Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
9
We explored an innovative approach to treating heart attacks, specifically looking at how selenium can make a difference. Our study focused on a special injectable hydrogel made from a combination of selenium, polypropylene glycol, and polyethylene glycol. The goal was to see if this formulation could help reduce inflammation and fibrosis after a myocardial infarction (heart attack).
We conducted our research on a mouse model of myocardial infarction, observing the effects of our selenium-containing hydrogel. The results were promising—our formulation demonstrated the ability to promote recovery in heart function. Through various tests, including enzyme-linked immunosorbent assays and tissue analysis, we confirmed that the gel effectively inhibits harmful inflammation and fibrosis that often occur after a heart attack.
Overall, this work highlights the potential of selenium as a beneficial component in therapies for heart attacks and possibly other inflammatory conditions. Our findings suggest that a selenium-infused polymeric hydrogel could be an effective strategy for improving heart health in the aftermath of a myocardial infarction.
We conducted our research on a mouse model of myocardial infarction, observing the effects of our selenium-containing hydrogel. The results were promising—our formulation demonstrated the ability to promote recovery in heart function. Through various tests, including enzyme-linked immunosorbent assays and tissue analysis, we confirmed that the gel effectively inhibits harmful inflammation and fibrosis that often occur after a heart attack.
Overall, this work highlights the potential of selenium as a beneficial component in therapies for heart attacks and possibly other inflammatory conditions. Our findings suggest that a selenium-infused polymeric hydrogel could be an effective strategy for improving heart health in the aftermath of a myocardial infarction.
Most Useful Reviews
9
Effective for detox
25 people found this helpful
It became an unpleasant world, and I bought it for detoxification. I heard it is effective not only for detox but also for asthma. When a 7-year-old child had an asthma attack, it worked remarkably well! There are many sold out, making it difficult to obtain, but I definitely recommend it.
0
Dangerous side effects
1 people found this helpful
I warn everyone about it; it has dangerous effects, altering pulmonary artery pressure and heart pressure, changing the electrocardiogram, and causing breathing problems, whether taken orally or intravenously. This really happened to me, and I plan to dispose of the rest of the box. I was left panting after seeking health and treatment.
7.5
Supports heart health
1 people found this helpful
Doctor's Best supplements are practical and high-quality. The capsules are small and easy to swallow. NAC offers benefits as an antioxidant, promoting liver and heart health.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.7
- All Researches
9.5
β-Glucan shows cardioprotective effects
We explored whether pretreatment with β-glucan, a compound from the yeast Saccharomyces cerevisiae, could shield against heart damage induced by isoprenaline in rats. Through a well-structured experiment involving control and treatment groups, we discovered that β-glucan significantly reduced heart strain by improving cardiac markers and minimizing harmful changes in heart tissue.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
9.5
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
9
Selenium's potential in cardiac recovery
We investigated how selenium, specifically in the form of selenium nanoparticles (Se NPs), can play a role in recovering from heart attacks. Our study focused on developing a unique hydrogel that combines Se NPs with a polymer base to improve cardiac repair after acute myocardial infarction (MI).
We explored the effects of the Se NPs on human heart cells and conducted experiments on mice models. The results were promising; the hearts of the treated mice showed a significant improvement with the left ventricular wall thickness increasing from a mere 235.6 micrometers to an impressive 390 micrometers.
Not only did these treatments help thicken the heart walls, but we also saw a remarkable reduction in scar thickness and infarct size when compared to control groups. This suggests that our selenium-infused hydrogel could be a valuable solution to promote heart healing post-MI, paving the way for potentially advanced treatments in the future.
We explored the effects of the Se NPs on human heart cells and conducted experiments on mice models. The results were promising; the hearts of the treated mice showed a significant improvement with the left ventricular wall thickness increasing from a mere 235.6 micrometers to an impressive 390 micrometers.
Not only did these treatments help thicken the heart walls, but we also saw a remarkable reduction in scar thickness and infarct size when compared to control groups. This suggests that our selenium-infused hydrogel could be a valuable solution to promote heart healing post-MI, paving the way for potentially advanced treatments in the future.
9
We explored the potential of a novel treatment involving L-arginine-loaded gold nanocages designed to help with heart attack recovery. This innovative approach aims to tackle the problem of myocardial ischemia/reperfusion injury, a condition that can cause additional damage to the heart after blood flow is restored post-heart attack.
The gold nanocages in this study were enhanced with selenium and targeted towards heart cells, allowing for better absorption and effectiveness. Our tests showed that this treatment reduced cell damage and improved cell health during oxygen and glucose deprivation, which is crucial during heart attacks.
Furthermore, we observed that this treatment can help maintain mitochondrial function, leading to better energy production in heart cells. By preventing harmful oxidative reactions, it helps preserve nitric oxide, a vital molecule that supports heart health.
