Last update
3/31/2026
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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
9
ALA improves CTS recovery outcomes
We aimed to see how alpha-lipoic acid (ALA) affects recovery from carpal tunnel syndrome (CTS) after surgery. In a well-structured study with 20 adults, half received ALA while the others received a placebo for three months.
The results were promising! Those taking ALA experienced significant improvements in both clinical signs and neurophysiologic measurements, even before their surgery. Notably, none in the ALA group showed positive signs of Tinel’s or Phalen’s tests at 12 weeks post-surgery, which is fantastic compared to the placebo group.
In the end, ALA appears to enhance recovery from CTS effectively, supporting its use alongside surgery.
The results were promising! Those taking ALA experienced significant improvements in both clinical signs and neurophysiologic measurements, even before their surgery. Notably, none in the ALA group showed positive signs of Tinel’s or Phalen’s tests at 12 weeks post-surgery, which is fantastic compared to the placebo group.
In the end, ALA appears to enhance recovery from CTS effectively, supporting its use alongside surgery.
Read More
5
A recent study sought to understand how Alpha-Lipoic Acid-R (ALA-R) affects patients with mild to moderate carpal tunnel syndrome. In a controlled trial involving 134 patients, those taking ALA-R experienced a notable reduction in pain compared to those who received no treatment.
However, we found no significant improvements in other symptoms or overall function. While ALA-R showed some promise, it remains clear that surgical options are still the preferred treatment for this condition.
However, we found no significant improvements in other symptoms or overall function. While ALA-R showed some promise, it remains clear that surgical options are still the preferred treatment for this condition.
Read More
We explored the effectiveness of a combination of alpha-lipoic acid and vitamin B complex in treating carpal tunnel syndrome. In a randomized, double-blind study with 70 participants, we compared this treatment to a placebo over six months. While the results suggested some pain relief for those taking the active treatment, the overall benefits were not groundbreaking. Patients reported that the treatment was well tolerated, which is encouraging, but further studies are needed to confirm these findings and enhance our understanding of this approach.
Read More
Most Useful Reviews
7
No surgery needed
9 people found this helpful
I take it on an empty stomach alongside L-Carnitine, Vitamin C, and Vitamin B. It is greatly beneficial for the nerves. After trying it for Carpal Tunnel Syndrome for six months, I experienced improvement, thank God. I did not require surgery, for which I am grateful... High quality.
Read More
9
Pain relief achieved
4 people found this helpful
Alpha Lipoic Acid for polyneuropathy and Carpal Tunnel Syndrome. I took it alongside phosphatidylserine; I experienced severe pain in my wrist joint and hand due to nerve entrapment and swelling caused by the nerve being clamped in the bone canal. After using it for approximately six months, the pain has dissipated. Alpha Lipoic Acid at 600 mg is a suitable dosage. I am pleased with the purchase.
Read More
8
Effective for long-term
Great for Carpal Tunnel. I have used this product for many years with positive results. A friend introduced it to me, and I am sharing this with you; give it a try, I'm sure you'll appreciate it!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
- All Researches
9
We investigated how alpha lipoic acid (ALA), administered both orally and intravenously, can alleviate pain associated with carpal tunnel syndrome (CTS).
In a study involving 115 patients, participants received either only physiotherapy and wrist splints, oral ALA, or intravenous ALA followed by oral ALA.
After three months, those who received intravenous ALA showed significantly reduced pain and improved symptoms compared to those on oral ALA alone or no treatment.
This suggests that intravenous ALA can be effective in treating CTS symptoms.
In a study involving 115 patients, participants received either only physiotherapy and wrist splints, oral ALA, or intravenous ALA followed by oral ALA.
After three months, those who received intravenous ALA showed significantly reduced pain and improved symptoms compared to those on oral ALA alone or no treatment.
This suggests that intravenous ALA can be effective in treating CTS symptoms.
Read More
9
ALA improves CTS recovery outcomes
We aimed to see how alpha-lipoic acid (ALA) affects recovery from carpal tunnel syndrome (CTS) after surgery. In a well-structured study with 20 adults, half received ALA while the others received a placebo for three months.
The results were promising! Those taking ALA experienced significant improvements in both clinical signs and neurophysiologic measurements, even before their surgery. Notably, none in the ALA group showed positive signs of Tinel’s or Phalen’s tests at 12 weeks post-surgery, which is fantastic compared to the placebo group.
In the end, ALA appears to enhance recovery from CTS effectively, supporting its use alongside surgery.
