Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
USERS' SCORE
Good
Based on 58 Reviews
8.1
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
8
We conducted a study to evaluate how hyaluronic acid (HA) treatments impact osteoarthritis (OA) in a rabbit model. Specifically, we compared a novel antioxidant-conjugated form of HA, known as HA-4-aminoresorcinol (HA4AR), to a standard high molecular weight HA treatment.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
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Most Useful Reviews
10
Eliminates arthritis pain
25 people found this helpful
Unbelievable! After using this for 30 days, the pain in my hands from arthritis vanished, and I regained 100% use of them. Great stuff!
Read More
10
Relieves knee arthritis
23 people found this helpful
I've taken this product for eight months for my knees due to arthritis pain from cycling. It seems to have regenerated the cartilage that doctors said wouldn't heal. It's worked wonders for me, and I plan to continue using it. By the way, I'm 70 years old.
Read More
10
Stops knee pain
17 people found this helpful
Great product! After a month of use, my knees stopped hurting, and I forgot about my arthritis!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
- All Researches
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
9
We aimed to explore how hyaluronic acid (HA) can improve treatments for rheumatoid arthritis (RA) through a novel delivery system. The study developed a specialized liposomal drug depot that incorporates HA and delivers dexamethasone, a common anti-inflammatory medication. This formulation is designed to target the inflamed areas within the joints, minimizing off-target effects.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Read More
9
Effective combination for arthritis
We conducted a thorough analysis exploring the effectiveness of hyaluronic acid (HA) combined with platelet-rich plasma (PRP) in treating knee osteoarthritis (KOA). The aim was to determine how this combination therapy stacks up against using PRP alone.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 58 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Eliminates arthritis pain
25 people found this helpful
Unbelievable! After using this for 30 days, the pain in my hands from arthritis vanished, and I regained 100% use of them. Great stuff!
Read More
10
Relieves knee arthritis
23 people found this helpful
I've taken this product for eight months for my knees due to arthritis pain from cycling. It seems to have regenerated the cartilage that doctors said wouldn't heal. It's worked wonders for me, and I plan to continue using it. By the way, I'm 70 years old.
Read More
10
Stops knee pain
17 people found this helpful
Great product! After a month of use, my knees stopped hurting, and I forgot about my arthritis!
Read More
9
Recommended for arthritis
10 people found this helpful
Awesome! I recommend this product to everyone I know. I originally bought it for my grandmother's arthritis, and she was amazed at how quickly it worked. It also improved her skin. Now my sister uses it for her skin, while I take it for my knees. When I stop taking it, I notice the pain returning. Highly recommend!
Read More
9
Incredible improvement
10 people found this helpful
This excellent product alleviated my pain. I'm 68 and need a total knee replacement due to arthritis, but after starting this on May 16th, I've been greatly improved by May 30th. I no longer limp and don't require a cane. I'm thankful for this product!
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Frequently Asked Questions
10
Eliminates arthritis pain
25 people found this helpful
Unbelievable! After using this for 30 days, the pain in my hands from arthritis vanished, and I regained 100% use of them. Great stuff!
10
Stops knee pain
17 people found this helpful
Great product! After a month of use, my knees stopped hurting, and I forgot about my arthritis!
10
Remarkable results
2 people found this helpful
My 88-year-old mother has arthritis in her feet. Despite getting shots from the doctor that barely helped, after taking this supplement for just a week, she was pain-free and hasn't needed any pain pills since.
9
Pain relief
5 people found this helpful
I bought this product for my mother, who has mild arthritis. Initially doubtful, she tried it and, after about two months, the pain in her finger joints vanished. She was pleasantly surprised.
9
Joint pain relief
4 people found this helpful
I bought this supplement for rheumatoid arthritis. Initially sceptical, I was surprised by my improvement in just two months. I hardly remember having joint pain now and have already ordered another supply to avoid running out.
9
Avoids knee surgery
14 people found this helpful
Fantastic product! My doctor discussed knee replacement surgery due to severe arthritis pain. I tried this product, and within three days, most of my pain was gone. I’m nearly pain-free now and have experienced increased mobility. I'm surprised that doctors don't recommend it for arthritis relief.
9
Recommended for arthritis
10 people found this helpful
Awesome! I recommend this product to everyone I know. I originally bought it for my grandmother's arthritis, and she was amazed at how quickly it worked. It also improved her skin. Now my sister uses it for her skin, while I take it for my knees. When I stop taking it, I notice the pain returning. Highly recommend!
9
Pain relief experienced
7 people found this helpful
I have been taking methotrexate and hydroxychloroquine for arthritis, resulting in side effects like headaches and fatigue without complete symptom relief. I switched to Doctor's Best Hyaluronic Acid with Chondroitin Sulfate, encouraged by positive reviews. After a month of use, I’m pain-free in my hand and ankle, with only minor foot pain and no relief for my psoriasis. However, I have no side effects, making this alternative worthwhile.