Ultimately, the results indicated that this approach could improve overall heart function and reduce cell death in heart tissue. The findings are promising and suggest a new pathway for effective heart attack treatments while ensuring safe and biocompatible use in living organisms.
The gold nanocages in this study were enhanced with selenium and targeted towards heart cells, allowing for better absorption and effectiveness. Our tests showed that this treatment reduced cell damage and improved cell health during oxygen and glucose deprivation, which is crucial during heart attacks.
Furthermore, we observed that this treatment can help maintain mitochondrial function, leading to better energy production in heart cells. By preventing harmful oxidative reactions, it helps preserve nitric oxide, a vital molecule that supports heart health.
Ultimately, the results indicated that this approach could improve overall heart function and reduce cell death in heart tissue. The findings are promising and suggest a new pathway for effective heart attack treatments while ensuring safe and biocompatible use in living organisms.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for detox
25 people found this helpful
It became an unpleasant world, and I bought it for detoxification. I heard it is effective not only for detox but also for asthma. When a 7-year-old child had an asthma attack, it worked remarkably well! There are many sold out, making it difficult to obtain, but I definitely recommend it.
0
Dangerous side effects
1 people found this helpful
I warn everyone about it; it has dangerous effects, altering pulmonary artery pressure and heart pressure, changing the electrocardiogram, and causing breathing problems, whether taken orally or intravenously. This really happened to me, and I plan to dispose of the rest of the box. I was left panting after seeking health and treatment.
7.5
Supports heart health
1 people found this helpful
Doctor's Best supplements are practical and high-quality. The capsules are small and easy to swallow. NAC offers benefits as an antioxidant, promoting liver and heart health.
0
Overall body benefits
Awesome product! The quality is excellent, with many ingredients and a good quantity. The package is of a medium size, suitable for adults. It benefits the whole body and supports a good diet. Plus, it has no distinct taste. 
Frequently Asked Questions
9
Effective for detox
25 people found this helpful
It became an unpleasant world, and I bought it for detoxification. I heard it is effective not only for detox but also for asthma. When a 7-year-old child had an asthma attack, it worked remarkably well! There are many sold out, making it difficult to obtain, but I definitely recommend it.
7.5
Supports heart health
1 people found this helpful
Doctor's Best supplements are practical and high-quality. The capsules are small and easy to swallow. NAC offers benefits as an antioxidant, promoting liver and heart health.
0
Dangerous side effects
1 people found this helpful
I warn everyone about it; it has dangerous effects, altering pulmonary artery pressure and heart pressure, changing the electrocardiogram, and causing breathing problems, whether taken orally or intravenously. This really happened to me, and I plan to dispose of the rest of the box. I was left panting after seeking health and treatment.
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
8
We explored the effects of selenium (Se) on heart health, specifically its ability to promote healing after a heart attack, also known as myocardial infarction (MI). Our research was conducted using a rat model where we induced heart attacks using a chemical agent called isoprenaline (ISP). After one week, we administered selenium either by itself or combined with another treatment, pentoxifylline (PTXF).
We found that selenium, both alone and with PTXF, showed promising potential in reducing damage caused by heart attacks. The treatment led to improvements in heart function indicators and enhanced angiogenesis, which is the formation of new blood vessels—critical for healing. Importantly, the combination of selenium and PTXF was more effective than using either treatment separately.
Our study highlights the beneficial effects of selenium on cardiac health and suggests a new avenue for treatment strategies following heart attacks. These results point to selenium, especially combined with PTXF, as a potentially impactful option for further investigation in clinical settings.
We found that selenium, both alone and with PTXF, showed promising potential in reducing damage caused by heart attacks. The treatment led to improvements in heart function indicators and enhanced angiogenesis, which is the formation of new blood vessels—critical for healing. Importantly, the combination of selenium and PTXF was more effective than using either treatment separately.
Our study highlights the beneficial effects of selenium on cardiac health and suggests a new avenue for treatment strategies following heart attacks. These results point to selenium, especially combined with PTXF, as a potentially impactful option for further investigation in clinical settings.
8
A recent case-control study within the PREDIMED trial aimed to find out if low selenium levels might increase the risk of heart attacks and other cardiovascular events. We focused on a group of 207 participants who had experienced significant cardiovascular events, such as heart attacks or strokes, and compared them to 436 controls that matched in sex, age, and intervention group.
The findings revealed that women with a heart condition had lower selenium levels compared to those without, suggesting a possible link between selenium deficiency and heart health. Interestingly, we discovered that, across all participants, there was an inverse relationship between selenium levels and cardiovascular risk. In fact, those with higher selenium concentrations experienced a reduced risk for their first cardiovascular event, highlighting the mineral's potential protective role.
