Last update
4/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
USERS' SCORE
Good
Based on 10 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
9
We explored the effects of mecobalamin, a form of B12, on carpal tunnel syndrome (CTS) in patients who have experienced a stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
Read More
7
Vitamin B12's effects on nerves
We examined how high doses of methylcobalamin, a form of vitamin B12, might improve conditions like carpal tunnel syndrome. Although methylcobalamin shows potential benefits for peripheral nerve conditions, our findings suggest that while it may help alleviate symptoms, the exact mechanisms remain unclear.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
Read More
4
Vitamin B12 and carpal tunnel syndrome
We explored how vitamin B12 can help manage carpal tunnel syndrome (CTS), a common condition affecting the wrist due to median nerve compression. Our findings indicate that while several conservative treatments exist, such as splints and pain relievers, the role of B12 specifically in alleviating CTS symptoms was noted among other options but not highlighted as distinctly effective.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Read More
Most Useful Reviews
9
Numbness alleviated
10 people found this helpful
I highly recommend it! After experiencing numbness at the base of my thumb, I discovered it was Carpal Tunnel Syndrome. Methylcobalamin was prescribed, and after researching, I found that vitamin B12 was the primary component. I took one capsule with dinner, along with a support band, and the numbness faded after three consecutive days. Although I still feel a little uncomfortable, it is improving daily, and I will continue taking it.
Read More
8
Pain relief achieved
9 people found this helpful
Seven years ago, I developed Carpal Tunnel Syndrome from a job change and was treated for about two months with Methycobal 500, which effectively cured me. Recently, while gardening, I felt pain around my thumbs again, so I started taking this supplement, which resembles Methycobal. It has provided similar pain relief effects, and I intend to keep taking it.
Read More
8
Nausea improved
7 people found this helpful
For my Carpal Tunnel Syndrome, I take one capsule each morning and evening. I used to wake up with numbness and felt this during the day as well. After about two weeks of taking it, my nausea diminished. I make an effort to perform light stretches and plan to continue this regimen.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
- All Researches
9
We examined the impact of needle Dao treatment on patients with carpal tunnel syndrome by comparing two groups. One received needle Dao, while the other was treated with braces and medication including B12.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
Read More
9
We investigated various treatments for early-stage carpal tunnel syndrome to find what works best. Sixty patients were randomly assigned to three groups, with one receiving basic treatments like Vitamin B12, while others also used acupuncture or herbal therapies.
Although electromyography results showed no significant changes, those in the acupuncture and herbal therapy groups reported better pain relief than the basic treatment group. Their success rates were notably higher, indicating these alternative therapies may be very effective for managing symptoms.
Although electromyography results showed no significant changes, those in the acupuncture and herbal therapy groups reported better pain relief than the basic treatment group. Their success rates were notably higher, indicating these alternative therapies may be very effective for managing symptoms.
Read More
9
We explored the effects of mecobalamin, a form of B12, on carpal tunnel syndrome (CTS) in patients who have experienced a stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
Read More
8
We examined the effectiveness of a dietary supplement containing various nutrients—including vitamin B12—on patients with early carpal tunnel syndrome (CTS).
The study involved 36 patients, split into two groups: one receiving physical therapy alone and the other combining therapy with the supplement.
While the findings suggest that the integrator may aid in improving nerve conduction and symptom resolution, it’s crucial to note that the extent of benefit specifically attributable to the B12 component remains unclear.
The study involved 36 patients, split into two groups: one receiving physical therapy alone and the other combining therapy with the supplement.
While the findings suggest that the integrator may aid in improving nerve conduction and symptom resolution, it’s crucial to note that the extent of benefit specifically attributable to the B12 component remains unclear.
Read More
We explored the effectiveness of a dietary supplement featuring B12 along with several other compounds in treating carpal tunnel syndrome (CTS) for patients awaiting surgery.
Patients were divided into two groups: one received the supplement for 60 days while the other did not.
Results showed significant improvement in symptoms and pain for those taking the supplement, but other functional metrics didn’t show notable changes. Surgery is still seen as the most effective treatment for severe cases.
Patients were divided into two groups: one received the supplement for 60 days while the other did not.
Results showed significant improvement in symptoms and pain for those taking the supplement, but other functional metrics didn’t show notable changes. Surgery is still seen as the most effective treatment for severe cases.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Numbness alleviated
10 people found this helpful
I highly recommend it! After experiencing numbness at the base of my thumb, I discovered it was Carpal Tunnel Syndrome. Methylcobalamin was prescribed, and after researching, I found that vitamin B12 was the primary component. I took one capsule with dinner, along with a support band, and the numbness faded after three consecutive days. Although I still feel a little uncomfortable, it is improving daily, and I will continue taking it.
