SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
Molybdenum may lower gout risk
Antioxidative effects of molybdenum and its association with reduced prevalence of hyperuricemia in the adult population.
Study connects molybdenum to gout
We explored the link between molybdenum levels and gout, particularly focusing on how this trace mineral might influence uric acid levels in our body. In a large-scale study involving over 15,000 adults, we observed that higher urinary molybdenum concentrations were associated with lower levels of serum uric acid, which is a key factor in gout development.
The results were quite promising. Participants with higher urinary molybdenum levels were found to have a significantly decreased prevalence of hyperuricemia (high uric acid levels) and gout. This suggests that molybdenum could potentially play a role in reducing the risk of these conditions.
We also noted that molybdenum was linked to lower inflammation and oxidative stress markers in the body. This may indicate that its antioxidative properties help manage chronic conditions, including those related to the kidneys. While our findings highlight the potential benefits of molybdenum, it’s important to consider them alongside dietary sources and other influencing factors.
The results were quite promising. Participants with higher urinary molybdenum levels were found to have a significantly decreased prevalence of hyperuricemia (high uric acid levels) and gout. This suggests that molybdenum could potentially play a role in reducing the risk of these conditions.
We also noted that molybdenum was linked to lower inflammation and oxidative stress markers in the body. This may indicate that its antioxidative properties help manage chronic conditions, including those related to the kidneys. While our findings highlight the potential benefits of molybdenum, it’s important to consider them alongside dietary sources and other influencing factors.
Read More
7
NAC's potential in gout relief
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
Moderate significance of NAC findings
In our investigation, we focused on understanding the role of N-acetylcysteine (NAC) in alleviating the painful symptoms of gout. Gout occurs due to inflammation caused by the accumulation of monosodium urate crystals in the joints, leading to painful flare-ups.
We found that NAC appears to address some of the oxidative stress associated with gout, potentially easing the inflammation tied to these flare-ups. Although NAC showed promise in our exploration, it's important to note that the specific overall effect of NAC alone wasn't thoroughly outlined in the study.
This raises questions about its effectiveness in treating acute gout symptoms independently. Despite these uncertainties, the findings highlight the relevance of antioxidants like NAC in managing oxidative stress during gout attacks, paving the way for further research into more clear-cut benefits.
We found that NAC appears to address some of the oxidative stress associated with gout, potentially easing the inflammation tied to these flare-ups. Although NAC showed promise in our exploration, it's important to note that the specific overall effect of NAC alone wasn't thoroughly outlined in the study.
This raises questions about its effectiveness in treating acute gout symptoms independently. Despite these uncertainties, the findings highlight the relevance of antioxidants like NAC in managing oxidative stress during gout attacks, paving the way for further research into more clear-cut benefits.
Read More
8
NAC's role in gout inflammation
Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model.
Mixed effects in acute gout
We explored the effect of N-acetylcysteine (NAC) on gout inflammation, particularly focusing on its potential to reduce harmful reactions caused by xanthine oxidase (XO) in macrophages. In this study, bone marrow-derived macrophages were stimulated with monosodium urate (MSU) crystals, known to trigger gout attacks, alongside treatments such as fingolimod (a PP2A activator) and febuxostat (an XO inhibitor).
Our findings revealed that NAC played a significant role in enhancing protein phosphatase 2A (PP2A) activity. This enhancement helped to lower XO activity, which is responsible for producing reactive oxygen species (ROS) during the inflammatory process. We noted that when NAC was combined with okadaic acid (a PP2A inhibitor), the secretion of IL-1β, a pro-inflammatory cytokine, increased.
While NAC showcased some benefits in modulating the inflammatory response in macrophages, its isolated effect on gout particularly remains unclear due to the combination of treatments used in this study. However, overall, it suggests that NAC could be a valuable player in the fight against inflammation in gout, notably through the modulation of oxidative stress.
Our findings revealed that NAC played a significant role in enhancing protein phosphatase 2A (PP2A) activity. This enhancement helped to lower XO activity, which is responsible for producing reactive oxygen species (ROS) during the inflammatory process. We noted that when NAC was combined with okadaic acid (a PP2A inhibitor), the secretion of IL-1β, a pro-inflammatory cytokine, increased.
While NAC showcased some benefits in modulating the inflammatory response in macrophages, its isolated effect on gout particularly remains unclear due to the combination of treatments used in this study. However, overall, it suggests that NAC could be a valuable player in the fight against inflammation in gout, notably through the modulation of oxidative stress.
Read More
Most Useful Reviews
9.5
No attacks observed
Gout My father experienced no gout attacks whilst taking these! Fantastic!
Read More
9.5
Immediate pain relief
As I was in the early stages of gout, I sought out recommendations and purchased this product. The results were immediate. I had intense pain in my legs and feet, but after two or three days of soaking, the pain subsided. The swelling has reduced, and I feel much lighter.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
- All Researches
9
Molybdenum may lower gout risk
Antioxidative effects of molybdenum and its association with reduced prevalence of hyperuricemia in the adult population.
Study connects molybdenum to gout
We explored the link between molybdenum levels and gout, particularly focusing on how this trace mineral might influence uric acid levels in our body. In a large-scale study involving over 15,000 adults, we observed that higher urinary molybdenum concentrations were associated with lower levels of serum uric acid, which is a key factor in gout development.
The results were quite promising. Participants with higher urinary molybdenum levels were found to have a significantly decreased prevalence of hyperuricemia (high uric acid levels) and gout. This suggests that molybdenum could potentially play a role in reducing the risk of these conditions.
We also noted that molybdenum was linked to lower inflammation and oxidative stress markers in the body. This may indicate that its antioxidative properties help manage chronic conditions, including those related to the kidneys. While our findings highlight the potential benefits of molybdenum, it’s important to consider them alongside dietary sources and other influencing factors.
