' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Excellent
Based on 25 Reviews
9.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
8
Nattokinase aids cold recovery
A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study.
Direct effect on cold response
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
Most Useful Reviews
10
Circulation improvement
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!
Read More
9.5
Constant warmth
This drug has worked wonders for my husband, who always had cold hands and feet. Since taking it, he no longer suffers from the cold and stays warm all the time. It's clear that it improves his circulation. Our whole family benefited from it when we had covid, and it positively affected us. If you find this review helpful, please give it a thumbs up!
Read More
10
Cold feet resolved
Nattokinase is sensational! I've suffered from cold feet for 40 years, but this product eliminated the issue in just 24 hours. I will continue purchasing it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Nattokinase aids cold recovery
A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study.
Direct effect on cold response
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 25 Reviews
9.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Circulation improvement
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!
Read More
9.5
Constant warmth
This drug has worked wonders for my husband, who always had cold hands and feet. Since taking it, he no longer suffers from the cold and stays warm all the time. It's clear that it improves his circulation. Our whole family benefited from it when we had covid, and it positively affected us. If you find this review helpful, please give it a thumbs up!
Read More
10
Cold feet resolved
Nattokinase is sensational! I've suffered from cold feet for 40 years, but this product eliminated the issue in just 24 hours. I will continue purchasing it.
9.5
Cold tolerance
This worked extremely quickly for me. I now tolerate the cold much better, with my hands becoming warm.
9.5
Instant symptom relief
I didn't expect such an instant effect! I initially took it for candida, but when my husband got a sore throat and cold symptoms, within two days of using this supplement, all his symptoms vanished without any gargling. It's a miracle supplement!
