' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 18 Reviews
8.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Combination treatment effects noted
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
B12 may reduce cold sensitivity
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats.
Combination treatment limits conclusions
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
Most Useful Reviews
9.5
Pain relief achieved
It worked well for pain in my spinal cord due to cervical spondylosis myelopathy. When I was having trouble sleeping and feeling emotional, I turned to vitamin B12 for nerve repair. After taking one capsule daily, the pain in my neck and shoulder blades eased within a month, and the numbness in my fingers vanished. Most notably, the feeling of cold also disappeared! I’m gradually returning to my pre-illness condition, and I plan to continue this treatment.
Read More
9.5
Cold hands improved
I believe it works. I used to suffer from cold hands and feet, but now I almost never feel that sensation anymore. It's a good product in my opinion.
Read More
8.8
Recovery improvement
Very good! A friend recommended zinc and B12 supplementation for my frequent muscle soreness and fatigue. Since I started taking it, I have noticed significant improvements. It also helped speed up my recovery during a cold.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Combination treatment effects noted
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
B12 may reduce cold sensitivity
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats.
Combination treatment limits conclusions
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Pain relief achieved
It worked well for pain in my spinal cord due to cervical spondylosis myelopathy. When I was having trouble sleeping and feeling emotional, I turned to vitamin B12 for nerve repair. After taking one capsule daily, the pain in my neck and shoulder blades eased within a month, and the numbness in my fingers vanished. Most notably, the feeling of cold also disappeared! I’m gradually returning to my pre-illness condition, and I plan to continue this treatment.
Read More
9.5
Cold hands improved
I believe it works. I used to suffer from cold hands and feet, but now I almost never feel that sensation anymore. It's a good product in my opinion.
8.8
Recovery improvement
Very good! A friend recommended zinc and B12 supplementation for my frequent muscle soreness and fatigue. Since I started taking it, I have noticed significant improvements. It also helped speed up my recovery during a cold.
9.5
Anemia treated
I suffered from anaemia and frequent colds, exhibiting weakness and drowsiness. My doctor recommended vitamin B12 with iron, and the results were swift. My ferritin levels increased, and I felt stronger and more energetic. The quality and ingredient composition of this product are excellent. After two months, my anaemia improved. My nervous system health has also seen a positive change. I will exclusively take this brand due to its superior absorption.
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9.5
Boosts immunity
This vitamin B12 is excellent quality! The ingredients are clean, without unnecessary additives. The capsules are small and easy to swallow. I feel better - more energy, reduced fatigue, and a more stable mood. My immunity is also reassuring, especially during the cold season. It's excellent health support for any age. I would advise and recommend it to everyone!
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