We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.
Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.
Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
Read More
8
Omega-3s reduce headache frequency
Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial.
We conducted a randomized controlled trial to explore whether increasing omega-3 fatty acids would help reduce headaches in adults suffering from migraines.
Over 16 weeks, 182 participants followed three different dietary plans focusing on varying levels of omega-3s while monitoring headache impact.
Though the diets with higher omega-3 levels did show a reduction in headache frequency and severity, they didn't significantly improve overall quality of life. This suggests that omega-3s may help with headaches but not enhance daily functioning.
Read More
8
Omega-3 fish oil reduces headaches
Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol.
We explored the effects of a 12-week omega-3 fish oil supplement, Omega3Q10, among older adults dealing with high blood pressure and cholesterol. The study included 97 participants, who were split between the omega-3 group and a control group receiving soybean oil.
While both groups saw improvements in cholesterol levels, those taking Omega3Q10 experienced greater benefits in managing blood pressure and reported fewer headaches. An impressive 95.5% of omega-3 participants were headache-free after the trial, compared to just 71.4% in the soybean oil group.
This suggests that omega-3 fish oil may be a valuable addition for older adults looking to improve both heart health and reduce headache symptoms.
Read More
Most Useful Reviews
9
Energy boost
Good composition, quick delivery, high-quality packaging with no damage. The capsules are a bit large, but easy to swallow, and taste like citrus. I take one daily with meals alongside vitamin D3+K2 and magnesium. After 10 days, I’ve noticed benefits; my frequent headaches, nausea, and fatigue have ceased. I’m more energised and my mood is excellent. Perfect for those into sports or on a diet. Omega-3 truly revitalises the body!
Read More
9
Mood enhancement
Great! This is the best Omega-3 I've tried so far. I can feel the effects—I feel energised, have no headaches, and my appetite is good. I was prescribed this dosage for three months, then to reduce it to 1000mg daily.
Read More
7.5
Reduced headaches
5 people found this helpful
Wonderful! This is not the first time I've ordered this Omega-3; it's fantastic! I take one capsule daily as I have high cholesterol. Since starting this Omega, I've felt much better! My headaches have lessened, and my blood pressure is stable. I also give one to my 17-year-old son for prevention. They are easy to swallow despite their size, with no fishy aftertaste. I highly recommend this Omega-3!
We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.
Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.
Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
Read More
9
Omega-3 diet improves headaches
Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysis of a randomized trial.
We examined how adjusting omega-3 and omega-6 fatty acids influences chronic headaches and overall well-being. In a randomized trial with 67 participants suffering from severe headaches, those who increased omega-3 intake while decreasing omega-6 saw significant improvements in their headaches and reductions in psychological distress.
Over 12 weeks, participants in this dietary intervention reported better mental and physical health, which also helped decrease the number of headache days. Overall, this approach not only targets headache relief but also enhances quality of life.
Read More
9
Omega-3s reduce chronic headaches
Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial.
We conducted a study to understand how changes in the intake of omega-3 and omega-6 fatty acids, particularly eicosapentaenoic acid (EPA), can influence chronic headaches. By focusing on one group consuming a high level of omega-3 and low omega-6, while another group maintained a low omega-6 diet, we aimed to identify any significant improvements in headache symptoms over a 12-week period.
Our findings revealed notable advantages in the group that increased their omega-3 intake. This group reported greater reductions in headache days and hours, alongside improved overall quality of life. Specifically, the high omega-3 group showed a remarkable drop in their headache impact scores, suggesting that eicosapentaenoic acid may play a beneficial role in managing headache pain.
These results shed light on the potential of dietary adjustments in fatty acid intake as a proactive approach to treating chronic headaches. Eicosapentaenoic acid, thanks to its effects on pain relief pathways, seems to contribute positively to this outcome, affording patients a new avenue to explore in their headache management strategies.
Read More
8
Omega-3s reduce headache frequency
Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial.
We conducted a randomized controlled trial to explore whether increasing omega-3 fatty acids would help reduce headaches in adults suffering from migraines.
Over 16 weeks, 182 participants followed three different dietary plans focusing on varying levels of omega-3s while monitoring headache impact.
