5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 37 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9
Selenium nanoparticles combat bacteria
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
Read More
Most Useful Reviews
9
Reduces bacterial symptoms
7 people found this helpful
Great ACC Long helps remove sputum during colds. It's more affordable than pharmacy prices, and with 600 mg per capsule, one daily suffices. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, aiding sputum discharge and breaking disulfide bonds in mucoproteins. Its antioxidant properties neutralise harmful oxidising radicals, protecting against free radical damage typical in inflammatory reactions. This is particularly beneficial for acute respiratory infections with a high fever. It also reduces bacterial exacerbations in chronic conditions like bronchitis and cystic fibrosis.
Read More
9
Improves lung recovery
3 people found this helpful
After contracting COVID in January, I took NAC daily alongside other medications. My lung damage was minor, and studies indicate that NAC can significantly control moderate COVID-associated pneumonia, improving blood oxygen levels and reducing hospital stays for those on NAC. I continue to take it for its benefits, including lowering homocysteine, which helps prevent blood clots and vascular damage. NAC is also effective against paracetamol overdoses.
Read More
9
Disrupts bacterial biofilm
3 people found this helpful
Studies show that over 80% of human bacterial infections relate to biofilm, and simple antibiotics often fail. Removing biofilm is vital for effective treatment. N-acetylcysteine (NAC) has shown efficacy in inhibiting biofilm formation and enhancing the effectiveness of antibiotics. It increases glutathione levels to flush toxins and protect the kidneys while supporting the respiratory system.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9.5
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9.5
We delved into how selenium nanoparticles (SeNPs) can raise our body's defenses against bacterial infections, specifically Mycobacterium bovis, which causes tuberculosis. The study focused on combining SeNPs with an antigen called AH (Ag85A-HspX) to see if this partnership could improve respiratory mucosal immunity and enhance protection against this serious illness.
In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.
Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.
Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
Read More
9.5
We explored how selenium-tellurium doped copper oxide nanoparticles (SeTe-CuO NPs) can effectively tackle bacterial infections and improve wound healing. This innovative study focused on the nanoparticles’ dual photodynamic and photothermal properties, which become activated under near-infrared (NIR) light.
In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.
We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.
We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
Read More
9
We explored how combining selenium-tellurium nanoparticles with zinc oxide can help tackle bacterial infections, especially those stubborn biofilms. The goal was to create a hybrid nanoparticle that could leverage both photodynamic and photothermal properties to effectively disrupt bacterial growth.
In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.
Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.
Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 37 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces bacterial symptoms
7 people found this helpful
Great ACC Long helps remove sputum during colds. It's more affordable than pharmacy prices, and with 600 mg per capsule, one daily suffices. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, aiding sputum discharge and breaking disulfide bonds in mucoproteins. Its antioxidant properties neutralise harmful oxidising radicals, protecting against free radical damage typical in inflammatory reactions. This is particularly beneficial for acute respiratory infections with a high fever. It also reduces bacterial exacerbations in chronic conditions like bronchitis and cystic fibrosis.
Read More
9
Improves lung recovery
3 people found this helpful
After contracting COVID in January, I took NAC daily alongside other medications. My lung damage was minor, and studies indicate that NAC can significantly control moderate COVID-associated pneumonia, improving blood oxygen levels and reducing hospital stays for those on NAC. I continue to take it for its benefits, including lowering homocysteine, which helps prevent blood clots and vascular damage. NAC is also effective against paracetamol overdoses.
Read More
9
Disrupts bacterial biofilm
3 people found this helpful
Studies show that over 80% of human bacterial infections relate to biofilm, and simple antibiotics often fail. Removing biofilm is vital for effective treatment. N-acetylcysteine (NAC) has shown efficacy in inhibiting biofilm formation and enhancing the effectiveness of antibiotics. It increases glutathione levels to flush toxins and protect the kidneys while supporting the respiratory system.
Read More
9
Prevents lung infection
1 people found this helpful
Irreplaceable. With a viral infection, it prevents progression to the lungs. It performed well, and the cough disappears before it begins.
Read More
7.5
Prevents throat infections
1 people found this helpful
This product is fantastic. I take two capsules daily and haven't experienced a throat infection since I started NAC.
Read More
Frequently Asked Questions
9
Increases energy post-illness
Very good! I took it after an acute respiratory infection. I had phlegm, but after a few days on this, the phlegm cleared up, and I felt cheerful and energetic again.
7.5
Alleviates cystitis symptoms
3 people found this helpful
Taking NAC significantly supports my immune system and helps reduce the risk of infections, including bacterial ones. It has improved my women's health, with symptoms related to cystitis easing after just a week. The quality of this brand is excellent, with a two-month supply.
