Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial.
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium reduces postoperative knee pain
Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial.
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
Most Useful Reviews
9
Knee improvement noted
16 people found this helpful
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
Read More
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
Read More
7.5
Effective pain relief
1 people found this helpful
Very good! It improved the knee pain my mother experienced in her legs and arms. I will certainly purchase it again.
Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial.
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium and bupivacaine effective
Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis.
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
Read More
9
Magnesium reduces postoperative knee pain
Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial.
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
9
Magnesium reduces post-surgery pain
Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty.
We looked into how magnesium can help ease knee pain after total knee arthroplasty. In a study of 80 patients, those who received an injection of magnesium sulfate and ropivacaine experienced significantly less pain and needed less morphine compared to those who got a saline injection. This approach not only reduced morphine use in the first 48 hours but also allowed patients to regain movement quicker. Overall, our findings suggest that magnesium may be a beneficial part of pain management in knee surgery.
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
Read More
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
Read More
7.5
Effective pain relief
1 people found this helpful
Very good! It improved the knee pain my mother experienced in her legs and arms. I will certainly purchase it again.
Read More
7.5
Knee recovery
28 people found this helpful
I had to switch to a pricier liposomal magnesium after experiencing stomach upset with this one. Despite that, magnesium has notably reduced my fatigue and remarkably aided my recovery from a knee ligament strain. I suggest finding a tolerable version if this one doesn’t suit you. Please thumbs up if you find this helpful!
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7.5
Knee relief attained
2 people found this helpful
I initially bought this magnesium for myself but realised it could help my husband. He takes two tablets each morning and night. Surprisingly, he only needs one in the morning. He and his knees have benefited greatly, resulting in improved sleep for both of us. I recommend it for peace of mind.
Knee pain is a common condition that can result from various causes, including injuries, overuse, and underlying medical conditions such as arthritis. The knee joint is a complex structure composed of bones, ligaments, tendons, and cartilage, all of which work together to enable movement and support body weight. When any of these components are damaged or inflamed, it can lead to discomfort, stiffness, swelling, and reduced mobility in the affected area.
In many cases, knee pain can manifest as acute pain following an injury, such as a tear in a ligament or cartilage damage. Alternatively, it may develop gradually due to factors like repetitive strain, age-related degeneration, or conditions like osteoarthritis and rheumatoid arthritis. Treatment options vary widely and may include rest, physical therapy, medication, or, in severe cases, surgical interventions. If you're experiencing persistent knee pain, it's advisable to consult with a healthcare professional for an accurate diagnosis and tailored treatment plan.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a critical role in numerous bodily functions, including muscle and nerve function, which can be beneficial in managing pain. While it is not a direct treatment for knee pain, some studies suggest that magnesium can help reduce inflammation and improve muscle function, which might alleviate discomfort associated with conditions such as arthritis or strains in the knee area. Magnesium deficiency has also been linked to increased inflammation, so ensuring adequate magnesium levels could potentially support overall joint health.
However, it's important to note that magnesium should not be considered a standalone solution for knee pain. It's best to adopt a comprehensive approach that includes other treatments such as physical therapy, proper exercise, and possibly anti-inflammatory medications recommended by healthcare providers. Always consult with a medical professional before starting any new supplementation, especially if you have existing health concerns or are taking other medications.
Based on user reviews, many individuals report experiencing noticeable improvements in knee pain within a few weeks of starting the supplement. For example, one user mentioned a significant improvement in knee pain after three weeks of use, stating that their knee no longer creaks and their energy levels increased during training Read Review. Another user noted enhancements in their mother’s knee pain after regular use, indicating that results can vary but often show up in a relatively short timeframe Read Review.
Additionally, the combination of taking the supplement and maintaining other healthy habits, like proper sleep, is frequently mentioned as a factor that may accelerate the relief of knee pain. One reviewer remarked on how improved sleep contributed to their overall well-being, alongside reduced knee discomfort Read Review. Therefore, if you're considering this magnesium supplement for knee pain, anticipate seeing results within a few weeks, especially if used along with a good lifestyle regimen.
