Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
Most Useful Reviews
9
Very useful product
Very good. This is very useful for Hashimoto's, and I will continue to purchase it.
Read More
9
Perfect supplement
This brand has amazing quality, often enhancing supplements with additional ingredients for better benefits. This NAC contains selenium and molybdenum, making its antioxidant effect stronger. Selenium is beneficial for my Hashimoto, so I believe I've found my ideal NAC supplements.
Read More
9
Selenium support
Hashimoto's thyroid requires selenium supplementation and NAC, which is very suitable. This product is excellent, affordable, and beneficial for healthy immunity.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
8
We explored the potential benefits of selenium supplementation for patients with Hashimoto thyroiditis (HT). In our systematic review of seven controlled trials with 342 participants, we found that while there was no notable change in thyroid peroxidase antibodies (TPOAb) levels after three months, there was a significant reduction in TPOAb and thyroglobulin antibodies (TgAb) levels after six months of treatment.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Read More
8
Selenium intake may reduce HT risk
We examined how dietary selenium influences Hashimoto's thyroiditis (HT) using data from the National Health and Nutrition Examination Survey, involving over 8,700 participants. The findings suggest that higher selenium intake is linked to a lower risk of developing HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Very useful product
Very good. This is very useful for Hashimoto's, and I will continue to purchase it.
Read More
9
Perfect supplement
This brand has amazing quality, often enhancing supplements with additional ingredients for better benefits. This NAC contains selenium and molybdenum, making its antioxidant effect stronger. Selenium is beneficial for my Hashimoto, so I believe I've found my ideal NAC supplements.
Read More
9
Selenium support
Hashimoto's thyroid requires selenium supplementation and NAC, which is very suitable. This product is excellent, affordable, and beneficial for healthy immunity.
Read More
9
Lowered antibodies
A good aid in reducing Hashimoto's antibodies; taking three capsules daily assisted me in lowering my Hashimoto's thyroid antibodies.
Read More
6
Mild detox benefits
41 people found this helpful
Mild detox. I bought it for a comprehensive bowel treatment with Hashimoto. I see the effect and recommend it as a quality drug; however, it may vary for each individual, so choose wisely. I hope my review is helpful.
Read More
Frequently Asked Questions
6
Good antioxidant support
Very good NAC! This NAC contains selenium and is suitable for Hashimoto's thyroiditis. After taking it for a period, I noticed positive indicators. It provides great antioxidant support for the body.
9
Lowered antibodies
A good aid in reducing Hashimoto's antibodies; taking three capsules daily assisted me in lowering my Hashimoto's thyroid antibodies.
6
Mild detox benefits
41 people found this helpful
Mild detox. I bought it for a comprehensive bowel treatment with Hashimoto. I see the effect and recommend it as a quality drug; however, it may vary for each individual, so choose wisely. I hope my review is helpful.
9
Perfect supplement
This brand has amazing quality, often enhancing supplements with additional ingredients for better benefits. This NAC contains selenium and molybdenum, making its antioxidant effect stronger. Selenium is beneficial for my Hashimoto, so I believe I've found my ideal NAC supplements.
9
Selenium support
Hashimoto's thyroid requires selenium supplementation and NAC, which is very suitable. This product is excellent, affordable, and beneficial for healthy immunity.
7.5
Effective detoxification
NAC is a highly effective antioxidant. It aids in maintaining normal hormone levels in Hashimoto, detoxifying the body, and promoting a healthy liver. Smokers may find their throat discomfort reduced. Both those with Hashimoto and throat issues can find benefits from this product. I believe persistence will yield results.
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
8
We evaluated how selenium supplementation might help patients with Hashimoto's thyroiditis (HT) in a structured study. Patients were split into two groups: one received selenium tablets for six months, while the other did not.
Results indicated that those taking selenium had lower levels of thyroid autoantibodies and improved thyroid function. Additionally, we noticed a rise in certain regulatory T cells, which may play a role in managing thyroid autoimmunity. Overall, selenium seems promising, especially for those with milder forms of HT.
