Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.1
USERS' SCORE
Good
Based on 14 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesiumlysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
8
Magnesium protects against bone erosion
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
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9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
Most Useful Reviews
9.5
Effective pain relief
26 people found this helpful
I recommend this supplement for arthritis in the knees. After enduring several surgeries and experiencing unbearable pain, I noticed an unbelievable difference just four days after starting this supplement. It provided me with significant relief, better than any painkiller I’ve tried, and restored my knee movement. I truly wish I’d discovered this 40 years ago.
Read More
9
Not easy to swallow
2 people found this helpful
Extremely hard to swallow! I have been taking this product for over a year, mainly for inflammation. It works. I have arthritis in my thumbs, and after a few weeks, it disappeared almost completely. Halting for a few weeks showed me the difference; my swollen thumbs returned. Upon resuming, the issue subsided again. However, the pill is exceedingly difficult to swallow, unlike other pills I take. I'm searching for another brand that works just as well but in capsules or a different type of tablet. I'm tired of taking two of these every night!
Read More
9
Gentle on stomach
1 people found this helpful
This magnesium supplement is gentle on my stomach and aids relaxation before bed. It significantly helps relieve my arthritis joint pain. I highly recommend it for those seeking a quality product to address arthritis symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.1
- All Researches
9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
9
Magnesium reduces arthritis severity
We investigated how a high magnesium diet affects arthritis, focusing on its impact on inflammation and T cell development in two mouse models of rheumatoid arthritis. Our findings revealed that the mice receiving a diet rich in magnesium experienced less severe arthritis and reduced joint damage.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
Read More
9
We investigated how magnesium-containing glycosaminoglycans, or Mg-GAGs, might improve cartilage health and combat osteoarthritis (OA). The study highlighted that OA is largely characterized by the breakdown of key components in the extracellular matrix (ECM), including collagen and aggrecan. The objective was to find out if introducing Mg-GAGs could help restore this matrix and mitigate inflammation linked to OA.
Our findings were promising. We observed that Mg-GAGs not only encouraged chondrocyte (cartilage cell) growth but also helped activate genes important for cartilage formation while reducing inflammatory responses. In laboratory experiments, these glycosaminoglycans showed significant positive effects.
Furthermore, in an animal model of OA, Mg-GAGs eased synovial inflammation, lessened chondrocyte death, and helped protect the bone beneath cartilage. These outcomes suggest that Mg-GAGs might represent a new way to treat OA, focusing on ECM repair and addressing inflammation to improve joint health.
Our findings were promising. We observed that Mg-GAGs not only encouraged chondrocyte (cartilage cell) growth but also helped activate genes important for cartilage formation while reducing inflammatory responses. In laboratory experiments, these glycosaminoglycans showed significant positive effects.
Furthermore, in an animal model of OA, Mg-GAGs eased synovial inflammation, lessened chondrocyte death, and helped protect the bone beneath cartilage. These outcomes suggest that Mg-GAGs might represent a new way to treat OA, focusing on ECM repair and addressing inflammation to improve joint health.
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User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective pain relief
26 people found this helpful
I recommend this supplement for arthritis in the knees. After enduring several surgeries and experiencing unbearable pain, I noticed an unbelievable difference just four days after starting this supplement. It provided me with significant relief, better than any painkiller I’ve tried, and restored my knee movement. I truly wish I’d discovered this 40 years ago.
Read More
9
Not easy to swallow
2 people found this helpful
Extremely hard to swallow! I have been taking this product for over a year, mainly for inflammation. It works. I have arthritis in my thumbs, and after a few weeks, it disappeared almost completely. Halting for a few weeks showed me the difference; my swollen thumbs returned. Upon resuming, the issue subsided again. However, the pill is exceedingly difficult to swallow, unlike other pills I take. I'm searching for another brand that works just as well but in capsules or a different type of tablet. I'm tired of taking two of these every night!
Read More
9
Gentle on stomach
1 people found this helpful
This magnesium supplement is gentle on my stomach and aids relaxation before bed. It significantly helps relieve my arthritis joint pain. I highly recommend it for those seeking a quality product to address arthritis symptoms.
Read More
9
Joint stiffness reduction
I have been taking this along with turmeric for improved joint health. I feel less stiff when getting out of bed, particularly in my knees and lower back. I suspected arthritis, but now I am feeling much better and don't need to visit the doctor.
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9
Joint pain relief
THIS IS THE BEST MAGNESIUM available! I've bought this brilliant quality magnesium supplement three times now and won’t change as long as it’s available. The caplet size is manageable and there’s no unpleasant aftertaste. Unlike other magnesium supplements, this one doesn’t upset my digestion. It significantly eases my arthritis pain, helps me sleep better, and I’ve not experienced restless legs since starting it. I feel much more emotionally stable and I’m truly impressed with this remarkable product, which contains an excellent combination of magnesium.