The results were promising! Those taking ALA experienced significant improvements in both clinical signs and neurophysiologic measurements, even before their surgery. Notably, none in the ALA group showed positive signs of Tinel’s or Phalen’s tests at 12 weeks post-surgery, which is fantastic compared to the placebo group.
In the end, ALA appears to enhance recovery from CTS effectively, supporting its use alongside surgery.
Read More
9
We explored how the combination of alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) can help people suffering from carpal tunnel syndrome (CTS). In our study with 112 participants, we compared this combination to a multivitamin B treatment over 90 days.
The results were promising: the ALA/GLA mix significantly improved symptoms and functional abilities, while the multivitamin treatment showed only slight improvements. This suggests that ALA and GLA are effective in reducing CTS symptoms, making them a viable option for early-stage treatment.
The results were promising: the ALA/GLA mix significantly improved symptoms and functional abilities, while the multivitamin treatment showed only slight improvements. This suggests that ALA and GLA are effective in reducing CTS symptoms, making them a viable option for early-stage treatment.
Read More
8
Our multicentric observational study included 377 patients from 34 Italian centers to discover how carpal tunnel syndrome is currently managed. We found that patients treated with a mix of therapies, including those containing alpha-lipoic acid, experienced notable improvements in their symptoms and functionality.
Over a two-month follow-up, patients reported a significant decrease in pain levels and better overall health status. Thus, a comprehensive, multidisciplinary approach to treating carpal tunnel syndrome seems to be beneficial.
Over a two-month follow-up, patients reported a significant decrease in pain levels and better overall health status. Thus, a comprehensive, multidisciplinary approach to treating carpal tunnel syndrome seems to be beneficial.
Read More
8
Alpha-lipoic acid aids CTS recovery
We evaluated how oral supplementation with alpha-lipoic acid, curcumin phytosome, and B-group vitamins impacts patients facing surgery for carpal tunnel syndrome (CTS).
In a study involving 180 participants, those who received supplements before and after surgery experienced fewer nocturnal symptoms and better overall outcomes than those who did not.
This suggests that incorporating this supplementation may enhance recovery for CTS patients, making it a safe and beneficial option in surgical preparation and aftercare.
In a study involving 180 participants, those who received supplements before and after surgery experienced fewer nocturnal symptoms and better overall outcomes than those who did not.
This suggests that incorporating this supplementation may enhance recovery for CTS patients, making it a safe and beneficial option in surgical preparation and aftercare.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7
No surgery needed
9 people found this helpful
I take it on an empty stomach alongside L-Carnitine, Vitamin C, and Vitamin B. It is greatly beneficial for the nerves. After trying it for Carpal Tunnel Syndrome for six months, I experienced improvement, thank God. I did not require surgery, for which I am grateful... High quality.
Read More
9
Pain relief achieved
4 people found this helpful
Alpha Lipoic Acid for polyneuropathy and Carpal Tunnel Syndrome. I took it alongside phosphatidylserine; I experienced severe pain in my wrist joint and hand due to nerve entrapment and swelling caused by the nerve being clamped in the bone canal. After using it for approximately six months, the pain has dissipated. Alpha Lipoic Acid at 600 mg is a suitable dosage. I am pleased with the purchase.
Read More
8
Effective for long-term
Great for Carpal Tunnel. I have used this product for many years with positive results. A friend introduced it to me, and I am sharing this with you; give it a try, I'm sure you'll appreciate it!
Read More
7
Happy benefits
I feel that this product has helped my Carpal Tunnel Syndrome. It contains the active ingredient found in a more widely advertised product, so I opted to use this instead, as it is more economical. I am happy with the benefits I have experienced.
Read More
6
Lessened symptoms
Inflammatory statement I have an autoimmune condition, mild compared to most, but with advancing age, I also experience increasing arthritis pains. Initially, I was recommended this for Carpal Tunnel Syndrome, and it had some effect. After having this condition corrected surgically in both wrists, I ran out of alpha-lipoic-acid (ALA); my arthritis in the thumbs and wrists reminded me of their presence! I have recently resumed ALA, and I seem to have noticed a reduction already.
Read More
Frequently Asked Questions
9
Pain relief achieved
4 people found this helpful
Alpha Lipoic Acid for polyneuropathy and Carpal Tunnel Syndrome. I took it alongside phosphatidylserine; I experienced severe pain in my wrist joint and hand due to nerve entrapment and swelling caused by the nerve being clamped in the bone canal. After using it for approximately six months, the pain has dissipated. Alpha Lipoic Acid at 600 mg is a suitable dosage. I am pleased with the purchase.