Results indicated that those taking selenium had lower levels of thyroid autoantibodies and improved thyroid function. Additionally, we noticed a rise in certain regulatory T cells, which may play a role in managing thyroid autoimmunity. Overall, selenium seems promising, especially for those with milder forms of HT.
4
We explored the effects of selenium supplementation on patients with chronic autoimmune thyroiditis (also known as Hashimoto's disease). We reviewed 23 studies that compared selenium use alongside standard treatment versus a placebo. While selenium appeared to reduce autoantibody levels, it did not significantly impact thyroid-stimulating hormone levels.
Ultimately, despite some positive findings, the overall evidence does not support the routine use of selenium in managing Hashimoto's disease, particularly given the potential for adverse effects.
Ultimately, despite some positive findings, the overall evidence does not support the routine use of selenium in managing Hashimoto's disease, particularly given the potential for adverse effects.
References
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556
- Wang W, Jiang QL, Xu Q, Zeng Y, Jiang R, et al. Selenium regulates T cell differentiation in experimental autoimmune thyroiditis in mice. Int Immunopharmacol. 2023;124:110993. doi:10.1016/j.intimp.2023.110993
- Wang YS, Liang SS, Ren JJ, Wang ZY, Deng XX, et al. The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews. Nutrients. 2023;15. doi:10.3390/nu15143194
- Kong XQ, Qiu GY, Yang ZB, Tan ZX, Quan XQ. Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e33791. doi:10.1097/MD.0000000000033791
- Zheng G, Cai Y, Guo Y, Song F, Hu Y, et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012. J Endocrinol Invest. 2023;46:1385. doi:10.1007/s40618-022-01987-0
- Kryczyk-Kozioł J, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, Sun Q, et al. Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto's Thyroiditis. Nutrients. 2022;14. doi:10.3390/nu14142869
- Wu Q, Wang Y, Chen P, Wei J, Lv H, et al. Increased Incidence of Hashimoto Thyroiditis in Selenium Deficiency: A Prospective 6-Year Cohort Study. J Clin Endocrinol Metab. 2022;107:e3603. doi:10.1210/clinem/dgac410
- Minnetti M, Sada V, Feola T, Giannetta E, Pozza C, et al. Selenium Supplementation in Pregnant Women with Autoimmune Thyroiditis: A Practical Approach. Nutrients. 2022;14. doi:10.3390/nu14112234
- Wang LF, Sun RX, Li CF, Wang XH. The effects of selenium supplementation on antibody titres in patients with Hashimoto's thyroiditis. Endokrynol Pol. 2021;72:666. doi:10.5603/EP.a2021.0074
- Kryczyk-Kozioł J, Zagrodzki P, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, et al. Positive effects of selenium supplementation in women with newly diagnosed Hashimoto's thyroiditis in an area with low selenium status. Int J Clin Pract. 2021;75:e14484. doi:10.1111/ijcp.14484
- Filipowicz D, Majewska K, Kalantarova A, Szczepanek-Parulska E, Ruchała M. The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge. Endokrynol Pol. 2021;72:153. doi:10.5603/EP.a2021.0017
- Zuo Y, Li Y, Gu X, Lei Z. The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis. Ann Palliat Med. 2021;10:4398. doi:10.21037/apm-21-449
- Qiu Y, Xing Z, Xiang Q, Yang Q, Zhu J, et al. Insufficient evidence to support the clinical efficacy of selenium supplementation for patients with chronic autoimmune thyroiditis. Endocrine. 2021;73:384. doi:10.1007/s12020-021-02642-z
- Hu Y, Feng W, Chen H, Shi H, Jiang L, et al. Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial. Clin Transl Sci. 2021;14:1390. doi:10.1111/cts.12993
- Pace C, Tumino D, Russo M, Le Moli R, Naselli A, et al. Role of selenium and myo-inositol supplementation on autoimmune thyroiditis progression. Endocr J. 2020;67:1093. doi:10.1507/endocrj.EJ20-0062
