We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
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Selenium reduces key AITD markersThe correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis.
Highly relevant to AITD treatment
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
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Selenium reduces certain thyroid markersSelenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Moderate evidence of effectiveness
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
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Selenium reduces HT antibody levelsClinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.
Moderately relevant clinical findings
We explored the potential benefits of selenium supplementation for patients with Hashimoto thyroiditis (HT). In our systematic review of seven controlled trials with 342 participants, we found that while there was no notable change in thyroid peroxidase antibodies (TPOAb) levels after three months, there was a significant reduction in TPOAb and thyroglobulin antibodies (TgAb) levels after six months of treatment.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
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Selenium intake may reduce HT riskThe association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012.
Study based on substantial data
We examined how dietary selenium influences Hashimoto's thyroiditis (HT) using data from the National Health and Nutrition Examination Survey, involving over 8,700 participants. The findings suggest that higher selenium intake is linked to a lower risk of developing HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
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