Last update
3/29/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
Most Useful Reviews
9
Supports liver function
5 people found this helpful
I used this for nutritional support during my weight loss journey. I found that this vitamin B complex helped to significantly lower my liver values. After undergoing gastric surgery, my test results improved, and I no longer needed it. It's a solid choice for those dealing with liver disease.
Read More
0
Ineffective for skin
I purchased this for someone with a skin condition, but unfortunately, they reported no improvement in terms of liver disease treatment.
Read More
8
Liver problem relief
3 people found this helpful
Excellent product; it helped me with my liver problems.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports liver function
5 people found this helpful
I used this for nutritional support during my weight loss journey. I found that this vitamin B complex helped to significantly lower my liver values. After undergoing gastric surgery, my test results improved, and I no longer needed it. It's a solid choice for those dealing with liver disease.
Read More
0
Ineffective for skin
I purchased this for someone with a skin condition, but unfortunately, they reported no improvement in terms of liver disease treatment.
Read More
8
Liver problem relief
3 people found this helpful
Excellent product; it helped me with my liver problems.
Read More
6
Stress relief
1 people found this helpful
I've noticed a significant difference when I skip these Active Bs. They help manage my stress levels and support liver function, keeping my health in check and enhancing my energy. I'm pleased with the results, especially concerning liver disease.
Read More
9
Liver detoxification
The composition of this Active B Complex is beneficial for liver detoxification and methylation. It's a good combination at a fair price that helps maintain my overall liver health.
Read More
Frequently Asked Questions
9
Supports liver function
5 people found this helpful
I used this for nutritional support during my weight loss journey. I found that this vitamin B complex helped to significantly lower my liver values. After undergoing gastric surgery, my test results improved, and I no longer needed it. It's a solid choice for those dealing with liver disease.
0
Ineffective for skin
I purchased this for someone with a skin condition, but unfortunately, they reported no improvement in terms of liver disease treatment.
6
Stress relief
1 people found this helpful
I've noticed a significant difference when I skip these Active Bs. They help manage my stress levels and support liver function, keeping my health in check and enhancing my energy. I'm pleased with the results, especially concerning liver disease.
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
References
- Ciftel S, Ciftel S, Altuner D, Huseynova G, Yucel N, et al. Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats. BMC Pharmacol Toxicol. 2025;26:67. 10.1186/s40360-025-00901-7
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. 10.1038/s41467-024-54826-6
- Zhu J, Liao X, Du L, Lv P, Deng J. Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1426103. 10.3389/fendo.2024.1426103
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. 10.1097/HC9.0000000000000599
Data last updated:
