' 
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.1
USERS' SCORE
Good
Based on 21 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
B12 deficiency linked to clots
A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis.
Case study highlights medical urgency
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
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8
Vitamin B12 deficiency and clot risk
Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review.
High relevance to clinical practice
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
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8
Pernicious anemia and DIC connection
A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation.
High significance of findings
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
9.5
Reduced fatigue
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
Read More
9.5
Effective for B12 deficiency
After battling B12 deficiency with regular supplements and injections, my blood test showed little improvement. A second opinion led to my discovery of Active B12. Since switching to Doctors Best, my blood test results showed significant improvement. I recommend this brand for its quality and effective results!
Read More
9.5
Effective vitamins
After a blood test revealed lowered neutrophils, linked to a lack of vitamin B12, I took one capsule daily with meals for two months. I retook the analysis, and everything recovered. These vitamins are effective.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.1
- All Researches
9
MTHFR mutation impacts blood clot recovery
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Mutations linked to thrombosis
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
Read More
9
Case study on hypoglycemia treatment
Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report.
Relevance score of clinical importance
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
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9
Homocysteine influences brain injury outcomes
Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence.
Significant relevance, clinical implications
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Read More
9
Vitamin B12's role in clot management
A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report.
Moderate relevance to findings
We examined a fascinating case involving a 25-year-old male who experienced severe headaches and vertigo due to cerebral venous thrombosis (CVT). This unique situation arose after the patient had been abusing nitrous oxide, leading to a vitamin B12 deficiency.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
Read More
9
Vitamin B12 and blood clot relationship
Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review.
Combination therapy complicates assessment
We explored a case involving cerebral venous thrombosis (CVT) coinciding with hyperhomocysteinemia and iron-deficiency anemia, a condition attributed to autoimmune gastritis. The patient, a 47-year-old woman, presented with various symptoms including impaired movement and consciousness. Imaging tests revealed significant brain swelling and clot formations in the venous sinuses.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced fatigue
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
Read More
9.5
Effective for B12 deficiency
After battling B12 deficiency with regular supplements and injections, my blood test showed little improvement. A second opinion led to my discovery of Active B12. Since switching to Doctors Best, my blood test results showed significant improvement. I recommend this brand for its quality and effective results!
Read More
9.5
Effective vitamins
After a blood test revealed lowered neutrophils, linked to a lack of vitamin B12, I took one capsule daily with meals for two months. I retook the analysis, and everything recovered. These vitamins are effective.
8.8
Improved blood flow
Wonderful! I am pleased with the application! The biologically active components of ginkgo alter the rheological properties of the circulatory system and reduce the risk of thrombosis. The antioxidant effect of the extract is excellent, promoting the normalisation of blood flow. It enhances oxygen saturation of cells, which is vital for treating vascular insufficiency. After using this dietary supplement fully, my blood counts have improved, my sugar levels have decreased, my sleep has normalised, and I am satisfied with the results.
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1.3
Unsatisfactory experience
I did not like this product due to its awful taste. It failed to help with my blood pressure, energy, fibre, and amino acid levels. The large capsule size was also a drawback. Quality was only okay, and it was expensive. Currently, I do not recommend it, although my opinion may change.
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