We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
Read More
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
Read More
9
Bone weakness solution
100 people found this helpful
Excellent! Magnesium has been a lifesaver for my bone weakness. It has improved muscle and heart functions and has strengthened my immune system. It’s a great find, even for preventative use.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 159 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
Read More
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
Read More
9
Bone weakness solution
100 people found this helpful
Excellent! Magnesium has been a lifesaver for my bone weakness. It has improved muscle and heart functions and has strengthened my immune system. It’s a great find, even for preventative use.
Read More
9
Joint pain improved
97 people found this helpful
I'm thrilled with this magnesium and use it for myself and my parents. It greatly calms their nervous system and enhances sleep quality. My mum often suffers from joint pain, and magnesium has notably alleviated her discomfort. It's well-absorbed and doesn’t cause diarrhoea. We take two tablets at night.
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9
Helps cramps and headaches
80 people found this helpful
My headaches have disappeared and my blood pressure has normalised thanks to this magnesium. It also aids in relieving leg cramps and pain during my menstrual period.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, individuals taking magnesium for bone pain often report positive results within one to three weeks of starting supplementation. For instance, one user noted a significant improvement in their knee bone pain within just a week, stating they strongly recommend it for anyone experiencing similar joint pain Read Review. Another user transformed their life after just 18 days of use, experiencing significant relief from debilitating nerve pain Read Review.
Overall, it appears that many users begin to notice alleviation of discomfort relatively quickly, often within the first week. This quick response time supports magnesium supplementation as a promising option for those suffering from various types of bone and joint pain, providing another reason to consider it in your health routine.
This supplement shows some promise in alleviating bone pain, supported by scientific research. One study highlighted the use of choline magnesium trisalicylate (CMT) in managing bone pain among patients with metastatic cancer. In this research, which involved 26 participants, a significant reduction in pain was reported just one hour after treatment with CMT, suggesting it may provide relief, particularly when used alongside traditional pain management methods [3]. However, while there were positive indications, these improvements may not be universally significant, and further investigations are warranted to better understand its effectiveness.
Additionally, another study on magnesium-based frameworks indicated that magnesium ions might support bone formation and contribute to pain relief associated with osteoporosis [1]. While the findings are encouraging, they also note the necessity for more extensive research to verify these effects in clinical settings. Overall, while there is some scientific backing for the use of this supplement in treating bone pain, it's important to approach its use with the understanding that further studies are needed to confirm its efficacy.
Many users report notable improvements in a variety of symptoms after incorporating magnesium supplements into their routines. For instance, individuals have experienced a rapid decrease in anxiety and fatigue, with one user sharing that their quality of life improved dramatically after struggling for over two years with constant headaches Read Review. Similarly, another user noted that leg pain associated with a sedentary lifestyle vanished within a week of starting magnesium, showcasing its effectiveness for both energy and pain relief Read Review.
Moreover, the supplement has been credited with alleviating chronic pain conditions; for example, users suffering from debilitating joint pain and leg cramps have reported significant relief within a matter of days Read Review. Those with menstrual pain and migraines have also expressed relief, indicating that magnesium can effectively manage various symptoms related to both physical discomfort and emotional wellbeing Read Review. While results can vary from person to person, a trend consistently emerges in user feedback that magnesium supplementation may enhance overall wellness and quality of life.
Users report positive experiences when combining magnesium supplements with other remedies. Specifically, one user highlighted how magnesium complements Omega 3 for improved sleep and helps reduce menstrual cramps alongside turmeric, diminishing the need for painkillers Read Review. This combination appears to enhance the overall effectiveness of the magnesium in managing discomfort associated with menstrual cycles.
Furthermore, some users indicate that magnesium taken with other vitamins has led to significant improvements in their quality of life. For instance, a bariatric patient mentioned that incorporating magnesium and other vitamins into their regimen resulted in reduced pain and improved sleep quality Read Review. Overall, users seem to appreciate the synergistic effects produced when magnesium is combined with other supplements, maximizing pain relief and promoting overall wellness.
According to the research on magnesium treatments for bone pain, there is no definitive optimal dose outlined specifically for magnesium in treating bone pain conditions. A study focusing on choline magnesium trisalicylate (CMT), which contains magnesium, indicated significant pain relief in patients with metastatic cancer, reportedly showing effects just one hour after treatment. However, the overall effectiveness and exact dosing remain under exploration, implying that while magnesium may have a role in alleviating pain, its precise dosing for optimal results has yet to be established [3].
Additionally, while magnesium plays a beneficial role in bone formation as part of a comprehensive treatment strategy for pain linked to osteoporosis, further studies are necessary to confirm effective dosages in real-world settings [1]. Due to these uncertainties, it is advisable for individuals to consult healthcare professionals for tailored recommendations regarding magnesium supplementation for bone pain.
9
Effective for knees
14 people found this helpful
Since I started using this product, my knee bone pain has significantly diminished. I strongly recommend this to anyone experiencing joint pain. I plan to order it again.
8
Reduced nerve pain
61 people found this helpful
I initially purchased this for my grandmother, who suffers from debilitating carpal and cubital tunnel issues. She has experienced significant numbness and pain, requiring immobilisers at night. For over two years, she endured incessant nerve pain and insomnia. After taking this magnesium for 18 days, she started recommending it to family, as it has greatly improved her situation and helped with better absorption.
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
9
Leg pain relief
62 people found this helpful
I consulted a doctor for severe cramps in my legs, and after finding out I had a magnesium deficiency, I tried Doctor's Best magnesium. Within two weeks, I noticed a marked improvement—my leg pain subsided, and cramps became rare. I recommend it to anyone suffering similar issues.
9
Helps cramps and headaches
80 people found this helpful
My headaches have disappeared and my blood pressure has normalised thanks to this magnesium. It also aids in relieving leg cramps and pain during my menstrual period.
9
Super supplement
9 people found this helpful
I take magnesium not only as an essential supplement for women but also for sleep, calming, and muscle soreness. It truly is a super supplement. It complements Omega 3 for deep sleep and helps with period cramps alongside turmeric, reducing the need for painkillers. After trying a different brand, I returned to this one due to its effectiveness. It's one of the top five supplements one should have in their life.
9
Eliminated joint pain
11 people found this helpful
As a bariatric patient, I lost considerable weight, leading to muscle weakness, joint pain, and insomnia. After introducing magnesium and other vitamins into my regimen, my quality of life has tremendously improved. My sleep quality has enhanced markedly, and the pain has subsided. I recommend this product; while a downside is taking four tablets, I find them worthwhile.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.