Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Calcium (from tricalcium phosphate and calcium stearate in Serrateric™)
29 mg
2%
Serrapeptase Enzyme (from Serratio sp.)
40,000 SPU**
Nattokinase (from fibrinase enzyme)
2,000 FU***

Top Medical Research Studies

7
Nattokinase identified as allergen
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Read More

Most Useful Reviews

0
Anaphylaxis risk
I intended to take this for cardiovascular benefits but had to return it due to a severe reaction. My throat is still swollen almost a day later. I’m unsure if it’s the serratiopeptidase or the nattokinase causing this. I have a history of anaphylaxis from food allergies, so I advise caution for anyone with similar conditions.
Read More
8.3
Better breathing
Ultimately, I started to wake up with a normal breathing nose and ceased taking allergy medicine at night. The allergy itself seems to have disappeared. I cannot say for certain if it’s coincidence, but my sense of smell has improved. Serrapeptase appears to have addressed the internal fibroses, making my body feel lighter and more agile.
Read More
9.5
Sinuses clear
Clears sinuses! No more allergies, it wonderfully clears out my sinuses. Great quality and ingredients, with a convenient size and dosage.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
  • All Researches
7
Nattokinase identified as allergen
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
0
Anaphylaxis risk
I intended to take this for cardiovascular benefits but had to return it due to a severe reaction. My throat is still swollen almost a day later. I’m unsure if it’s the serratiopeptidase or the nattokinase causing this. I have a history of anaphylaxis from food allergies, so I advise caution for anyone with similar conditions.
Read More
8.3
Better breathing
Ultimately, I started to wake up with a normal breathing nose and ceased taking allergy medicine at night. The allergy itself seems to have disappeared. I cannot say for certain if it’s coincidence, but my sense of smell has improved. Serrapeptase appears to have addressed the internal fibroses, making my body feel lighter and more agile.
Read More
9.5
Sinuses clear
Clears sinuses! No more allergies, it wonderfully clears out my sinuses. Great quality and ingredients, with a convenient size and dosage.
Read More
9.5
Seasonal relief
I bought this for my boyfriend to assist with his seasonal allergies! He loves it and says it works better than allergy pills.
Read More
9.5
Allergy medication alternative
My nasal passages used to get blocked at night and sometimes during the day due to allergies. This product has truly worked! I haven’t taken any allergy or sinus medications since February. If it also benefits circulatory health, that’s a bonus. This is definitely a must-buy for anyone struggling with allergies.
Read More

Frequently Asked Questions

Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.

Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.

Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.

While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.

Based on user reviews, the time it typically takes to see results from this supplement can vary. Some users have reported experiencing noticeable improvements shortly after starting the supplement. For instance, one reviewer mentioned that they started to wake up with a "normal breathing nose" and suggested that their allergy symptoms seemed to have disappeared within a relatively short time frame (Read Review). Another reviewer also indicated an immediate effect, noting that the supplement "clears sinuses" effectively (Read Review).

However, some users indicated that while they felt improvements, the full effects related to allergy relief may take longer, mentioning a duration of several weeks as they transitioned from other allergy medications to this supplement (Read Review). Another user's experience suggested that noticeable changes could manifest within a week in terms of overall health and symptom management, although they were not solely focused on allergies (Read Review). Overall, while some users report quick relief, individual experiences may vary significantly.

Based on user reviews, many individuals have reported significant improvements in their allergy symptoms after using this supplement. Multiple users noted the effective relief from sinus congestion and overall allergy symptoms, with one stating they no longer needed allergy medication at night and found their sense of smell improved (Read Review). Another reviewer emphasized the product’s ability to clear sinuses successfully, indicating that it helped eliminate their allergies entirely (Read Review).

Additionally, another user highlighted a shift from traditional allergy pills to the supplement, expressing satisfaction with its effectiveness for seasonal allergies, suggesting it could work more efficiently for some than conventional treatments (Read Review). While some users also reported benefits beyond allergies, such as improved intestinal function and reduced anxiety, it's important to note that individual results can vary widely, and factors like duration of use and personal health conditions may influence outcomes (Read Review).

Based on user reviews, many have reported positive experiences when combining this supplement with their allergy management routines. Several users specifically noted that switching from traditional allergy medications to this supplement resulted in significant improvements in their symptoms. One reviewer mentioned that after using the supplement, they no longer needed to take allergy medicine at night, indicating a substantial reduction in their allergy issues (Read Review). Another user expressed satisfaction, stating it worked better than conventional allergy pills for seasonal issues, showcasing its effectiveness as an alternative treatment (Read Review).

Furthermore, reviews highlighted the complementing effects of this supplement with other health improvements, such as enhanced sinus clarity and alleviation from phlegm, which can be beneficial for those dealing with seasonal allergies (Read Review). Users have indicated that the natural ingredients seem to promote overall wellness without adverse reactions, as one reviewer noted improvements in both intestinal function and general health without experiencing any allergic responses (Read Review). This suggests that for many, the supplement can effectively enhance allergy management when used in conjunction with or as a substitute for more conventional allergy treatments.

Based on user reviews, many individuals report positive outcomes when using Nattokinase for treating allergies, often emphasizing its effectiveness in alleviating sinus congestion and improving overall breathing. For instance, one user mentioned experiencing a normal breathing nose upon waking and even ceased using nighttime allergy medication, although they acknowledged the possibility of coincidence in their improvements (Read Review). Another user praised the product for clearing their sinuses and noted that their allergies have significantly diminished (Read Review).

While the reviews predominantly highlight the benefits of Nattokinase regarding allergies, specific dosage recommendations are not directly stated. However, users seem to appreciate the product's quality and effectiveness compared to traditional allergy medications, with one review noting that it works better than pills (Read Review). Overall, those seeking natural allergy relief may find Nattokinase to be a compelling option, though individual responses may vary, and precise dosage information remains unspecified.

8.3
Better breathing
Ultimately, I started to wake up with a normal breathing nose and ceased taking allergy medicine at night. The allergy itself seems to have disappeared. I cannot say for certain if it’s coincidence, but my sense of smell has improved. Serrapeptase appears to have addressed the internal fibroses, making my body feel lighter and more agile.
9.5
Sinuses clear
Clears sinuses! No more allergies, it wonderfully clears out my sinuses. Great quality and ingredients, with a convenient size and dosage.
8.5
Eased seasonal allergies
I had been taking Dr Best serrapeptase for a while before switching to Natto-Serra a couple of months ago. This supplement aids with phlegm and my seasonal allergies. I also hope to see improvements concerning spider veins, but that will require time.
9.5
No allergies observed
An excellent quality product with excellently chosen ingredients. I experienced no allergies or adverse reactions. The packaging is large and sufficient for a long time. The medium-sized capsules are neutral in taste. Delivery was quick and undamaged. The composition includes only healthy, natural ingredients, along with folic acid. I've noticed an improvement in my intestinal function and metabolism; changes were evident within a week, and my nervous system is functioning better now, with reduced anxiety.
9.5
Seasonal relief
I bought this for my boyfriend to assist with his seasonal allergies! He loves it and says it works better than allergy pills.

References

  1. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, et al. Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int. 2023;72:279. doi:10.1016/j.alit.2022.11.010
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