9
Prevents lung infection
1 people found this helpful
Irreplaceable. With a viral infection, it prevents progression to the lungs. It performed well, and the cough disappears before it begins.
9
Aids antibiotic treatment
It's vital to take during bacterial infections and when using antibiotics, as it helps eliminate bacterial biofilms.
10
Cured cough
Excellent! My family used it during the Covid-19 infection, and our cough was completely cured, with no lingering effects.
9
Destroys bacterial biofilms
N-acetylcysteine is effective in destroying bacterial biofilms in the bladder, a primary cause of chronic cystitis. It is an excellent supplement of good quality with a convenient capsule size.
9
Prevents colds
I can't definitively prove this supplement's efficacy, but since taking NAC, I've stopped catching colds. I believe it's thanks to NAC, as my infection prevention measures haven't changed.
9
Boosts energy post-infection
I take it as a detox following a coronavirus infection. My strength has noticeably increased, without a doubt.
7.5
Supports infection recovery
I began taking this amino acid, which is crucial for health, during Covid at a dosage of 600 mg daily. In combination with other antioxidants (quercetin, taurine), it helped alleviate the bacterial infection. NAC resolves many health issues; it is a potent antioxidant and aids in lung and liver ailments, enhancing brain function. Acetylcysteine, paired with selenium and molybdenum, supports optimal glutathione production, the body's main defence against infections and inflammation. Convenient small capsules are easily consumed, with a daily dosage of one capsule. It’s a high-quality product, frequently available on sale.
9
Disrupts bacterial biofilm
3 people found this helpful
Studies show that over 80% of human bacterial infections relate to biofilm, and simple antibiotics often fail. Removing biofilm is vital for effective treatment. N-acetylcysteine (NAC) has shown efficacy in inhibiting biofilm formation and enhancing the effectiveness of antibiotics. It increases glutathione levels to flush toxins and protect the kidneys while supporting the respiratory system.
7.5
Supports lung function
Keeping NAC in the first aid kit is essential today. Research suggests NAC may help with COVID-19 by increasing glutathione levels, fighting oxidative stress caused by cytokine storms. It also aids in breaking down blood clots and loosening thick mucus in the lungs, addressing issues like pneumonia and ARDS. Moreover, NAC inhibits influenza replication and can enhance T-cell responses, potentially improving outcomes in COVID-19 infections.
7.5
Supports immune system
Great! NAC protects the liver from the effects of alcohol and drugs and helps normalise blood pressure and reduce cholesterol levels. It aids in removing phlegm during prolonged coughs. Additionally, NAC supports the immune system and mitigates the risk of infections—bacterial, viral, or fungal—thereby enhancing the body's resistance. N-acetylcysteine also assists in combating existing infections within the body. The quality of the supplement is excellent, with a good dosage, and the large packaging is sufficient for a course for two adult family members. The composition is clean.
9
Reduces bacterial symptoms
7 people found this helpful
Great ACC Long helps remove sputum during colds. It's more affordable than pharmacy prices, and with 600 mg per capsule, one daily suffices. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, aiding sputum discharge and breaking disulfide bonds in mucoproteins. Its antioxidant properties neutralise harmful oxidising radicals, protecting against free radical damage typical in inflammatory reactions. This is particularly beneficial for acute respiratory infections with a high fever. It also reduces bacterial exacerbations in chronic conditions like bronchitis and cystic fibrosis.
7.5
Speeds up recovery
This NAC remedy from Doctor's Best has an expectorant effect and loosens phlegm. It aided me in managing mucus in the nasopharynx, and as an antioxidant, it is impressive. I found it especially helpful for lung detoxification. The recommended dosage is 500mg twice daily. It appears to assist with feelings of impending illness and speeds recovery from sickness, especially with a viral infection. I'll be taking it again for the autumn-winter season and highly recommend it.
9
Selenium nanoparticles combat bacteria
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
9.5
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
9
Selenium’s role in antibacterial therapies
We explored the effectiveness of hybrid nanoparticles that incorporate selenium, created from Carica papaya extract, along with chitosan or trimethyl chitosan, to combat multidrug-resistant bacterial infections. This study highlights the potential of these nanoparticles to enhance antibacterial properties, targeting common clinical strains like E. coli, S. aureus, and K. pneumoniae.
Our findings revealed that the trimethyl chitosan hybrid nanoparticles (TMC/SeHNPs) significantly outperformed other formulations. We observed impressive antibacterial activity with minimum inhibition concentrations as low as 3.9 µg/mL against S. aureus and K. pneumoniae, along with robust activity against biofilm formation.
