Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesiumlysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
8
We explored the potential benefits of magnesium-L-threonate for Alzheimer's disease, particularly how it interacts with the gut microbiome. In our study, we focused on a specific mouse model that simulates Alzheimer's by using double-transgenic groups expressing particular proteins associated with the disease. By administering magnesium-L-threonate, we aimed to see if it could improve cognitive functions and alter gut bacteria positively.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Read More
4
Magnesium's role in Alzheimer's treatment
We explored the connection between magnesium levels and Alzheimer's disease (AD), particularly focusing on how magnesium deficiency affects patients. Research indicates that lower levels of magnesium in the serum or brain could be linked to the progression of AD, suggesting that boosting magnesium might be a promising new therapy.
However, while the potential is there, we also faced some challenges. The unique properties of magnesium make it tough to implement effective treatments. Despite these hurdles, the idea that magnesium could play a role in mitigating the symptoms of Alzheimer’s is gaining attention in the scientific community.
It’s clear from the current findings that magnesium may act as a beneficial therapy for those dealing with Alzheimer’s disease. We find the prospect of using magnesium supplementation intriguing as a fresh approach in the ongoing fight against this complex condition.
However, while the potential is there, we also faced some challenges. The unique properties of magnesium make it tough to implement effective treatments. Despite these hurdles, the idea that magnesium could play a role in mitigating the symptoms of Alzheimer’s is gaining attention in the scientific community.
It’s clear from the current findings that magnesium may act as a beneficial therapy for those dealing with Alzheimer’s disease. We find the prospect of using magnesium supplementation intriguing as a fresh approach in the ongoing fight against this complex condition.
Read More
8
We conducted a study to explore the potential of Magnesium-L-threonate (MgT) in protecting against oxidative stress related to Alzheimer's Disease (AD). Our focus was on understanding whether MgT could mitigate damage to neurons caused by amyloid beta (Aβ), a protein that accumulates in the brains of those affected by AD.
In our investigation, we treated HT22 cells, which were induced with Aβ, with MgT for 12 hours. Additionally, we administered MgT orally to APPswe/PS1dE9 (APP/PS1) mice—known models for AD—for three months. The outcomes were significant. We found that MgT treatment improved cell viability in the Aβ-treated HT22 cells.
We also observed notable improvements in cognition among the APP/PS1 mice, assessed through their performance in the Morris Water Maze. Our flow cytometry analyses revealed that MgT effectively reduced oxidative stress by lowering the levels of reactive oxygen species (ROS) and apoptosis rates in the cells. Furthermore, Western blot assessments indicated beneficial changes in the expression of various proteins related to cell survival and oxidative stress response.
Overall, our findings suggest that Magnesium-L-threonate can provide protective effects against oxidative stress and neuronal apoptosis, offering a glimmer of hope in the context of Alzheimer's Disease.
In our investigation, we treated HT22 cells, which were induced with Aβ, with MgT for 12 hours. Additionally, we administered MgT orally to APPswe/PS1dE9 (APP/PS1) mice—known models for AD—for three months. The outcomes were significant. We found that MgT treatment improved cell viability in the Aβ-treated HT22 cells.
We also observed notable improvements in cognition among the APP/PS1 mice, assessed through their performance in the Morris Water Maze. Our flow cytometry analyses revealed that MgT effectively reduced oxidative stress by lowering the levels of reactive oxygen species (ROS) and apoptosis rates in the cells. Furthermore, Western blot assessments indicated beneficial changes in the expression of various proteins related to cell survival and oxidative stress response.
Overall, our findings suggest that Magnesium-L-threonate can provide protective effects against oxidative stress and neuronal apoptosis, offering a glimmer of hope in the context of Alzheimer's Disease.
Read More
Most Useful Reviews
9
Alleviates symptoms
4 people found this helpful
The best of the best! Researchers have shown that magnesium helps reduce blood clotting in type 2 diabetes patients, lowering thrombosis risk. Magnesium is the second most prevalent intracellular electrolyte after potassium and is crucial for numerous enzymatic reactions related to glucose metabolism and vascular functions. Recent studies suggest inadequate magnesium intake correlates with higher incidences of type 2 diabetes and cardiovascular ailments. My 74-year-old mother, who has type 2 diabetes, has been taking this chelated magnesium regularly. A diet rich in magnesium, such as that from Dr. Best, even eases Alzheimer's symptomatology. Some scientists even propose that a magnesium deficit in the brain may trigger Parkinson's disease. I sincerely hope this insight proves helpful!
