Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.2
USERS' SCORE
Good
Based on 20 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg

Top Medical Research Studies

9
Selenium nanoparticles reduce allergies
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
We explored how perinatal administration of Saccharomyces cerevisiae UFMG A-905 could help prevent asthma in mouse offspring. This study involved various groups of mice receiving the yeast at different stages: before conception, during pregnancy, or only during lactation.

Our results showed that those exposed to S. cerevisiae exhibited significantly less airway hyperresponsiveness and lower levels of certain inflammatory markers compared to those that didn’t receive the treatment. Notably, the greatest protection occurred when the yeast was given during lactation.

Overall, it seems that S. cerevisiae UFMG A-905 shows promise in the management of asthma, especially when administered early in the offspring's development.
Read More
9
Selenium polysaccharides reduce allergies
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.

Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.

Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More

Most Useful Reviews

9
Effective breathing aid
96 people found this helpful
This helps with colds, allergies, sinus infections, and bronchitis, allowing me to breathe without side effects. Introduced to acetylcysteine during a bout of bronchitis, I was able to breathe more easily with no adverse effects from usual medications. Now, I can easily handle fall allergies and sinus issues as well, without needing Sudafed or Claritin. I take 2 a day as the maximum dose. It's incredibly beneficial and crucial for my body.
Read More
9
Child's improvement
2 people found this helpful
It’s very effective; my child’s nose allergy has improved considerably, and he no longer coughs. The benefits include fighting free radicals and anti-oxidation, despite the slightly unpleasant smell.
Read More
9
Relieves sinus pressure
2 people found this helpful
Incredible for sinus pressure and allergies. I'm amazed I'm off Claritin this Spring. I take it every other day; the instant I feel sinus pressure, one dose works like a miracle.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.2
  • All Researches
We explored how perinatal administration of Saccharomyces cerevisiae UFMG A-905 could help prevent asthma in mouse offspring. This study involved various groups of mice receiving the yeast at different stages: before conception, during pregnancy, or only during lactation.

Our results showed that those exposed to S. cerevisiae exhibited significantly less airway hyperresponsiveness and lower levels of certain inflammatory markers compared to those that didn’t receive the treatment. Notably, the greatest protection occurred when the yeast was given during lactation.

Overall, it seems that S. cerevisiae UFMG A-905 shows promise in the management of asthma, especially when administered early in the offspring's development.
Read More
9
Selenium polysaccharides reduce allergies
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.

Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.

Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More
9
Selenium nanoparticles reduce allergies
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
9
Selenium influences milk allergy response
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.

After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.

This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
Read More
9
Selenium compound reduces allergy symptoms
We explored how a novel water-soluble selenium compound, known as SeTal, impacts atopic dermatitis (AD), a common allergic skin condition. In experiments, we applied 2,4-dinitrochlorobenzene (DNCB) to sensitized mice, creating a model for AD symptoms. By treating these mice with either SeTal or hydrocortisone, we aimed to measure the severity of skin lesions and related inflammation.

The results were compelling. SeTal, at concentrations of 1% and 2%, showed significant effectiveness in reducing the symptoms and inflammatory indicators of AD. In fact, the results were comparable to, and in some cases, even better than the results achieved with hydrocortisone, a traditional steroid treatment often used for such conditions.

This study suggests that SeTal could offer a promising alternative for treating atopic dermatitis, providing a new avenue for those seeking relief from this chronic and often bothersome allergy-related skin issue. With common steroid treatments posing potential side effects, our findings around SeTal support exploring safer, more effective options in the future.
Read More

User Reviews

USERS' SCORE
Good
Based on 20 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective breathing aid
96 people found this helpful
This helps with colds, allergies, sinus infections, and bronchitis, allowing me to breathe without side effects. Introduced to acetylcysteine during a bout of bronchitis, I was able to breathe more easily with no adverse effects from usual medications. Now, I can easily handle fall allergies and sinus issues as well, without needing Sudafed or Claritin. I take 2 a day as the maximum dose. It's incredibly beneficial and crucial for my body.
Read More
9
Child's improvement
2 people found this helpful
It’s very effective; my child’s nose allergy has improved considerably, and he no longer coughs. The benefits include fighting free radicals and anti-oxidation, despite the slightly unpleasant smell.
Read More
9
Relieves sinus pressure
2 people found this helpful
Incredible for sinus pressure and allergies. I'm amazed I'm off Claritin this Spring. I take it every other day; the instant I feel sinus pressure, one dose works like a miracle.
Read More
10
Miracle product
1 people found this helpful
It perfectly cleanses the body! The results are phenomenal as my liver normalised and the allergy vanished, along with improved skin condition. Truly a miracle!
Read More
9
Immunity boost
1 people found this helpful
A great product from a reputable brand. I use it daily to boost my immune system, and it seems effective, as I rarely get sick or experience respiratory issues with allergies now.
Read More