Read More
Frequently Asked Questions
9.5
Effective pain relief
26 people found this helpful
I recommend this supplement for arthritis in the knees. After enduring several surgeries and experiencing unbearable pain, I noticed an unbelievable difference just four days after starting this supplement. It provided me with significant relief, better than any painkiller I’ve tried, and restored my knee movement. I truly wish I’d discovered this 40 years ago.
9
Relaxes and relieves
1 people found this helpful
This product is ideal for my husband, helping alleviate arthritis pain and providing muscle relaxation. After a week of use, I noticed it effectively controls my body's needs, particularly magnesium glycinate, which has no taste and helps detoxify.
9
Joint stiffness reduction
I have been taking this along with turmeric for improved joint health. I feel less stiff when getting out of bed, particularly in my knees and lower back. I suspected arthritis, but now I am feeling much better and don't need to visit the doctor.
7.5
Improves sleep
This high-quality magnesium has improved my sleep and relieves muscle pain associated with arthritis. The ingredients are good, and the quantity is sufficient for long-term use, benefitting my overall health.
8
Reduced migraines
5 people found this helpful
I bought this for arthritis, migraines, eyelid spasms, and cramps from magnesium deficiency. Since taking it, my migraines have decreased significantly, and I experience almost no eyelid spasms or cramps now. I'm hopeful it will also help with arthritis after exercise.
9
Gentle on stomach
1 people found this helpful
This magnesium supplement is gentle on my stomach and aids relaxation before bed. It significantly helps relieve my arthritis joint pain. I highly recommend it for those seeking a quality product to address arthritis symptoms.
7.5
Pain management
3 people found this helpful
I purchased this product to assist with my arthritis, particularly in my knees and hands. I found it good quality and effective for pain management. The cost is worth it when combined with other vitamins, and the site delivers promptly.
9
Joint pain relief
THIS IS THE BEST MAGNESIUM available! I've bought this brilliant quality magnesium supplement three times now and won’t change as long as it’s available. The caplet size is manageable and there’s no unpleasant aftertaste. Unlike other magnesium supplements, this one doesn’t upset my digestion. It significantly eases my arthritis pain, helps me sleep better, and I’ve not experienced restless legs since starting it. I feel much more emotionally stable and I’m truly impressed with this remarkable product, which contains an excellent combination of magnesium.
7.5
Joint and muscle calm
One of the best types of magnesium. It calms nerves and muscles, improves sleep, and is beneficial for arthritis. The quantity is substantial and it genuinely makes me feel better.
7.5
Affordable relief
I have been taking this affordable magnesium for years. It greatly benefits my arthritis and helps with histamine intolerance and body functioning.
8
Magnesium supports cartilage repair
We examined how magnesium microparticles might help in repairing cartilage and bone affected by osteoarthritis (OA). Our research focused on understanding if these particles could slow down OA's progression, particularly in the context of inflammation prompted by cytokines like IL-1β and TNF-α.
Using mesenchymal stem cells, we tested the compatibility and function of magnesium. Encouragingly, we observed that at concentrations below 10 mM, over 90% of the cells remained viable after three days. As we explored further, we noticed that magnesium degradation products encouraged the differentiation of these stem cells into tissue-repairing cells.
The findings showed that magnesium not only helped in reducing the inflammatory cytokines IL-6 and IL-8 but also boosted the production of important proteins like collagen X, collagen I, and osteopontin. This suggests that magnesium microparticles might offer a promising pathway for treating osteoarthritis, supporting both bone and cartilage repair even in inflamed conditions.
Using mesenchymal stem cells, we tested the compatibility and function of magnesium. Encouragingly, we observed that at concentrations below 10 mM, over 90% of the cells remained viable after three days. As we explored further, we noticed that magnesium degradation products encouraged the differentiation of these stem cells into tissue-repairing cells.
The findings showed that magnesium not only helped in reducing the inflammatory cytokines IL-6 and IL-8 but also boosted the production of important proteins like collagen X, collagen I, and osteopontin. This suggests that magnesium microparticles might offer a promising pathway for treating osteoarthritis, supporting both bone and cartilage repair even in inflamed conditions.
8
We delved into how magnesium oxide nanoparticles (MgO NPs) could serve as a treatment for osteoarthritis (OA) by delivering magnesium directly to affected joints. Through a well-designed study involving rabbit models, we examined the effectiveness and safety of these nanoparticles.
Our investigation utilized advanced techniques such as transmission electron microscopy and x-ray diffraction to understand the properties of the nanoparticles. One of our key findings was that MgO NPs could significantly extend the release of magnesium, lasting from just half an hour to a full twelve hours. This prolonged release could play a crucial role in effectively managing the symptoms of OA.
