Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
Most Useful Reviews
9
Depression alleviated
4 people found this helpful
After using it for over a month, it proved effective, and my symptoms of vitamin B12 deficiency largely dissipated, particularly the depression caused by this deficiency. It caused no allergies or complications. It is safe and reasonably priced for me.
Read More
10
Increased B12 levels
2 people found this helpful
Great product. I had no allergies or discomfort with the ingredients. It arrived promptly, and I was not taxed. It worked very well for me; I've taken exams and my B12 has doubled. I had a great result. If this comment helped, please like.
Read More
10
Happy with product
1 people found this helpful
A wonderful vitamin! No allergies; I am delighted to take this group of B vitamins and enzymes! Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Depression alleviated
4 people found this helpful
After using it for over a month, it proved effective, and my symptoms of vitamin B12 deficiency largely dissipated, particularly the depression caused by this deficiency. It caused no allergies or complications. It is safe and reasonably priced for me.
Read More
10
Increased B12 levels
2 people found this helpful
Great product. I had no allergies or discomfort with the ingredients. It arrived promptly, and I was not taxed. It worked very well for me; I've taken exams and my B12 has doubled. I had a great result. If this comment helped, please like.
Read More
10
Happy with product
1 people found this helpful
A wonderful vitamin! No allergies; I am delighted to take this group of B vitamins and enzymes! Thank you!
Read More
10
Enhanced energy levels
Small capsules but essential. I have taken Doctor's Best Active Vitamin B12 for several months, 1-2 times a week unless taking a multivitamin. It helps maintain my energy and improves concentration. I experienced no allergies or side effects and recommend it.
Read More
10
Highly recommend
Excellent product! It does not cause allergies or stomach problems. I highly recommend it; it's easy to swallow and very beneficial.
Read More
Frequently Asked Questions
9
Depression alleviated
4 people found this helpful
After using it for over a month, it proved effective, and my symptoms of vitamin B12 deficiency largely dissipated, particularly the depression caused by this deficiency. It caused no allergies or complications. It is safe and reasonably priced for me.
10
Increased B12 levels
2 people found this helpful
Great product. I had no allergies or discomfort with the ingredients. It arrived promptly, and I was not taxed. It worked very well for me; I've taken exams and my B12 has doubled. I had a great result. If this comment helped, please like.
9
Boosted energy
I have used this B12 brand for years with good results. As someone with food intolerances and allergies, it’s difficult to find a high-quality supplement. This exceeded my expectations; I noticed a significant increase in energy and better sleep quality. I warmly recommend it.
10
Happy with product
1 people found this helpful
A wonderful vitamin! No allergies; I am delighted to take this group of B vitamins and enzymes! Thank you!
10
Enhanced energy levels
Small capsules but essential. I have taken Doctor's Best Active Vitamin B12 for several months, 1-2 times a week unless taking a multivitamin. It helps maintain my energy and improves concentration. I experienced no allergies or side effects and recommend it.
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
References
- Guillot AJ, Martínez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. doi:10.1016/j.jconrel.2024.09.032
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. doi:10.33029/0042-8833-2023-92-3-79-86
- El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. doi:10.1016/j.jaip.2023.10.037