Though the diets with higher omega-3 levels did show a reduction in headache frequency and severity, they didn't significantly improve overall quality of life. This suggests that omega-3s may help with headaches but not enhance daily functioning.
Read More
8
Omega-3 fish oil reduces headaches
Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol.
We explored the effects of a 12-week omega-3 fish oil supplement, Omega3Q10, among older adults dealing with high blood pressure and cholesterol. The study included 97 participants, who were split between the omega-3 group and a control group receiving soybean oil.
While both groups saw improvements in cholesterol levels, those taking Omega3Q10 experienced greater benefits in managing blood pressure and reported fewer headaches. An impressive 95.5% of omega-3 participants were headache-free after the trial, compared to just 71.4% in the soybean oil group.
This suggests that omega-3 fish oil may be a valuable addition for older adults looking to improve both heart health and reduce headache symptoms.
Good composition, quick delivery, high-quality packaging with no damage. The capsules are a bit large, but easy to swallow, and taste like citrus. I take one daily with meals alongside vitamin D3+K2 and magnesium. After 10 days, I’ve noticed benefits; my frequent headaches, nausea, and fatigue have ceased. I’m more energised and my mood is excellent. Perfect for those into sports or on a diet. Omega-3 truly revitalises the body!
Read More
9
Mood enhancement
Great! This is the best Omega-3 I've tried so far. I can feel the effects—I feel energised, have no headaches, and my appetite is good. I was prescribed this dosage for three months, then to reduce it to 1000mg daily.
Read More
7.5
Reduced headaches
5 people found this helpful
Wonderful! This is not the first time I've ordered this Omega-3; it's fantastic! I take one capsule daily as I have high cholesterol. Since starting this Omega, I've felt much better! My headaches have lessened, and my blood pressure is stable. I also give one to my 17-year-old son for prevention. They are easy to swallow despite their size, with no fishy aftertaste. I highly recommend this Omega-3!
Read More
7.5
Skin improvement
Pure oil from South Pacific anchovies. I frequently order Omega-3 as it alleviates my headaches and improves my skin's smoothness and hydration. Additionally, it supports heart, eye, and joint health.
Read More
7.5
Pain relief
For many years, I've struggled with musculoskeletal issues, but after starting Fitoliton extract, I’ve experienced great relief. Although I had some pain initially as the stone passed, now my heart no longer hurts, my sleep has improved, and my headaches have disappeared. It’s wonderful that such beneficial products exist with a pleasant taste!
A headache is a common condition characterized by pain or discomfort in the head, scalp, or neck. It can vary in intensity, frequency, and duration, and is often classified into two primary categories: primary and secondary headaches. Primary headaches, such as tension-type headaches, migraines, and cluster headaches, are not caused by other medical conditions. Instead, they are conditions in themselves, often resulting from factors like stress, hormonal changes, or environmental triggers. Secondary headaches, on the other hand, are symptoms of an underlying issue, such as an infection, injury, or other medical conditions.
The experience of a headache can differ widely among individuals. Depending on the type, headaches can be throbbing or constant and may be accompanied by other symptoms like nausea, sensitivity to light, or aura effects before the headache strikes. Effective management strategies vary by headache type and may include over-the-counter pain relievers, lifestyle changes, and in some cases, prescription medications. Understanding the specific triggers and patterns related to your headaches can be crucial for prevention and treatment, so maintaining a headache diary may be beneficial for those experiencing frequent or severe episodes.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Research suggests that Omega-3 fish oil may have potential benefits for reducing certain types of headaches, particularly migraines. Omega-3 fatty acids, found in fish oil, are known for their anti-inflammatory properties, which can play a role in alleviating headache symptoms. A few studies indicate that individuals who consume higher amounts of Omega-3s tend to experience fewer and less severe headaches compared to those with lower intake. However, it's essential to note that while Omega-3 fish oil can be beneficial for overall health, its effectiveness as a treatment for headaches can vary significantly from person to person.
