Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
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8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
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8
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
9
Reduced fatigue
1 people found this helpful
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
Read More
9
Effective for B12 deficiency
1 people found this helpful
After battling B12 deficiency with regular supplements and injections, my blood test showed little improvement. A second opinion led to my discovery of Active B12. Since switching to Doctors Best, my blood test results showed significant improvement. I recommend this brand for its quality and effective results!
Read More
9
Effective vitamins
1 people found this helpful
After a blood test revealed lowered neutrophils, linked to a lack of vitamin B12, I took one capsule daily with meals for two months. I retook the analysis, and everything recovered. These vitamins are effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
- All Researches
9
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
Read More
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
Read More
9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Read More
9
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced fatigue
1 people found this helpful
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
Read More
9
Effective for B12 deficiency
1 people found this helpful
After battling B12 deficiency with regular supplements and injections, my blood test showed little improvement. A second opinion led to my discovery of Active B12. Since switching to Doctors Best, my blood test results showed significant improvement. I recommend this brand for its quality and effective results!
Read More
9
Effective vitamins
1 people found this helpful
After a blood test revealed lowered neutrophils, linked to a lack of vitamin B12, I took one capsule daily with meals for two months. I retook the analysis, and everything recovered. These vitamins are effective.
Read More
7.5
Improved blood flow
1 people found this helpful
Wonderful! I am pleased with the application! The biologically active components of ginkgo alter the rheological properties of the circulatory system and reduce the risk of thrombosis. The antioxidant effect of the extract is excellent, promoting the normalisation of blood flow. It enhances oxygen saturation of cells, which is vital for treating vascular insufficiency. After using this dietary supplement fully, my blood counts have improved, my sugar levels have decreased, my sleep has normalised, and I am satisfied with the results.
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0
Unsatisfactory experience
I did not like this product due to its awful taste. It failed to help with my blood pressure, energy, fibre, and amino acid levels. The large capsule size was also a drawback. Quality was only okay, and it was expensive. Currently, I do not recommend it, although my opinion may change.
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Frequently Asked Questions
9
Fresh vitality
1 people found this helpful
Already after a week of daily intake, I feel a sense of fresh vitality and an improved mood. The 1500mcg dosage is optimal, and I'm satisfied with the quality of the herbal ingredients. I recommend getting a blood test to check B12 levels. It’s a must-have supplement with small capsules that are easy to swallow—definitely worth the price and quality!
9
Effective vitamins
1 people found this helpful
After a blood test revealed lowered neutrophils, linked to a lack of vitamin B12, I took one capsule daily with meals for two months. I retook the analysis, and everything recovered. These vitamins are effective.
9
Enhanced alertness
1 people found this helpful
These strong, sweetener-free B12 capsules won't disrupt intermittent fasting. The effects are noticeable after the first pill, with increased alertness and energy. It's best taken on an empty stomach in the morning for optimal energy. Compared to other B12 supplements, this one stands out for its noticeable benefits. I'm giving it five stars!
9
Reduced fatigue
1 people found this helpful
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
9
Effective for B12 deficiency
1 people found this helpful
After battling B12 deficiency with regular supplements and injections, my blood test showed little improvement. A second opinion led to my discovery of Active B12. Since switching to Doctors Best, my blood test results showed significant improvement. I recommend this brand for its quality and effective results!
6
Improved sleep quality
9 people found this helpful
I took a vitamin B supplement after my doctor diagnosed me with a severe deficiency of this vitamin, which caused sleep difficulties and a low mood. After starting the supplement, my sleep improved, but my mood has not changed, likely due to my nature.
7.5
Improved blood flow
1 people found this helpful
I believe that my blood flow has notably improved since I began taking this alongside iron supplements, and even during winter, my limbs feel warm.
7.5
Improves blood pressure
1 people found this helpful
It's been a week since I started taking this to improve my blood pressure, which was too low, and I can feel it definitely increasing. No repeat mistakes.
7
We explored the relationship between Vitamin B12 deficiency and cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each presented with headaches, and two experienced visual disturbances, which led to evaluations revealing CVST and high homocysteine levels, a known risk factor for clots. Notably, two patients had very low Vitamin B12 levels. All received anticoagulation treatment along with Vitamin B supplements and showed positive responses, with imaging confirming the resolution of thrombosis in two cases. This suggests an important connection between B12 levels and clot formation, particularly in vegetarians.
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
References
- Bizouard T, Caplette C, Duval D, Savary D, Douillet D. Right iliac deep vein thrombosis and pulmonary embolism associated with recreational nitrous oxide: a case report. Int J Emerg Med. 2024;17:169. 10.1186/s12245-024-00689-z
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. 10.3390/diagnostics14151609
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. 10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. 10.7759/cureus.41428
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Coelho T, Freitas A, Carmona Alexandrino H, Pinto S. Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report. Cureus. 2022;14:e32265. 10.7759/cureus.32265
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. 10.1177/19714009221147224
- Aboona MB, Rapaich L, Etman A, Thomas SW. A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation. J Med Cases. 2022;13:557. 10.14740/jmc4020
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. 10.3390/jcm11020394
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. 10.7759/cureus.76962
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. 10.7759/cureus.20228
