Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
Most Useful Reviews
9
Revitalising experience
57 people found this helpful
These are the first vitamins I ordered for Ayurber and what a surprise! I chose a budget option for hair and nails but ended up calming my nerves. The clump of hair in the bath after washing reduced significantly! Most astonishingly, the unpleasant body odour I had under my breast, which I thought was an unavoidable part of ageing at 39, vanished. Once the vitamins were finished, the smell returned, but once I resumed taking them, I felt fresh again. My neck and back pain eased, and the headache returned during a pause in taking them, but subsided once I resumed. My energy levels surged in the mornings, especially after breakfast. Niacin did give a slight headache, but it soon disappeared. Overall, excellent for my health!
Read More
0
Negative side effects
3 people found this helpful
I used this daily, which was a mistake as the large dose caused me a headache, diarrhoea, and fatigue. After a while, I tried taking a pill again, but I ended up with a migraine, so I've decided to stop using it entirely.
Read More
9
Effective relief
1 people found this helpful
This product contains a full range of B vitamins, which I take twice a year due to instability in my cervical vertebrae and frequent headaches. It improves my condition significantly, easing my headaches, enhancing my sleep quality, and calming my nerves. It's crucial for overall well-being; I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
- All Researches
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
9
We looked at a rare case involving a 14-year-old girl experiencing persistent headaches and high intracranial pressure. Testing revealed a significant plasma homocysteine level and a mutation related to the MTHFR gene, previously unreported in cerebral venous thrombosis (CVT) cases.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
Read More
8
We explored the potential of riboflavin, or vitamin B2, as a treatment for migraine prevention in adults. The findings suggest that riboflavin can be recommended for adults dealing with migraines, albeit with no proven benefit for children.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Revitalising experience
57 people found this helpful
These are the first vitamins I ordered for Ayurber and what a surprise! I chose a budget option for hair and nails but ended up calming my nerves. The clump of hair in the bath after washing reduced significantly! Most astonishingly, the unpleasant body odour I had under my breast, which I thought was an unavoidable part of ageing at 39, vanished. Once the vitamins were finished, the smell returned, but once I resumed taking them, I felt fresh again. My neck and back pain eased, and the headache returned during a pause in taking them, but subsided once I resumed. My energy levels surged in the mornings, especially after breakfast. Niacin did give a slight headache, but it soon disappeared. Overall, excellent for my health!
Read More
0
Negative side effects
3 people found this helpful
I used this daily, which was a mistake as the large dose caused me a headache, diarrhoea, and fatigue. After a while, I tried taking a pill again, but I ended up with a migraine, so I've decided to stop using it entirely.
Read More
9
Effective relief
1 people found this helpful
This product contains a full range of B vitamins, which I take twice a year due to instability in my cervical vertebrae and frequent headaches. It improves my condition significantly, easing my headaches, enhancing my sleep quality, and calming my nerves. It's crucial for overall well-being; I highly recommend it.
Read More
2
Not suitable
1 people found this helpful
I found this product caused me headaches and made me feel terribly unwell, likely due to my IBS. The dosage seems too strong for me, which explains the headaches.
Read More
9
Headaches resolved
I've experienced good results with this product. The quick delivery, quality packaging, and natural herbal composition are commendable. While the capsules are slightly large, I have no issue swallowing them. I take one capsule daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days, I've noticed increased energy, my headaches have ceased, and my mood remains positive. I highly recommend it, especially for those keen on sports, fitness, or dieting, as omega-3 replenishes what the body lacks.
Read More
Frequently Asked Questions
9
Stopped headaches
I am very pleased with the fast delivery and high-quality packaging. Initially, I suffered from frequent headaches, but after taking this for 10 days, I noticed a significant reduction in headaches, along with improved energy and mood.
9
Headaches resolved
I've experienced good results with this product. The quick delivery, quality packaging, and natural herbal composition are commendable. While the capsules are slightly large, I have no issue swallowing them. I take one capsule daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days, I've noticed increased energy, my headaches have ceased, and my mood remains positive. I highly recommend it, especially for those keen on sports, fitness, or dieting, as omega-3 replenishes what the body lacks.
2
Overdose warning
Perhaps the dose was too high for me, as I experienced a headache by the second day and bloating in my stomach, which made it difficult to continue. I eventually opened the capsule to consume only half, and I certainly felt less tired afterwards.
9
Revitalising experience
57 people found this helpful
These are the first vitamins I ordered for Ayurber and what a surprise! I chose a budget option for hair and nails but ended up calming my nerves. The clump of hair in the bath after washing reduced significantly! Most astonishingly, the unpleasant body odour I had under my breast, which I thought was an unavoidable part of ageing at 39, vanished. Once the vitamins were finished, the smell returned, but once I resumed taking them, I felt fresh again. My neck and back pain eased, and the headache returned during a pause in taking them, but subsided once I resumed. My energy levels surged in the mornings, especially after breakfast. Niacin did give a slight headache, but it soon disappeared. Overall, excellent for my health!
9
Relieved headaches
This B vitamin complex helped with my headaches. I took it to strengthen my body during cold season, and I noticed my head felt clearer, providing me much relief from migraines.
9
Effective relief
1 people found this helpful
This product contains a full range of B vitamins, which I take twice a year due to instability in my cervical vertebrae and frequent headaches. It improves my condition significantly, easing my headaches, enhancing my sleep quality, and calming my nerves. It's crucial for overall well-being; I highly recommend it.
0
Negative side effects
3 people found this helpful
I used this daily, which was a mistake as the large dose caused me a headache, diarrhoea, and fatigue. After a while, I tried taking a pill again, but I ended up with a migraine, so I've decided to stop using it entirely.
2
Not suitable
1 people found this helpful
I found this product caused me headaches and made me feel terribly unwell, likely due to my IBS. The dosage seems too strong for me, which explains the headaches.
7.5
Improves condition
I take this for my headache. As I am on vitamin C megadoses, my primary pill is taken in the afternoon, but when I combine it with a vitamin drink, my condition improves significantly for about an hour.
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
8
We investigated how dietary intake of folate, or vitamin B, relates to severe headaches among adults in the U.S. By analyzing data from the National Health and Nutrition Examination Survey involving nearly 10,000 participants, we found that higher folate intake was significantly linked to lower instances of severe headaches.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. doi:10.1016/j.nutres.2023.11.008
- Sadeghvand S, Barzegar M, Shiva S, Tarmahi V, Hamed H, et al. The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial. Iran J Child Neurol. 2023;17:143. doi:10.22037/ijcn.v17i3.40053
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Chutko LS, Surushkina SY, Yakovenko EA, Rozhkova AV, Volov MB, et al. [Possibilities of using Cytoflavin in the treatment of cognitive and emotional disorders in patients with tension headaches]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119:32. doi:10.17116/jnevro201911911132
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. doi:10.23736/S0026-4946.19.05533-6
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