Recent research indicates that magnesium, particularly in the form of magnesium sulfate, can be beneficial in managing knee pain after surgery. In several studies, including one that involved 148 patients undergoing total knee arthroplasty, magnesium sulfate was linked to reduced postoperative pain and better overall recovery outcomes compared to standard treatments [2]. Another controlled trial demonstrated that magnesium enhanced pain relief and helped minimize the need for opioids following knee surgeries [3]. Moreover, findings show that when magnesium is combined with other analgesics, it further improves pain management and recovery, suggesting a synergistic effect [5].
Additionally, magnesium's role extends into non-surgical contexts as well. A larger study with over 2,500 participants revealed that insufficient dietary magnesium was associated with increased knee pain and reduced function in individuals with osteoarthritis [10]. This highlights magnesium's potential for not just postoperative recovery, but also for ongoing knee pain management. While magnesium does not appear to be the sole solution for knee pain, its substantial positive effects in both surgical recovery and in managing chronic conditions like osteoarthritis make it a promising supplement to consider for those suffering from knee pain.
Users have reported diverse improvements in their symptoms after incorporating this magnesium supplement into their routines. Many have shared that it significantly alleviated knee pain and enhanced overall joint function. For example, one user highlighted a remarkable reduction in knee discomfort related to arthrosis, stating, "My knee arthrosis has improved significantly" Read Review. Another reviewer noted relief from knee pain experienced by their mother, reinforcing the supplement's potential benefits for joint health Read Review.
Additionally, improvements in sleep quality and general well-being were frequently mentioned. A user remarked that their sleep routine, combined with the magnesium, made them feel revitalized each morning and brought relief to their knees and legs Read Review. Some users even reported enhanced energy levels and decreased fatigue alongside the reduction in pain Read Review. While results vary among individuals, the collective feedback suggests that this magnesium supplement could provide significant relief for those experiencing joint discomfort and related symptoms.
Based on user reviews, there is a consensus that combining this magnesium supplement with other healthy habits, particularly a proper sleep routine, significantly enhances its benefits for managing knee pain. Several users reported noticeable improvements in their knee symptoms attributed to the supplement, especially when taken with good sleep practices. For instance, one user mentioned feeling revitalized every morning and experiencing noticeable relief in their knees and legs alongside improved sleep quality after starting the supplement Read Review. Similarly, another reviewer noted significant improvements in their mother's knee pain, reinforcing the idea that when combined with a supportive lifestyle, this supplement can yield positive outcomes Read Review.
Additionally, users have highlighted the importance of dosage and consistency in using the supplement alongside other health considerations. One reviewer found that taking multiple tablets daily enhanced absorption and that even though their knee still ached, magnesium significantly aided in alleviating the pain Read Review. Overall, feedback indicates that for those dealing with knee pain, using this magnesium supplement in conjunction with other supportive practices—such as prioritizing sleep and adjusting dosages—can lead to meaningful relief and improved well-being.
Research indicates that magnesium, particularly in the form of magnesium sulfate, can significantly aid in managing knee pain after surgery. Studies have demonstrated that magnesium not only helps in reducing postoperative pain but also decreases the reliance on additional pain medications. For instance, one study involving 148 elderly patients found that those receiving magnesium sulfate reported lower pain levels and improved overall recovery compared to those receiving a saline solution [2]. Furthermore, using magnesium in combination with local anesthetics, such as bupivacaine, has been shown to enhance pain relief more effectively than bupivacaine alone [6].
While there isn't a universally optimal dose established, treatments often involve the use of magnesium sulfate as part of a modified analgesic cocktail during surgical procedures. The specific dosage can vary based on individual patient needs and the surgical context, but magnesium's benefits in pain management are clear. It's recommended that patients consult with their healthcare providers about incorporating magnesium in their pain management protocols to ensure the best outcomes tailored to their unique situations [8].
6
Knee noise stopped
2 people found this helpful
Great vitamins! After three weeks, I've noticed much less fatigue. I have difficulty getting up in the mornings and have noticed my knee no longer creaks. My energy levels during training have increased, and my cravings for sweets have diminished. I highly recommend it!
7.5
Effective pain relief
1 people found this helpful
Very good! It improved the knee pain my mother experienced in her legs and arms. I will certainly purchase it again.