Before incorporating Omega-3 fish oil into your regimen specifically for headaches, it’s advisable to consult with a healthcare professional. They can provide personalized recommendations based on your medical history and the characteristics of your headaches. Additionally, it's crucial to consider that while Omega-3s can be a helpful supplement, they should not replace prescribed medications or treatments for headache management. As with any supplement, moderation and proper dosage are key—overconsumption can lead to side effects. Ultimately, a comprehensive approach that includes lifestyle changes, stress management, and dietary adjustments may yield the best results.
Based on user reviews, most individuals report experiencing noticeable improvements in their headaches after taking the Omega-3 supplement for about 10 days. One user specifically noted that their frequent headaches, nausea, and fatigue ceased, and they felt more energized within this time frame Read Review. Another reviewer mentioned a significant reduction in headaches and overall better well-being after starting the supplement Read Review.
Users also express a sense of immediate benefit, with some stating that they feel energized and do not experience headaches after beginning the supplement regimen. For instance, one user shared that they felt energised and had no headaches right after starting their Omega-3 routine Read Review. Overall, if you're considering Omega-3 for headache relief, it seems that a period of around 10 days is a reasonable timeframe to start expecting positive results.
The scientific research increasingly supports the effectiveness of fish oil, particularly its active component eicosapentaenoic acid (EPA), in alleviating headache symptoms, notably migraines. A study showed that participants ingesting 2000 mg of EPA daily reported significant reductions in migraine frequency and severity over eight weeks [2]. Additional trials indicated that high doses of EPA not only decreased headache days but also led to improvements in quality of life, particularly among women [3]. Moreover, dietary modifications to increase omega-3 intake appear to correlate with reduced headache intensity and frequency, with some studies suggesting substantial benefits from integrating fish oil or omega-3-rich diets into treatment plans [17].
While not all studies yield consistent results, the overall trend indicates that omega-3 fatty acids can play a preventive role in headache management, particularly for chronic migraines. For instance, participants in a trial who adjusted their diets to prioritize omega-3 over omega-6 showed marked improvements in their headaches and overall well-being [19]. These findings suggest that incorporating omega-3 fatty acids, particularly EPA, could be a promising strategy for those seeking relief from persistent headache conditions.
Users report a variety of improvements in symptoms after taking Omega-3 supplements, particularly regarding headaches and overall well-being. Many reviewers experienced significant reductions in headache frequency and intensity. For example, one user noticed that their frequent headaches, nausea, and fatigue ceased after about 10 days of daily intake, leading to increased energy levels and an improved mood Read Review. Another reviewer echoed these sentiments, sharing that they have had no headaches since starting the Omega-3, which contributed to feeling more energized and maintaining a healthy appetite Read Review.
Additional anecdotal experiences highlight enhanced well-being beyond headache relief. Users also noted improved skin hydration and smoothness, as well as benefits such as stable blood pressure and lower cholesterol levels Read Review. Overall, while individual results may vary, the consensus among users is that Omega-3 provides noticeable benefits in health, especially concerning headaches.
Users report positive experiences when combining Omega-3 supplements with other dietary supplements for headache relief. One user noted significant improvements in their headaches, nausea, and fatigue after taking Omega-3 alongside vitamin D3+K2 and magnesium, leading to increased energy and an excellent mood within just 10 days Read Review. Another reviewer echoed these findings, indicating that the combination of Omega-3 and vitamins was effective, as they experienced no headaches and felt energized after starting their routine Read Review.
Additionally, a user shared their success in combining Omega-3 with vitamin D3, which also led to a decrease in headache frequency and an overall improvement in well-being Read Review. This suggests that blending Omega-3 with other vitamins may enhance the overall benefits, particularly for those seeking relief from headaches while supporting general health. Overall, user feedback appears to support the notion that combining Omega-3 with other supplements can lead to compounded health benefits, especially in managing headache symptoms.
Recent research suggests that eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, may be effective in reducing the frequency and severity of migraines and headaches. A notable study found that participants taking a daily dose of 2000 mg of EPA experienced significant reductions in migraine attacks, indicating its potential as a valuable option for chronic migraine management [2]. Another trial involving a higher dose of EPA—specifically 2 grams daily—showed similar results, with participants reporting about 4.4 fewer migraine days per month compared to the placebo group [3].
