Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
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9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
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8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
Most Useful Reviews
9
Nausea alleviated
7 people found this helpful
I take 1 capsule each morning and evening for carpal tunnel syndrome. It used to be numb when I woke up, and I often felt numb during the day. Nausea was alleviated after about two weeks of taking it. I am mindful of light stretching and would like to continue taking more.
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10
No nausea felt
I do not feel any nausea when I take this product!
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9
No nausea experienced
High quality and one of the best on the market. The capsules are small and easy to swallow, and I did not experience any nausea or stomach issues. The price is favourable with discounts available.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
- All Researches
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
Read More
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
Read More
8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
8
We observed how the B12-Ex4 conjugate may be a game-changer in managing type 2 diabetes. It effectively improved glucose tolerance in male rats without causing the nausea and malaise commonly associated with its unconjugated counterpart, Ex4.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
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8
We examined a case of a 28-year-old man who experienced persistent headaches, nausea, and vomiting, ultimately diagnosed with cerebral venous thrombosis (CVT). This condition was linked to a mutation in the MTHFR gene and resulted in elevated homocysteine levels.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
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User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nausea alleviated
7 people found this helpful
I take 1 capsule each morning and evening for carpal tunnel syndrome. It used to be numb when I woke up, and I often felt numb during the day. Nausea was alleviated after about two weeks of taking it. I am mindful of light stretching and would like to continue taking more.
Read More
10
No nausea felt
I do not feel any nausea when I take this product!
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9
No nausea experienced
High quality and one of the best on the market. The capsules are small and easy to swallow, and I did not experience any nausea or stomach issues. The price is favourable with discounts available.
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9
No nausea issues
The capsules are nice and small. I've never experienced nausea or heartburn as I do with some other supplements. My energy and focus improve significantly when I supplement my meatless diet with this.
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9
Convenient without nausea
These capsules effectively raise B12 levels and are small and convenient to take. They do not cause nausea or irritate my stomach. I highly recommend them!
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Frequently Asked Questions
9
Nausea alleviated
7 people found this helpful
I take 1 capsule each morning and evening for carpal tunnel syndrome. It used to be numb when I woke up, and I often felt numb during the day. Nausea was alleviated after about two weeks of taking it. I am mindful of light stretching and would like to continue taking more.
9
Nausea ceased
Very satisfied with the fast delivery. The capsules are small and convenient when swallowed, with a neutral taste. I've experienced significant benefits in energy and mood after 10 days. Headaches and nausea have stopped, and my metabolism has improved. Highly recommended!
9
Convenient without nausea
These capsules effectively raise B12 levels and are small and convenient to take. They do not cause nausea or irritate my stomach. I highly recommend them!
9
Nausea avoided
Recommended by my doctor, I take it along with other vitamins. This product is well tolerated, especially as some vitamins typically cause nausea. I find these great!
10
No nausea felt
I do not feel any nausea when I take this product!
9
Nausea reduced
I have a clean composition and the capsules are easy to swallow. After just two weeks of taking them to address insulin resistance, I’ve noticed increased energy, reduced snacking, and fewer cravings. Nausea and headaches have decreased, and I feel calmer. I recommend this supplement for metabolism improvement.
9
No nausea issues
The capsules are nice and small. I've never experienced nausea or heartburn as I do with some other supplements. My energy and focus improve significantly when I supplement my meatless diet with this.
7
We explored the impact of vitamin B12 deficiency on symptoms, including nausea, through a case study of a 60-year-old woman. When she presented with weakness, dizziness, and abdominal pain, lab tests revealed severe vitamin B12 deficiency linked to pernicious anemia.
After receiving treatment with intramuscular cyanocobalamin injections, her overall health improved significantly. This case highlights the importance of diagnosing vitamin B12 deficiency not only for its hematologic effects but also for alleviating symptoms like nausea. Early recognition is key to effective management.
After receiving treatment with intramuscular cyanocobalamin injections, her overall health improved significantly. This case highlights the importance of diagnosing vitamin B12 deficiency not only for its hematologic effects but also for alleviating symptoms like nausea. Early recognition is key to effective management.
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
7
We examined a case of a 20-year-old woman with type 1 diabetes who experienced symptoms like diarrhea and nausea due to autoimmune gastritis. Despite no initial signs of vitamin B12 deficiency, she was given B12 supplements. Remarkably, this treatment led to improvements in both her gastrointestinal and neurological problems.
This highlights the importance of recognizing underlying autoimmune disorders in diabetes patients and considering B12 therapy, even if deficiency isn't present. Understanding these connections may help prevent further complications down the line.
This highlights the importance of recognizing underlying autoimmune disorders in diabetes patients and considering B12 therapy, even if deficiency isn't present. Understanding these connections may help prevent further complications down the line.
References
- Salimiaghdam N, Jumaah O, Acob T, Hakobyan K, Chen E. Vitamin B12 Deficiency in Pernicious Anemia: A Hemolytic Anemia Mimic. Cureus. 2025;17:e79176. 10.7759/cureus.79176
- Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. 10.7759/cureus.64676
- Meyers TM, Reeves PT, Lombardo JL, Anisowicz SK, Larson NS, et al. Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report. J Med Case Rep. 2023;17:342. 10.1186/s13256-023-04039-0
- Albai O, Timar B, Paun DL, Sima A, Roman D, et al. Metformin Treatment: A Potential Cause of Megaloblastic Anemia in Patients with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:3873. 10.2147/DMSO.S270393
- Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, et al. Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis. Cell Rep. 2020;31:107768. 10.1016/j.celrep.2020.107768
- Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, et al. A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes Obes Metab. 2018;20:1223. 10.1111/dom.13222
- Dikici S, Saritas A, Besir FH, Celbek G, Arslan G. May headache be the first sign of mutation in the MTHFR gene?. World J Emerg Med. 2013;4:69.
