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Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Our findings indicated that magnesium sulfate significantly enhances the total response rate and improves lung function, specifically measured by peak expiratory flow and forced expiratory volume. Importantly, we observed no increase in adverse reactions among those treated with magnesium sulfate.
However, we must emphasize that the overall number and quality of studies included in our analysis were limited. This suggests a need for further high-quality research to confirm these benefits in the future.
After treatment, we observed that the groups receiving either magnesium or caffeine showed no significant differences in key outcomes. The Paediatric Respiratory Assessment Measure (PRAM) scores, which help assess the severity of asthma symptoms, did not improve markedly between the two. Additionally, there was no notable difference in the length of the pediatric intensive care unit stay or duration of oxygen therapy needed for each group.
While magnesium sulfate has been used in the past for asthma treatment, our findings suggest that it may not offer substantial benefits when used as a rescue option for these difficult cases. This emphasizes the need for more extensive, multicenter studies to confirm these findings and explore the overall effectiveness of magnesium in pediatric asthma management.
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Our findings indicated that magnesium sulfate significantly enhances the total response rate and improves lung function, specifically measured by peak expiratory flow and forced expiratory volume. Importantly, we observed no increase in adverse reactions among those treated with magnesium sulfate.
However, we must emphasize that the overall number and quality of studies included in our analysis were limited. This suggests a need for further high-quality research to confirm these benefits in the future.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
After treatment, we observed that the groups receiving either magnesium or caffeine showed no significant differences in key outcomes. The Paediatric Respiratory Assessment Measure (PRAM) scores, which help assess the severity of asthma symptoms, did not improve markedly between the two. Additionally, there was no notable difference in the length of the pediatric intensive care unit stay or duration of oxygen therapy needed for each group.
While magnesium sulfate has been used in the past for asthma treatment, our findings suggest that it may not offer substantial benefits when used as a rescue option for these difficult cases. This emphasizes the need for more extensive, multicenter studies to confirm these findings and explore the overall effectiveness of magnesium in pediatric asthma management.
Almost all children received standard treatments, including nebulizations, steroids, and magnesium sulfate, prior to their PICU admission. Among these patients, around 34% had received a salbutamol infusion before being admitted for intensive care. In the PICU, more than 90% of the children received non-invasive respiratory support, showing the severity of their conditions. Notably, while magnesium was used in conjunction with other treatments, the specific isolated effectiveness of magnesium for managing asthma couldn't be clearly assessed.
The findings indicated a steady increase in PICU admissions for ASA throughout the decade. Importantly, no children in the study died, and the average length of stay in PICU was short, typically around one day. While magnesium was part of the treatment regimen, the results didn't provide evidence that it significantly improved outcomes when compared to other treatment options.
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Frequently Asked Questions
Asthma is a chronic condition that affects the airways in the lungs, resulting in symptoms like wheezing, coughing, shortness of breath, and chest tightness. The airways can become inflamed and narrowed, making it difficult to breathe, especially during physical activities or during an asthma attack triggered by allergens, irritants, or stress. While asthma can affect individuals of any age, it often begins in childhood, and its severity can vary from mild to life-threatening.
Management of asthma involves avoiding known triggers and using medications such as inhalers that contain bronchodilators and corticosteroids to reduce inflammation and improve airflow. Regular check-ups with a healthcare provider can help individuals manage their condition effectively and develop an asthma action plan tailored to their specific needs. With proper management, many individuals with asthma lead active, healthy lives.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is known for its role in various bodily functions, and some studies suggest it may have a potential therapeutic effect on asthma. As a natural bronchodilator, magnesium can help open up the airways, making it easier to breathe. In some cases, magnesium sulfate has been used in emergency treatments for severe asthma attacks, particularly in a hospital setting, where it serves to relax the smooth muscles surrounding the airways. However, the evidence regarding oral magnesium supplementation for asthma management is limited and mixed.
While it's always a good idea to consult with your healthcare provider before incorporating supplements into your routine, magnesium can contribute to overall respiratory health, particularly in individuals with a deficiency. Nonetheless, it should not be viewed as a first-line treatment for asthma. Instead, consider it a potential complementary option to more conventional treatments prescribed by a physician. Monitoring your symptoms and maintaining an open dialog with your healthcare provider will always be your best strategy in managing asthma effectively.
Based on user reviews, the time it takes to see results from this supplement, particularly for asthma, can vary. One user mentioned they experienced significant benefits after six months of consistent use, emphasizing that it has been a tremendous help for their allergies and asthma symptoms, allowing them to feel a boost in strength and energy (Read Review). Another reviewer noted that after switching from magnesium infusions to this supplement, they felt it had a notable effect on their asthma symptoms after starting to take it regularly, although they did not specify an exact timeframe (Read Review).
While experiences can differ, it seems that many users appreciate the gradual benefits that come with consistent use, suggesting that it may take several weeks to months to notice significant improvements in asthma management. One user specifically mentioned that magnesium has alleviated their asthma symptoms and better sleep quality (Read Review), reinforcing the idea that outcomes may be observed over a sustained period.
While there are several studies exploring the role of magnesium sulfate in treating asthma, the evidence is inconclusive. A retrospective cohort study on children with severe asthma exacerbations found that magnesium did not significantly improve outcomes compared to conventional treatments, such as intravenous caffeine citrate [1]. Similarly, another study examined the treatment's use in acute severe asthma among pediatric patients in an ICU, but it was unable to demonstrate any clear isolated benefits of magnesium sulfate for managing asthma [2].