Notably, the TMC/SeHNPs also exhibited excellent antioxidant abilities and showed good biocompatibility with human cells, indicating their promising application in nanomedicine. This research underlines the potential of selenium-based therapies in addressing the pressing challenge of antibiotic resistance, providing hope for new treatments against stubborn infections.
Our findings revealed that the trimethyl chitosan hybrid nanoparticles (TMC/SeHNPs) significantly outperformed other formulations. We observed impressive antibacterial activity with minimum inhibition concentrations as low as 3.9 µg/mL against S. aureus and K. pneumoniae, along with robust activity against biofilm formation.
Notably, the TMC/SeHNPs also exhibited excellent antioxidant abilities and showed good biocompatibility with human cells, indicating their promising application in nanomedicine. This research underlines the potential of selenium-based therapies in addressing the pressing challenge of antibiotic resistance, providing hope for new treatments against stubborn infections.
References
- Iwata H, Ikeda A, Itoh M, Ketema RM, Tamura N, et al. Association between prenatal exposure to maternal metal and trace elements and Streptococcus infection: A prospective birth cohort in the Japan Environment and Children's Study. PLoS One. 2025;20:e0319356. 10.1371/journal.pone.0319356
- Wang Y, Khan SS, Ullah I, Rady A, Aldahmash B, et al. One pot synthesis of SeTe-ZnO nanoparticles for antibacterial and wound healing applications. RSC Adv. 2025;15:3439. 10.1039/d4ra06594h
- Perfileva AI, Zakharova OV, Graskova IA, Krutovsky KV. Effect of Selenium, Copper and Manganese Nanocomposites in Arabinogalactan Matrix on Potato Colonization by Phytopathogens and . Plants (Basel). 2024;13. 10.3390/plants13243496
- Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, et al. Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways. Vet Sci. 2024;11. 10.3390/vetsci11120674
- Thamayandhi C, El-Tayeb MA, Syed SR, Sivaramakrishnan R, Gunasekar B. Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis. Microb Pathog. 2024;196:106998. 10.1016/j.micpath.2024.106998
- Tran P, Abidi N, Bergfeld N, Shashtri M, Reid TW. Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds. Mil Med. 2024;189:179. 10.1093/milmed/usae069
- Wang Y, Feng L, Jiang WD, Wu P, Liu Y, et al. The effect of selenium on the intestinal health of juvenile grass carp based on the ERS-autophagy pathway. Fish Shellfish Immunol. 2024;153:109808. 10.1016/j.fsi.2024.109808
- Canbaz FA, Yurtçu M, Oltulu P, Taştekin G, Kocabaş R, et al. Investigation of the Effects of N-acetylcysteine and Selenium on Vesicoureteral Reflux Nephropathy: An Experimental Study. J Pediatr Surg. 2024;59:161616. 10.1016/j.jpedsurg.2024.06.024
- Gamal AA, Hussein MAM, Sayed HAE, El-Sayed EM, Youssef AM, et al. Hybrid nanoparticles combining nanoselenium-mediated Carica papaya extract and trimethyl chitosan for combating clinical multidrug-resistant bacteria. Int J Biol Macromol. 2024;277:134359. 10.1016/j.ijbiomac.2024.134359
- Joshi P, Soares JM, Martins GM, Zucolotto Cocca LH, De Boni L, et al. Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications. Photochem Photobiol. 2025;101:359. 10.1111/php.14000
- Gokhale KM, Patravale V, Pingale R, Pandey P, Vavilala SL. Se-functionalized ZIF-8 nanoparticles: synthesis, characterization and disruption of biofilms and quorum sensing in. Biomed Mater. 2024;19. 10.1088/1748-605X/ad6549
- Bian Y, Zhao K, Hu T, Tan C, Liang R, et al. A Se Nanoparticle/MgFe-LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction. Adv Sci (Weinh). 2024;11:e2403791. 10.1002/advs.202403791
- Bu Q, Jiang D, Yu Y, Deng Y, Chen T, et al. Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection. Drug Resist Updat. 2024;76:101102. 10.1016/j.drup.2024.101102
- Ge X, Liang Z, Li K, Dong Y, Wang Y, et al. Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection. Int Immunopharmacol. 2024;137:112384. 10.1016/j.intimp.2024.112384
- Yang F, Shu R, Dai W, Li B, Liu C, et al. HSe-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence. Biomaterials. 2024;311:122659. 10.1016/j.biomaterials.2024.122659
- Ullah I, Khan SS, Ahmad W, Liu L, Rady A, et al. NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing. Commun Chem. 2024;7:131. 10.1038/s42004-024-01215-1