The results were quite promising. Participants with higher urinary molybdenum levels were found to have a significantly decreased prevalence of hyperuricemia (high uric acid levels) and gout. This suggests that molybdenum could potentially play a role in reducing the risk of these conditions.
We also noted that molybdenum was linked to lower inflammation and oxidative stress markers in the body. This may indicate that its antioxidative properties help manage chronic conditions, including those related to the kidneys. While our findings highlight the potential benefits of molybdenum, it’s important to consider them alongside dietary sources and other influencing factors.
Read More
8
NAC's role in gout inflammation
Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model.
Mixed effects in acute gout
We explored the effect of N-acetylcysteine (NAC) on gout inflammation, particularly focusing on its potential to reduce harmful reactions caused by xanthine oxidase (XO) in macrophages. In this study, bone marrow-derived macrophages were stimulated with monosodium urate (MSU) crystals, known to trigger gout attacks, alongside treatments such as fingolimod (a PP2A activator) and febuxostat (an XO inhibitor).
Our findings revealed that NAC played a significant role in enhancing protein phosphatase 2A (PP2A) activity. This enhancement helped to lower XO activity, which is responsible for producing reactive oxygen species (ROS) during the inflammatory process. We noted that when NAC was combined with okadaic acid (a PP2A inhibitor), the secretion of IL-1β, a pro-inflammatory cytokine, increased.
While NAC showcased some benefits in modulating the inflammatory response in macrophages, its isolated effect on gout particularly remains unclear due to the combination of treatments used in this study. However, overall, it suggests that NAC could be a valuable player in the fight against inflammation in gout, notably through the modulation of oxidative stress.
Our findings revealed that NAC played a significant role in enhancing protein phosphatase 2A (PP2A) activity. This enhancement helped to lower XO activity, which is responsible for producing reactive oxygen species (ROS) during the inflammatory process. We noted that when NAC was combined with okadaic acid (a PP2A inhibitor), the secretion of IL-1β, a pro-inflammatory cytokine, increased.
While NAC showcased some benefits in modulating the inflammatory response in macrophages, its isolated effect on gout particularly remains unclear due to the combination of treatments used in this study. However, overall, it suggests that NAC could be a valuable player in the fight against inflammation in gout, notably through the modulation of oxidative stress.
Read More
7
NAC's potential in gout relief
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
Moderate significance of NAC findings
In our investigation, we focused on understanding the role of N-acetylcysteine (NAC) in alleviating the painful symptoms of gout. Gout occurs due to inflammation caused by the accumulation of monosodium urate crystals in the joints, leading to painful flare-ups.
We found that NAC appears to address some of the oxidative stress associated with gout, potentially easing the inflammation tied to these flare-ups. Although NAC showed promise in our exploration, it's important to note that the specific overall effect of NAC alone wasn't thoroughly outlined in the study.
This raises questions about its effectiveness in treating acute gout symptoms independently. Despite these uncertainties, the findings highlight the relevance of antioxidants like NAC in managing oxidative stress during gout attacks, paving the way for further research into more clear-cut benefits.
We found that NAC appears to address some of the oxidative stress associated with gout, potentially easing the inflammation tied to these flare-ups. Although NAC showed promise in our exploration, it's important to note that the specific overall effect of NAC alone wasn't thoroughly outlined in the study.
This raises questions about its effectiveness in treating acute gout symptoms independently. Despite these uncertainties, the findings highlight the relevance of antioxidants like NAC in managing oxidative stress during gout attacks, paving the way for further research into more clear-cut benefits.
Read More
4
Molybdenum's role in gout unclear
The influence of dietary molybdenum and copper supplementation on the contents of serum uric acid and some trace elements in cocks.
Moderation of essential trace minerals
We explored how molybdenum (Mo) and copper (Cu) supplementation might influence blood parameters related to gout in cocks. The study involved feeding these birds commercial poultry feed along with specific amounts of Mo or Cu for four weeks.
Our findings revealed that when cocks received a higher supplementation of 400 micrograms of either Mo or Cu, their serum uric acid levels decreased. However, a lower dosage of 100 micrograms of Cu actually led to an increase in uric acid levels. Notably, the differences between groups that received moderate and excessive Cu supplementation were significantly distinct, indicating that too much copper can potentially lead to negative outcomes, such as decreased hemoglobin levels, while no signs of copper toxicity were observed.
We acknowledge that our analysis of trace elements, including Mo and Cu, in the liver and kidneys was preliminary. Moreover, the impact of Mo and Cu on uric acid metabolism needs further exploration. We suggested that future histochemical studies on specific enzymes related to uric acid production could shed more light on their role in avian gout.
Our findings revealed that when cocks received a higher supplementation of 400 micrograms of either Mo or Cu, their serum uric acid levels decreased. However, a lower dosage of 100 micrograms of Cu actually led to an increase in uric acid levels. Notably, the differences between groups that received moderate and excessive Cu supplementation were significantly distinct, indicating that too much copper can potentially lead to negative outcomes, such as decreased hemoglobin levels, while no signs of copper toxicity were observed.
We acknowledge that our analysis of trace elements, including Mo and Cu, in the liver and kidneys was preliminary. Moreover, the impact of Mo and Cu on uric acid metabolism needs further exploration. We suggested that future histochemical studies on specific enzymes related to uric acid production could shed more light on their role in avian gout.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
No attacks observed
Gout My father experienced no gout attacks whilst taking these! Fantastic!
9.5
Immediate pain relief
As I was in the early stages of gout, I sought out recommendations and purchased this product. The results were immediate. I had intense pain in my legs and feet, but after two or three days of soaking, the pain subsided. The swelling has reduced, and I feel much lighter.
Frequently Asked Questions
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