Read More
7.5
Improves memory
Magnesium in its chelated form is essential. As we age, intracellular magnesium levels decrease. This mineral enhances the effectiveness of diabetes treatment. Magnesium cannot be produced by the body and must come from diet or supplements. It also reduces the risk of Alzheimer's and boosts memory by lowering amyloid plaque formation in the brain and enhancing synaptic functions. Stress, alcohol, and tobacco are key factors that deplete magnesium. Moreover, excessive calcium without adequate magnesium may result in tissue calcification. Hence, if taking high vitamin D doses for calcium absorption, magnesium is absolutely crucial.
Read More
7.5
Supports maintenance
This product stands out among many supplements I've tried, specifically aiding in the maintenance and strengthening of nerve tissue crucial for those with dementia and Alzheimer's. While managing migraine symptoms without obvious triggers can be challenging, there are numerous instances where prolonged use proves effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
- All Researches
9
Magnesium shows potential in AD therapy
We investigated the potential of a new magnesium-loaded nanocomposite to alleviate symptoms associated with Alzheimer's disease (AD). The treatment utilized a blend of chitosan and polylactic acid enhanced with magnesium oxide, delivered to male Wistar rats through intracerebroventricular injections. Our aim was to see how this innovative blend could impact cognitive decline, neuroinflammation, and oxidative stress often observed in Alzheimer's.
After treating the rats, we observed a notable improvement in their memory and cognitive functions. The magnesium component, integrated into the treatment, appears to play a significant role in this improvement. We noted enhancements in various antioxidant activities, which ultimately lessened both oxidative stress and neuroinflammation in the rats, suggesting that magnesium contributes positively to mitochondrial function.
The histological analysis confirmed a healthier neuronal environment post-treatment, further supporting our findings that the magnesium-loaded nanocomposite may reverse some of the deleterious effects seen in AD pathology. Furthermore, in silico studies indicated that these compounds could potentially inhibit harmful amyloid-beta aggregation, a key factor in Alzheimer's development.
In conclusion, our research supports the idea that magnesium, especially when combined into a nanocomposite, holds therapeutic promise for alleviating symptoms associated with Alzheimer's disease by mitigating oxidative stress and neuroinflammation. This could pave the way for new treatment strategies in the future.
After treating the rats, we observed a notable improvement in their memory and cognitive functions. The magnesium component, integrated into the treatment, appears to play a significant role in this improvement. We noted enhancements in various antioxidant activities, which ultimately lessened both oxidative stress and neuroinflammation in the rats, suggesting that magnesium contributes positively to mitochondrial function.
The histological analysis confirmed a healthier neuronal environment post-treatment, further supporting our findings that the magnesium-loaded nanocomposite may reverse some of the deleterious effects seen in AD pathology. Furthermore, in silico studies indicated that these compounds could potentially inhibit harmful amyloid-beta aggregation, a key factor in Alzheimer's development.
In conclusion, our research supports the idea that magnesium, especially when combined into a nanocomposite, holds therapeutic promise for alleviating symptoms associated with Alzheimer's disease by mitigating oxidative stress and neuroinflammation. This could pave the way for new treatment strategies in the future.
Read More
9
In this study, we explored the combined effects of atorvastatin and magnesium L-threonate on Alzheimer's disease in aged female rats. Our experiment involved 30 rats, divided into different groups to compare the effects of a vehicle control, aluminum chloride to induce Alzheimer's symptoms, and various treatments, including rivastigmine, atorvastatin alone, and a combination of atorvastatin with magnesium L-threonate.
We observed that the groups receiving atorvastatin, especially with magnesium L-threonate, showed significant improvements in cognitive functions. This was evident as the rats had better performance in tests designed to evaluate memory and anxiety, such as the radial arm maze and the elevated plus maze. The combination treatment also displayed enhanced anti-cholinesterase activity and reduced oxidative stress in the brain, suggesting a protective effect against the common features of Alzheimer's.
Through our findings, we noted that magnesium L-threonate, when used alongside atorvastatin, may enhance the medication's effectiveness in combating Alzheimer's symptoms. However, we also recognize that isolating magnesium's effects alone in this study is challenging due to its concurrent use with atorvastatin. The potential for this combination therapy offers a hopeful avenue for patients in the early stages of Alzheimer's disease.
