Last update
8/7/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Moderately Good
Based on 102 Reviews
7.7
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesiumlysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Significant improvement
216 people found this helpful
I tried taking magnesium from local brands with no noticeable changes. After ordering this product, I immediately observed a significant difference. I recommend that everyone gives it a go.
Read More
9
Significant sleep improvement
53 people found this helpful
Magnesium has been exceptional for my deep sleep and mental stability. After nine and a half years on prescribed sleeping pills, I was unable to find stable sleep even after stopping them. Since taking this magnesium along with vitamin D, I noticed a reduction in my anxiety about sleep and awakenings. My gastrointestinal tract is sensitive, making this high-absorption magnesium a great choice. The effects of melatonin and niacin have improved, leading to enhanced mental stability. I intend to continue using it long-term!
Read More
9
Hypertension improvement
25 people found this helpful
Great product! I ordered this for my mother, who has hypertension and often felt dizzy when lying down. After one month of taking one tablet every morning, her hypertension improved significantly, and her dizziness is nearly gone. I will certainly buy it again!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 102 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
216 people found this helpful
I tried taking magnesium from local brands with no noticeable changes. After ordering this product, I immediately observed a significant difference. I recommend that everyone gives it a go.
Read More
9
Significant sleep improvement
53 people found this helpful
Magnesium has been exceptional for my deep sleep and mental stability. After nine and a half years on prescribed sleeping pills, I was unable to find stable sleep even after stopping them. Since taking this magnesium along with vitamin D, I noticed a reduction in my anxiety about sleep and awakenings. My gastrointestinal tract is sensitive, making this high-absorption magnesium a great choice. The effects of melatonin and niacin have improved, leading to enhanced mental stability. I intend to continue using it long-term!
Read More
9
Hypertension improvement
25 people found this helpful
Great product! I ordered this for my mother, who has hypertension and often felt dizzy when lying down. After one month of taking one tablet every morning, her hypertension improved significantly, and her dizziness is nearly gone. I will certainly buy it again!
Read More
9
Restored sleep stability
14 people found this helpful
I had long suffered from severe sleep disorders and managed to overcome years of psychiatric medication withdrawal using iHerb's supplements. Although my mind remained unstable at first, I began taking magnesium when I read a review, hoping for relief. This chelated form is gentle on the stomach and absorbs well. It has significantly improved my sleep onset and depth, allowing for nearly consistent rest and restoring my daily energy. The synergy with vitamin D and zinc has been amazing; I truly commend this supplement!
Read More
9
Emotional stability
14 people found this helpful
This form of magnesium is excellent! I began taking it during pregnancy, then paused for a year. Upon resuming, emotional and physical stress became easier to manage. After being diagnosed with a heart rhythm disorder, I use it consistently. Many of my issues have been resolved, and a high dosage worked wonders for my emotional stress. Unlike others, this magnesium doesn't cause diarrhoea.
Read More
Frequently Asked Questions
9
Sleep disorder relief
2 people found this helpful
This magnesium is essential for my husband, who is frequently anxious at work. The cardiologist recommended it, and after three days of use, there was significant improvement in his sleep. It has not caused any adverse reactions, and its mineral form is well absorbed.
9
Hypertension improvement
25 people found this helpful
Great product! I ordered this for my mother, who has hypertension and often felt dizzy when lying down. After one month of taking one tablet every morning, her hypertension improved significantly, and her dizziness is nearly gone. I will certainly buy it again!
9
Balanced temperament
10 people found this helpful
After taking this magnesium for three months, I can confidently say it has improved my sleep and helped regulate my emotions. I feel balanced and no longer sweat the small stuff, even in difficult situations. I wholeheartedly give it five stars!
9
Migraine management
13 people found this helpful
Since becoming a teenager, I suffered from severe migraines, especially before my period. After trying various supplements, nothing worked until I started taking this magnesium. It has been life-changing— I've said goodbye to migraines, and living without them feels like a dream. I also found relief from physical and mental disorders during the luteal phase. I hope more individuals can experience this benefit, though it is a bit tricky to swallow!
9
Enhanced sleep quality
2 people found this helpful
This magnesium is exceptional! From the first days of use, I’ve slept like a child and awaken feeling refreshed. I had been struggling with insomnia prior, and I highly recommend it. I will definitely order more.
9
Significant sleep improvement
53 people found this helpful
Magnesium has been exceptional for my deep sleep and mental stability. After nine and a half years on prescribed sleeping pills, I was unable to find stable sleep even after stopping them. Since taking this magnesium along with vitamin D, I noticed a reduction in my anxiety about sleep and awakenings. My gastrointestinal tract is sensitive, making this high-absorption magnesium a great choice. The effects of melatonin and niacin have improved, leading to enhanced mental stability. I intend to continue using it long-term!
9
Life-changing experience
7 people found this helpful
After a long search for relief from my debilitating migraines, I came upon Doctor's Best Magnesium and, after taking it, I can confidently say these are the best supplements I've ever used. Normally, I get migraines at least three weeks each month, but in the last two months, I've only experienced one mild headache. If you're a migraine sufferer like me, this could truly change your life!
9
Restored sleep stability
14 people found this helpful
I had long suffered from severe sleep disorders and managed to overcome years of psychiatric medication withdrawal using iHerb's supplements. Although my mind remained unstable at first, I began taking magnesium when I read a review, hoping for relief. This chelated form is gentle on the stomach and absorbs well. It has significantly improved my sleep onset and depth, allowing for nearly consistent rest and restoring my daily energy. The synergy with vitamin D and zinc has been amazing; I truly commend this supplement!
0
Adverse formulation change
4 people found this helpful
Without any communication to consumers, Doctor’s Best altered the formulation and reduced the lysine and glycine content in their magnesium. They also added Silicon Dioxide, which has adversely affected those with autoimmune disorders, causing pancreatic inflammation. After using their magnesium for over four years without issues, I am disheartened by this change, which appears inconsiderate of our health concerns. I would now caution others against using this magnesium, as the added fillers could lead to serious health problems.
9
Better sleep
3 people found this helpful
Improved Sleep And Become Less Nervous. I've been taking one tablet at bedtime for a month (even though 2 are recommended, it seems a large dose for me). I ordered due to my nerves (work-related) and poor sleep, waking several times at night for the past few months. After the first tablet, I slept soundly until morning. There are no side effects, but I need a specific amount of sleep; otherwise, I'm sleepy all day. Very pleased. I will definitely order magnesium from this manufacturer again. Before this, I had never found magnesium preparations so helpful.
7.5
Stress reduction
3 people found this helpful
This magnesium form is my favourite for combatting stress, enhancing sleep, and alleviating bruxism. It reduces heart rate and helps with overall mental performance. I often take one to two tablets in stressful periods, two at night on calmer days. It significantly aids in achieving deeper sleep. Remember to drink plenty of water before taking, as the tablets are rather large.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. 10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. 10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. 10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. 10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
