A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study.
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
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Most Useful Reviews
10
Circulation improvement
48 people found this helpful
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!
Read More
9
Constant warmth
23 people found this helpful
This drug has worked wonders for my husband, who always had cold hands and feet. Since taking it, he no longer suffers from the cold and stays warm all the time. It's clear that it improves his circulation. Our whole family benefited from it when we had covid, and it positively affected us. If you find this review helpful, please give it a thumbs up!
Read More
10
Cold feet resolved
10 people found this helpful
Nattokinase is sensational! I've suffered from cold feet for 40 years, but this product eliminated the issue in just 24 hours. I will continue purchasing it.
A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study.
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.7
All Reviews
Positive Reviews
Negative Reviews
10
Circulation improvement
48 people found this helpful
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!
Read More
9
Constant warmth
23 people found this helpful
This drug has worked wonders for my husband, who always had cold hands and feet. Since taking it, he no longer suffers from the cold and stays warm all the time. It's clear that it improves his circulation. Our whole family benefited from it when we had covid, and it positively affected us. If you find this review helpful, please give it a thumbs up!
Read More
10
Cold feet resolved
10 people found this helpful
Nattokinase is sensational! I've suffered from cold feet for 40 years, but this product eliminated the issue in just 24 hours. I will continue purchasing it.
Read More
9
Cold tolerance
2 people found this helpful
This worked extremely quickly for me. I now tolerate the cold much better, with my hands becoming warm.
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9
Supports lung function
We take this to enhance lung and bronchi function since we live in a cold climate and frequently lack oxygen. Thanks to nattokinase, I easily endured COVID without feeling heaviness in my airways and suffer less from laryngitis. The capsules are small and convenient.
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.
While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.
Based on user reviews, the time it takes to see results when taking this supplement for cold symptoms can vary widely. Many users report significant improvements within 24 to 48 hours of starting the supplement. For instance, one review describes a user regaining feeling in cold extremities just a day after taking the product Read Review. Another reviewer noted that cold symptoms disappeared within two days of use Read Review.
Conversely, some individuals mentioned a gradual improvement over a week, particularly for ongoing issues like cold extremities or overall immunity support Read Review. Overall, while immediate effects are common, longer-term users emphasize the cumulative benefits of the supplement, suggesting a consistent regimen may optimize results over time.
Based on user reviews, many individuals have reported significant improvements in their symptoms, particularly related to cold extremities, within a short time frame after starting the supplement. For example, one user mentioned that her husband regained feeling in his cold foot within 24 hours, claiming it transformed his quality of life Read Review. Additionally, another reviewer found that their chronic cold feet issue was resolved in just 24 hours Read Review. Overall, users frequently note an enhancement in circulation, leading to warmer hands and feet Read Review.
Aside from immediate effects on cold symptoms, users have experienced broader health benefits like improved immunity and reduced incidence of colds, particularly during seasonal changes Read Review. Some have even reported that their overall health and energy levels have noticeably improved after consistently taking the supplement Read Review. While these anecdotal experiences are encouraging, it is important to remember that individual results may vary, and not everyone will experience the same level or speed of improvement.
Users report a variety of experiences when combining this supplement with other supplements for managing cold symptoms. Some individuals have noted that taking it alongside other vitamins, like NAC and Serrareptase, positively impacts their immunity, making colds easier and quicker to manage Read Review. Additionally, one user emphasized the efficacy of taking multiple supplements while dealing with a cold, suggesting clear benefits from the combination Read Review.
Moreover, several reviews emphasize the importance of not combining nattokinase with food for optimal effects Read Review. Despite this, many users echoed that they have achieved remarkable results both from the supplements individually and as part of a broader regimen consisting of other health-supportive products. Overall, while some users highlight effective combinations that enhance the supplement's benefits, individual responses vary, warranting personal experimentation to find the most effective regimen.
Based on user reviews, the dosage of Nattokinase for treating cold symptoms often varies among individuals, but there are some common patterns noted by reviewers. Many users reported taking one or two capsules daily, with some recommending specific timings such as in the morning and before dinner for optimal effect Read Review. One reviewer mentioned taking it before bed, suggesting it aids in recovery during the night Read Review. A typical effective dose indicated in these reviews appears to be around 2,000 fibrinolytic units (FUs) per serving, as highlighted by a user emphasizing its impact on circulation and cold extremities Read Review.
Additionally, users have shared positive feedback regarding the rapid efficacy of Nattokinase when taken regularly. For instance, some reported noticeable improvements in symptoms related to circulation, such as warm hands and feet, within 24 hours of starting the supplement Read Review. Overall, users seem to agree that consistent use at effective doses leads to better outcomes when dealing with cold symptoms and associated discomforts.
10
Circulation improvement
48 people found this helpful
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!
9
Instant symptom relief
I didn't expect such an instant effect! I initially took it for candida, but when my husband got a sore throat and cold symptoms, within two days of using this supplement, all his symptoms vanished without any gargling. It's a miracle supplement!
7.5
Effective for cold extremities
1 people found this helpful
Very good for cold extremities in winter; it works after a week of taking the treatment.
10
Cold feet resolved
10 people found this helpful
Nattokinase is sensational! I've suffered from cold feet for 40 years, but this product eliminated the issue in just 24 hours. I will continue purchasing it.
9
Constant warmth
23 people found this helpful
This drug has worked wonders for my husband, who always had cold hands and feet. Since taking it, he no longer suffers from the cold and stays warm all the time. It's clear that it improves his circulation. Our whole family benefited from it when we had covid, and it positively affected us. If you find this review helpful, please give it a thumbs up!
7.5
Immunity support
Great! I take this vitamin in autumn and winter to support my immunity. I have only caught a cold once! I feel brilliant, and the supplement in capsules is convenient and easy to wash down with water.
7.5
Leg heaviness relief
I decided to try nattokinase for its blood vessel benefits. After a month’s course, I noticed my legs tire less often and I experience cold extremities much less. My overall health has improved significantly, and I have more energy. I plan to continue this during sedentary periods.
7.5
Positive immunity boost
Good quantity at a reasonable price. Contrary to reviews mentioning a smell, I found none upon opening. I take NAC alongside Serrareptase, and it positively impacts my immunity. Colds have become easier and quicker to manage.
9
Effective remedy
My sister advised me to take various supplements when I caught a cold. The effect is obvious. I will purchase it again.
6
Helps with blood flow
1 people found this helpful
An excellent natural remedy for thinning blood; the main thing is not to combine it with food for best effects. It also loosens mucus from colds and promotes excretion.
7.5
Prevents colds
3 people found this helpful
I recommend it. I read in other reviews to take it before bed, so I have taken one tablet at night. It helps me rise in the morning, and I have yet to catch a cold.
7.5
Improved circulation
The quality of this nattokinase supplement is excellent, containing a potent dose of 2,000 fibrinolytic units (FUs) per serving, which supports circulation and healthy blood flow. The biggest benefit I've observed is the enhancement of my circulation; I’ve experienced fewer instances of cold hands and feet, which used to be a challenge for me.
References
Nara N, Kurosawa Y, Fuse-Hamaoka S, Kuroiwa M, Endo T, et al. A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon. 2023;9:e17951. 10.1016/j.heliyon.2023.e17951