Frequently Asked Questions

4
No approval worries
1 people found this helpful
I aim to give an honest review. Taking one pill with breakfast for only five days noticeably improved my allergies, yet I experienced muscle tremors. Concerned due to no approval from the American Drug Administration, I discontinued use.
7.5
Enhanced breathing
1 people found this helpful
After several months with this supplement, I find it beneficial in numerous ways. My allergies have lessened, and my breathing has improved. The quality of the ingredients reassures me of my continued purchase.
9
Minimal improvement noted
After using one bottle, I noticed no significant improvement in my allergies.
9
Child's improvement
2 people found this helpful
It’s very effective; my child’s nose allergy has improved considerably, and he no longer coughs. The benefits include fighting free radicals and anti-oxidation, despite the slightly unpleasant smell.
7.5
Improved respiratory health
Marvellous! One significant benefit I've experienced is improved respiratory health. NAC thins mucus and aids the body's ability to clear it, which is especially beneficial during allergy seasons or when congested. My energy levels remain stable, enhancing my overall mental well-being.
9
Healthy nose
1 people found this helpful
I often experience nose allergies and thick mucus, but taking this product has completely restored my nasal health.
9
Highly recommended
Great! I purchased it for the second time; my doctor recommended it for detox. It works wonders and cleanses the liver while alleviating my allergy symptoms.
9
Immunity boost
1 people found this helpful
A great product from a reputable brand. I use it daily to boost my immune system, and it seems effective, as I rarely get sick or experience respiratory issues with allergies now.
7.5
Reduced antihistamine use
1 people found this helpful
Since the onset of Covid, my husband and I have taken one capsule daily for prophylaxis throughout spring and summer. With my seasonal allergies, I noticed I hardly need antihistamines anymore; I believe Nak has genuinely assisted me.
8
Prenatal selenium reduces allergy risk
We delved into the connections between prenatal exposure to certain metals—specifically, selenium, mercury, and manganese—and the risk of allergic diseases during early childhood. Using data from 94,794 mother-infant pairs from the Japan Environment and Children's study, we analyzed maternal blood samples taken during mid-pregnancy to assess levels of these metallic elements.

Our findings point to a promising role for selenium: it appears to be linked with a reduced risk of atopic dermatitis, food allergies, allergic rhinitis, and overall allergic diseases in children by their third birthday. Notably, this beneficial effect seems even more pronounced when mercury exposure during pregnancy is lower.

While we also explored the interaction between selenium and mercury, the highlights of our results firmly place selenium in a positive light regarding its potential to mitigate allergy risks in early childhood.
9
Selenium nanoparticles reduce allergies
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
9
Selenium influences milk allergy response
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.

After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.

This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
9
Selenium polysaccharides reduce allergies
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.

Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.

Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.

References

  1. Sandy CM, Guimarães CC, Fonseca VMB, Nicoli JR, Martins FS, et al. Perinatal administration of Saccharomyces cerevisiae UFMG A-905 prevents asthma development in the offspring of mice. Benef Microbes. 2024;16:125. 10.1163/18762891-bja00044
  2. Singh RG, Garcia-Campayo V, Green JB, Paton N, Saunders JD, et al. Efficacy of a yeast postbiotic on cold/flu symptoms in healthy children: A randomized-controlled trial. Pediatr Res. 2024;96:1739. 10.1038/s41390-024-03331-z
  3. Calazans APCT, Milani TMS, Prata AS, Clerici MTPS, Nicoli JR, et al. A Functional Bread Fermented with UFMG A-905 Prevents Allergic Asthma in Mice. Curr Dev Nutr. 2024;8:102142. 10.1016/j.cdnut.2024.102142
  4. Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
  5. Ma J, Zhao M, Wang Y, Lv L, Qin L, et al. Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation. Int J Biol Macromol. 2024;269:132128. 10.1016/j.ijbiomac.2024.132128
  6. Miyazaki J, Ikehara S, Tanigawa K, Kimura T, Ueda K, et al. Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study. Environ Int. 2023;179:108123. 10.1016/j.envint.2023.108123
  7. Xie B, Zeng D, Yang M, Tang Z, He L, et al. Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins. ACS Nano. 2023;17:14053. 10.1021/acsnano.3c04344
  8. Zhao X, Thijssen S, Chen H, Garssen J, Knippels LMJ, et al. Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy. Nutrients. 2021;13. 10.3390/nu13082479
  9. Voss GT, de Oliveira RL, Davies MJ, Domingues WB, Campos VF, et al. Suppressive effect of 1,4-anhydro-4-seleno-D-talitol (SeTal) on atopic dermatitis-like skin lesions in mice through regulation of inflammatory mediators. J Trace Elem Med Biol. 2021;67:126795. 10.1016/j.jtemb.2021.126795
  10. Dubrovina VI, Starovoitova TP, Yur'eva OV, Pyatidesyatnikova AB, Potapov VA, et al. Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV. Bull Exp Biol Med. 2021;171:651. 10.1007/s10517-021-05287-0
  11. Groth S, Budke C, Weber T, Neugart S, Brockmann S, et al. Relationship between Phenolic Compounds, Antioxidant Properties, and the Allergenic Protein Mal d 1 in Different Selenium-Biofortified Apple Cultivars (). Molecules. 2021;26. 10.3390/molecules26092647
  12. Lodge CJ, Dharmage SC. Breastfeeding and perinatal exposure, and the risk of asthma and allergies. Curr Opin Allergy Clin Immunol. 2016;16:231. 10.1097/ACI.0000000000000266
  13. Qin S, Huang B, Ma J, Wang X, Zhang J, et al. Effects of selenium-chitosan on blood selenium concentration, antioxidation status, and cellular and humoral immunity in mice. Biol Trace Elem Res. 2015;165:145. 10.1007/s12011-015-0243-5
  14. Arakawa T, Deguchi T, Sakazaki F, Ogino H, Okuno T, et al. Supplementary seleno-L-methionine suppresses active cutaneous anaphylaxis reaction. Biol Pharm Bull. 2013;36:1969.
  15. Carneiro MF, Rhoden CR, Amantéa SL, Barbosa F. Low concentrations of selenium and zinc in nails are associated with childhood asthma. Biol Trace Elem Res. 2011;144:244. 10.1007/s12011-011-9080-3
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