In terms of dietary adjustments, increasing omega-3 fatty acids like EPA and docosahexaenoic acid (DHA) while reducing omega-6 fatty acids can enhance the benefits. This approach was successful in several studies, which highlighted that higher omega-3 levels correlate with decreases in migraine intensity and frequency [18]. Although more extensive and focused studies are necessary for a deeper understanding, current findings recommend a daily intake of up to 2000 mg of EPA for potential migraine relief and management [14].
9
Energy boost
Good composition, quick delivery, high-quality packaging with no damage. The capsules are a bit large, but easy to swallow, and taste like citrus. I take one daily with meals alongside vitamin D3+K2 and magnesium. After 10 days, I’ve noticed benefits; my frequent headaches, nausea, and fatigue have ceased. I’m more energised and my mood is excellent. Perfect for those into sports or on a diet. Omega-3 truly revitalises the body!
7.5
Reduced headaches
5 people found this helpful
Wonderful! This is not the first time I've ordered this Omega-3; it's fantastic! I take one capsule daily as I have high cholesterol. Since starting this Omega, I've felt much better! My headaches have lessened, and my blood pressure is stable. I also give one to my 17-year-old son for prevention. They are easy to swallow despite their size, with no fishy aftertaste. I highly recommend this Omega-3!
9
Mood enhancement
Great! This is the best Omega-3 I've tried so far. I can feel the effects—I feel energised, have no headaches, and my appetite is good. I was prescribed this dosage for three months, then to reduce it to 1000mg daily.
7.5
Effective relief
I really liked this Omega-3. I had headaches previously, but now it's brilliant! I also take vitamin D3, and I'm very pleased with the results. Thank you very much!
7
EPA supplementation may reduce migraines
Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial.
We conducted a randomized, placebo-controlled trial to explore the effects of daily 2000 mg of eicosapentaenoic acid (EPA) on chronic migraines. Over 8 weeks, participants recorded their headache symptoms, with some taking EPA and others receiving a placebo.
Our findings suggest that EPA may significantly reduce the frequency of migraine attacks and improve overall quality of life for chronic migraine sufferers. However, we believe that more research is needed for a clearer understanding of its benefits and dosage.
9.5
EPA shows promise for migraine relief
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.
Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.
Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.
8
Eicosapentaenoic acid reduces migraine
The relationship between different fatty acids intake and frequency of migraine attacks.
We aimed to understand how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, may influence the frequency of migraine attacks among individuals suffering from this debilitating condition. In our study, we assessed 105 migraine patients aged between 15 and 50 years. Participants provided information about their typical dietary habits through a food frequency questionnaire, and we recorded the number of migraine attacks they experienced over a month.
Our findings were enlightening; we observed that lower intake of EPA was linked to a higher frequency of migraine attacks. Specifically, the analysis revealed that as EPA consumption decreased, the number of migraine incidents increased significantly, with a beta value of -335.07 and a P-value of 0.006. Additionally, similar patterns were noted for docosahexaenoic acid (DHA), another omega-3 fatty acid, which showed a beta value of -142.51 and a P-value of 0.001.
However, we found no significant connection between saturated fatty acid intake and migraine frequency, suggesting that not all fats play a role in this context. This research indicates a compelling relationship between omega-3 intake and migraine occurrences, urging us to consider dietary adjustments as a potential strategy for managing this condition.
Further studies could build on these findings to deepen our understanding of dietary influences on migraine and explore how specific nutrients like EPA might serve as effective components in treatment plans.
9
Omega-3s reduce chronic headaches
Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial.
We conducted a study to understand how changes in the intake of omega-3 and omega-6 fatty acids, particularly eicosapentaenoic acid (EPA), can influence chronic headaches. By focusing on one group consuming a high level of omega-3 and low omega-6, while another group maintained a low omega-6 diet, we aimed to identify any significant improvements in headache symptoms over a 12-week period.
Our findings revealed notable advantages in the group that increased their omega-3 intake. This group reported greater reductions in headache days and hours, alongside improved overall quality of life. Specifically, the high omega-3 group showed a remarkable drop in their headache impact scores, suggesting that eicosapentaenoic acid may play a beneficial role in managing headache pain.