7.5
Knee relief attained
2 people found this helpful
I initially bought this magnesium for myself but realised it could help my husband. He takes two tablets each morning and night. Surprisingly, he only needs one in the morning. He and his knees have benefited greatly, resulting in improved sleep for both of us. I recommend it for peace of mind.
9
Knee improvement noted
16 people found this helpful
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
7
Knee pain support
15 people found this helpful
I purchased this magnesium for its dosage and quality. I take 100 mg three to four times a day for better absorption. It helps me sleep better, and while my knee still hurts, magnesium significantly aids this. The capsules are easy to swallow, making it a convenient choice.
7
Magnesium aids knee surgery recovery
Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.
We investigated how magnesium sulfate influences recovery after knee surgery. In our study, 148 elderly patients undergoing total knee arthroplasty were divided into two groups: one received magnesium sulfate, while the other received a saline solution.
This double-blind setup allowed us to see if magnesium sulfate could enhance recovery quality after surgery. Our findings indicate that magnesium sulfate does help reduce early postoperative pain and improves overall recovery in these patients.
Overall, magnesium sulfate appears beneficial in managing pain during the recovery process.
9
Magnesium sulfate alleviates postoperative pain
Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial.
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
7
Magnesium intake impacts knee pain
Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative.
We explored whether magnesium intake affects knee pain and function in individuals with knee osteoarthritis. In a study involving over 2,500 participants, we followed their magnesium intake for 48 months.
Our findings showed that lower magnesium intake was linked to worse pain and reduced function over time. This trend was particularly noticeable in people who also had low fiber intake. These results suggest that maintaining adequate magnesium levels could be beneficial for managing knee pain.
9
Magnesium and bupivacaine effective
Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis.
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
8
Magnesium enhances post-surgery pain relief
Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty.
We examined the impact of magnesium sulfate paired with levobupivacaine on pain relief after total knee arthroplasty (TKA). In our study, 60 patients were divided into two groups: one received the magnesium cocktail, while the other only got levobupivacaine. Our findings revealed that the magnesium group experienced prolonged pain relief, reduced reliance on additional pain medication, and effective management of early postoperative pain. Overall, this suggests that magnesium sulfate could be a valuable addition to pain management protocols following knee surgery.
References
Zhu Y, Shen S, Cui L, Wu L, Zhang B. Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2024;19:764. doi:10.1186/s13018-024-05233-6
Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. doi:10.2147/DDDT.S444896
Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. doi:10.1186/s13018-023-03790-w
Wang Q, Zhao C, Hu J, Ma T, Yang J, et al. Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2023;105:354. doi:10.2106/JBJS.22.00614
Choi JW, Lahori A, Merlo JA, Gill O, Ghoddoussi F, et al. Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial. Clin J Pain. 2022;38:388. doi:10.1097/AJP.0000000000001036
He Y, He H, Li X, Lei G, Xie D, et al. Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis. Arthroscopy. 2022;38:2897. doi:10.1016/j.arthro.2022.03.013
Shi L, Zhu H, Ma J, Shi LL, Gao F, et al. Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:111. doi:10.1186/s13018-021-02264-1
Zhao Z, Zhang X, Peng H, Li W, Liu H, et al. Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty. J Knee Surg. 2021;34:1463. doi:10.1055/s-0040-1710364
Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, et al. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis. Biomed Res Int. 2018;2018:7937089. doi:10.1155/2018/7937089
Shmagel A, Onizuka N, Langsetmo L, Vo T, Foley R, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26:651. doi:10.1016/j.joca.2018.02.002
Shin HJ, Kim EY, Na HS, Kim TK, Kim MH, et al. Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial. Br J Anaesth. 2016;117:497. doi:10.1093/bja/aew227
Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2012;40:2032.
Ekmekci P, Bengisun ZK, Akan B, Kazbek BK, Ozkan KS, et al. The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013;21:1119. doi:10.1007/s00167-012-2093-4
Koltka K, Koknel-Talu G, Asik M, Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc. 2011;19:1884. doi:10.1007/s00167-011-1497-x
Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2009;37:1733.
Farouk S, Aly A. A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery. J Anesth. 2009;23:508. doi:10.1007/s00540-009-0822-8