We observed that the groups receiving atorvastatin, especially with magnesium L-threonate, showed significant improvements in cognitive functions. This was evident as the rats had better performance in tests designed to evaluate memory and anxiety, such as the radial arm maze and the elevated plus maze. The combination treatment also displayed enhanced anti-cholinesterase activity and reduced oxidative stress in the brain, suggesting a protective effect against the common features of Alzheimer's.
Through our findings, we noted that magnesium L-threonate, when used alongside atorvastatin, may enhance the medication's effectiveness in combating Alzheimer's symptoms. However, we also recognize that isolating magnesium's effects alone in this study is challenging due to its concurrent use with atorvastatin. The potential for this combination therapy offers a hopeful avenue for patients in the early stages of Alzheimer's disease.
Read More
8
We explored the potential benefits of magnesium-L-threonate for Alzheimer's disease, particularly how it interacts with the gut microbiome. In our study, we focused on a specific mouse model that simulates Alzheimer's by using double-transgenic groups expressing particular proteins associated with the disease. By administering magnesium-L-threonate, we aimed to see if it could improve cognitive functions and alter gut bacteria positively.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Read More
8
We explored the role of magnesium in halting mitochondrial dysfunction, a key player in the development of Alzheimer’s disease (AD). In this innovative approach, magnesium acts as a natural antagonist to calcium overload in mitochondria. Along with magnesium, siRNA targeted at a crucial mPTP regulator were used, creating a unique therapy dubbed the "nano-brake."
By employing this dual strategy, we observed that the nano-brake effectively prevented the harmful cascade of mitochondrial dysfunction in brain cells. The treatment not only mitigated the brain's neuropathology associated with Alzheimer’s but also significantly improved cognitive function.
These findings highlight the potential of magnesium as part of a powerful therapeutic approach to address Alzheimer's disease. Thus, integrating a natural mineral like magnesium with advanced nanotechnology offers an exciting avenue for modifying disease progression and enhancing brain health.
By employing this dual strategy, we observed that the nano-brake effectively prevented the harmful cascade of mitochondrial dysfunction in brain cells. The treatment not only mitigated the brain's neuropathology associated with Alzheimer’s but also significantly improved cognitive function.
These findings highlight the potential of magnesium as part of a powerful therapeutic approach to address Alzheimer's disease. Thus, integrating a natural mineral like magnesium with advanced nanotechnology offers an exciting avenue for modifying disease progression and enhancing brain health.
Read More
8
Magnesium shows potential against Alzheimer's
We investigated the effects of a unique magnesium-based nanocomposite designed to combat the neurotoxicity associated with Alzheimer’s disease (AD). This composite, made from gelatin, polyvinyl alcohol, and magnesium hydroxide, was created through a special process that ensured its safety for brain cells.
Our research highlighted several key findings regarding this magnesium nanocomposite. In cell studies conducted in the lab, we saw encouraging signs that it could help reduce harmful amyloid-beta proteins, which are known to contribute to AD, and protect against the death of neuronal cells. Further imaging studies confirmed that the nanocomposite lowers the levels of these troublesome proteins in the cells.
We also conducted tests on rats that had been treated to mimic Alzheimer’s symptoms. Here, we observed that the magnesium nanocomposite effectively improved cognitive abilities and supported synaptic health. Additionally, our analysis of brain chemicals showed a significant reduction in harmful substances related to oxidative stress. At the same time, beneficial antioxidant enzyme levels increased, painting a hopeful picture for magnesium's role in AD treatment.
Overall, our findings suggest that the magnesium-infused nanocomposite holds substantial potential for targeting and mitigating the effects of Alzheimer’s disease, paving the way for clinical applications in the future.
Our research highlighted several key findings regarding this magnesium nanocomposite. In cell studies conducted in the lab, we saw encouraging signs that it could help reduce harmful amyloid-beta proteins, which are known to contribute to AD, and protect against the death of neuronal cells. Further imaging studies confirmed that the nanocomposite lowers the levels of these troublesome proteins in the cells.
