We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
Most Useful Reviews
9
Affordable choice
289 people found this helpful
A good vitamin at a reasonable price, suitable for both adults and children, with no allergies reported.
Read More
9
Tasty and effective
2 people found this helpful
The best vitamin D for children! Being from St. Petersburg, with our lack of sunshine, vitamin D is essential for both adults and children. Initially, we tried a different product, but an allergy occurred with a dosage of 400ME. We switched to these tasty gummies, which our child loves. They do not cause allergies and contain 1000 IU per piece. I recommend them to all my friends with children.
Read More
9
Child's favourite
1 people found this helpful
My child asks for vitamin D every morning and enjoys the taste. One jelly a day is sufficient and does not cause any allergic reactions.
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Read More
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
7
Vitamin D's role in allergies
Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.7
All Reviews
Positive Reviews
Negative Reviews
9
Affordable choice
289 people found this helpful
A good vitamin at a reasonable price, suitable for both adults and children, with no allergies reported.
Read More
9
Tasty and effective
2 people found this helpful
The best vitamin D for children! Being from St. Petersburg, with our lack of sunshine, vitamin D is essential for both adults and children. Initially, we tried a different product, but an allergy occurred with a dosage of 400ME. We switched to these tasty gummies, which our child loves. They do not cause allergies and contain 1000 IU per piece. I recommend them to all my friends with children.
Read More
9
Child's favourite
1 people found this helpful
My child asks for vitamin D every morning and enjoys the taste. One jelly a day is sufficient and does not cause any allergic reactions.
Read More
9
Reliable product
1 people found this helpful
A good vitamin D3 that children enjoy, and they do not cause allergies.
Read More
9
Jelly candy fun
1 people found this helpful
I bought these for my granddaughter, who thinks they are like jelly candies, and she hasn't experienced any allergies.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Children's Vitamin D is a dietary supplement specifically formulated to support the health and development of children. Vitamin D is crucial for maintaining healthy bones and teeth, and it plays an essential role in the functioning of the immune system. Young children, especially those who may have limited sun exposure or dietary intake of vitamin D, are often recommended to take these supplements to ensure they receive adequate levels for optimal growth and development.
Typically, children's vitamin D supplements come in various forms such as chewable tablets, gummies, or liquid drops, making them more palatable for younger audiences. The most common form is vitamin D3 (cholecalciferol), which is considered more effective in raising vitamin D levels in the body than D2 (ergocalciferol). It's essential for parents to consult with a pediatrician before starting any supplement to determine the right dosage based on individual health needs and lifestyle factors. Proper intake of vitamin D not only supports bone health but also has been linked to other health benefits, such as improved mood and immune response, making it a valuable addition to children's wellness routines.
Based on user reviews, it appears that many parents have reported positive experiences with vitamin D supplements for their children, often not experiencing allergies. However, specific details regarding the timeline for seeing results in terms of allergies are not readily available. Users generally mentioned that they did not encounter any allergic reactions soon after starting the vitamins, suggesting that the supplements may be effective at preventing such issues from the outset Read Review.Read Review.
Vitamin D3 has garnered attention in recent studies for its potential role in alleviating allergy symptoms, although the evidence remains nuanced. One study focused on vitamin D3's effect on cytokines associated with allergies, specifically IL-4 and IL-13, and found that calcitriol (the active form of vitamin D3) effectively reduced their levels in immune cells. This reduction could explain the association between low vitamin D3 concentrations and increased allergic reactions, indicating that vitamin D3 might offer a therapeutic avenue for managing allergies [2].
Additionally, research has linked vitamin D3 deficiency with allergic rhinitis, demonstrating that individuals with this condition often present significantly lower vitamin D3 levels compared to healthy controls. The study further revealed that fluctuations in vitamin D3 could account for a considerable variation in immunoglobulin E (IgE) levels, which are critical in allergic responses [4]. While these findings present a compelling case for considering vitamin D3 as a supportive measure for allergy management, further investigations are necessary to clarify its isolated effects on various allergic conditions, including eczema and allergic sinusitis [3][5]. Overall, while evidence suggests vitamin D3 may benefit some allergy-related conditions, it is vital to approach supplementation cautiously and await more definitive research.
