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SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Medium or Average
Based on 165 Reviews
6.8
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesium lysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Strong relevance to diarrhea treatment
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
Relevant findings on magnesium treatment
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
Highlights treatment complexities in patients
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
Most Useful Reviews
9.5
No diarrhea issue
Delivery took six days, which I found impressive. I ordered magnesium glycinate for my mother, as it's better absorbed and doesn't cause diarrhoea. She's using it to prevent arthrosis and anaemia. The size is manageable, and I appreciate the quality packaging from Doctor's Best. I plan to explore more products from this brand. The effect of magnesium is easily noticeable.
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9.5
No diarrhoea effect
I'm quite pleased with this magnesium. I take it for myself and my parents, and it's proving effective. It calms my parents' nerves and helps Mum with joint pain, and it doesn’t lead to diarrhoea. The tablets are sizeable, but they can be split if needed. We take two each night.
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9.5
No diarrhoea concerns
After taking this magnesium, I feel a gradual relaxation physically and mentally, especially helpful before bed. It alleviates muscle tension and has helped with menstrual pain. I'd recommend starting with one tablet, as I've experienced no side effects or diarrhoea.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Strong relevance to diarrhea treatment
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
Highlights treatment complexities in patients
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
Magnesium reduces diarrhea incidence
Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets.
Potassium complicates magnesium effects
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
9
Impact of magnesium on diarrhea
Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes.
Magnesium's effectiveness unclear
We conducted a study to assess the effectiveness of magnesium in treating diarrhea, particularly focusing on its role in extracts from (Wall.) leaves. To evaluate this, we utilized several tests that mimic diarrhea conditions. Our findings showed that while magnesium was mentioned in connection with the extracts, it was administered alongside other treatments. This means we're not entirely sure how much of the anti-diarrheal effect was due to magnesium itself.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
Relevant findings on magnesium treatment
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 165 Reviews
6.8
10
No diarrhea experience
I have used this for years to lower blood pressure and manage migraine headaches. Even when I increase my dosage to 600 mg, I don’t experience diarrhea. The large pressed tablets are easy to swallow, and overall, this magnesium product offers great value.
10
Normal stools
I consume this daily with excellent absorbency and no diarrhoea, even with high amounts. It’s crucial for muscle growth and I notice swelling in my legs if I forget to take it.
10
Improved sleep
This is my second time using it, and it’s excellent quality with high absorption. I take it at night for better sleep and wake up feeling rested, without any stomach pain or diarrhoea. It’s a great value for quality magnesium.
10
Helps cramps
I got this product to ease menstrual cramps, and it has helped significantly. I take two tablets without experiencing stomach upset or diarrhoea, and I'm pleased that it does not affect my stools.
10
No side effects
Magnesium does not agree with me, but I found this one works well without causing diarrhoea. I was suffering from leg cramps that disrupted my sleep, but since taking two tablets a day, the cramps have disappeared completely. I am thrilled!
