Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
USERS' SCORE
Moderately Good
Based on 28 Reviews
7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
Selenium's antifungal potential explored
We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
Read More
9
We explored the effects of selenium nanoparticles on Candida albicans, particularly focusing on their ability to inhibit biofilm formation. The nanoparticles were created using a cutting-edge technique known as femtosecond pulsed laser ablation in de-ionized water, ensuring they were free from contaminants.
Our observations revealed that these pure selenium nanoparticles could effectively attach to the biofilm of Candida albicans. Once adhered, the nanoparticles penetrated the pathogen and began to disrupt its cellular structure by substituting sulfur. Remarkably, we achieved a 50% reduction in biofilm formation at a low concentration of just 25 parts per million (ppm).
Furthermore, our analysis highlighted two important factors affecting the effectiveness of the selenium treatment: the crystallinity and size of the particles. This study suggests that pure selenium nanoparticles hold promising potential for advancing future treatments for candidiasis by targeting harmful biofilm formations.
Our observations revealed that these pure selenium nanoparticles could effectively attach to the biofilm of Candida albicans. Once adhered, the nanoparticles penetrated the pathogen and began to disrupt its cellular structure by substituting sulfur. Remarkably, we achieved a 50% reduction in biofilm formation at a low concentration of just 25 parts per million (ppm).
Furthermore, our analysis highlighted two important factors affecting the effectiveness of the selenium treatment: the crystallinity and size of the particles. This study suggests that pure selenium nanoparticles hold promising potential for advancing future treatments for candidiasis by targeting harmful biofilm formations.
Read More
9
We focused on the effectiveness of selenium nanoparticles (SeNPs) incorporated into acrylic resins to combat candidiasis, specifically in the context of denture-induced stomatitis. Current treatments often come with side effects and can lead to drug resistance, making this research particularly relevant.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
Read More
Most Useful Reviews
9
Daily detox aid
3 people found this helpful
Detox! I take this daily, finding it especially effective in eliminating candida. I also purchase vitamin C and biotin along with this product, which has high quality. The NAC does emit a sulphurous odour upon opening, so I've learned to hold my breath when consuming it. The ingredient list is perfect, which is why I continue to buy it.
Read More
9
Effective against biofilm
This product is beneficial in my battle against candida biofilm. It's easy to take, although I recommend not taking it on an empty stomach as that can lead to stomach pain.
Read More
9
Maintains gut health
Great for gut health! I've discovered that NAC keeps my gut well-regulated, preventing chronic nausea and combatting candida. I take it every morning without fail.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
- All Researches
9
We focused on the effectiveness of selenium nanoparticles (SeNPs) incorporated into acrylic resins to combat candidiasis, specifically in the context of denture-induced stomatitis. Current treatments often come with side effects and can lead to drug resistance, making this research particularly relevant.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
Read More
9
Selenium's antifungal potential explored
We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
Read More
9
Effective selenium delivery against candidiasis
We aimed to evaluate how diphenyl diselenide, encapsulated in poly(ε-caprolactone) nanocapsules, affects candidiasis treatment. By preparing a suspension of these nanocapsules and creating a gellan gum hydrogel, we studied the in vitro antifungal properties and their effectiveness in a mouse model of vulvovaginal candidiasis.
The study involved testing both the encapsulated form of diphenyl diselenide and a version without the nanocapsules against several Candida strains. Interestingly, we found that the nanocapsules demonstrated equal or improved antifungal activity compared to the free compound.
In our model, female Swiss mice were infected with Candida albicans and then treated with the hydrogels containing either the encapsulated form or the free compound. We monitored the fungal burden after treatment and found that the nano-encapsulated version exhibited superior antifungal action, indicating that the encapsulation effectively preserves and enhances the treatment properties of diphenyl diselenide.
Overall, our findings suggest that this innovative, nano-based hydrogel formulation holds promise as a significant advancement in treating vulvovaginal candidiasis.
The study involved testing both the encapsulated form of diphenyl diselenide and a version without the nanocapsules against several Candida strains. Interestingly, we found that the nanocapsules demonstrated equal or improved antifungal activity compared to the free compound.
In our model, female Swiss mice were infected with Candida albicans and then treated with the hydrogels containing either the encapsulated form or the free compound. We monitored the fungal burden after treatment and found that the nano-encapsulated version exhibited superior antifungal action, indicating that the encapsulation effectively preserves and enhances the treatment properties of diphenyl diselenide.
Overall, our findings suggest that this innovative, nano-based hydrogel formulation holds promise as a significant advancement in treating vulvovaginal candidiasis.