We also conducted tests on rats that had been treated to mimic Alzheimer’s symptoms. Here, we observed that the magnesium nanocomposite effectively improved cognitive abilities and supported synaptic health. Additionally, our analysis of brain chemicals showed a significant reduction in harmful substances related to oxidative stress. At the same time, beneficial antioxidant enzyme levels increased, painting a hopeful picture for magnesium's role in AD treatment.
Overall, our findings suggest that the magnesium-infused nanocomposite holds substantial potential for targeting and mitigating the effects of Alzheimer’s disease, paving the way for clinical applications in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates symptoms
4 people found this helpful
The best of the best! Researchers have shown that magnesium helps reduce blood clotting in type 2 diabetes patients, lowering thrombosis risk. Magnesium is the second most prevalent intracellular electrolyte after potassium and is crucial for numerous enzymatic reactions related to glucose metabolism and vascular functions. Recent studies suggest inadequate magnesium intake correlates with higher incidences of type 2 diabetes and cardiovascular ailments. My 74-year-old mother, who has type 2 diabetes, has been taking this chelated magnesium regularly. A diet rich in magnesium, such as that from Dr. Best, even eases Alzheimer's symptomatology. Some scientists even propose that a magnesium deficit in the brain may trigger Parkinson's disease. I sincerely hope this insight proves helpful!
Read More
7.5
Improves memory
Magnesium in its chelated form is essential. As we age, intracellular magnesium levels decrease. This mineral enhances the effectiveness of diabetes treatment. Magnesium cannot be produced by the body and must come from diet or supplements. It also reduces the risk of Alzheimer's and boosts memory by lowering amyloid plaque formation in the brain and enhancing synaptic functions. Stress, alcohol, and tobacco are key factors that deplete magnesium. Moreover, excessive calcium without adequate magnesium may result in tissue calcification. Hence, if taking high vitamin D doses for calcium absorption, magnesium is absolutely crucial.
Read More
7.5
Supports maintenance
This product stands out among many supplements I've tried, specifically aiding in the maintenance and strengthening of nerve tissue crucial for those with dementia and Alzheimer's. While managing migraine symptoms without obvious triggers can be challenging, there are numerous instances where prolonged use proves effective.
Read More
6
Beneficial effect
The quality of this magnesium supplement is excellent; it’s quickly absorbed and comes in a good dosage, though the tablet is somewhat large. Additionally, it contains ginkgo biloba, which positively impacts brain function. The packaging is good, and I’ve noticed it helps with both Parkinson's and Alzheimer's diseases.
Read More
Frequently Asked Questions
7.5
Supports maintenance
This product stands out among many supplements I've tried, specifically aiding in the maintenance and strengthening of nerve tissue crucial for those with dementia and Alzheimer's. While managing migraine symptoms without obvious triggers can be challenging, there are numerous instances where prolonged use proves effective.
6
Beneficial effect
The quality of this magnesium supplement is excellent; it’s quickly absorbed and comes in a good dosage, though the tablet is somewhat large. Additionally, it contains ginkgo biloba, which positively impacts brain function. The packaging is good, and I’ve noticed it helps with both Parkinson's and Alzheimer's diseases.
7.5
Improves memory
Magnesium in its chelated form is essential. As we age, intracellular magnesium levels decrease. This mineral enhances the effectiveness of diabetes treatment. Magnesium cannot be produced by the body and must come from diet or supplements. It also reduces the risk of Alzheimer's and boosts memory by lowering amyloid plaque formation in the brain and enhancing synaptic functions. Stress, alcohol, and tobacco are key factors that deplete magnesium. Moreover, excessive calcium without adequate magnesium may result in tissue calcification. Hence, if taking high vitamin D doses for calcium absorption, magnesium is absolutely crucial.
9
Alleviates symptoms
4 people found this helpful
The best of the best! Researchers have shown that magnesium helps reduce blood clotting in type 2 diabetes patients, lowering thrombosis risk. Magnesium is the second most prevalent intracellular electrolyte after potassium and is crucial for numerous enzymatic reactions related to glucose metabolism and vascular functions. Recent studies suggest inadequate magnesium intake correlates with higher incidences of type 2 diabetes and cardiovascular ailments. My 74-year-old mother, who has type 2 diabetes, has been taking this chelated magnesium regularly. A diet rich in magnesium, such as that from Dr. Best, even eases Alzheimer's symptomatology. Some scientists even propose that a magnesium deficit in the brain may trigger Parkinson's disease. I sincerely hope this insight proves helpful!