7
No surgery needed
9 people found this helpful
I take it on an empty stomach alongside L-Carnitine, Vitamin C, and Vitamin B. It is greatly beneficial for the nerves. After trying it for Carpal Tunnel Syndrome for six months, I experienced improvement, thank God. I did not require surgery, for which I am grateful... High quality.
6
Lessened symptoms
Inflammatory statement I have an autoimmune condition, mild compared to most, but with advancing age, I also experience increasing arthritis pains. Initially, I was recommended this for Carpal Tunnel Syndrome, and it had some effect. After having this condition corrected surgically in both wrists, I ran out of alpha-lipoic-acid (ALA); my arthritis in the thumbs and wrists reminded me of their presence! I have recently resumed ALA, and I seem to have noticed a reduction already.
8
Effective for long-term
Great for Carpal Tunnel. I have used this product for many years with positive results. A friend introduced it to me, and I am sharing this with you; give it a try, I'm sure you'll appreciate it!
References
- Barrera-Ochoa S, Prieto-Meré JA, Mora E, Martinez-Garza JA, Méndez G, et al. Role of Alpha-Lipoic Acid as a Co-adjuvant Treatment with Surgical Decompression of Carpal Tunnel Syndrome: A Retrospective Study. J Hand Surg Asian Pac Vol. 2026;31:81. 10.1142/S2424835526500104
- Zainal NA, Abdul Rashid AM, A Rauf AL, Yusof Khan AHK, Wan Sulaiman WA, et al. Evaluating the efficacy and tolerability of the oral combination of alpha lipoic acid and vitamin B complex preparation in carpal tunnel syndrome: a single center, randomized, double-blind, placebo-controlled trial. BMC Neurol. 2025;26:7. 10.1186/s12883-025-04430-y
- Gülsah Ö, Bekir DE. Efficacy of intravenous alpha lipoic acid in the treatment of neuropatic pain due to carpal tunnel syndrome. Ideggyogy Sz. 2023;76:319. 10.18071/isz.76.0319
- D'Orio M, De Vitis R, Taccardo G, Rocchi L, Ferrari F, et al. Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study. Acta Biomed. 2023;94:e2023050. 10.23750/abm.v94iS2.12513
- Marvulli R, Ianieri G, De Venuto G, Falcicchio M, Gallo GA, et al. Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome. Endocr Metab Immune Disord Drug Targets. 2021;21:345. 10.2174/1871530320666200728152953
- Passiatore M, Perna A, De-Vitis R, Taccardo G. The Use of Alfa-Lipoic Acid-R (ALA-R) in Patients with Mild-Moderate Carpal Tunnel Syndrome: A Randomised Controlled Open Label Prospective Study. Malays Orthop J. 2020;14:1. 10.5704/MOJ.2003.001
- Monroy Guízar EA, García Benavides L, Ambriz Plascencia AR, Pascoe González S, Totsuka Sutto SE, et al. Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial. J Med Food. 2018;21:521. 10.1089/jmf.2017.0056
- Boriani F, Granchi D, Roatti G, Merlini L, Sabattini T, et al. Alpha-lipoic Acid After Median Nerve Decompression at the Carpal Tunnel: A Randomized Controlled Trial. J Hand Surg Am. 2017;42:236. 10.1016/j.jhsa.2017.01.011
- Luchetti R, Tognon S, Cacciavillani M, Ronco S, Buzzelli N, et al. Observational multicentric survey on carpal tunnel syndrome: demographic and clinical data from 34 Italian centers. Eur Rev Med Pharmacol Sci. 2017;21:460. PubMed
- Notarnicola A, Maccagnano G, Tafuri S, Fiore A, Pesce V, et al. Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome. Int J Immunopathol Pharmacol. 2015;28:256. 10.1177/0394632015584501
- Costantino M, Guaraldi C, Costantino D, De Grazia S, Unfer V. Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation. Eur Rev Med Pharmacol Sci. 2014;18:2766. PubMed
- Pajardi G, Bortot P, Ponti V, Novelli C. Clinical usefulness of oral supplementation with alpha-lipoic Acid, curcumin phytosome, and B-group vitamins in patients with carpal tunnel syndrome undergoing surgical treatment. Evid Based Complement Alternat Med. 2014;2014:891310. 10.1155/2014/891310
- Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci. 2009;13:133. PubMed
Data last updated:
