Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9
We explored the benefits of butyrylated hyaluronic acid (BHA) in treating gout by examining its effects in specific animal models. Using Wistar rats, we evaluated how BHA can influence inflammation linked with gouty arthritis, specifically by measuring joint swelling and inflammatory markers after injecting monosodium urate crystals.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
8
Chondroitin sulfate shows promise for gout
We explored the potential benefits of chondroitin sulfate (CS) in managing gout, particularly its effects on inflammation triggered by monosodium urate (MSU) crystals. To understand this, we conducted an in vitro study using THP-1 monocytes, which were turned into macrophages. After treating these cells with CS at various doses, we stimulated them with MSU crystals.
Our findings revealed that MSU crystals significantly increased the production of pro-inflammatory cytokines like IL-1β, IL-8, and TNFα in macrophages. Interestingly, when CS was introduced, it reduced the levels of IL-1β and TNFα in a dose-dependent manner, indicating its potential anti-inflammatory properties. Although CS also suggested a decrease in IL-8, it wasn't statistically significant.
These results suggest that chondroitin sulfate could play a beneficial role in mitigating inflammation associated with gout. However, while our study presents promising findings, it still requires further investigation, especially in clinical settings to fully ascertain its effectiveness for gout sufferers.
Our findings revealed that MSU crystals significantly increased the production of pro-inflammatory cytokines like IL-1β, IL-8, and TNFα in macrophages. Interestingly, when CS was introduced, it reduced the levels of IL-1β and TNFα in a dose-dependent manner, indicating its potential anti-inflammatory properties. Although CS also suggested a decrease in IL-8, it wasn't statistically significant.
These results suggest that chondroitin sulfate could play a beneficial role in mitigating inflammation associated with gout. However, while our study presents promising findings, it still requires further investigation, especially in clinical settings to fully ascertain its effectiveness for gout sufferers.
9
We aimed to explore how butyrylated hyaluronic acid (BHA) can help with the inflammation associated with gout. In our investigation, we looked at BHA's anti-inflammatory and antioxidative powers using both laboratory tests with LPS-induced cells and a live rat model that simulates gout.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
Most Useful Reviews
10
Gout attack prevention
After suffering from gout for many years and being unable to walk for six weeks at a time, I found prescribed medication ineffective. However, having taken these tablets for 18 months now, I've not had a single gout attack. I recommend these to many others experiencing similar issues. They're excellent!
6
Improved condition
I purchased this for my husband, who has been diagnosed with both arthritis and gout. His condition has certainly improved. He additionally takes a B complex and Vitamin D3, and I've noticed he's been relying less on painkillers.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
- All Researches
9
We explored a new approach to treating acute gout using dissolvable microneedles filled with colchicine, a well-known medication for this condition. The microneedles were created with hyaluronic acid, an ingredient often used in skincare, and designed for transdermal delivery—meaning they can deliver medication through the skin without needing needles like those found in injections.
During our study, we evaluated the mechanical properties of these microneedles, ensuring they could effectively penetrate the skin and release the medication. Importantly, our findings showed that using these microneedles allowed for a significant increase in the amount of colchicine that entered the bloodstream compared to traditional gel applications. We also noted no skin irritation after application, indicating that this method is not only effective but also gentle on the skin.
Furthermore, we found that this method significantly reduced swelling and pain in rats with acute gout. By minimizing the gastrointestinal side effects commonly associated with oral colchicine, we hope this innovative delivery system can enhance treatment effectiveness and improve patient adherence to medication. Overall, our study suggests that using hyaluronic acid in microneedles could be a promising way to deliver colchicine for better gout management.
During our study, we evaluated the mechanical properties of these microneedles, ensuring they could effectively penetrate the skin and release the medication. Importantly, our findings showed that using these microneedles allowed for a significant increase in the amount of colchicine that entered the bloodstream compared to traditional gel applications. We also noted no skin irritation after application, indicating that this method is not only effective but also gentle on the skin.
Furthermore, we found that this method significantly reduced swelling and pain in rats with acute gout. By minimizing the gastrointestinal side effects commonly associated with oral colchicine, we hope this innovative delivery system can enhance treatment effectiveness and improve patient adherence to medication. Overall, our study suggests that using hyaluronic acid in microneedles could be a promising way to deliver colchicine for better gout management.
9
We aimed to explore how butyrylated hyaluronic acid (BHA) can help with the inflammation associated with gout. In our investigation, we looked at BHA's anti-inflammatory and antioxidative powers using both laboratory tests with LPS-induced cells and a live rat model that simulates gout.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
9
We explored the benefits of butyrylated hyaluronic acid (BHA) in treating gout by examining its effects in specific animal models. Using Wistar rats, we evaluated how BHA can influence inflammation linked with gouty arthritis, specifically by measuring joint swelling and inflammatory markers after injecting monosodium urate crystals.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
8
We explored how hyaluronic acid (HA) can be beneficial in managing the pain and inflammation caused by gout. In our study, we injected rats with monosodium urate (MSU) crystals, mimicking the painful arthritis associated with gout. We observed that this injection resulted in significant joint swelling, increased pain sensitivity, and heightened nerve activity indicative of pain.