8
We explored the potential benefits of magnesium-L-threonate for Alzheimer's disease, particularly how it interacts with the gut microbiome. In our study, we focused on a specific mouse model that simulates Alzheimer's by using double-transgenic groups expressing particular proteins associated with the disease. By administering magnesium-L-threonate, we aimed to see if it could improve cognitive functions and alter gut bacteria positively.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
9
Magnesium shows potential in AD therapy
We investigated the potential of a new magnesium-loaded nanocomposite to alleviate symptoms associated with Alzheimer's disease (AD). The treatment utilized a blend of chitosan and polylactic acid enhanced with magnesium oxide, delivered to male Wistar rats through intracerebroventricular injections. Our aim was to see how this innovative blend could impact cognitive decline, neuroinflammation, and oxidative stress often observed in Alzheimer's.
After treating the rats, we observed a notable improvement in their memory and cognitive functions. The magnesium component, integrated into the treatment, appears to play a significant role in this improvement. We noted enhancements in various antioxidant activities, which ultimately lessened both oxidative stress and neuroinflammation in the rats, suggesting that magnesium contributes positively to mitochondrial function.
The histological analysis confirmed a healthier neuronal environment post-treatment, further supporting our findings that the magnesium-loaded nanocomposite may reverse some of the deleterious effects seen in AD pathology. Furthermore, in silico studies indicated that these compounds could potentially inhibit harmful amyloid-beta aggregation, a key factor in Alzheimer's development.
In conclusion, our research supports the idea that magnesium, especially when combined into a nanocomposite, holds therapeutic promise for alleviating symptoms associated with Alzheimer's disease by mitigating oxidative stress and neuroinflammation. This could pave the way for new treatment strategies in the future.
After treating the rats, we observed a notable improvement in their memory and cognitive functions. The magnesium component, integrated into the treatment, appears to play a significant role in this improvement. We noted enhancements in various antioxidant activities, which ultimately lessened both oxidative stress and neuroinflammation in the rats, suggesting that magnesium contributes positively to mitochondrial function.
The histological analysis confirmed a healthier neuronal environment post-treatment, further supporting our findings that the magnesium-loaded nanocomposite may reverse some of the deleterious effects seen in AD pathology. Furthermore, in silico studies indicated that these compounds could potentially inhibit harmful amyloid-beta aggregation, a key factor in Alzheimer's development.
In conclusion, our research supports the idea that magnesium, especially when combined into a nanocomposite, holds therapeutic promise for alleviating symptoms associated with Alzheimer's disease by mitigating oxidative stress and neuroinflammation. This could pave the way for new treatment strategies in the future.
8
We conducted a study to explore the potential of Magnesium-L-threonate (MgT) in protecting against oxidative stress related to Alzheimer's Disease (AD). Our focus was on understanding whether MgT could mitigate damage to neurons caused by amyloid beta (Aβ), a protein that accumulates in the brains of those affected by AD.
In our investigation, we treated HT22 cells, which were induced with Aβ, with MgT for 12 hours. Additionally, we administered MgT orally to APPswe/PS1dE9 (APP/PS1) mice—known models for AD—for three months. The outcomes were significant. We found that MgT treatment improved cell viability in the Aβ-treated HT22 cells.
We also observed notable improvements in cognition among the APP/PS1 mice, assessed through their performance in the Morris Water Maze. Our flow cytometry analyses revealed that MgT effectively reduced oxidative stress by lowering the levels of reactive oxygen species (ROS) and apoptosis rates in the cells. Furthermore, Western blot assessments indicated beneficial changes in the expression of various proteins related to cell survival and oxidative stress response.
Overall, our findings suggest that Magnesium-L-threonate can provide protective effects against oxidative stress and neuronal apoptosis, offering a glimmer of hope in the context of Alzheimer's Disease.
In our investigation, we treated HT22 cells, which were induced with Aβ, with MgT for 12 hours. Additionally, we administered MgT orally to APPswe/PS1dE9 (APP/PS1) mice—known models for AD—for three months. The outcomes were significant. We found that MgT treatment improved cell viability in the Aβ-treated HT22 cells.
We also observed notable improvements in cognition among the APP/PS1 mice, assessed through their performance in the Morris Water Maze. Our flow cytometry analyses revealed that MgT effectively reduced oxidative stress by lowering the levels of reactive oxygen species (ROS) and apoptosis rates in the cells. Furthermore, Western blot assessments indicated beneficial changes in the expression of various proteins related to cell survival and oxidative stress response.