Based on user reviews, many parents report significant improvements in their children’s experiences with vitamin D supplements, particularly noting the absence of allergic reactions. For instance, one parent mentioned switching from a different product due to an allergy and found that these gummies, with a dosage of 1000 IU, did not cause any allergic issues while being well-received by the child Read Review. Another user shared how their child, prone to allergies, was able to take the gummies without any adverse effects, highlighting the product's suitability for sensitive individuals Read Review.
Overall, users appreciate not only the taste of the gummies but also their effectiveness and safety, leading to a stress-free experience during daily vitamin intake. Compliments regarding the pleasant flavors and enjoyable consumption have become common among users, suggesting that children are more likely to take these supplements willingly, further supporting their routine vitamin D needs Read Review. While results can vary among individuals, the consistent absence of allergies across multiple reviews is a reassuring factor for parents considering these gummies for their children.
Users report positive experiences when combining this vitamin D supplement with other supplements for handling allergies. Many parents noted that their children not only enjoy the taste of the gummies but also do not experience any allergic reactions, making it a stress-free addition to their routine. For instance, one parent shared how they switched from a different product due to an allergy incident but found these gummies, with a dosage of 1000 IU, did not cause any allergic issues and were well-liked by their child Read Review. Another user emphasized that their child, prone to allergies, could safely take the gummies without any adverse effects Read Review.
Overall, user reviews consistently highlight the gummies' effectiveness and compatibility with children who have sensitivities, suggesting they can safely be paired with other supplements Read Review. Parents appreciate the natural composition of the vitamins, which lack artificial colors and preservatives, reinforcing their belief that it is a safe choice for allergy-prone children Read Review. With no significant side effects reported across a range of reviews, these gummies may be an excellent option for families looking to navigate allergies while ensuring adequate vitamin D intake.
Based on user reviews, parents reported that the optimal dose for Children's Vitamin D to treat allergies generally aligns with a single gummy or jelly per day, which typically contains around 1000 IU. Users appreciated that this dosage was both effective and safe, with many claiming their children did not experience any allergic reactions. One mother noted, after switching from a dosage of 400 IU due to allergies, her child thrived on the 1000 IU gummies, stating, "They do not cause allergies and contain 1000 IU per piece" Read Review.
Furthermore, several reviews echoed similar sentiments, emphasizing that one gummy a day was sufficient for their children without any side effects or allergy concerns. Comments like "One jelly a day is sufficient and does not cause any allergic reactions" Read Review and "I give my daughters one gummy each, and they do not have allergies despite being prone to them" Read Review showcase that users found this dosage effective for their children's health and safety. Overall, it seems that a daily intake of one gummy with 1000 IU is widely reported as a safe and pleasant option.
9
Tasty and effective
2 people found this helpful
The best vitamin D for children! Being from St. Petersburg, with our lack of sunshine, vitamin D is essential for both adults and children. Initially, we tried a different product, but an allergy occurred with a dosage of 400ME. We switched to these tasty gummies, which our child loves. They do not cause allergies and contain 1000 IU per piece. I recommend them to all my friends with children.
9
Preventive dosage
Excellent vitamin D3 at a preventive dosage suitable for northern children. The taste is liked, and there have been no allergies.
9
Convenient for kids
I give my daughters one gummy each, and they do not have allergies despite being prone to them. The dosage and quality are excellent.
9
Natural and effective
Delicious fruit jellies! They are natural and the dosage is good, without causing allergies or side effects.
4
Son delights in gummies
My son loves these jelly vitamins, which didn't cause allergies, even though he is sensitive to vitamin D.
7.5
Natural ingredients
A key advantage is the natural composition; these chewable tablets are made from fruit pectin, making them safe for children. They taste pleasant, which makes them easy to take, especially for kids averse to pills. Importantly, there are no artificial colours or preservatives, suitable for children with allergies.
9
Child's favourite
1 people found this helpful
My child asks for vitamin D every morning and enjoys the taste. One jelly a day is sufficient and does not cause any allergic reactions.
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
7
Vitamin D's role in allergies
Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
References
Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis. J Immunol. 2024;213:831. 10.4049/jimmunol.2400078
Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. 10.3390/nu16091303
Al-Allaff RGM, Bakr Al-Sawaf TM. Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis. Pak J Biol Sci. 2024;27:27. 10.3923/pjbs.2024.27.34
Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. 10.2174/0127722708281623240116100806