Read More
9
We explored the effects of selenium nanoparticles on Candida albicans, particularly focusing on their ability to inhibit biofilm formation. The nanoparticles were created using a cutting-edge technique known as femtosecond pulsed laser ablation in de-ionized water, ensuring they were free from contaminants.
Our observations revealed that these pure selenium nanoparticles could effectively attach to the biofilm of Candida albicans. Once adhered, the nanoparticles penetrated the pathogen and began to disrupt its cellular structure by substituting sulfur. Remarkably, we achieved a 50% reduction in biofilm formation at a low concentration of just 25 parts per million (ppm).
Furthermore, our analysis highlighted two important factors affecting the effectiveness of the selenium treatment: the crystallinity and size of the particles. This study suggests that pure selenium nanoparticles hold promising potential for advancing future treatments for candidiasis by targeting harmful biofilm formations.
Our observations revealed that these pure selenium nanoparticles could effectively attach to the biofilm of Candida albicans. Once adhered, the nanoparticles penetrated the pathogen and began to disrupt its cellular structure by substituting sulfur. Remarkably, we achieved a 50% reduction in biofilm formation at a low concentration of just 25 parts per million (ppm).
Furthermore, our analysis highlighted two important factors affecting the effectiveness of the selenium treatment: the crystallinity and size of the particles. This study suggests that pure selenium nanoparticles hold promising potential for advancing future treatments for candidiasis by targeting harmful biofilm formations.
Read More
8
Selenium miconazole improves candidiasis treatment
We examined the effectiveness of new selenium-containing miconazole derivatives against candidiasis, specifically focusing on how these compounds can tackle Candida albicans infections. In our previous research, we identified compound A03, which showed significant antifungal activity, but also had concerning side effects like hemolysis and cytotoxicity.
To improve upon this, we optimized our compounds, ultimately leading us to compound B17. Not only did B17 maintain impressive antifungal potency, but it also showcased a much better pharmacological profile. With less tendency to be metabolized and diminished toxic effects, B17 offers a promising option for treating resistant Candida infections.
Additionally, we found that B17 effectively disrupted important fungal processes, such as ergosterol biosynthesis and biofilm formation, which are crucial for fungal survival. Our tests even showed that B17 has promising efficacy in live models, which is an encouraging step forward. Overall, these selenium-infused miconazole compounds hold great potential as innovative treatments for fungal infections, particularly candidiasis.
To improve upon this, we optimized our compounds, ultimately leading us to compound B17. Not only did B17 maintain impressive antifungal potency, but it also showcased a much better pharmacological profile. With less tendency to be metabolized and diminished toxic effects, B17 offers a promising option for treating resistant Candida infections.
Additionally, we found that B17 effectively disrupted important fungal processes, such as ergosterol biosynthesis and biofilm formation, which are crucial for fungal survival. Our tests even showed that B17 has promising efficacy in live models, which is an encouraging step forward. Overall, these selenium-infused miconazole compounds hold great potential as innovative treatments for fungal infections, particularly candidiasis.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 28 Reviews
7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Daily detox aid
3 people found this helpful
Detox! I take this daily, finding it especially effective in eliminating candida. I also purchase vitamin C and biotin along with this product, which has high quality. The NAC does emit a sulphurous odour upon opening, so I've learned to hold my breath when consuming it. The ingredient list is perfect, which is why I continue to buy it.
Read More
9
Effective against biofilm
This product is beneficial in my battle against candida biofilm. It's easy to take, although I recommend not taking it on an empty stomach as that can lead to stomach pain.
Read More
9
Maintains gut health
Great for gut health! I've discovered that NAC keeps my gut well-regulated, preventing chronic nausea and combatting candida. I take it every morning without fail.
Read More
9
Supports parasite treatment
Perfectly! NAC is an amino acid made of two interconnected cysteine molecules, which is hard to obtain through a standard diet, thus necessitating special medications. Acetylcysteine helps maintain glutathione production for safe toxin removal. I combine it with other treatments against parasites and candidiasis, and I've not experienced any side effects.
Read More
9
Mucolytic and detox
Excellent! NAC not only has a mucolytic effect by liquefying phlegm with a dry cough, but also aids in destroying biofilms formed by pathogenic bacteria, especially Candida. It's also beneficial for the liver, protecting it from the toxic effects of antibiotics and other drugs. I always keep NAC in my medicine cabinet, and this time I ordered from this company. The capsules are convenient and the quality is commendable. I highly recommend it!
Read More
Frequently Asked Questions
7.5
Relieves die-off symptoms
It has helped alleviate the die-off symptoms (like body heaviness and stiff shoulders) from candida eradication. Since then, I regularly use it to support my liver health.