The exciting part of our findings was that after administering HA into the joint, there was a notable reduction in these painful symptoms. The HA appeared to not only alleviate the behavioral signs of pain but also diminish the heightened nerve activity linked with the gout flare-up.
Our investigation suggests that the pain and nerve activation induced by MSU crystals are not solely due to mechanical irritation but rather stem from inflammatory responses triggered by these crystals. HA seems to ease the discomfort, possibly by filtering out some of the mechanical stress placed on the sensitive nerve endings in the joint and by interacting with the pain receptors directly.
Overall, the results indicate that hyaluronic acid could be a promising treatment option for individuals suffering from gout, helping to manage the pain and improve their quality of life.
The exciting part of our findings was that after administering HA into the joint, there was a notable reduction in these painful symptoms. The HA appeared to not only alleviate the behavioral signs of pain but also diminish the heightened nerve activity linked with the gout flare-up.
Our investigation suggests that the pain and nerve activation induced by MSU crystals are not solely due to mechanical irritation but rather stem from inflammatory responses triggered by these crystals. HA seems to ease the discomfort, possibly by filtering out some of the mechanical stress placed on the sensitive nerve endings in the joint and by interacting with the pain receptors directly.
Overall, the results indicate that hyaluronic acid could be a promising treatment option for individuals suffering from gout, helping to manage the pain and improve their quality of life.
8
Chondroitin sulfate shows promise for gout
We explored the potential benefits of chondroitin sulfate (CS) in managing gout, particularly its effects on inflammation triggered by monosodium urate (MSU) crystals. To understand this, we conducted an in vitro study using THP-1 monocytes, which were turned into macrophages. After treating these cells with CS at various doses, we stimulated them with MSU crystals.
Our findings revealed that MSU crystals significantly increased the production of pro-inflammatory cytokines like IL-1β, IL-8, and TNFα in macrophages. Interestingly, when CS was introduced, it reduced the levels of IL-1β and TNFα in a dose-dependent manner, indicating its potential anti-inflammatory properties. Although CS also suggested a decrease in IL-8, it wasn't statistically significant.
These results suggest that chondroitin sulfate could play a beneficial role in mitigating inflammation associated with gout. However, while our study presents promising findings, it still requires further investigation, especially in clinical settings to fully ascertain its effectiveness for gout sufferers.
Our findings revealed that MSU crystals significantly increased the production of pro-inflammatory cytokines like IL-1β, IL-8, and TNFα in macrophages. Interestingly, when CS was introduced, it reduced the levels of IL-1β and TNFα in a dose-dependent manner, indicating its potential anti-inflammatory properties. Although CS also suggested a decrease in IL-8, it wasn't statistically significant.
These results suggest that chondroitin sulfate could play a beneficial role in mitigating inflammation associated with gout. However, while our study presents promising findings, it still requires further investigation, especially in clinical settings to fully ascertain its effectiveness for gout sufferers.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Gout attack prevention
After suffering from gout for many years and being unable to walk for six weeks at a time, I found prescribed medication ineffective. However, having taken these tablets for 18 months now, I've not had a single gout attack. I recommend these to many others experiencing similar issues. They're excellent!
6
Improved condition
I purchased this for my husband, who has been diagnosed with both arthritis and gout. His condition has certainly improved. He additionally takes a B complex and Vitamin D3, and I've noticed he's been relying less on painkillers.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu Y, Zhu X, Ji S, Huang Z, Zang Y, et al. Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model. Drug Deliv. 2022;29:2984. doi:10.1080/10717544.2022.2122632
- Luan X, Cong Z, Anastassiades TP, Gao Y. -Butyrylated Hyaluronic Acid Achieves Anti-Inflammatory Effects In Vitro and in Adjuvant-Induced Immune Activation in Rats. Molecules. 2022;27. doi:10.3390/molecules27103267
- Li L, Wang D, Wang X, Bai R, Wang C, et al. -Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models. Pharm Biol. 2019;57:717. doi:10.1080/13880209.2019.1672755
- Marcotti A, Miralles A, Dominguez E, Pascual E, Gomis A, et al. Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan. Pain. 2018;159:739. doi:10.1097/j.pain.0000000000001137
- Orlowsky EW, Stabler TV, Montell E, Vergés J, Kraus VB. Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?. BMC Musculoskelet Disord. 2014;15:318. doi:10.1186/1471-2474-15-318