Read More
8
Pain relief achieved
9 people found this helpful
Seven years ago, I developed Carpal Tunnel Syndrome from a job change and was treated for about two months with Methycobal 500, which effectively cured me. Recently, while gardening, I felt pain around my thumbs again, so I started taking this supplement, which resembles Methycobal. It has provided similar pain relief effects, and I intend to keep taking it.
Read More
8
Nausea improved
7 people found this helpful
For my Carpal Tunnel Syndrome, I take one capsule each morning and evening. I used to wake up with numbness and felt this during the day as well. After about two weeks of taking it, my nausea diminished. I make an effort to perform light stretches and plan to continue this regimen.
Read More
7
Numbness reduced
3 people found this helpful
I’m not fond of vitamin complexes as they obscure individual vitamin dosages. I prefer taking specific vitamins separately, like B12. I developed Carpal Tunnel Syndrome from poor working habits. My fingers were extremely numb and painful. After considering surgery or finding a less invasive route, I incorporated wrist exercises and realised I was deficient in vitamin B12. This adjustment has helped; my fingers are no longer numb, thanks to the combination of exercises and vitamins.
Read More
0
Ineffective for relief
2 people found this helpful
I wish I could provide a positive review, but these simply do not work for treating my Carpal Tunnel Syndrome. I have previously taken B12 for this condition with great results, but these capsules failed to produce any effect at all. I won’t be purchasing them again. However, I recognise that everyone is different, so they may work for someone else.
Read More
Frequently Asked Questions
9
Numbness alleviated
10 people found this helpful
I highly recommend it! After experiencing numbness at the base of my thumb, I discovered it was Carpal Tunnel Syndrome. Methylcobalamin was prescribed, and after researching, I found that vitamin B12 was the primary component. I took one capsule with dinner, along with a support band, and the numbness faded after three consecutive days. Although I still feel a little uncomfortable, it is improving daily, and I will continue taking it.
8
Nausea improved
7 people found this helpful
For my Carpal Tunnel Syndrome, I take one capsule each morning and evening. I used to wake up with numbness and felt this during the day as well. After about two weeks of taking it, my nausea diminished. I make an effort to perform light stretches and plan to continue this regimen.
10
Complete recovery
I’ve regularly taken this vitamin B12 (methylcobalamin type) due to wrist pain and Carpal Tunnel Syndrome-like symptoms. After about a month, the pain and numbness nearly vanished. Although it might have healed naturally, three months later, I’m completely cured. B12 benefits both the eyes and brain, making it essential for me.
9
Significant improvement
Excellent! Thanks to this, my Carpal Tunnel Syndrome condition has greatly improved. I used to wake up with numbness, and now it feels much easier to recover. I’m truly grateful for it.
0
Ineffective for relief
2 people found this helpful
I wish I could provide a positive review, but these simply do not work for treating my Carpal Tunnel Syndrome. I have previously taken B12 for this condition with great results, but these capsules failed to produce any effect at all. I won’t be purchasing them again. However, I recognise that everyone is different, so they may work for someone else.
7
Numbness reduced
3 people found this helpful
I’m not fond of vitamin complexes as they obscure individual vitamin dosages. I prefer taking specific vitamins separately, like B12. I developed Carpal Tunnel Syndrome from poor working habits. My fingers were extremely numb and painful. After considering surgery or finding a less invasive route, I incorporated wrist exercises and realised I was deficient in vitamin B12. This adjustment has helped; my fingers are no longer numb, thanks to the combination of exercises and vitamins.
4
Vitamin B12 and carpal tunnel syndrome
We explored how vitamin B12 can help manage carpal tunnel syndrome (CTS), a common condition affecting the wrist due to median nerve compression. Our findings indicate that while several conservative treatments exist, such as splints and pain relievers, the role of B12 specifically in alleviating CTS symptoms was noted among other options but not highlighted as distinctly effective.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
Ultimately, surgery remains a key method for severe cases. However, the overall effectiveness of vitamin B12 as a treatment for CTS lacks significant evidence for its unique benefit.
9
We examined the impact of needle Dao treatment on patients with carpal tunnel syndrome by comparing two groups. One received needle Dao, while the other was treated with braces and medication including B12.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
After treatment, we noticed significant improvements in nerve function tests among those treated with needle Dao. Their sensory nerve conduction and action potentials showed marked enhancement.
In contrast, while the control group saw some improvement, it wasn’t as pronounced. Overall, our findings suggest that needle Dao may offer better clinical outcomes for carpal tunnel syndrome compared to conventional methods.
7
Vitamin B12's effects on nerves
We examined how high doses of methylcobalamin, a form of vitamin B12, might improve conditions like carpal tunnel syndrome. Although methylcobalamin shows potential benefits for peripheral nerve conditions, our findings suggest that while it may help alleviate symptoms, the exact mechanisms remain unclear.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
We highlighted both animal and human studies that suggest it can positively impact nerve health. However, further research is needed to fully understand its effectiveness and mechanisms.
