Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
USERS' SCORE
Good
Based on 16 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Bromelain (from pineapple ext.) (stem)(3,000 Gelatin Digesting Units per gram)
500 mg (1,500 GDU)
†
Top Medical Research Studies
8
We explored a new way to deliver bromelain, a natural enzyme, using nanostructured lipid carriers (Br-NCs).
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
Read More
8
We evaluated the effects of a new glucosamine combination, which includes bromelain, on cartilage damage in rats induced by formalin. The study involved different groups of rats, including a control group, and assessed various biochemical and gene expression markers after 30 days of treatment.
Our findings showed that the new combination significantly reduced markers of inflammation and oxidative damage while improving antioxidants compared to the control group. Notably, this new formula helped protect cartilage, indicating its potential clinical relevance for osteoarthritis treatment. However, the standard glucosamine combination did not demonstrate similar benefits.
Our findings showed that the new combination significantly reduced markers of inflammation and oxidative damage while improving antioxidants compared to the control group. Notably, this new formula helped protect cartilage, indicating its potential clinical relevance for osteoarthritis treatment. However, the standard glucosamine combination did not demonstrate similar benefits.
Read More
4
We aimed to understand how bromelain, an enzyme from pineapples, affects knee osteoarthritis (OA) over a 16-week period. Our randomized, single-blind pilot study involved 40 participants who received either bromelain or diclofenac.
While both groups showed improvements in pain and function after four weeks, no significant differences emerged between the treatments. By week 16, bromelain users showed some enhancements in WOMAC scores and reductions in oxidative stress markers. However, bromelain didn't significantly outperform diclofenac in relieving OA symptoms.
While both groups showed improvements in pain and function after four weeks, no significant differences emerged between the treatments. By week 16, bromelain users showed some enhancements in WOMAC scores and reductions in oxidative stress markers. However, bromelain didn't significantly outperform diclofenac in relieving OA symptoms.
Read More
Most Useful Reviews
9
Best I've tried
22 people found this helpful
Finally relief! My doctor recommended Bromelain for joint pain. After trying various brands, Doctor's Best Bromelain is the best. Due to stomach issues, anti-inflammatory drugs are not suitable for me. This brand offers 3000 GDU, far stronger than others. I am now a loyal customer and recommend this to others with arthritis.
Read More
10
Relieves back pain
15 people found this helpful
Works for arthritis pain! Just one or two of these pills a day on an empty stomach has taken away most of the arthritis pain in my lower back!
Read More
7.5
Pain significantly reduced
10 people found this helpful
They work for me! I began taking three capsules a day of DR'S BEST Bromelain 500 on an empty stomach for considerable hip pain due to arthritis. They truly help! After running out for several days, my hip pain returned dramatically. While it doesn't eliminate all pain, there is a substantial reduction in pain levels when taking Bromelain compared to when I don't. I'd rate it a 2-3 while using it against a 10 without. I'm ordering more today!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
- All Researches
8
We explored a new way to deliver bromelain, a natural enzyme, using nanostructured lipid carriers (Br-NCs).
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
Read More
8
This pilot study focused on whether a food supplement containing bromelain and Boswellia could enhance the quality of life for osteoarthritis (OA) patients. Over 49 participants took the supplement for 1 to 6 months and reported on their daily activities.
We found that, after treatment, 7 out of 10 questions regarding patient quality of life showed significant improvements, especially in the joints most affected. Notably, no adverse effects were reported.
These findings suggest that this combination may serve as a helpful, non-drug option for OA patients, paving the way for further research.
We found that, after treatment, 7 out of 10 questions regarding patient quality of life showed significant improvements, especially in the joints most affected. Notably, no adverse effects were reported.
These findings suggest that this combination may serve as a helpful, non-drug option for OA patients, paving the way for further research.
Read More
8
We evaluated the effects of a new glucosamine combination, which includes bromelain, on cartilage damage in rats induced by formalin. The study involved different groups of rats, including a control group, and assessed various biochemical and gene expression markers after 30 days of treatment.
Our findings showed that the new combination significantly reduced markers of inflammation and oxidative damage while improving antioxidants compared to the control group. Notably, this new formula helped protect cartilage, indicating its potential clinical relevance for osteoarthritis treatment. However, the standard glucosamine combination did not demonstrate similar benefits.
Our findings showed that the new combination significantly reduced markers of inflammation and oxidative damage while improving antioxidants compared to the control group. Notably, this new formula helped protect cartilage, indicating its potential clinical relevance for osteoarthritis treatment. However, the standard glucosamine combination did not demonstrate similar benefits.
Read More
8
We evaluated how a blend of three natural ingredients—Devil's claw, turmeric, and bromelain—could help alleviate osteoarthritis pain. Conducted in eight rheumatology centers, the study looked at both acute and chronic pain experienced by 42 participants, mostly women around 67 years old.