While compared to dietary habits, selenium levels were found to be influenced by factors such as protein and fish intake, as well as age and body mass index. This connection indicates that a well-rounded diet might enhance selenium levels, potentially bolstering heart health.
Ultimately, though we found some positive associations between selenium levels and cardiovascular risk, it’s essential to note the varying factors at play, especially given that lifestyle and diet also play a significant role in cardiovascular health.
The findings revealed that women with a heart condition had lower selenium levels compared to those without, suggesting a possible link between selenium deficiency and heart health. Interestingly, we discovered that, across all participants, there was an inverse relationship between selenium levels and cardiovascular risk. In fact, those with higher selenium concentrations experienced a reduced risk for their first cardiovascular event, highlighting the mineral's potential protective role.
While compared to dietary habits, selenium levels were found to be influenced by factors such as protein and fish intake, as well as age and body mass index. This connection indicates that a well-rounded diet might enhance selenium levels, potentially bolstering heart health.
Ultimately, though we found some positive associations between selenium levels and cardiovascular risk, it’s essential to note the varying factors at play, especially given that lifestyle and diet also play a significant role in cardiovascular health.
References
- Çetin E. Pretreatment with β-glucan attenuates isoprenaline-induced myocardial injury in rats. Exp Physiol. 2019;104:505. doi:10.1113/EP086739
- Al-Rasheed NM, Attia HA, Mohamed RA, Al-Rasheed NM, Al-Amin MA. Preventive effects of selenium yeast, chromium picolinate, zinc sulfate and their combination on oxidative stress, inflammation, impaired angiogenesis and atherogenesis in myocardial infarction in rats. J Pharm Pharm Sci. 2013;16:848.
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
- Elseweidy MM, Ali SI, Shaheen MA, Abdelghafour AM, Hammad SK. Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4677. doi:10.1007/s00210-023-02904-9
- Sun Q, Yao J, Zhang Z, Li J, Zhang X, et al. Facile fabrication of biocompatible injectable blended polymeric hydrogel with bioactive nanoformulation to improving cardiac tissue regeneration efficiency after myocardial infarction for nursing care potential applications. Nanotoxicology. 2023;17:432. doi:10.1080/17435390.2023.2252921
- Wang Z, Yang N, Hou Y, Li Y, Yin C, et al. L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function. Adv Sci (Weinh). 2023;10:e2302123. doi:10.1002/advs.202302123
- Sun Q, Ma H, Zhang J, You B, Gong X, et al. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Adv Sci (Weinh). 2023;10:e2204999. doi:10.1002/advs.202204999
- Gutiérrez-Bedmar M, Gil F, Olmedo P, Ruiz-Canela M, Martínez-González MÁ, et al. Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11226664
- Yang C, Zhu C, Li Y, Li Z, Zhang Z, et al. Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction. Front Bioeng Biotechnol. 2022;10:912562. doi:10.3389/fbioe.2022.912562
- Filonenko M, Zhuravlyova L, Sokolnikova N. CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION. Wiad Lek. 2022;75:362.
- Frączek-Jucha M, Kabat M, Szlósarczyk B, Czubek U, Nessler J, et al. Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure. Kardiol Pol. 2019;77:674. doi:10.33963/KP.14822
- Büttner P, Obradovic D, Wunderlich S, Feistritzer HJ, Holzwirth E, et al. Selenoprotein P in Myocardial Infarction With Cardiogenic Shock. Shock. 2020;53:58. doi:10.1097/SHK.0000000000001342
- Khaki-Khatibi F, Mansouri F, Hajahmadipoorrafsanjani M, Ghojazadeh M, Gholikhani-Darbroud R. Study of rs1137101 polymorphism of leptin receptor gene with serum levels of selenium and copper in the patients of non-ST-segment elevation myocardial infarction (NSTEMI) in an Iranian population. Clin Biochem. 2018;60:64. doi:10.1016/j.clinbiochem.2018.06.016
- Dallak M. A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Arch Physiol Biochem. 2017;123:344. doi:10.1080/13813455.2017.1347687
- Hu XF, Eccles KM, Chan HM. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ Int. 2017;102:200. doi:10.1016/j.envint.2017.03.002
- Afridi HI, Kazi TG, Talpur FN, Kazi A, Arain SS, et al. Interaction between selenium and mercury in biological samples of Pakistani myocardial infarction patients at different stages as related to controls. Biol Trace Elem Res. 2014;158:143. doi:10.1007/s12011-014-9932-8
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
- Siniavskiĭ IuA, Kraĭsman VA, Suleĭmenova ZhM. [Using of a specialized fermented soy milk product on the basis of soybeans in cardiology practice]. Vopr Pitan. 2013;82:51.
- Ošt'ádalová I. Biological effects of selenium compounds with a particular attention to the ontogenetic development. Physiol Res. 2012;61:S19.
