Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 48 Reviews
7.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Read More
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Read More
Most Useful Reviews
7.5
Cleanses toxins
188 people found this helpful
This product is indispensable for managing insulin resistance, with impressive results in helping me lose weight while on a diet. It effectively detoxifies the liver, allowing it to eliminate toxins and cleanse the body. I take it before meals, twice daily, and recommend it to others.
Read More
7.5
Improves liver function
118 people found this helpful
ALA has significantly aided my insulin resistance, allowing me to manage my intake with a low-carb diet. Now, I take 1 capsule every other day, and it serves as an effective antioxidant with notable benefits for liver health. Always consult a doctor prior to starting any new supplement.
Read More
9
Liver damage aid
35 people found this helpful
Alpha lipoic acid is beneficial for any liver damage and in treating complicated diabetes mellitus. It slows the ageing process, promotes weight reduction, and helps regulate metabolism. It's best taken in the morning, 30 minutes before meals.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Read More
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 48 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cleanses toxins
188 people found this helpful
This product is indispensable for managing insulin resistance, with impressive results in helping me lose weight while on a diet. It effectively detoxifies the liver, allowing it to eliminate toxins and cleanse the body. I take it before meals, twice daily, and recommend it to others.
Read More
7.5
Improves liver function
118 people found this helpful
ALA has significantly aided my insulin resistance, allowing me to manage my intake with a low-carb diet. Now, I take 1 capsule every other day, and it serves as an effective antioxidant with notable benefits for liver health. Always consult a doctor prior to starting any new supplement.
Read More
9
Liver damage aid
35 people found this helpful
Alpha lipoic acid is beneficial for any liver damage and in treating complicated diabetes mellitus. It slows the ageing process, promotes weight reduction, and helps regulate metabolism. It's best taken in the morning, 30 minutes before meals.
Read More
9
Decreased fatty hepatosis
18 people found this helpful
An indispensable product! If I could, I would give 10 or 20 stars. It has been irreplaceable for my health, significantly improving my blood vessels, liver (fatty hepatosis has decreased), spine, and intestines. I take it for 2-3 months, followed by a 1-2 month break. Perfect dosage; I take it once daily on an empty stomach.
Read More
10
Restores liver cells
4 people found this helpful
Super! This is the most powerful antioxidant that restores liver cells. It is exceptionally effective.
Read More
Frequently Asked Questions
7.5
Better overall health
10 people found this helpful
I've been using alpha-lipoic acid to improve my overall well-being. It reduces hunger, stimulates energy expenditure, and curbs the liver's tendency to store fat. After two weeks, my health has significantly improved. I recommend it for anyone with insulin resistance. The quality is excellent, taste neutral, and packaging reliable.
9
Improved liver comfort
4 people found this helpful
Excellent! After a week of treatment, the discomfort in my liver area ceased. My sugar levels remain stable. I take courses for neuropathy, and it seems to help. I have low acidity, so I experience no unpleasant stomach sensations after taking it; on the contrary, my stomach feels better. Those with normal or high acidity should exercise caution.
9
Decreased fatty hepatosis
18 people found this helpful
An indispensable product! If I could, I would give 10 or 20 stars. It has been irreplaceable for my health, significantly improving my blood vessels, liver (fatty hepatosis has decreased), spine, and intestines. I take it for 2-3 months, followed by a 1-2 month break. Perfect dosage; I take it once daily on an empty stomach.
9
Restores liver function
1 people found this helpful
I bought this product for my mother to help restore her liver, and she feels fantastic! Her test results have significantly improved, making it very recommendable.
7.5
Weight management benefits
10 people found this helpful
Very good. My nutritionist advised me to take it to help my liver break down sugars and control my weight. After my weight plateaued for a time, it has gradually started to decrease. It’s not a magic pill, as I'm also exercising and following a healthy, balanced diet with a 10% calorie reduction. Due to insulin resistance, my weight hadn’t budged until I began taking this. Now I’ve lost 10lbs in over 3 months, without changing my regular Pilates workouts or diet. The only adjustment has been this supplement. I am very pleased with it! It truly benefits me and supports my overall health.
7.5
Improved metabolic balance
1 people found this helpful
I take 1 capsule each morning on an empty stomach. Initially, I experienced slight heartburn, which subsided. This supplement has a positive impact on my liver and kidneys, reducing my appetite so that I now eat smaller portions. I previously noticed that my portions shrank while on these supplements. My sleep, memory, and energy have all improved. There is a modest weight reduction alongside physical activity, making it easier to reach my goals. I believe alpha-lipoic acid is essential for those with diabetes and insulin resistance.
10
Restores liver cells
4 people found this helpful
Super! This is the most powerful antioxidant that restores liver cells. It is exceptionally effective.
7.5
Improved insulin resistance
2 people found this helpful
A functional preparation! I take it to improve my liver condition related to insulin resistance, as prescribed by my endocrinologist alongside L-carnitine. I take one capsule and 1000 mg of L-carnitine on an empty stomach, drink a full glass of water, and avoid eating for an hour. To enhance the drug's effect, some aerobic exercise like walking or cycling is beneficial.
9
Miracle improvement
1 people found this helpful
I highly recommend this! My husband was prescribed this by a gastroenterologist for his fat liver condition. After using it alongside walking, we witnessed fantastic results; his sugar level dropped from 6.5 to 4.7!
9
Improves liver indicators
1 people found this helpful
I bought this for my father when his liver enzyme levels were high. Following a diet and taking lipoic acid alongside Liver refresh has helped to normalise his indicators.
9
Normalises liver function
1 people found this helpful
An excellent antioxidant! Recommended by my trainer to enhance my well-being, metabolism, and weight management. Just one capsule in the morning suffices. It noticeably improves liver function, and I am very pleased with my purchase and results!
7.5
Convenient daily dose
2 people found this helpful
This therapeutic dosage of 600mg is recommended by my doctor to support liver function and lower cholesterol. Taking it once daily is convenient, and it causes no unpleasant sensations. I like it.
9
Normalises liver enzymes
2 people found this helpful
Must have items if you are diabetic or have digestive lining issues such as GERD, ulcers, or Barrett's. It is also effective for normalising my liver enzymes. Amazing product! Don't take too little, as it won't have any impact. I take 2 capsules twice daily—once before breakfast and another before bed.
8
Alpha-lipoic acid improves liver health
We conducted a clinical trial to evaluate the effectiveness of a special formulation combining alpha-lipoic acid (ALA) with a Mediterranean diet in improving liver health for individuals with metabolic dysfunction-associated steatosis (MASLD). In this study, patients were divided into two groups: one received the ALA and Mediterranean diet while the other was given a placebo along with the Mediterranean diet over a span of 24 weeks.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
Throughout the trial, we carefully measured various health indicators and liver function. Our findings were promising; those who took the ALA alongside the Mediterranean diet showed significant reductions in visceral fat and waist circumference, translating to improvements in metabolic parameters. Notably, the controlled attenuation parameter, an indicator of liver fat, steadily decreased in this group, reinforcing the potential benefits of ALA in conjunction with a healthy diet.
While both groups reported mild side effects at similar rates, these did not overshadow the positive outcomes associated with ALA and the Mediterranean diet. Overall, our results emphasize the potential of this combination approach in enhancing liver health among individuals dealing with MASLD.
8
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
References
- Zhao Y, Guo M, Pei T, Shang C, Chen Y, et al. α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte. Adv Sci (Weinh). 2025. doi:10.1002/advs.202413255
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. doi:10.4254/wjh.v17.i1.101704