On the other hand, research that focused on adults indicated some positive effects of magnesium sulfate, noting improvements in lung function when combined with standard treatments for acute severe asthma [3]. However, the authors also acknowledged the limitations in the number and quality of studies. Meanwhile, a pediatric study suggested that intravenous magnesium sulfate could provide some benefits during moderate to severe asthma exacerbations, linked to increases in magnesium levels within a specific range in the blood [4]. Overall, while magnesium sulfate shows potential as a supplementary treatment in certain cases, further high-quality research is necessary to establish its efficacy and safety profile for asthma management.
Based on user reviews, many individuals have reported various improvements in their symptoms after using this magnesium supplement. One user expressed that, after six months of consistent use, they experienced a tremendous reduction in allergies and asthma symptoms, remarking on a significant boost in strength and energy (Read Review). Another reviewer noted that transitioning from magnesium infusions to this supplement resulted in notable effects on their asthma symptoms, further highlighting the link between magnesium supplementation and respiratory health (Read Review).
Additionally, users have cited improvements in sleep quality and overall health, with one individual stating that the product helped alleviate both their asthma symptoms and enhanced sleep (Read Review). Overall, while individual experiences vary, many have reported beneficial effects pertaining to asthma management and overall wellness, suggesting that regular use of magnesium supplements might yield similar positive results for others.
Based on user reviews, many individuals have reported positive experiences when combining this magnesium supplement with other supplements for managing asthma. One user transitioned from hospital-administered magnesium infusions to this supplement and noted a decrease in asthma symptoms, specifically mentioning that the magnesium has had a notable effect on their condition, alongside zinc and flaxseed oil (Read Review). This suggests that users believe the combined approach of magnesium with other supplements may enhance overall respiratory health.
Furthermore, other reviewers highlighted the supplement’s capacity to support their asthma management, with one individual claiming substantial benefits from using magnesium, which also played a role in improving their sleep quality (Read Review). Overall, user experiences indicate that pairing this magnesium supplement with other dietary additions may contribute to improved asthma symptoms, while also addressing broader health factors.
Based on user reviews, there seems to be an overarching belief in the benefits of magnesium for asthma treatment, but specific dosing information is not consistently provided. Users have reported substantial improvements in their asthma symptoms upon incorporating magnesium supplements into their routines. One user highlighted a significant reduction in seizures and asthma symptoms after switching to magnesium tablets, stating that they felt this supplement had a notable effect on their condition (Read Review). Another review noted the positive impact magnesium had on asthma, alongside benefits for sleep and other health aspects (Read Review).
While users report feeling better overall with the inclusion of magnesium in their diets, exact dosing recommendations appear to be lacking. The reviews focus more on the qualitative benefits rather than quantifying an ideal dosage. For someone considering magnesium for asthma, it may be best to consult a healthcare professional to determine an appropriate dosage tailored to individual needs, as personal experiences vary widely and no specific dosing guidelines were articulated in the provided reviews.
After treatment, we observed that the groups receiving either magnesium or caffeine showed no significant differences in key outcomes. The Paediatric Respiratory Assessment Measure (PRAM) scores, which help assess the severity of asthma symptoms, did not improve markedly between the two. Additionally, there was no notable difference in the length of the pediatric intensive care unit stay or duration of oxygen therapy needed for each group.
While magnesium sulfate has been used in the past for asthma treatment, our findings suggest that it may not offer substantial benefits when used as a rescue option for these difficult cases. This emphasizes the need for more extensive, multicenter studies to confirm these findings and explore the overall effectiveness of magnesium in pediatric asthma management.
Almost all children received standard treatments, including nebulizations, steroids, and magnesium sulfate, prior to their PICU admission. Among these patients, around 34% had received a salbutamol infusion before being admitted for intensive care. In the PICU, more than 90% of the children received non-invasive respiratory support, showing the severity of their conditions. Notably, while magnesium was used in conjunction with other treatments, the specific isolated effectiveness of magnesium for managing asthma couldn't be clearly assessed.
The findings indicated a steady increase in PICU admissions for ASA throughout the decade. Importantly, no children in the study died, and the average length of stay in PICU was short, typically around one day. While magnesium was part of the treatment regimen, the results didn't provide evidence that it significantly improved outcomes when compared to other treatment options.
Our findings indicated that magnesium sulfate significantly enhances the total response rate and improves lung function, specifically measured by peak expiratory flow and forced expiratory volume. Importantly, we observed no increase in adverse reactions among those treated with magnesium sulfate.
However, we must emphasize that the overall number and quality of studies included in our analysis were limited. This suggests a need for further high-quality research to confirm these benefits in the future.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
References
- Brooks R, Babushkin V, Rekhtman D, Cohen-Cymberknoh M, Shoseyov D, et al. Can Intravenous Caffeine Citrate Be Used for Severe Asthma Exacerbation in Children? A Retrospective Comparative Study. J Paediatr Child Health. 2025. doi:10.1111/jpc.16799
- Salie M, Salie S. A Retrospective Review of Children Admitted With Acute Severe Asthma to the Paediatric Intensive Care Unit, Red Cross War Memorial Children's Hospital Between 2009 and 2019. J Paediatr Child Health. 2025. doi:10.1111/jpc.16776
- Zhong Z, Wang Z, Qi S, Li C, Yang X. [Efficacy and safety of magnesium sulfate in the treatment of adult patients with acute severe asthma: a Meta-analysis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024;36:1256. doi:10.3760/cma.j.cn121430-20240617-00514
- Rower JE, Johnson MD, Zorc JJ, Shihabuddin B, Dai M, et al. Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. J Clin Pharmacol. 2025. doi:10.1002/jcph.6179