Overall, our findings suggest that Magnesium-L-threonate can provide protective effects against oxidative stress and neuronal apoptosis, offering a glimmer of hope in the context of Alzheimer's Disease.
8
We conducted a thorough assessment of magnesium valproate (VPM) and its effects on individuals suffering from dementia. Our research involved 22 randomized controlled trials, including nearly 1,900 participants, which compared VPM combined with standard treatments to treatments on their own.
The results showed promise for VPM as an adjuvant therapy. We observed significant improvements in various cognitive and behavioral measures, such as mental state assessments and daily living activities. Additionally, inflammatory marker levels were notably lower in those receiving VPM than in those who were not.
Importantly, we found that the side effects did not significantly increase with VPM use, indicating it is generally well tolerated by patients. While these findings suggest VPM could be beneficial in alleviating symptoms of dementia, further research is necessary to understand its role fully and assess the varying severity of dementia among patients participating in these studies.
The results showed promise for VPM as an adjuvant therapy. We observed significant improvements in various cognitive and behavioral measures, such as mental state assessments and daily living activities. Additionally, inflammatory marker levels were notably lower in those receiving VPM than in those who were not.
Importantly, we found that the side effects did not significantly increase with VPM use, indicating it is generally well tolerated by patients. While these findings suggest VPM could be beneficial in alleviating symptoms of dementia, further research is necessary to understand its role fully and assess the varying severity of dementia among patients participating in these studies.
References
- Wang D, Yang J, Liu B, Luo W. The effect of dietary magnesium intake on cognitive decline related to olfactory impairment in older adults: a cross-sectional study from the NHANES database. Magnes Res. 2024;37:81. doi:10.1684/mrh.2024.0530
- Liao W, Wei J, Liu C, Luo H, Ruan Y, et al. Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis. Neural Regen Res. 2024;19:2281. doi:10.4103/1673-5374.391310
- Rajkumar M, Govindaraj P, Vimala K, Thangaraj R, Kannan S. Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease. Metab Brain Dis. 2024;39:487. doi:10.1007/s11011-023-01336-x
- Gangoda DM, Saiyed MS, Pathan SR, Sharma KB, Patel VA, et al. Enhanced Neuroprotective Synergy of Atorvastatin and Magnesium L-Threonate in a Rat Model of Alzheimer's Disease Induced by Aluminum Chloride. Cureus. 2023;15:e48400. doi:10.7759/cureus.48400
- Babylon L, Meißner J, Eckert GP. Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease. Int J Mol Sci. 2023;24. doi:10.3390/ijms241210029
- Zhang Q, Song Q, Yu R, Wang A, Jiang G, et al. Nano-Brake Halts Mitochondrial Dysfunction Cascade to Alleviate Neuropathology and Rescue Alzheimer's Cognitive Deficits. Adv Sci (Weinh). 2023;10:e2204596. doi:10.1002/advs.202204596
- Rajkumar M, Vimala K, Tamiliniyan DD, Thangaraj R, Jaganathan R, et al. Gelatin/polyvinyl alcohol loaded magnesium hydroxide nanocomposite attenuates neurotoxicity and oxidative stress in Alzheimer's disease induced rats. Int J Biol Macromol. 2022;222:2122. doi:10.1016/j.ijbiomac.2022.10.010
- Lei DY, Sun J. Magnesium may be an effective therapy for Alzheimer's disease. World J Psychiatry. 2022;12:1261. doi:10.5498/wjp.v12.i9.1261
- Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP. Effects of Combining Biofactors on Bioenergetic Parameters, Aβ Levels and Survival in Alzheimer Model Organisms. Int J Mol Sci. 2022;23. doi:10.3390/ijms23158670
- Zhang C, Sun L, Sun H. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis. Medicine (Baltimore). 2022;101:e29642. doi:10.1097/MD.0000000000029642
- Xiong Y, Ruan YT, Zhao J, Yang YW, Chen LP, et al. Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer's disease mouse model. World J Psychiatry. 2022;12:410. doi:10.5498/wjp.v12.i3.410
- Tao MH, Liu J, Cervantes D. Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Alzheimers Dement (N Y). 2022;8:e12250. doi:10.1002/trc2.12250
