Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Chloride (from glucosamine hydrochloride potassium sulfate)
170 mg
7%
Sodium (from chondroitin sulfate sodium)
120 mg
5%
Potassium (from glucosamine hydrochloride potassium sulfate)
190 mg
4%
GlucosamineHydrochloride Potassium Sulfate
1500 mg
†
Chondroitin sulfate Sodium
1200 mg
†
MSM (Methylsulfonylmethane)(OptiMSM®)
1000 mg
†
Top Medical Research Studies
9
This study aimed to explore how Modified Simiaowan (MSM), a traditional six-herb formula, can help treat gouty arthritis (GA). We examined its effects on macrophages in the lab, as well as in animal models with induced gout. Using various techniques, we analyzed the inflammation response and the underlying biological pathways affected by MSM.
Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.
Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.
Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.
Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.
Read More
7
Chondroitin sulfate reduces macrophage inflammation
We explored the effects of chondroitin sulfate (CS) on inflammation caused by monosodium urate (MSU) crystals, which are commonly responsible for gout attacks. By differentiating THP-1 monocytes into mature macrophages and stimulating them with MSU crystals, we were able to observe how CS influences the production of key inflammatory cytokines.
Our study found that MSU crystals significantly increased the levels of cytokines like IL-1β, IL-8, and TNFα, which are known contributors to the inflammatory response in gout. When we pre-treated the macrophages with CS, we noticed a considerable reduction in the production of IL-1β and TNFα—a decline we measured as statistically significant. Although CS showed a positive trend with IL-8 levels, this particular finding did not reach statistical significance.
Overall, our results suggest that CS can effectively reduce MSU-induced inflammation in macrophages, indicating a potential role for CS in gout prevention. While further research is warranted, these findings highlight an underexplored avenue for managing gout symptoms with a natural compound.
Our study found that MSU crystals significantly increased the levels of cytokines like IL-1β, IL-8, and TNFα, which are known contributors to the inflammatory response in gout. When we pre-treated the macrophages with CS, we noticed a considerable reduction in the production of IL-1β and TNFα—a decline we measured as statistically significant. Although CS showed a positive trend with IL-8 levels, this particular finding did not reach statistical significance.
Overall, our results suggest that CS can effectively reduce MSU-induced inflammation in macrophages, indicating a potential role for CS in gout prevention. While further research is warranted, these findings highlight an underexplored avenue for managing gout symptoms with a natural compound.
Read More
Most Useful Reviews
9.5
Knee recovery noted
Good super useful food supplement. My father enjoyed it for many years and always uses this brand. His knee, which was damaged by a gout attack and left him unable to walk, fully recovered within a month and has continued to improve since. Now it remains in a normal state.
Read More
9.5
Crutches no longer needed
Good Dongdong! My father had gout a few years ago, suffering from a painful knee after the attack. He started taking this glycine supplement and, after 21 days, he discarded the crutches and began walking normally. Since then, he has continued taking it regularly and has remained with the same brand. He is now much more aware of his waist.
Read More
2.5
Worsened gout symptoms
After 20 days of taking the supplement, my gout worsened, which had not troubled me for five years. I am unsure if this is coincidental.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
This study aimed to explore how Modified Simiaowan (MSM), a traditional six-herb formula, can help treat gouty arthritis (GA). We examined its effects on macrophages in the lab, as well as in animal models with induced gout. Using various techniques, we analyzed the inflammation response and the underlying biological pathways affected by MSM.
Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.
Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.
Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.
Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.
Read More
7
Chondroitin sulfate reduces macrophage inflammation
We explored the effects of chondroitin sulfate (CS) on inflammation caused by monosodium urate (MSU) crystals, which are commonly responsible for gout attacks. By differentiating THP-1 monocytes into mature macrophages and stimulating them with MSU crystals, we were able to observe how CS influences the production of key inflammatory cytokines.
Our study found that MSU crystals significantly increased the levels of cytokines like IL-1β, IL-8, and TNFα, which are known contributors to the inflammatory response in gout. When we pre-treated the macrophages with CS, we noticed a considerable reduction in the production of IL-1β and TNFα—a decline we measured as statistically significant. Although CS showed a positive trend with IL-8 levels, this particular finding did not reach statistical significance.
Overall, our results suggest that CS can effectively reduce MSU-induced inflammation in macrophages, indicating a potential role for CS in gout prevention. While further research is warranted, these findings highlight an underexplored avenue for managing gout symptoms with a natural compound.
Our study found that MSU crystals significantly increased the levels of cytokines like IL-1β, IL-8, and TNFα, which are known contributors to the inflammatory response in gout. When we pre-treated the macrophages with CS, we noticed a considerable reduction in the production of IL-1β and TNFα—a decline we measured as statistically significant. Although CS showed a positive trend with IL-8 levels, this particular finding did not reach statistical significance.
Overall, our results suggest that CS can effectively reduce MSU-induced inflammation in macrophages, indicating a potential role for CS in gout prevention. While further research is warranted, these findings highlight an underexplored avenue for managing gout symptoms with a natural compound.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Knee recovery noted
Good super useful food supplement. My father enjoyed it for many years and always uses this brand. His knee, which was damaged by a gout attack and left him unable to walk, fully recovered within a month and has continued to improve since. Now it remains in a normal state.
Read More
9.5
Crutches no longer needed
Good Dongdong! My father had gout a few years ago, suffering from a painful knee after the attack. He started taking this glycine supplement and, after 21 days, he discarded the crutches and began walking normally. Since then, he has continued taking it regularly and has remained with the same brand. He is now much more aware of his waist.
Read More
2.5
Worsened gout symptoms
After 20 days of taking the supplement, my gout worsened, which had not troubled me for five years. I am unsure if this is coincidental.
Read More
8
Supports joint health
Good composition. I take it a couple of times a year, using a blend of glucosamine, chondroitin, and MSM, which is beneficial for supporting my joints affected by gout. While the effects may not be directly noticeable, the combination is effective. I would prefer a higher dosage of MSM and am currently on a separate course of it, taking 3000 mg per day. My joints may not show appreciation now, but they will in time.
Read More
8.8
Helps manage symptoms
I'm taking it for Dad, who has joint issues and gout. He consumes a course of 240 capsules each year and claims it helps. However, he maintains a careful diet, avoiding meat and other purine-rich foods, while monitoring his uric acid levels during tests.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Orlowsky EW, Stabler TV, Montell E, Vergés J, Kraus VB. Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?. BMC Musculoskelet Disord. 2014;15:318. doi:10.1186/1471-2474-15-318
- Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, et al. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. J Ethnopharmacol. 2024;318:116906. doi:10.1016/j.jep.2023.116906