4
Vitamin B12's limited effectiveness observed
In our study, we aimed to assess the effectiveness of vitamin B12 as part of a multivitamin treatment for individuals suffering from carpal tunnel syndrome (CTS). We compared two groups: one receiving a combination of alpha-lipoic acid and gamma-linolenic acid, and the other taking a multivitamin preparation containing vitamin B1, B6, and B12.
Over the course of 90 days, we monitored the participants' symptoms using questionnaires and conducted electro-myography to evaluate nerve function. While we noted a slight improvement in symptoms among those taking vitamins, it was not as pronounced as in the alpha-lipoic acid and gamma-linolenic acid group.
Additionally, the multivitamin group experienced a worsening of functional scores, indicating that the vitamin B12 component did not provide significant benefits for CTS. Thus, our findings suggest that vitamin B12, while included in a multivitamin, may not be effective for improving the symptoms and functionality in carpal tunnel syndrome patients.
Over the course of 90 days, we monitored the participants' symptoms using questionnaires and conducted electro-myography to evaluate nerve function. While we noted a slight improvement in symptoms among those taking vitamins, it was not as pronounced as in the alpha-lipoic acid and gamma-linolenic acid group.
Additionally, the multivitamin group experienced a worsening of functional scores, indicating that the vitamin B12 component did not provide significant benefits for CTS. Thus, our findings suggest that vitamin B12, while included in a multivitamin, may not be effective for improving the symptoms and functionality in carpal tunnel syndrome patients.
4
We explored the effectiveness of different treatments for carpal tunnel syndrome, focusing specifically on vitamin B12's role. In our study, we looked at 61 patients with a total of 99 affected hands and compared five treatment approaches. These included the use of vitamins B6 and B12, steroid injections, hand splints, and combinations of these methods.
After assessing each patient with electrodiagnostic studies before treatment and again after one and two months, we found that treatments involving hand splinting, local steroid injections, and combination therapies delivered better results when it came to sensory nerve conduction studies. Notably, vitamin B12 used alone did not show substantial benefits. In fact, the combined treatments that included steroid injections appeared to work faster and more effectively for relieving symptoms.
Overall, our findings suggest that relying solely on vitamin B12 for carpal tunnel syndrome is not sufficient. Instead, a combination approach, particularly involving steroid injections and splinting, seems to be a more effective conservative treatment option for this condition.
After assessing each patient with electrodiagnostic studies before treatment and again after one and two months, we found that treatments involving hand splinting, local steroid injections, and combination therapies delivered better results when it came to sensory nerve conduction studies. Notably, vitamin B12 used alone did not show substantial benefits. In fact, the combined treatments that included steroid injections appeared to work faster and more effectively for relieving symptoms.
Overall, our findings suggest that relying solely on vitamin B12 for carpal tunnel syndrome is not sufficient. Instead, a combination approach, particularly involving steroid injections and splinting, seems to be a more effective conservative treatment option for this condition.
References
- D'Orio M, De Vitis R, Taccardo G, Rocchi L, Ferrari F, et al. Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study. Acta Biomed. 2023;94:e2023050. 10.23750/abm.v94iS2.12513
- Kokubo R, Kim K. [Carpal Tunnel Syndrome:Diagnosis and Treatment]. No Shinkei Geka. 2021;49:1306. 10.11477/mf.1436204516
- Marvulli R, Ianieri G, De Venuto G, Falcicchio M, Gallo GA, et al. Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome. Endocr Metab Immune Disord Drug Targets. 2021;21:345. 10.2174/1871530320666200728152953
- Zhang KY, Yang Y, Xu SW, Shou Y, Jiang HR, et al. [A case-control study on the treatment of carpal tunnel syndrome with needle Dao]. Zhongguo Gu Shang. 2018;31:497. 10.3969/j.issn.1003-0034.2018.06.002
- Negrão L, Nunes P. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag. 2016;6:25. 10.2217/pmt.15.60
- Tanaka H. [Old or new medicine? Vitamin B12 and peripheral nerve neuropathy]. Brain Nerve. 2013;65:1077. PubMed
- Zhang CY, Wang YX. [Observation on therapeutic effects of acupuncture combined with TDP irradiation and chinese herbal steaming and washing therapy for treatment of carpal tunnel syndrome in early stage]. Zhongguo Zhen Jiu. 2009;29:708. PubMed
- Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci. 2005;231:13. PubMed
- Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci. 2009;13:133. PubMed
- Wu SF, Chan RC, Hsu TC. [Electrodiagnostic evaluation of conservative treatment in carpal tunnel syndrome]. Zhonghua Yi Xue Za Zhi (Taipei). 1991;48:125. PubMed
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