These results shed light on the potential of dietary adjustments in fatty acid intake as a proactive approach to treating chronic headaches. Eicosapentaenoic acid, thanks to its effects on pain relief pathways, seems to contribute positively to this outcome, affording patients a new avenue to explore in their headache management strategies.
7
Dietary omega-3s study results
Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools.
We set out to understand how changes in dietary fatty acids could influence headache symptoms, particularly focusing on eicosapentaenoic acid (EPA). In a 12-week study, individuals suffering from chronic headaches followed specific diets: one group reduced their omega-6 fatty acids while maintaining an average intake of omega-3s, and another group increased their omega-3 intake alongside lowering omega-6.
Our results were revealing. Reducing omega-6 fatty acids, such as linoleic acid, led to a notable increase in omega-3 levels, particularly EPA and docosahexaenoic acid (DHA), in the participants' plasma. Interestingly, while dietary changes improved omega-3 availability in the body, they did not significantly affect arachidonic acid (AA) levels, a key omega-6 fatty acid linked to inflammation.
In the group that bumped up their omega-3 intake significantly, there was an even more pronounced increase in the levels of these beneficial fatty acids. However, we did not find evidence suggesting that these changes led to a direct reduction in headache frequency or severity. This indicates that while eicosapentaenoic acid and other omega-3s may enhance bioavailability when omega-6s are lowered, they did not expressly alleviate headaches during the study period.
8
Omega-3 reduces migraine frequency
A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline.
We explored the effectiveness of omega-3 fatty acids in preventing chronic migraine attacks through a well-structured double-blind study. Sixty patients diagnosed with chronic migraines were split into two groups: one received omega-3 alongside amitriptyline, while the other got a placebo.
After 60 days, we observed that 66.7% of the omega-3 group reported more than an 80% reduction in headache days, compared to only 33.3% in the control group. This shows promise for omega-3 as a migraine preventive, though further study is needed to solidify these findings.
References
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Mohammadnezhad G, Assarzadegan F, Koosha M, Esmaily H. Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial. Headache. 2025;65:153. 10.1111/head.14808
Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. 10.1016/j.bbi.2024.03.019
Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. 10.1016/j.jpain.2022.10.008
Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. 10.1016/j.cct.2022.106851
Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. 10.1136/bmj.n1448
Honarvar NM, Soveid N, Abdolahi M, Djalali M, Hatami M, et al. Anti-Neuroinflammatory Properties of n-3 Fatty Acids and Nano- Curcumin on Migraine Patients from Cellular to Clinical Insight: A Randomized, Double-Blind and Placebo-Controlled Trial. Endocr Metab Immune Disord Drug Targets. 2021;21:365. 10.2174/1871530320666200729144430
Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, et al. The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Endocr Metab Immune Disord Drug Targets. 2019;19:874. 10.2174/1871530319666190212170140
Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. 10.1016/j.plefa.2018.06.008
Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. 10.1016/j.plefa.2017.11.002
Shen T, Xing G, Zhu J, Zhang S, Cai Y, et al. Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol. Lipids Health Dis. 2017;16:253. 10.1186/s12944-017-0617-0
Soveyd N, Abdolahi M, Djalali M, Hatami M, Tafakhori A, et al. The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients. CNS Neurol Disord Drug Targets. 2018;16:1120. 10.2174/1871527317666171213154749
Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, et al. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017;69:371. 10.1007/s00251-017-0992-8
Soares AA, Louçana PMC, Nasi EP, Sousa KMH, Sá OMS, et al. A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline. Nutr Neurosci. 2018;21:219. 10.1080/1028415X.2016.1266133
Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. 10.1016/j.jpain.2015.04.007
Ramsden CE, Faurot KR, Zamora D, Palsson OS, MacIntosh BA, et al. Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysis of a randomized trial. Pain. 2015;156:587. 10.1097/01.j.pain.0000460348.84965.47
Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
Taha AY, Cheon Y, Faurot KF, Macintosh B, Majchrzak-Hong SF, et al. Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins Leukot Essent Fatty Acids. 2014;90:151. 10.1016/j.plefa.2014.02.003
Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. 10.1016/j.pain.2013.07.028