7.5
Effective for joints
2 people found this helpful
Hyaluronic acid is not only used in facial treatments but can also be consumed for similar effects. It is safer than injections and equally effective. Athletes use it to restore joints and prevent arthritis. Combined with chondroitin, it works wonders, and I highly recommend it!
10
Relieves knee arthritis
23 people found this helpful
I've taken this product for eight months for my knees due to arthritis pain from cycling. It seems to have regenerated the cartilage that doctors said wouldn't heal. It's worked wonders for me, and I plan to continue using it. By the way, I'm 70 years old.
9
Aches and pains relief
16 people found this helpful
Works great! This is the best remedy for fibromyalgia and arthritis pain. I take 6 tablets three times a day. It doesn’t upset my stomach as there’s no vitamin C in it, and it also benefits wrinkles.
9
Type II collagen
The composition of this supplement is excellent for arthritis. While it’s too early to speak of results, it’s reassuring that it can be taken without strict timing and supports joint health.
5
Hyaluronic Acid Shows Limited Effectiveness
We set out to explore the effects of hyaluronic acid (HA) when used alongside exosomes from adipose-derived mesenchymal stem cells (Ad-MSCs) in treating osteoarthritis (OA). Conducting the study on a group of eighteen male sheep that underwent total lateral meniscectomy, we observed the condition of their knees before and after treatment. After confirming low-grade OA six weeks post-surgery, we divided the sheep into three groups: one received repeated exosome injections, another got HA injections, and the third group benefited from both treatments together.
Our findings indicated that the combination of HA and exosomes significantly reduced lameness in the group that received both treatments, particularly noted two months in when scores were notably lower. However, while there was some improvement in radiographic scores at the three-month mark for this group, the overall clinical lameness scores did not show significant differences across the groups by that time. Notably, when we looked at macroscopic evaluations using OARSI scores, no significant differences were found.
Overall, the study suggests that the combined approach of repeated exosome and HA injections may delay the progression of OA. However, further long-term follow-up is needed to fully understand the lasting effects. This work offers hope for more effective treatments, but it also highlights the challenges in assessing the isolated benefits of HA alone.
Our findings indicated that the combination of HA and exosomes significantly reduced lameness in the group that received both treatments, particularly noted two months in when scores were notably lower. However, while there was some improvement in radiographic scores at the three-month mark for this group, the overall clinical lameness scores did not show significant differences across the groups by that time. Notably, when we looked at macroscopic evaluations using OARSI scores, no significant differences were found.
Overall, the study suggests that the combined approach of repeated exosome and HA injections may delay the progression of OA. However, further long-term follow-up is needed to fully understand the lasting effects. This work offers hope for more effective treatments, but it also highlights the challenges in assessing the isolated benefits of HA alone.
4
Hyaluronic acid efficacy remains unclear
We examined the overall effectiveness of hyaluronic acid (HA) treatment for knee osteoarthritis (KOA) compared to platelet-rich plasma (PRP) in a series of systematic reviews and meta-analyses. The research involved an extensive review of 17 studies that aimed to clarify the benefits of HA shots for arthritis patients.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
7
We conducted a thorough meta-analysis to understand the effectiveness of intra-articular hyaluronic acid (HA) injections for patients experiencing early to mild knee osteoarthritis (OA). The results show that these injections can provide similar benefits as other biologically active treatments commonly used in managing knee OA.
Our investigation particularly looked at outcomes that matter to patients, such as pain relief measured by the visual analogue scale (VAS) and overall joint function assessed through the Western Ontario McMaster Osteoarthritis Index (WOMAC). We found that both HA and other injectable therapies delivered comparable results over at least three months of treatment.
This means that for those suffering from early-stage knee OA, choosing HA injections could be just as effective as opting for other similar treatments. While there may be various options available, the evidence points toward a level playing field regarding efficacy.
Our investigation particularly looked at outcomes that matter to patients, such as pain relief measured by the visual analogue scale (VAS) and overall joint function assessed through the Western Ontario McMaster Osteoarthritis Index (WOMAC). We found that both HA and other injectable therapies delivered comparable results over at least three months of treatment.
This means that for those suffering from early-stage knee OA, choosing HA injections could be just as effective as opting for other similar treatments. While there may be various options available, the evidence points toward a level playing field regarding efficacy.
5
Hyaluronic acid shows mixed results
We reviewed multiple studies to see how well hyaluronic acid (HA) works for pain relief and improved function in hip osteoarthritis patients. By analyzing data from 18 randomized controlled trials with over 1,600 participants, we found that HA provided some benefits, particularly in reducing pain based on specific measures. However, there was no strong evidence to suggest that HA significantly outperformed placebo in the short, mid, or long term. The safety of HA was generally acceptable, but complications did occur in some cases.