Importantly, we ensured that the nanoparticles were safe for use. When we tested concentrations below 250 μg/ml, we did not observe any significant cytotoxicity. Moreover, the intra-articular administration of these nanoparticles helped to alleviate cartilage degeneration and damage, highlighting their potential for treating OA effectively.
Overall, our study showcases the promise of magnesium oxide nanoparticles as a viable option for osteoarthritis treatment, indicating that their size and sustained release capabilities might be key to enhancing therapeutic outcomes.
Our investigation utilized advanced techniques such as transmission electron microscopy and x-ray diffraction to understand the properties of the nanoparticles. One of our key findings was that MgO NPs could significantly extend the release of magnesium, lasting from just half an hour to a full twelve hours. This prolonged release could play a crucial role in effectively managing the symptoms of OA.
Importantly, we ensured that the nanoparticles were safe for use. When we tested concentrations below 250 μg/ml, we did not observe any significant cytotoxicity. Moreover, the intra-articular administration of these nanoparticles helped to alleviate cartilage degeneration and damage, highlighting their potential for treating OA effectively.
Overall, our study showcases the promise of magnesium oxide nanoparticles as a viable option for osteoarthritis treatment, indicating that their size and sustained release capabilities might be key to enhancing therapeutic outcomes.
8
We explored the connection between dietary magnesium intake and all-cause mortality among patients with rheumatoid arthritis (RA). Our study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018, tracking the health outcomes of nearly 3,000 RA patients until the end of 2019. The goal was to determine whether higher magnesium consumption could reduce the risk of death in these individuals.
During our analysis, we discovered that those RA patients who had a higher intake of magnesium—whether through food or supplements—experienced an 11.12% reduction in the risk of all-cause mortality. This significant finding was particularly pronounced in women, individuals under 65 years of age, and those with a lower body mass index (BMI). Our results suggest that an adequate intake of magnesium could play a beneficial role in enhancing overall health and potentially extending life expectancy for those suffering from RA.
The implications are noteworthy, as including more magnesium-rich foods in our diets or considering supplements could offer a straightforward way for RA patients to improve their health outcomes. Hence, we underline the importance of proper dietary management in chronic health conditions such as RA.
During our analysis, we discovered that those RA patients who had a higher intake of magnesium—whether through food or supplements—experienced an 11.12% reduction in the risk of all-cause mortality. This significant finding was particularly pronounced in women, individuals under 65 years of age, and those with a lower body mass index (BMI). Our results suggest that an adequate intake of magnesium could play a beneficial role in enhancing overall health and potentially extending life expectancy for those suffering from RA.
The implications are noteworthy, as including more magnesium-rich foods in our diets or considering supplements could offer a straightforward way for RA patients to improve their health outcomes. Hence, we underline the importance of proper dietary management in chronic health conditions such as RA.
9
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
References
- He J, Wu J, Zheng J, Xu Y, Li K, et al. Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment. ACS Appl Mater Interfaces. 2025;17:11898. doi:10.1021/acsami.4c22415
- Chathoth BM, Helmholz H, Angrisani N, Wiese B, Reifenrath J, et al. Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In Vitro Osteoarthritis Model. J Biomed Mater Res A. 2025;113:e37862. doi:10.1002/jbm.a.37862
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. doi:10.3389/fendo.2024.1375871
- Mei S, Jiang F, Liu N, Feng Z, Zheng Y, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine (Lond). 2024;19:1867. doi:10.1080/17435889.2024.2382421
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Zheng L, Zhao S, Li Y, Xu J, Yan W, et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy. Sci Adv. 2024;10:eadk6084. doi:10.1126/sciadv.adk6084
- Pinto ACMD, de Melo Nunes R, de Freitas Carvalho WV, Girão VCC, Rocha FAC. Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis. Adv Rheumatol. 2024;64:6. doi:10.1186/s42358-023-00346-8
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Yilmaz E, Ünver S. Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis. Magnes Res. 2023;36:40. doi:10.1684/mrh.2023.0515
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Zheng Z, Luo H, Xu W, Shi L, Wang F, et al. Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative. J Nutr Health Aging. 2023;27:775. doi:10.1007/s12603-023-1979-9
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Zhang Y, Chen T, Luo P, Li S, Zhu J, et al. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis. Nutrients. 2022;14. doi:10.3390/nu14173576
- Chen R, Li X, Sun Z, Yin J, Hu X, et al. Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. J Orthop Surg Res. 2022;17:400. doi:10.1186/s13018-022-03294-z
- Wu G, Ma F, Liu Z, Liu J, Xue Y, et al. Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair. Int J Biol Macromol. 2022;220:1104. doi:10.1016/j.ijbiomac.2022.08.071
- Ma R, Zhang C, Liu J, Ren J, Huang H, et al. Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study. Front Immunol. 2025;16:1512293. doi:10.3389/fimmu.2025.1512293
