Hyaluronic acid gel shows promiseOpen, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy.
Important alternative treatment option
We examined the effects of a gel containing hyaluronic acid on women experiencing vaginal atrophy symptoms after menopause. The pilot and multicenter studies involved 110 postmenopausal participants using the gel both externally and vaginally. Results showed significant improvements in vaginal dryness, burning, itching, and rash from the first week of treatment, without any reported adverse effects. Overall, the gel was well-accepted and demonstrated promise as a safe alternative to traditional hormone replacement therapies.
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Effective treatment for atopic dermatitisA multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults.
Highly relevant efficacy findings
We explored the impact of MAS063DP cream on mild to moderate atopic dermatitis in a clinical study involving 218 adults. Patients were randomly assigned to use either the MAS063DP cream or a placebo for 50 days, applying it three times daily to affected skin areas. Our results showed that MAS063DP was significantly more effective in reducing symptoms compared to the vehicle, with lower rates of rash reported in the treatment group. This indicates that MAS063DP cream is a promising option for managing atopic dermatitis.
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Hyaluronic acid enhances skin regenerationTransfersomal serum loading amniotic mesenchymal stem cells metabolite products with hyaluronic acid addition for skin regeneration in UV aging-induced mice.
Significant relevance in skin therapy
This study investigated how hyaluronic acid (HA) enhances the effects of transfersomal serum containing amniotic mesenchymal stem cells metabolite products on skin regeneration.
We found that adding HA significantly improved skin hydration, collagen density, and fibroblast cell numbers in UV-induced aged mice. Encouragingly, there were no reports of skin rash or irritation after topical application.
This shows that the combination of HA and AMSC-MP can effectively support skin health without causing adverse effects.
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We observed a compelling case where a 74-year-old woman experienced a severe flare of dermatitis herpetiformis, a rare autoimmune skin condition, following a COVID-19 infection.
Initially, she presented with blisters and oral ulcers. After treatment that included hyaluronic acid mouthwash, her oral lesions showed remarkable improvement over four weeks.
Unfortunately, after contracting COVID-19, she had another flare-up, but again, her symptoms resolved after a month of treatment. This highlights the impact of COVID-19 on existing autoimmune conditions.
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Hyaluronic acid treatments reduce wrinklesA Randomized, Blinded, Prospective Clinical Study Comparing Small-Particle Versus Cohesive Polydensified Matrix Hyaluronic Acid Fillers for the Treatment of Perioral Rhytids.
Study shows relevant clinical comparisons.
We explored the effectiveness of two hyaluronic acid fillers in treating superficial wrinkles around the mouth. In a double-blind study involving 48 patients, we compared small-particle hyaluronic acid with lidocaine to cohesive polydensified matrix hyaluronic acid.
Both treatments reduced wrinkling, with notable results maintained for 180 days. However, the small-particle approach showed superior effectiveness as rated by both patients and investigators after the treatment period. While both products had similar safety profiles, adverse reactions included some rash among patients using cohesive matrix fillers.
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