9
Effective detoxification
Excellent! I acquired this product to enhance my body’s detoxification from toxins, food, parasites, and Candida. The effect is evident! I am very pleased with the product and would recommend it!
2
Strict diet required
3 people found this helpful
I consumed this medication as part of a complex anti-Candidiasis protocol. Getting rid of Candida was challenging; without a strict diet (mainly eating buckwheat), it seemed futile. However, even with strict eating, Candida manages to find carbohydrates. I'm unsure what additional treatments to use as I am constantly on antifungal medications.
9
Maintains gut health
Great for gut health! I've discovered that NAC keeps my gut well-regulated, preventing chronic nausea and combatting candida. I take it every morning without fail.
7.5
Effective for thrush
Helped with thrush.
7.5
Cleansing effect noted
Perfect! Combined with Lecithin, probiotics, monolaurin, and Candida caliper, it creates a wonderful effect. I feel my body is being cleansed, with mucus flowing out. My skin has cleared up (I have acne), and I feel well overall. My relationship with food has improved.
9
Daily detox aid
3 people found this helpful
Detox! I take this daily, finding it especially effective in eliminating candida. I also purchase vitamin C and biotin along with this product, which has high quality. The NAC does emit a sulphurous odour upon opening, so I've learned to hold my breath when consuming it. The ingredient list is perfect, which is why I continue to buy it.
9
Supports parasite treatment
Perfectly! NAC is an amino acid made of two interconnected cysteine molecules, which is hard to obtain through a standard diet, thus necessitating special medications. Acetylcysteine helps maintain glutathione production for safe toxin removal. I combine it with other treatments against parasites and candidiasis, and I've not experienced any side effects.
2
Versatile detox support
4 people found this helpful
I adore this product and regularly use it myself; my parents also take it. It’s stocked in our medicine cabinet and included in regimens for Covid and other viral infections. N-acetylcysteine is a precursor to glutathione, our body's primary antioxidant, and supports detoxification thanks to added selenium and molybdenum. The only downside is the lack of yeast-free selenium. It can help clear phlegm, particularly in the mornings. If you're looking to support detox, this combined with a diet low in sugar, milk, and gluten while emphasising vegetables works well. However, if candidiasis is present, it may exacerbate fungal growth.
7.5
Powerful antioxidant
1 people found this helpful
NAC (N-Acetyl-L-Cysteine) works as a powerful antioxidant, boosting glutathione levels. It's valuable in detoxification protocols, particularly for candida, as it helps destroy harmful bacterial films. I take it 30 minutes before breakfast for maximum effect.
9
Effective against biofilm
This product is beneficial in my battle against candida biofilm. It's easy to take, although I recommend not taking it on an empty stomach as that can lead to stomach pain.
9
We focused on the effectiveness of selenium nanoparticles (SeNPs) incorporated into acrylic resins to combat candidiasis, specifically in the context of denture-induced stomatitis. Current treatments often come with side effects and can lead to drug resistance, making this research particularly relevant.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
Our study involved formulating acrylic resins with varying concentrations of SeNPs—0.2, 2, and 10 g/mL—and testing them against clinical isolates. We determined the minimum inhibitory concentration (MIC) and developed fungal biofilms on acrylic samples, assessing the level of biofilm through various methods, including scanning electron microscopy (SEM).
We found that the MIC for SeNPs stood at 25%, with the highest antifungal activity observed at a concentration of 10%. The optical density measurements indicated that the 10% SeNPs group effectively reduced biofilm formation compared to lower concentrations. SEM analysis confirmed significant damage to the fungal cell walls, aligning with our findings of decreased colonization.
These results suggest that selenium nanoparticles can be a promising alternative treatment for candidiasis, particularly for those wearing dentures. Their ability to inhibit fungal growth demonstrates SeNPs' potential in addressing oral health issues connected to candidiasis.
9
Selenium's antifungal potential explored
We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
9
Effective selenium delivery against candidiasis
We aimed to evaluate how diphenyl diselenide, encapsulated in poly(ε-caprolactone) nanocapsules, affects candidiasis treatment. By preparing a suspension of these nanocapsules and creating a gellan gum hydrogel, we studied the in vitro antifungal properties and their effectiveness in a mouse model of vulvovaginal candidiasis.
The study involved testing both the encapsulated form of diphenyl diselenide and a version without the nanocapsules against several Candida strains. Interestingly, we found that the nanocapsules demonstrated equal or improved antifungal activity compared to the free compound.
In our model, female Swiss mice were infected with Candida albicans and then treated with the hydrogels containing either the encapsulated form or the free compound. We monitored the fungal burden after treatment and found that the nano-encapsulated version exhibited superior antifungal action, indicating that the encapsulation effectively preserves and enhances the treatment properties of diphenyl diselenide.
Overall, our findings suggest that this innovative, nano-based hydrogel formulation holds promise as a significant advancement in treating vulvovaginal candidiasis.
The study involved testing both the encapsulated form of diphenyl diselenide and a version without the nanocapsules against several Candida strains. Interestingly, we found that the nanocapsules demonstrated equal or improved antifungal activity compared to the free compound.
In our model, female Swiss mice were infected with Candida albicans and then treated with the hydrogels containing either the encapsulated form or the free compound. We monitored the fungal burden after treatment and found that the nano-encapsulated version exhibited superior antifungal action, indicating that the encapsulation effectively preserves and enhances the treatment properties of diphenyl diselenide.
Overall, our findings suggest that this innovative, nano-based hydrogel formulation holds promise as a significant advancement in treating vulvovaginal candidiasis.
8
Selenium miconazole improves candidiasis treatment
We examined the effectiveness of new selenium-containing miconazole derivatives against candidiasis, specifically focusing on how these compounds can tackle Candida albicans infections. In our previous research, we identified compound A03, which showed significant antifungal activity, but also had concerning side effects like hemolysis and cytotoxicity.
To improve upon this, we optimized our compounds, ultimately leading us to compound B17. Not only did B17 maintain impressive antifungal potency, but it also showcased a much better pharmacological profile. With less tendency to be metabolized and diminished toxic effects, B17 offers a promising option for treating resistant Candida infections.
Additionally, we found that B17 effectively disrupted important fungal processes, such as ergosterol biosynthesis and biofilm formation, which are crucial for fungal survival. Our tests even showed that B17 has promising efficacy in live models, which is an encouraging step forward. Overall, these selenium-infused miconazole compounds hold great potential as innovative treatments for fungal infections, particularly candidiasis.
To improve upon this, we optimized our compounds, ultimately leading us to compound B17. Not only did B17 maintain impressive antifungal potency, but it also showcased a much better pharmacological profile. With less tendency to be metabolized and diminished toxic effects, B17 offers a promising option for treating resistant Candida infections.
Additionally, we found that B17 effectively disrupted important fungal processes, such as ergosterol biosynthesis and biofilm formation, which are crucial for fungal survival. Our tests even showed that B17 has promising efficacy in live models, which is an encouraging step forward. Overall, these selenium-infused miconazole compounds hold great potential as innovative treatments for fungal infections, particularly candidiasis.
References
- Rostamzadeh M, Sadeghi Sangdehi SA, Salimizand H, Nouri B, Rahimi F. Evaluating the anti- effects of selenium nanoparticles impregnated in acrylic resins: An in vitro study. J Dent Res Dent Clin Dent Prospects. 2024;18:258. doi:10.34172/joddd.41113
- de Siqueira VM, da Silva BGM, Passos JCDS, Pinto AP, da Rocha JBT, et al. (MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation. J Trace Elem Med Biol. 2022;73:127019. doi:10.1016/j.jtemb.2022.127019
- Zimmermann ES, Ferreira LM, Denardi LB, Sari MHM, Cervi VF, et al. Mucoadhesive gellan gum hydrogel containing diphenyl diselenide-loaded nanocapsules presents improved anti-candida action in a mouse model of vulvovaginal candidiasis. Eur J Pharm Sci. 2021;167:106011. doi:10.1016/j.ejps.2021.106011
- Xu H, Yan ZZ, Guo MB, An R, Wang X, et al. Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. Eur J Med Chem. 2021;216:113337. doi:10.1016/j.ejmech.2021.113337
- Vartak R, Patki M, Menon S, Jablonski J, Mediouni S, et al. β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV. Int J Pharm. 2020;589:119863. doi:10.1016/j.ijpharm.2020.119863
- Lara HH, Guisbiers G, Mendoza J, Mimun LC, Vincent BA, et al. Synergistic antifungal effect of chitosan-stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids against biofilms. Int J Nanomedicine. 2018;13:2697. doi:10.2147/IJN.S151285
- Guisbiers G, Lara HH, Mendoza-Cruz R, Naranjo G, Vincent BA, et al. Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids. Nanomedicine. 2017;13:1095. doi:10.1016/j.nano.2016.10.011
- Boyne R, Arthur JR, Wilson AB. An in vivo and in vitro study of selenium deficiency and infection in rats. J Comp Pathol. 1986;96:379.
- Boyne R, Arthur JR. The response of selenium-deficient mice to Candida albicans infection. J Nutr. 1986;116:816.