After taking AINAT capsules, patients reported a significant reduction in joint pain within three days for acute cases and 60 days for chronic cases. With an excellent safety profile, this natural remedy offers a promising alternative to conventional painkillers for those suffering from joint discomfort.
After taking AINAT capsules, patients reported a significant reduction in joint pain within three days for acute cases and 60 days for chronic cases. With an excellent safety profile, this natural remedy offers a promising alternative to conventional painkillers for those suffering from joint discomfort.
Read More
8
We explored how bromelain affects mild acute knee pain in healthy individuals. This study involved volunteers taking either 200 mg or 400 mg of bromelain per day for a month.
The results were promising: both dosage groups reported significant reductions in pain and overall improvement in well-being. The high-dose group experienced even greater benefits, suggesting that more bromelain leads to better outcomes.
However, further double-blind, placebo-controlled studies are necessary to confirm these findings and fully understand bromelain's role in joint health.
The results were promising: both dosage groups reported significant reductions in pain and overall improvement in well-being. The high-dose group experienced even greater benefits, suggesting that more bromelain leads to better outcomes.
However, further double-blind, placebo-controlled studies are necessary to confirm these findings and fully understand bromelain's role in joint health.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Best I've tried
22 people found this helpful
Finally relief! My doctor recommended Bromelain for joint pain. After trying various brands, Doctor's Best Bromelain is the best. Due to stomach issues, anti-inflammatory drugs are not suitable for me. This brand offers 3000 GDU, far stronger than others. I am now a loyal customer and recommend this to others with arthritis.
Read More
10
Relieves back pain
15 people found this helpful
Works for arthritis pain! Just one or two of these pills a day on an empty stomach has taken away most of the arthritis pain in my lower back!
Read More
7.5
Pain significantly reduced
10 people found this helpful
They work for me! I began taking three capsules a day of DR'S BEST Bromelain 500 on an empty stomach for considerable hip pain due to arthritis. They truly help! After running out for several days, my hip pain returned dramatically. While it doesn't eliminate all pain, there is a substantial reduction in pain levels when taking Bromelain compared to when I don't. I'd rate it a 2-3 while using it against a 10 without. I'm ordering more today!
Read More
9
Effective support
6 people found this helpful
It helps so. It genuinely aids in managing my arthritis and plantar fasciitis.
Read More
9
Recovery aid
2 people found this helpful
Great alternative to regular over-the-counter meds. This product works effectively for my arthritis pain. After my hip replacement, it assisted in my recovery and should be taken on an empty stomach for best results.
Read More
Frequently Asked Questions
9
Supports inflammation control
This seems to help with my rheumatoid arthritis inflammation, and my partner is also taking it for his arthritic pains. We combine it with the Doterra Vitality Pack supplements and Forever Living bee propolis while reducing gluten, and it all works beautifully together.
7.5
Thumb pain relief
Great for arthritis; my physical therapist suggested this supplement for my thumb. I realise that when I don’t take it, my thumb hurts significantly. So, I take it daily to benefit from it. The ingredients are of excellent quality, and my dosage is 2 per day. The pill size is easy to swallow, with no aftertaste.
7.5
Must-have post-surgery
Does a great job with inflammation; this is a potent brand. It’s an essential supplement to take for inflammation and arthritis, especially after surgery, as it aids in healing.
7.5
Significant anti-inflammatory
6 people found this helpful
Bromelain is useful for more than just digestion. I use it for seasonal allergies and as an anti-inflammatory for arthritis. It works remarkably well; the effect is notable. The dosage is quite potent, and this is not my first time using it.
7.5
Joint inflammation relief
I buy bromelain to help reduce my joint inflammation due to arthritis.
7
We observed that human synovial cells from osteoarthritis (OA) patients respond to lipopolysaccharide (LPS) by mimicking changes seen in inflamed joint tissues. Our study tested a unique blend of curcumin, bromelain, and harpagophytum for their potential to reduce inflammation.
The results showed that this combination of natural compounds has anti-inflammatory and anti-catabolic effects. This suggests they might help alleviate pain and slow the progression of OA, offering a glimpse of hope for those battling this common form of arthritis.
The results showed that this combination of natural compounds has anti-inflammatory and anti-catabolic effects. This suggests they might help alleviate pain and slow the progression of OA, offering a glimpse of hope for those battling this common form of arthritis.
8
We explored a new way to deliver bromelain, a natural enzyme, using nanostructured lipid carriers (Br-NCs).
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
Our research aimed to improve bromelain's stability and effectiveness in managing rheumatoid arthritis.
The study showed that Br-NCs significantly reduced joint swelling and stiffness in preclinical trials.
These carriers also enhanced bromelain's shelf-life and showed promise as a novel treatment option for arthritis.
4
We aimed to understand how bromelain, an enzyme from pineapples, affects knee osteoarthritis (OA) over a 16-week period. Our randomized, single-blind pilot study involved 40 participants who received either bromelain or diclofenac.
While both groups showed improvements in pain and function after four weeks, no significant differences emerged between the treatments. By week 16, bromelain users showed some enhancements in WOMAC scores and reductions in oxidative stress markers. However, bromelain didn't significantly outperform diclofenac in relieving OA symptoms.
While both groups showed improvements in pain and function after four weeks, no significant differences emerged between the treatments. By week 16, bromelain users showed some enhancements in WOMAC scores and reductions in oxidative stress markers. However, bromelain didn't significantly outperform diclofenac in relieving OA symptoms.
8
This pilot study focused on whether a food supplement containing bromelain and Boswellia could enhance the quality of life for osteoarthritis (OA) patients. Over 49 participants took the supplement for 1 to 6 months and reported on their daily activities.
We found that, after treatment, 7 out of 10 questions regarding patient quality of life showed significant improvements, especially in the joints most affected. Notably, no adverse effects were reported.
These findings suggest that this combination may serve as a helpful, non-drug option for OA patients, paving the way for further research.
We found that, after treatment, 7 out of 10 questions regarding patient quality of life showed significant improvements, especially in the joints most affected. Notably, no adverse effects were reported.
These findings suggest that this combination may serve as a helpful, non-drug option for OA patients, paving the way for further research.
8
We evaluated how a blend of three natural ingredients—Devil's claw, turmeric, and bromelain—could help alleviate osteoarthritis pain. Conducted in eight rheumatology centers, the study looked at both acute and chronic pain experienced by 42 participants, mostly women around 67 years old.
After taking AINAT capsules, patients reported a significant reduction in joint pain within three days for acute cases and 60 days for chronic cases. With an excellent safety profile, this natural remedy offers a promising alternative to conventional painkillers for those suffering from joint discomfort.
After taking AINAT capsules, patients reported a significant reduction in joint pain within three days for acute cases and 60 days for chronic cases. With an excellent safety profile, this natural remedy offers a promising alternative to conventional painkillers for those suffering from joint discomfort.
8
We explored how bromelain affects mild acute knee pain in healthy individuals. This study involved volunteers taking either 200 mg or 400 mg of bromelain per day for a month.
The results were promising: both dosage groups reported significant reductions in pain and overall improvement in well-being. The high-dose group experienced even greater benefits, suggesting that more bromelain leads to better outcomes.
However, further double-blind, placebo-controlled studies are necessary to confirm these findings and fully understand bromelain's role in joint health.
The results were promising: both dosage groups reported significant reductions in pain and overall improvement in well-being. The high-dose group experienced even greater benefits, suggesting that more bromelain leads to better outcomes.
However, further double-blind, placebo-controlled studies are necessary to confirm these findings and fully understand bromelain's role in joint health.
7
We explored how an oral enzyme combination, including bromelain, stacks up against diclofenac for treating knee osteoarthritis. In a well-designed study involving 103 patients over six weeks, both treatments showed improvements in pain and function.
The enzyme combination was found to be non-inferior to diclofenac, showing similar benefits in pain relief and functionality. Interestingly, the enzyme treatment even received better ratings from physicians for efficacy in some cases.
While both options were well-tolerated, further placebo-controlled studies are needed for confirmation.
The enzyme combination was found to be non-inferior to diclofenac, showing similar benefits in pain relief and functionality. Interestingly, the enzyme treatment even received better ratings from physicians for efficacy in some cases.
While both options were well-tolerated, further placebo-controlled studies are needed for confirmation.
References
- Brochard S, Pontin J, Bernay B, Boumediene K, Conrozier T, et al. The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells. BMC Complement Med Ther. 2021;21:261. doi:10.1186/s12906-021-03435-7
- Sharma M, Chaudhary D. Exploration of bromelain laden nanostructured lipid carriers: An oral platform for bromelain delivery in rheumatoid arthritis management. Int J Pharm. 2021;594:120176. doi:10.1016/j.ijpharm.2020.120176
- Italiano G, Raimondo M, Giannetti G, Gargiulo A. Benefits of a Food Supplement Containing and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study. J Altern Complement Med. 2020;26:123. doi:10.1089/acm.2019.0258
- Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016;35:2531. doi:10.1007/s10067-016-3363-1
- Ucuncu Y, Celik N, Ozturk C, Turkoglu M, Cetin N, et al. Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation. Life Sci. 2015;130:31. doi:10.1016/j.lfs.2015.03.012
- Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, et al. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20 Suppl 1:32.
- Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004;23:410.
- Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002;9:681.
- Desser L, Holomanova D, Zavadova E, Pavelka K, Mohr T, et al. Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood. Cancer Chemother Pharmacol. 2001;47 Suppl:S10.
