dependent relationship. Overall, this study suggests that CoQ10 holds promise as an effective treatment for ulcerative colitis due to its ability to protect the intestines and promote healing.

References

  1. Abdeen A, Abdelkader A, Elgazzar D, Aboubakr M, Abdulah OA, et al. Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney. Biomed Pharmacother. 2020;130:110627. 10.1016/j.biopha.2020.110627
  2. Farsi F, Ebrahimi-Daryani N, Barati M, Janani L, Karimi MY, et al. Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial. Med J Islam Repub Iran. 2021;35:3. 10.47176/mjiri.35.3
  3. Farsi F, Ebrahimi-Daryani N, Golab F, Akbari A, Janani L, et al. A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis. Eur J Nutr. 2021;60:3397. 10.1007/s00394-021-02514-2
  4. Khodir AE, Atef H, Said E, ElKashef HA, Salem HA. Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis. Inflammopharmacology. 2017;25:119. 10.1007/s10787-016-0305-0
  5. Ewees MG, Messiha BA, Abo-Saif AA, Abd El-Latif HA. Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats. Biol Pharm Bull. 2016;39:1159. 10.1248/bpb.b16-00124
  6. Gumus K. Topical Coenzyme Q10 Eye Drops as an Adjuvant Treatment in Challenging Refractory Corneal Ulcers: A Case Series and Literature Review. Eye Contact Lens. 2017;43:73. 10.1097/ICL.0000000000000229
  7. El Morsy EM, Kamel R, Ahmed MA. Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats. Immunopharmacol Immunotoxicol. 2015;37:244. 10.3109/08923973.2015.1021357
  8. Karakaya K, Barut F, Hanci V, Can M, Comert M, et al. Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions. Bratisl Lek Listy. 2015;116:51.
  9. El-Abhar HS. Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model. Eur J Pharmacol. 2010;649:314. 10.1016/j.ejphar.2010.09.012
  10. Palacka P, Kucharska J, Murin J, Dostalova K, Okkelova A, et al. Complementary therapy in diabetic patients with chronic complications: a pilot study. Bratisl Lek Listy. 2010;111:205.
  11. Liu C, Russell RM, Smith DE, Bronson RT, Milbury PE, et al. The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice. Int J Vitam Nutr Res. 2004;74:74.
  12. Kohli Y, Suto Y, Kodama T. Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10. Jpn J Exp Med. 1981;51:105.
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