References
- Gupta N, Khatri K, Lakhani A, Dahuja A, Randhawa A, et al. Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis. J Orthop Surg Res. 2025;20:227. doi:10.1186/s13018-025-05574-w
- Powantia Pontoh LA, Fiolin J, Dilogo IH, Prasetyo M, Antarianto RD, et al. Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation. F1000Res. 2024;13:494.
- Bernetti A, Agostini F, Finamore N, Dal Borgo M, Mangone M, et al. Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: A systematic review. J Back Musculoskelet Rehabil. 2025;38:19. doi:10.1177/10538127241296338
- Migliorini F, Maffulli N, Pipino G, Jeyaraman M, Ramasubramanian S, et al. Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials : A meta-analysis. Orthopadie (Heidelb). 2025;54:218. doi:10.1007/s00132-025-04615-w
- Zhang C, Lu Y, Huang Y. Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid. J Orthop Surg Res. 2025;20:153. doi:10.1186/s13018-025-05543-3
- Nisha M, Adnan M, Sakure K, Jain P. Innovations in Glycosaminoglycan Delivery: Transforming Joint Health Therapies. Pharm Nanotechnol. 2025. doi:10.2174/0122117385329819241212040246
- Zhang Z, Wang G, Zhang Z, Liang X, Wang G, et al. Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair. J Nanobiotechnology. 2025;23:69. doi:10.1186/s12951-025-03110-w
- Heller S, Seemann RJ, Burgkart R, Obermeier A, Locher H. Lidocaine Shows Significant Antimicrobial Effects Against Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injectables, like Steroids and Hyaluronan, in the Context of Arthritis Management. Biomedicines. 2025;13. doi:10.3390/biomedicines13010106
- Kumaran K, Vasudevan AK, Jayakumar R, Biswas R. Injectable vancomycin loaded hyaluronic acid-chitosan hydrogel for the treatment of Staphylococcus aureus septic arthritis. Carbohydr Res. 2025;550:109384. doi:10.1016/j.carres.2025.109384
- Du D, Liang Y. A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20:57. doi:10.1186/s13018-024-05429-w
- Zhou Q, Chen J, Yu W, Cao D, Ye Y, et al. A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis. Clin Rheumatol. 2025;44:547. doi:10.1007/s10067-024-07264-0
- Rieger R, Kaderli S, Boulocher C. In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate. BMC Musculoskelet Disord. 2024;25:1018. doi:10.1186/s12891-024-07921-0
- Migliorini F, Schäfer L, Pilone M, Bell A, Simeone F, et al. Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Arch Orthop Trauma Surg. 2024;145:68. doi:10.1007/s00402-024-05614-w
- Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. doi:10.4081/reumatismo.2024.1699
- Oon SF, Lazarakis S, Mallawa G, Nguyen C. Intra-articular hyaluronic acid and platelet-rich plasma as monotherapy or combination therapy in knee osteoarthritis?. Regen Med. 2024;19:637. doi:10.1080/17460751.2024.2439221
- Zhou C, Hao W, Yao J, Zhu T, Sun M, et al. Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment. Int J Biol Macromol. 2025;287:138610. doi:10.1016/j.ijbiomac.2024.138610
- Said M, Tavakoli C, Dumot C, Toupet K, Olivier C, et al. A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis. Theranostics. 2025;15:4054. doi:10.7150/thno.104551
- Liu Q, Ye H, Yang Y, Chen H. The efficacy and safety of intra-articular platelet-rich plasma versus sodium hyaluronate for the treatment of osteoarthritis: Meta-analysis. PLoS One. 2025;20:e0314878. doi:10.1371/journal.pone.0314878
- Woo I, Park JJ, Park CH. Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial. BMC Musculoskelet Disord. 2025;26:239. doi:10.1186/s12891-025-08488-0
- Bensa A, Bianco Prevot L, Moraca G, Sangiorgio A, Boffa A, et al. Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis - literature trends are shifting in the injectable treatments' evidence: a systematic review and expert opinion. Expert Opin Biol Ther. 2025;25:309. doi:10.1080/14712598.2025.2465833
- Mirghaderi P, Mortezaei A, Javidan A, Ghaseminejad-Raeini A, Nematollahi B. Efficacy and safety of biological products in hip osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Clin Rheumatol. 2025;44:1403. doi:10.1007/s10067-025-07366-3
- Wu J, Tang Q, Tan X. Sodium hyaluronate and acupotomy bone decompression alleviates inflammatory responses in patients with knee osteoarthritis. Inflammopharmacology. 2025;33:1997. doi:10.1007/s10787-025-01667-4
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Ma Y, Yang X, Jiang M, Ye W, Qin H, et al. Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway. J Orthop Surg Res. 2025;20:11. doi:10.1186/s13018-024-05411-6
