Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.3
Supplement Facts
Serving Size: 2 Marine Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Fish Oil ConcentrateTotal Omega-3 Fatty Acids as Ethyl EstersEPA (EicosaPentaenoic Acid), min.DHA (DocosaHexaenoic Acid), min.
2000 mg1400 mg800 mg400 mg
††††
Top Medical Research Studies
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Most Useful Reviews
9
Alleviates pain
I currently take this supplement for my arthritis pain and inflammation, alongside other supplements. It has been beneficial in managing my condition.
9
Reduces joint pain
Omega-3 fatty acids have an anti-inflammatory effect, making them useful for chronic inflammation treatment. In conditions like rheumatoid arthritis, supplements containing Omega-3 have been shown to diminish joint pain and enhance mobility and function.
9
Controls pain effectively
This product helps me maintain control over my arthritis pain effectively.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
9
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates pain
I currently take this supplement for my arthritis pain and inflammation, alongside other supplements. It has been beneficial in managing my condition.
9
Reduces joint pain
Omega-3 fatty acids have an anti-inflammatory effect, making them useful for chronic inflammation treatment. In conditions like rheumatoid arthritis, supplements containing Omega-3 have been shown to diminish joint pain and enhance mobility and function.
9
Controls pain effectively
This product helps me maintain control over my arthritis pain effectively.
7.5
Promotes joint well-being
I use Omega-3 for its cardiovascular benefits and its ability to help alleviate arthritis due to knee roughness.
7.5
Reduces inflammatory symptoms
Fish oil, obtained from fatty fish, is rich in omega-3 fatty acids, particularly EPA and DHA, which benefit the body in various ways. It helps balance cholesterol, supports brain function and mood, and protects against age-related vision loss. Additionally, its anti-inflammatory properties are beneficial for arthritis and other inflammatory conditions, while also enhancing immune system strength.
Frequently Asked Questions
7.5
Eases pain gradually
I started taking these supplements, and while it took time for them to work, they are finally alleviating my arthritis pain in my hands.
9
Reduces joint pain
Omega-3 fatty acids have an anti-inflammatory effect, making them useful for chronic inflammation treatment. In conditions like rheumatoid arthritis, supplements containing Omega-3 have been shown to diminish joint pain and enhance mobility and function.
9
Alleviates pain
I currently take this supplement for my arthritis pain and inflammation, alongside other supplements. It has been beneficial in managing my condition.
7.5
Aids arthritis symptoms
Omega-3 fatty acids prevent osteoporosis and maintain healthy joints, relieving pain during flare-ups. They combat bone loss and inflammation, effectively helping to reduce symptoms of rheumatoid arthritis and slow cartilage destruction in arthrosis.
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
4
Omega-3 has limited arthritis impact
We investigated the effects of omega-3 fatty acid supplements on rheumatoid arthritis using data from 23 randomized placebo-controlled trials. Our analysis showed only a small effect in reducing pain, joint tenderness, and swelling.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
8
Omega-3s alleviate osteoarthritis progression
We explored how omega-3 polyunsaturated fatty acids (PUFAs) could ease the pain of obesity-related osteoarthritis (OA). In our study, we found that a diet rich in omega-3s helped reduce damage to cartilage in experimental mice.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
8
Dietary compliance and EPA impact
We observed participants in the ADIRA trial, which aimed to see how different diets could affect rheumatoid arthritis. The study divided fifty patients into two groups: one followed an anti-inflammatory diet rich in whole grains, fruits, vegetables, and seafood, while the other consumed a control diet heavy in meat and high-fat dairy products for ten weeks. After this period, participants switched diets, allowing researchers to monitor their compliance with the prescribed eating patterns.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
7
We investigated the link between omega-3 fatty acids and osteoarthritis using data from over 22,800 participants in the NHANES study between 2003 and 2016. The findings revealed that omega-3 intake was linked to lower rates of osteoarthritis in adults aged 40 to 59.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
References
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- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. doi:10.1017/S0007114524002721
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0
- Scherer D, Leite BF, Morimoto MA, Oliveira TL, Klemz BNC, et al. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. Adv Rheumatol. 2024;64:47. doi:10.1186/s42358-024-00389-5
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- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. doi:10.1007/s00394-024-03397-9
- Doucet MR, Laevski AM, Doiron JA, Boudreau LH, Surette ME. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLoS One. 2024;19:e0291399. doi:10.1371/journal.pone.0291399
- Xiong T, Huang S, Wang X, Shi Y, He J, et al. n-3 polyunsaturated fatty acids alleviate the progression of obesity-related osteoarthritis and protect cartilage through inhibiting the HMGB1-RAGE/TLR4 signaling pathway. Int Immunopharmacol. 2024;128:111498. doi:10.1016/j.intimp.2024.111498
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. doi:10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. doi:10.1016/j.biopha.2022.113608
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. doi:10.3390/nu14142947
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
- Jannas-Vela S, Candia AA, Peñailillo L, Barrios-Troncoso P, Zapata-Urzúa J, et al. Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial. F1000Res. 2023;12:942. doi:10.12688/f1000research.138392.1
- Deng C, Presle N, Pizard A, Guillaume C, Bianchi A, et al. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. Int J Mol Sci. 2024;25. doi:10.3390/ijms25031810
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. doi:10.26355/eurrev_202308_33310
- Wadell AT, Bärebring L, Hulander E, Gjertsson I, Landberg R, et al. Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial. Front Nutr. 2023;10:1209787. doi:10.3389/fnut.2023.1209787
- Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, et al. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023;28. doi:10.3390/molecules28020717
- Kuang X, Shao X, Li H, Jiang D, Gao T, et al. Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial. J Sci Food Agric. 2023;103:2970. doi:10.1002/jsfa.12346
- Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, et al. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021;19. doi:10.3390/md19100542
- Ceotto BH, Figueroba SR, Ferreira LEN, Amorim KS, Sánchez JB, et al. The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis. Ann Anat. 2022;239:151812. doi:10.1016/j.aanat.2021.151812
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. doi:10.3389/fimmu.2021.680073
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. doi:10.1093/jn/nxaa156
- Brown Z, Metcalf R, Bednarz J, Spargo L, Lee A, et al. Modifiable Lifestyle Factors Associated With Response to Treatment in Early Rheumatoid Arthritis. ACR Open Rheumatol. 2020;2:371. doi:10.1002/acr2.11132
- Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, et al. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38:2157. doi:10.1002/jor.24688
